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Entry version 95 (02 Jun 2021)
Sequence version 2 (05 May 2009)
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Protein

Protein Shroom

Gene

Shrm

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to Rho-kinase Rok and targets it to the apical cell cortex where it mediates apical constriction (PubMed:20549743, PubMed:22493320).

During embryogenic axis elongation, required for the localization to adherens junctions and the establishment of planar polarization of both Rho-kinase Rok and myosin regulatory light chain sqh (PubMed:24535826).

May be involved in the assembly of microtubule arrays during cell elongation (By similarity).

By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: UniProtKB
  • kinase binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Shroom1 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Shrm1 PublicationImported
Synonyms:ShroomImported
ORF Names:CG34379Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0085408, Shrm

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

During axis elongation in the embryo decreases localization to adherens junctions and planar polarization for both Rho-kinase Rok and myosin regulatory light chain sqh (PubMed:24535826). The mislocalization of sqh impairs the generation of sustained actomyosin contractility during cell rearrangement and can account for the reduction in the formation of multicellular rosette and convergent extension (PubMed:24535826). RNAi-mediated knockdown in the embryo decreases Rho-kinase Rok localization to adherens junctions and planar polarization during axis elongation (PubMed:24535826). Has no effect on Rho1 localization or activity (PubMed:24535826). Isoform D: RNAi-mediated knockdown in the embryo, ecreases localization to adherens junctions and planar polarization for both Rho-kinase Rok and myosin regulatory light chain sqh (PubMed:24535826).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1402 – 1406KMDEL → AMDRA: Does not affect dimerization or binding to Rok. 5
Mutagenesisi1468 – 1471LLSL → AASA: Loss of dimerization and binding to Rok. 1 Publication4
Mutagenesisi1470 – 1476SLSERLA → ALEEDLE: Reduces binding to Rok. 1 Publication7
Mutagenesisi1509 – 1516LKSDIERR → AASDIEDA: Loss of binding to Rok. 1 Publication8
Mutagenesisi1546 – 1553LIADARDL → AAADARDA: Loss of dimerization and binding to Rok. 1 Publication8

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002860691 – 1576Protein ShroomAdd BLAST1576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei404Phosphoserine1 Publication1
Modified residuei667Phosphoserine1 Publication1
Modified residuei668Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1Z9P3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A1Z9P3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the embryo (at protein level) (PubMed:20549743). Expressed in the dorsal trunk of the trachea (at protein level) (PubMed:20549743). Isoform D: Expressed in the invaginating foregut (at protein level) (PubMed:20549743). Planar polarized during axis elongation from stage 7 (at protein level) (PubMed:24535826).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0085408, Expressed in saliva-secreting gland and 83 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A1Z9P3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1Z9P3, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer or homodimer (PubMed:22493320).

Interacts with Rok (PubMed:22493320).

1 Publication

Binds (via N-terminus) to F-actin (PubMed:20549743).

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
62342, 13 interactors

Protein interaction database and analysis system

More...
IntActi
A1Z9P3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0111526

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11576
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1Z9P3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1305 – 1572ASD2PROSITE-ProRule annotationAdd BLAST268

