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Entry version 124 (16 Oct 2019)
Sequence version 2 (13 Nov 2007)
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Protein
Submitted name:

Acid labile subunit

Gene

conv

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Acid labile subunitImported
Submitted name:
Convoluted, isoform AImported
Submitted name:
Convoluted, isoform BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:convImported
Synonyms:ALSImported, AlsImported, capricious-likeImported, CT24963Imported, dALSImported, Dmel\CG8561Imported, l(2)k06507bImported, tartanImported
ORF Names:CG8561Imported, Dmel_CG8561Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0261269 conv

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501508596521 – 1092Sequence analysisAdd BLAST1072

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A1Z9N6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261269 Expressed in 15 organ(s), highest expression level in imaginal disc

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0086669

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

Identification of Orthologs from Complete Genome Data

More...
OMAi
GWCNVSH

Database of Orthologous Groups

More...
OrthoDBi
826997at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR026906 LRR_5
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13306 LRR_5, 1 hit
PF13855 LRR_8, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 23 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 26 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1Z9N6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIQLRLRTLV LLHFIALASS EYVYGEPEFK CPKKSKALYP CECVKGSDNG
60 70 80 90 100
LYIRCENTNL ATLSVALQNL ASFGMPIEEL TIYRGHFVRL YGPLFAHIKA
110 120 130 140 150
RMLIIEETPL ATIEDYVFYG VNNTLEQLHL LRTNLSHVGL LGFGILGKAK
160 170 180 190 200
ELVIDGHAFQ QLPKDLFAGQ EIANSLGIIR VTNGNLSDLP IETFQPLRKL
210 220 230 240 250
KTLDLHGNQL ENLKRNQFKN LRELEVLDIS HNQIKKLEAQ HIADLTKLGW
260 270 280 290 300
CNVSHNALSE LSRGTFARNS VLKVLHLSHN QIARLDANSF RGMRFLRRLF
310 320 330 340 350
LSDNVLTDIG RGTFGSIARI GTIDLARNRL KKIEFQMFTQ MNYVELLDLA
360 370 380 390 400
ENNITKIEKN SFKDIYQAII NVSHNALELI ETAAFENCVN ITVLDLSHNR
410 420 430 440 450
LANFSRRSFD ETTFATYFQL SYNNLTNLAQ IPIQNMTGLK VLNASYNSIT
460 470 480 490 500
EIPKNCFPKL YELHTIDVSH NNISSIFNGV FQTLFSLRSI DLSHNSMREI
510 520 530 540 550
KSSTFGTLPT LLEMDLSHNE LVSVVRGSLA KLTSLRQLYL NNNQLEKLFQ
560 570 580 590 600
LPISLNELYF SHNRLTNIPS GTWPVMNSLI YLDLSHNQLG DTLNGESFTG
610 620 630 640 650
LLVVQRLKLQ NNGISQPPKD AVAVMSTLQY LHLENNNITT LERSAFGKLP
660 670 680 690 700
VLFELNLYGN QVKDISKRAF EGLLQLLTLN LSSNGIQTLQ NDIFVGLPSL
710 720 730 740 750
RNLDLSFNSL TKLDNKTNGV LDDLLSLETL DLSHNRISFV TKKTFPSHQY
760 770 780 790 800
IPYNLRNLNL SYNLMPILTY DITFGTKKLV RLDVSHNQIN DLRRGVISNF
810 820 830 840 850
TSLQSLDMSY NELSNLKSEE HIFDLPQNLS WLDLSHNKIY HLPFANLVKV
860 870 880 890 900
KSLKYVDLTN NSLEDVPASI VGSMRNGSQV LLAGNPLHCG CNARPLKYFM
910 920 930 940 950
LQQTIAGEDL KSIYCGTPAL IKDKQLISLD DEYLHCAEDE QEMYKGIDYE
960 970 980 990 1000
QLTDVRFREV KTNKAGMLTL CWYVSGFSDV SDFHVYIRSS SNDVLHQSDY
1010 1020 1030 1040 1050
AYNNRTAQIP VEELSTLGEE KLRGAEICIV SRDSDGNTRK WFSGQCQQLP
1060 1070 1080 1090
SLKRPRTFFF GNFQVRGGVS RTSSSLPRCL LYIILVLFVA RL
Length:1,092
Mass (Da):123,827
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C570C8013902CDB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58265.2
EU814872 mRNA Translation: ACI23397.1
AE013599 Genomic DNA Translation: AHN56214.1

NCBI Reference Sequences

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RefSeqi
NP_001286416.1, NM_001299487.1
NP_610948.2, NM_137104.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087540; FBpp0086669; FBgn0261269
FBtr0339967; FBpp0308988; FBgn0261269

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36588

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8561

UCSC genome browser

More...
UCSCi
CG8561-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58265.2
EU814872 mRNA Translation: ACI23397.1
AE013599 Genomic DNA Translation: AHN56214.1
RefSeqiNP_001286416.1, NM_001299487.1
NP_610948.2, NM_137104.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0086669

Proteomic databases

PRIDEiA1Z9N6

Genome annotation databases

EnsemblMetazoaiFBtr0087540; FBpp0086669; FBgn0261269
FBtr0339967; FBpp0308988; FBgn0261269
GeneIDi36588
KEGGidme:Dmel_CG8561
UCSCiCG8561-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36588
FlyBaseiFBgn0261269 conv

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
OMAiGWCNVSH
OrthoDBi826997at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36588

Protein Ontology

More...
PROi
PR:A1Z9N6

Gene expression databases

BgeeiFBgn0261269 Expressed in 15 organ(s), highest expression level in imaginal disc

Family and domain databases

Gene3Di3.80.10.10, 6 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR026906 LRR_5
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13306 LRR_5, 1 hit
PF13855 LRR_8, 6 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 23 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 26 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1Z9N6_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1Z9N6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: November 13, 2007
Last modified: October 16, 2019
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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