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Entry version 135 (10 Feb 2021)
Sequence version 1 (06 Feb 2007)
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Protein

Pre-mRNA-splicing factor syf1 homolog

Gene

fand

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunit of the NTC(Nineteen)/Prp19 complex, which is part of the spliceosome (PubMed:24755291, PubMed:28087625). The complex participates in spliceosome assembly, its remodeling and is required for efficient spliceosome activation (PubMed:24755291, PubMed:28087625). Essential for efficient pre-mRNA splicing (PubMed:24755291, PubMed:28087625). In embryos, efficient pre-mRNA splicing of zygotic transcripts is essential during dynamic cellular processes that require rapid division and/or dramatic changes in gene expression such as blastoderm cellularization, tracheal branching morphogenesis, Malpighian morphogenesis and epidermal development (PubMed:24755291, PubMed:28087625, PubMed:10502111). Part of its role in promoting embryo tracheal development is also due to specifically splicing bnl transcripts which results in the activation of the BNL-FGF pathway (PubMed:28087625).3 Publications

Miscellaneous

Named 'fandango' after the Iberian folk dance to highlight the similarity of the blastoderm cellularization phenotype to the charleston/kuk phenotype (PubMed:24755291). The phenotype 'faint sausage (fas)', consisting of a poorly differentiated cuticle and head, was previously associated with the immunoglobulin domain protein CG17716 but is now known to be caused by mutations in the protein 'fandango' (PubMed:24755291).1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-6781823, Formation of TC-NER Pre-Incision Complex
R-DME-6782135, Dual incision in TC-NER
R-DME-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-DME-72163, mRNA Splicing - Major Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-mRNA-splicing factor syf1 homologBy similarity
Alternative name(s):
Pre-mRNA-splicing factor fandango1 Publication
Protein faint sausage1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fand1 PublicationImported
Synonyms:fas1 Publication
ORF Names:CG6197Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0033859, fand

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi69 – 883Missing : Embryonic lethal and displays defects in primary tracheal branching and Malpighian morphogenesis. Displays abnormal splicing of zygotic transcripts resulting in qualitative (intron retention) as well as quantitative (transcript abundance) changes in gene expression. Tracheal defects are likely due, at least in part, to the mis-splicing of bnl transcripts. Embryonic Malpighian tubules are shortened and round. 2 PublicationsAdd BLAST815
Mutagenesisi219 – 883Missing : H124; embryonic lethal and displays defects in primary tracheal branching. Tracheal defects are likely due at least in part, to the mis-splicing of bnl transcripts. Earlier developmental processes, such as gastrulation and germband retraction are unaffected. 1 PublicationAdd BLAST665
Mutagenesisi355 – 360Missing : Fand2; embryos display significant splicing defects in the small zygotic kuk transcript whereas there is no effect on splicing of the large maternal kuk transcript. Reduced protein levels of ISY1/CG9667 but no effect on Prp19. 1 Publication6
Mutagenesisi401A → V: Fand1; a large subset of zygotic but not maternally encoded pre-mRNAs, including the kuk transcript, display splicing defects. Consequently, maternally controlled oogenesis, such as primordial germ-cell formation and syncytial nuclear divisions, appear normal but during zygotically controlled blastoderm cellularization the cortical nuclei fail to elongate and become mislocalized. Reduced protein levels of ISY1/CG9667 but no effect on Prp19. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004478901 – 883Pre-mRNA-splicing factor syf1 homologAdd BLAST883

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1Z9G2

PRoteomics IDEntifications database

More...
PRIDEi
A1Z9G2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in adult ovaries and 0-3 hours embryos (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0033859, Expressed in saliva-secreting gland and 33 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A1Z9G2, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the NTC(Nineteen)/Prp19 complex composed of at least fand, Prp19,CG9667/ISY1 and Cdc5/CDC5L. Within the complex, interacts with Prp19 and ISY1/CG9667.

1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A1Z9G2, 5 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0086749

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1Z9G2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati13 – 45HAT 1Sequence analysisAdd BLAST33
Repeati46 – 78HAT 2Sequence analysisAdd BLAST33
Repeati88 – 120HAT 3Sequence analysisAdd BLAST33
Repeati122 – 156HAT 4Sequence analysisAdd BLAST35
Repeati158 – 190HAT 5Sequence analysisAdd BLAST33
Repeati268 – 303HAT 6Sequence analysisAdd BLAST36
Repeati368 – 406HAT 7Sequence analysisAdd BLAST39
Repeati463 – 495HAT 8Sequence analysisAdd BLAST33
Repeati531 – 565HAT 9Sequence analysisAdd BLAST35
Repeati570 – 604HAT 10Sequence analysisAdd BLAST35
Repeati642 – 676HAT 11Sequence analysisAdd BLAST35
Repeati678 – 712HAT 12Sequence analysisAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the crooked-neck family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2047, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000075140

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007736_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
TCKAVYD

Database of Orthologous Groups

More...
OrthoDBi
370051at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1Z9G2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003107, HAT
IPR011990, TPR-like_helical_dom_sf

