FI24033p1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• GTPase activator activity Source: FlyBase

GO - Biological processⁱ

• cell fate determination Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation."
    Jones W.M., Chao A.T., Zavortink M., Saint R., Bejsovec A.
    J Cell Sci 123:2179-2189(2010) [PubMed] [Europe PMC] [Abstract]
• cellular protein localization Source: FlyBaseInferred from mutant phenotypeⁱ
  • "RacGAP50C directs perinuclear gamma-tubulin localization to organize the uniform microtubule array required for Drosophila myotube extension."
    Guerin C.M., Kramer S.G.
    Development 136:1411-1421(2009) [PubMed] [Europe PMC] [Abstract]
• dendrite morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Genes regulating dendritic outgrowth, branching, and routing in Drosophila."
    Gao F.B., Brenman J.E., Jan L.Y., Jan Y.N.
    Genes Dev 13:2549-2561(1999) [PubMed] [Europe PMC] [Abstract]
• maintenance of protein location in cell Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis."
    Dean S.O., Rogers S.L., Stuurman N., Vale R.D., Spudich J.A.
    Proc Natl Acad Sci U S A 102:13473-13478(2005) [PubMed] [Europe PMC] [Abstract]
• mitotic cytokinesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cells."
    Somma M.P., Fasulo B., Cenci G., Cundari E., Gatti M.
    Mol. Biol. Cell 13:2448-2460(2002) [PubMed] [Europe PMC] [Abstract]
  • "Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis."
    Dean S.O., Rogers S.L., Stuurman N., Vale R.D., Spudich J.A.
    Proc Natl Acad Sci U S A 102:13473-13478(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of canonical Wnt signaling pathway Source: FlyBaseInferred from mutant phenotypeⁱ
  • "RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development."
    Jones W.M., Bejsovec A.
    Genetics 169:2075-2086(2005) [PubMed] [Europe PMC] [Abstract]
  • "Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation."
    Jones W.M., Chao A.T., Zavortink M., Saint R., Bejsovec A.
    J Cell Sci 123:2179-2189(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of epidermal growth factor receptor signaling pathway Source: FlyBaseInferred from mutant phenotypeⁱ
  • "DRacGAP, a novel Drosophila gene, inhibits EGFR/Ras signalling in the developing imaginal wing disc."
    Sotillos S., Campuzano S.
    Development 127:5427-5438(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of ERK1 and ERK2 cascade Source: FlyBaseInferred from mutant phenotypeⁱ
  • "DRacGAP, a novel Drosophila gene, inhibits EGFR/Ras signalling in the developing imaginal wing disc."
    Sotillos S., Campuzano S.
    Development 127:5427-5438(2000) [PubMed] [Europe PMC] [Abstract]
• regulation of cytokinesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster."
    Zavortink M., Contreras N., Addy T., Bejsovec A., Saint R.
    J. Cell Sci. 118:5381-5392(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of microtubule cytoskeleton organization Source: FlyBaseInferred from mutant phenotypeⁱ
  • "RacGAP50C directs perinuclear gamma-tubulin localization to organize the uniform microtubule array required for Drosophila myotube extension."
    Guerin C.M., Kramer S.G.
    Development 136:1411-1421(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of stem cell differentiation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila."
    Liu Y., Ge Q., Chan B., Liu H., Singh S.R., Manley J., Lee J., Weideman A.M., Hou G., Hou S.X.
    Nat Commun 7:12149-12149(2016) [PubMed] [Europe PMC] [Abstract]
• response to wounding Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Prepatterning by RhoGEFs governs Rho GTPase spatiotemporal dynamics during wound repair."
    Nakamura M., Verboon J.M., Parkhurst S.M.
    J Cell Biol 216:3959-3969(2017) [PubMed] [Europe PMC] [Abstract]
• Rho protein signal transduction Source: FlyBase <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "DRacGAP, a novel Drosophila gene, inhibits EGFR/Ras signalling in the developing imaginal wing disc."
    Sotillos S., Campuzano S.
    Development 127:5427-5438(2000) [PubMed] [Europe PMC] [Abstract]
• somatic muscle development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "RacGAP50C directs perinuclear gamma-tubulin localization to organize the uniform microtubule array required for Drosophila myotube extension."
    Guerin C.M., Kramer S.G.
    Development 136:1411-1421(2009) [PubMed] [Europe PMC] [Abstract]
• wound healing Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Prepatterning by RhoGEFs governs Rho GTPase spatiotemporal dynamics during wound repair."
    Nakamura M., Verboon J.M., Parkhurst S.M.
    J Cell Biol 216:3959-3969(2017) [PubMed] [Europe PMC] [Abstract]

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MALSALASFD DLRRCMQVLT DGTPEEEFLR FLRMFEQYHE KCAGYAAETA 
        60         70         80         90        100
RIQNELDKSL TKMGDLEGKL FHARRIIDME IKARRQAEHE RDAMESKIMA 
       110        120        130        140        150
VADLLRHERN LNNETRDKLA FLHTLPSSRK RKSLNAVRED KSYGDINSTG 
       160        170        180        190        200
SLLSDLSITH SEDDFLDVRT SKSWREHRPS LPKNQIPSVG NKRSRLSTGL 
       210        220        230        240        250
NGSMSGTTPT TGKSRRSSVG IGVEQHTVDV GQGAERFCAT TKVTIPQDGQ 
       260        270        280        290        300
GVIRAESTIE SLPVIAGNER IGDGLSSTPR RSVLKEATAP PLTPVNAMAP 
       310        320        330        340        350
HVVAESGTPL QHRPLMRNHT FSQKTFLRGD NCVQCQKRIR FGAVGLRCRD 
       360        370        380        390        400
CPVRCHIDCR YLLTVSCVPQ TGTPTTKTMT GYVTDFAPSI APMIPALIVH 
       410        420        430        440        450
CVNEIEARGL TEVGLYRLSS SEREYKALKE QFLRGKATPH LGNTDIYVLC 
       460        470        480        490        500
CCVKDFLRSL TEPLIPTSQW KDFANAVQNP DTKTAQDMLV KSVKQLPQAN 
       510        520        530        540        550
RDTLAFLILH FQRIAQCPVV LMPIDNISLI FGPTIVGYST PDPDQHAIYT 
       560        570        580        590        600
EVFTQKQVMK ALLELPVSFW EQYIVIDPTR TPATVIKRVP SNKNDLLSLY 
       610        620 
ATPFKGGTIK KRKFYGTPPA SAHKK                            

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