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 31DisorderedSequence analysisAdd BLAST31
Regioni46 – 100DisorderedSequence analysisAdd BLAST55
Regioni112 – 142DisorderedSequence analysisAdd BLAST31
Regioni187 – 244DisorderedSequence analysisAdd BLAST58
Regioni267 – 434DisorderedSequence analysisAdd BLAST168
Regioni445 – 920F-actin binding region required for planar polarity and cortical localization2 PublicationsAdd BLAST476
Regioni589 – 609DisorderedSequence analysisAdd BLAST21
Regioni621 – 660DisorderedSequence analysisAdd BLAST40
Regioni699 – 728DisorderedSequence analysisAdd BLAST30
Regioni743 – 823DisorderedSequence analysisAdd BLAST81
Regioni849 – 876DisorderedSequence analysisAdd BLAST28
Regioni910 – 939DisorderedSequence analysisAdd BLAST30
Regioni1036 – 1055DisorderedSequence analysisAdd BLAST20
Regioni1091 – 1116DisorderedSequence analysisAdd BLAST26
Regioni1210 – 1244DisorderedSequence analysisAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1232 – 1296Sequence analysisAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi14 – 31Polar residuesSequence analysisAdd BLAST18
Compositional biasi191 – 207Basic residuesSequence analysisAdd BLAST17
Compositional biasi208 – 244Polar residuesSequence analysisAdd BLAST37
Compositional biasi267 – 281Polar residuesSequence analysisAdd BLAST15
Compositional biasi297 – 321Polar residuesSequence analysisAdd BLAST25
Compositional biasi352 – 434Polar residuesSequence analysisAdd BLAST83
Compositional biasi626 – 643Polar residuesSequence analysisAdd BLAST18
Compositional biasi765 – 786Pro residuesSequence analysisAdd BLAST22
Compositional biasi796 – 817Pro residuesSequence analysisAdd BLAST22
Compositional biasi910 – 933Polar residuesSequence analysisAdd BLAST24
Compositional biasi1094 – 1108Pro residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ASD2 domain mediates the interaction with Rok and is required for apical constriction induction.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the shroom family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QUU2, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167525

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_242240_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1Z9P3

Identification of Orthologs from Complete Genome Data

More...
OMAi
TMIYGQA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1Z9P3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014799, ASD2_dom
IPR030493, Shroom
IPR027685, Shroom_fam

The PANTHER Classification System

More...
PANTHERi
PTHR15012, PTHR15012, 1 hit
PTHR15012:SF32, PTHR15012:SF32, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08687, ASD2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51307, ASD2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform DImported (identifier: A1Z9P3-3) [UniParc]FASTAAdd to basket
Also known as: dShrmA2 Publications