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00386, HAT, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1Z9G2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTKTIKSLN LEINFEVEDV PYEEEILRNA YSVKHWLRYI DHKAKAPNNG
60 70 80 90 100
VNMVYERALK ELPGSYKIWH NYLRTRRKQV RGKIPTDPMY EEVNSAFERA
110 120 130 140 150
LVFMHKMPRI WMDYGAFMTS QCKITRTRHV FDRALRALPI TQHGRIWPLY
160 170 180 190 200
LQFVRRFEMP ETALRVYRRY LKLFPEDTEE YVDYLQEADR LDEAAQQLAH
210 220 230 240 250
IVDNEHFVSK HGKSNHQLWN ELCDLISKNP HKVHSLNVDA IIRGGLRRYT
260 270 280 290 300
DQLGHLWNSL ADYYVRSGLF DRARDIYEEA IQTVTTVRDF TQVFDEYAQF
310 320 330 340 350
EELSLNRRME QVAANEAATE EDDIDVELRL SRFEYLMERR LLLLNSVLLR
360 370 380 390 400
QNPHNVHEWH KRVTLYEDKP AEIISTYTEA VQTVQPKQAV GKLHTLWVEF
410 420 430 440 450
AKFYEANGQV EDARVVFERG TEVEYVKVED LAAVWCEWAE MELRQQQFEA
460 470 480 490 500
ALKLMQRATA MPKRKIAYYD DTETVQARLH RSLKVWSMYA DLEESFGTFK
510 520 530 540 550
TCKAVYERII DLKICTPQII INYGMFLEEH NYFEEAYRAY EKGISLFKWP
560 570 580 590 600
NVYDIWNSYL TKFLERYGGT KLERARDLFE QCLDQCPPEH AKYFYLLYAK
610 620 630 640 650
LEEEHGLARH AMSVYDRATS AVKEDEMFDM YNIFIKKAAE IYGLPRTREI
660 670 680 690 700
YEKAIESLPE QNMRHMCVKF AELETKLGEV DRARAIYAHC SQVCDPRITA
710 720 730 740 750
DFWQTWKEFE VRHGNEDTMR EMLRIKRSVQ ATYNTQVNMM AAQFLSTNNG
760 770 780 790 800
AAADAGAGAG PDAMRLLEEK ARQAAAESKQ KPIEKAASNI MFVRGETQGG
810 820 830 840 850
AKDKKDTVVN PDEIDIGDSD EDDEEEDDDE ENEMTNENQA SAAVTKTDEE
860 870 880
GLVMKKLRFE QKAIPAKVFG SLKPSNQGDS DGE
Length:883
Mass (Da):103,327
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35F5D93C849954FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti575A → V in ACO95726 (Ref. 3) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58348.1
BT082048 mRNA Translation: ACO95726.1
BT133178 mRNA Translation: AEZ68806.1

NCBI Reference Sequences

More...
RefSeqi
NP_610891.1, NM_137047.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087623; FBpp0086749; FBgn0033859

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36514

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6197

UCSC genome browser

More...
UCSCi
CG6197-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58348.1
BT082048 mRNA Translation: ACO95726.1
BT133178 mRNA Translation: AEZ68806.1
RefSeqiNP_610891.1, NM_137047.3

3D structure databases

SMRiA1Z9G2
ModBaseiSearch...

Protein-protein interaction databases

IntActiA1Z9G2, 5 interactors
STRINGi7227.FBpp0086749

Proteomic databases

PaxDbiA1Z9G2
PRIDEiA1Z9G2

Genome annotation databases

EnsemblMetazoaiFBtr0087623; FBpp0086749; FBgn0033859
GeneIDi36514
KEGGidme:Dmel_CG6197
UCSCiCG6197-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36514
FlyBaseiFBgn0033859, fand

Phylogenomic databases

eggNOGiKOG2047, Eukaryota
GeneTreeiENSGT00550000075140
HOGENOMiCLU_007736_0_0_1
OMAiTCKAVYD
OrthoDBi370051at2759
PhylomeDBiA1Z9G2

Enzyme and pathway databases

ReactomeiR-DME-6781823, Formation of TC-NER Pre-Incision Complex
R-DME-6782135, Dual incision in TC-NER
R-DME-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-DME-72163, mRNA Splicing - Major Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
36514, 1 hit in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
fas, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36514

Protein Ontology

More...
PROi
PR:A1Z9G2

Gene expression databases

BgeeiFBgn0033859, Expressed in saliva-secreting gland and 33 other tissues
ExpressionAtlasiA1Z9G2, baseline and differential

Family and domain databases

Gene3Di1.25.40.10, 5 hits
InterProiView protein in InterPro
IPR003107, HAT
IPR011990, TPR-like_helical_dom_sf
SMARTiView protein in SMART
SM00386, HAT, 13 hits
SUPFAMiSSF48452, SSF48452, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYF1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1Z9G2
Secondary accession number(s): C3KGI3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 18, 2019
Last sequence update: February 6, 2007
Last modified: February 10, 2021
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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