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKMRNHKENG NGSEMGESTK SLAKMEPENN NKISVVSVSK LLLKDSNGAN
60 70 80 90 100
SRSSNSNASF SSASVAGSVQ DDLPHHNSSS SQLGQQHGSS LDQCGLTQAG
110 120 130 140 150
LEEYNNRSSS YYDQTAFHHQ KQPSYAQSEG YHSYVSSSDS TSATPFLDKL
160 170 180 190 200
RQESDLLSRQ SHHWSENDLS SVCSNSVAPS PIPLLARQSH SHSHSHAHSH
210 220 230 240 250
SNSHGHSHGH AHSASSSSSS NNNSNGSATN NNNNNSSEST SSTETLKWLG
260 270 280 290 300
SMSDISEASH ATGYSAISES VSSSQRIVHS SRVPTPKRHH SESVLYLHNN
310 320 330 340 350
EEQGDSSPTA SNSSQMMISE EANGEESPPS VQPLRIQHRH SPSYPPVHTS
360 370 380 390 400
MVLHHFQQQQ QQQQDYQHPS RHHTNQSTLS TQSSLLELAS PTEKPRSLMG
410 420 430 440 450
QSHSMGDLQQ KNPHQNPMLG RSAGQQHKSS ISVTISSSEA VVTIAPQPPA
460 470 480 490 500
GKPSKLQLSL GKSEALSCST PNMGEQSPTN SIDSYRSNHR LFPVSTYTEP
510 520 530 540 550
VHSNTSQYVQ HPKPQFSSGL HKSAKLPVIT PAGATVQPTW HSVAERINDF
560 570 580 590 600
ERSQLGEPPK FAYLEPTKTH RLSNPALKAL QKNAVQSYVE RQQQQQKEEQ
610 620 630 640 650
QLLRPHSQSY QACHVERKSL PNNLSPIMVG LPTGSNSAST RDCSSPTPPP
660 670 680 690 700
PPRRSGSLLP NLLRRSSSAS DYAEFRELHQ AQGQVKGPSI RNISNAEKIS
710 720 730 740 750
FNDCGMPPPP PPPRGRLAVP TRRTSSATEY APMRDKLLLQ QAAALAHQQH
760 770 780 790 800
HPQQHRHAQP PHVPPERPPK HPNLRVPSPE LPPPPQSELD ISYTFDEPLP
810 820 830 840 850
PPPPPEVLQP RPPPSPNRRN CFAGASTRRT TYEAPPPTAI VAAKVPPLVP
860 870 880 890 900
KKPTSLQHKH LANGGGGSRK RPHHATPQPI LENVASPVAP PPPLLPRARS
910 920 930 940 950
TAHDNVIASN LESNQQKRSN SKASYLPRQS LEKLNNTDPD HGIYKLTLTS
960 970 980 990 1000
NEDLVAHTKP SYGVTGKLPN NLPDVLPLGV KLHQQPKLQP GSPNGDANVT
1010 1020 1030 1040 1050
LRYGSNNNLT GNSPTVAPPP YYGGGQRYST PVLGQGYGKS SKPVTPQQYT
1060 1070 1080 1090 1100
RSQSYDVKHT SAVTMPTMSQ SHVDLKQAAH DLETTLEEVL PTATPTPTPT
1110 1120 1130 1140 1150
PTPTPPRLSP ASSHSDCSLS TSSLECTINP IATPIPKPEA HIFRAEVIST
1160 1170 1180 1190 1200
TLNTNPLTTP PKPAMNRQES LRENIEKITQ LQSVLMSAHL CDASLLGGYT
1210 1220 1230 1240 1250
TPLITSPTAS FANEPLMTPP LPPSPPPPLE PEEEEEQEEN DVHDKQPEIE
1260 1270 1280 1290 1300
ELQLMQRSEL VLMVNPKPST TDMACQTDEL EDRDTDLEAA REEHQTRTTL
1310 1320 1330 1340 1350
QPRQRQPIEL DYEQMSRELV KLLPPGDKIA DILTPKICKP TSQYVSNLYN
1360 1370 1380 1390 1400
PDVPLRLAKR DVGTSTLMRM KSITSSAEIR VVSVELQLAE PSEEPTNLIK
1410 1420 1430 1440 1450
QKMDELIKHL NQKIVSLKRE QQTISEECSA NDRLGQDLFA KLAEKVRPSE
1460 1470 1480 1490 1500
ASKFRTHVDA VGNITSLLLS LSERLAQTES SLETRQQERG ALESKRDLLY
1510 1520 1530 1540 1550
EQMEEAQRLK SDIERRGVSI AGLLAKNLSA DMCADYDYFI NMKAKLIADA
1560 1570
RDLAVRIKGS EEQLSSLSDA LVQSDC
Length:1,576
Mass (Da):172,713
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52A7D124F9559D13
GO
Isoform FImported (identifier: A1Z9P3-2) [UniParc]FASTAAdd to basket
Also known as: dShrmB1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     2-10: KMRNHKENG → AQWFQWLNF
     11-917: Missing.

Show »
Length:669
Mass (Da):74,175
Checksum:iF22B2C2E0F946C2B
GO
Isoform GImported (identifier: A1Z9P3-1) [UniParc]FASTAAdd to basket
Also known as: dShrmC1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     2-10: KMRNHKENG → VFGGKFRIR
     11-917: Missing.

Show »
Length:669
Mass (Da):74,015
Checksum:iCC509350FB342EDE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4LFC0A0A0B4LFC0_DROME
Shroom, isoform H
Shrm CG13942, CG13944, CG8603, Dmel\CG34379, dmShroom
1,576Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0249712 – 10KMRNHKENG → AQWFQWLNF in isoform F. 1 Publication9
Alternative sequenceiVSP_0369992 – 10KMRNHKENG → VFGGKFRIR in isoform G. Curated9
Alternative sequenceiVSP_03700011 – 917Missing in isoform F and isoform G. 1 PublicationAdd BLAST907

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58259.2
AE013599 Genomic DNA Translation: AAM70999.2
AE013599 Genomic DNA Translation: AAF58260.2
AY069213 mRNA Translation: AAL39358.1
BT023900 mRNA Translation: ABA81834.1

NCBI Reference Sequences

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RefSeqi
NP_001097307.1, NM_001103837.2 [A1Z9P3-3]
NP_001286417.1, NM_001299488.1 [A1Z9P3-3]
NP_610952.1, NM_137108.3 [A1Z9P3-2]
NP_725378.2, NM_166047.2 [A1Z9P3-1]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0112614; FBpp0111526; FBgn0085408 [A1Z9P3-3]
FBtr0112616; FBpp0111528; FBgn0085408 [A1Z9P3-2]
FBtr0290253; FBpp0288692; FBgn0085408 [A1Z9P3-1]
FBtr0339991; FBpp0309010; FBgn0085408 [A1Z9P3-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
36592

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG34379

UCSC genome browser

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UCSCi
CG34379-RD, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58259.2
AE013599 Genomic DNA Translation: AAM70999.2
AE013599 Genomic DNA Translation: AAF58260.2
AY069213 mRNA Translation: AAL39358.1
BT023900 mRNA Translation: ABA81834.1
RefSeqiNP_001097307.1, NM_001103837.2 [A1Z9P3-3]
NP_001286417.1, NM_001299488.1 [A1Z9P3-3]
NP_610952.1, NM_137108.3 [A1Z9P3-2]
NP_725378.2, NM_166047.2 [A1Z9P3-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3THFX-ray2.70A/B1393-1576[»]
SMRiA1Z9P3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi62342, 13 interactors
IntActiA1Z9P3, 1 interactor
STRINGi7227.FBpp0111526

PTM databases

iPTMnetiA1Z9P3

Proteomic databases

PaxDbiA1Z9P3

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
36592

Genome annotation databases

EnsemblMetazoaiFBtr0112614; FBpp0111526; FBgn0085408 [A1Z9P3-3]
FBtr0112616; FBpp0111528; FBgn0085408 [A1Z9P3-2]
FBtr0290253; FBpp0288692; FBgn0085408 [A1Z9P3-1]
FBtr0339991; FBpp0309010; FBgn0085408 [A1Z9P3-3]
GeneIDi36592
KEGGidme:Dmel_CG34379
UCSCiCG34379-RD, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36592
FlyBaseiFBgn0085408, Shrm

Phylogenomic databases

eggNOGiENOG502QUU2, Eukaryota
GeneTreeiENSGT00940000167525
HOGENOMiCLU_242240_0_0_1
InParanoidiA1Z9P3
OMAiTMIYGQA
PhylomeDBiA1Z9P3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
36592, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
36592

Protein Ontology

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PROi
PR:A1Z9P3

Gene expression databases

BgeeiFBgn0085408, Expressed in saliva-secreting gland and 83 other tissues
ExpressionAtlasiA1Z9P3, baseline and differential
GenevisibleiA1Z9P3, DM

Family and domain databases

InterProiView protein in InterPro
IPR014799, ASD2_dom
IPR030493, Shroom
IPR027685, Shroom_fam
PANTHERiPTHR15012, PTHR15012, 1 hit
PTHR15012:SF32, PTHR15012:SF32, 1 hit
PfamiView protein in Pfam
PF08687, ASD2, 1 hit
PROSITEiView protein in PROSITE
PS51307, ASD2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHRM_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1Z9P3
Secondary accession number(s): A1Z9P2, Q3KN39, Q7K1B1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 5, 2009
Last modified: June 2, 2021
This is version 95 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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