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UniProtKB - A1Z942 (A1Z942_DROME)
Protein
Glutaminase
Gene
GLS
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalytic activityi
- EC:3.5.1.2ARBA annotation
GO - Molecular functioni
- glutaminase activity Source: FlyBase
GO - Biological processi
- glutamate biosynthetic process Source: GO_Central
- glutamine catabolic process Source: GO_Central
- glutamine metabolic process Source: FlyBase
Keywordsi
Molecular function | HydrolaseImportedARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:CG42708Imported, Dmel_CG42708Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0261625, GLS |
VEuPathDBi | VectorBase:FBgn0261625 |
Expressioni
Gene expression databases
Bgeei | FBgn0261625, Expressed in adult hindgut (Drosophila) and 41 other tissues |
ExpressionAtlasi | A1Z942, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 143 | EF-hand_14InterPro annotationAdd BLAST | 91 | |
Repeati | 510 – 532 | ANKPROSITE-ProRule annotationAdd BLAST | 23 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 574 – 648 | DisorderedSequence analysisAdd BLAST | 75 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 587 – 640 | Polar residuesSequence analysisAdd BLAST | 54 |
Sequence similaritiesi
Belongs to the glutaminase family.ARBA annotation
Keywords - Domaini
ANK repeatPROSITE-ProRule annotationARBA annotation, RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000010463 |
OMAi | QCCSMEA |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 3.40.710.10, 1 hit |
HAMAPi | MF_00313, Glutaminase, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR012338, Beta-lactam/transpept-like IPR015868, Glutaminase IPR041541, Glutaminase_EF-hand |
PANTHERi | PTHR12544, PTHR12544, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF17959, EF-hand_14, 1 hit PF04960, Glutaminase, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF56601, SSF56601, 1 hit |
TIGRFAMsi | TIGR03814, Gln_ase, 1 hit |
PROSITEi | View protein in PROSITE PS50088, ANK_REPEAT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
A1Z942-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIAITILKNL RAPPLMNLVF ANRKLSFYDT SSTPKTKEDN AKLHREQEQR
60 70 80 90 100
NAEDVLFDMF ASEETGLISM GKFLAGLKTT GIRRNDPRVR ELMDNLKKVH
110 120 130 140 150
KLNNYETGSS AETQHLNRET FKAVVAPNIV LIAKAFRQQF VIPDFTSFVK
160 170 180 190 200
DIEDIYNRCK TNTLGKLADY IPQLARYNPD SWGLSICTID GQRFSIGDVD
210 220 230 240 250
VPFTLQSCSK PLTYAIALEK LGPKVVHSYV GQEPSGRNFN ELVLDQNKKP
260 270 280 290 300
HNPMINAGAI LTCSLMNALV KPDMTSAEIF DYTMSWFKRL SGGEYIGFNN
310 320 330 340 350
AVFLSEREAA DRNYALGFYM RENKCFPKRT NLKEVMDFYF QCCSMETNCE
360 370 380 390 400
AMSVIAASLA NGGICPTTEE KVFRPEVIRD VLSIMHSCGT YDYSGQFAFK
410 420 430 440 450
VGLPAKSGVS GGMMLVIPNV MGIFAWSPPL DHLGNTVRGL QFCEELVSMF
460 470 480 490 500
NFHRYDNLKH LSNKKDPRKH RYETKGLSIV NLLFSAASGD VTALRRHRLS
510 520 530 540 550
GMDITLADYD GRTALHLAAS EGHLECVKFL LEQCHVPHNP KDRWGNLPVD
560 570 580 590 600
EAENFGHCHV VEFLRSWAEK ADQSSEECKP EAVTSKTQAD EEICSTSDLE
610 620 630 640
TSPTTSPIPT PVESGSRAGS GRSSPVPSDA GSTASAGSSI DDKTKPGL
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA1Z944 | A1Z944_DROME | Glutaminase | GLS CG8772, CG8872, Dmel\CG42708, nemy, nemy-RB | 737 | Annotation score: | ||
Q0E9A1 | Q0E9A1_DROME | Glutaminase | GLS CG8772, CG8872, Dmel\CG42708, nemy, CG42708 | 671 | Annotation score: | ||
Q1RL13 | Q1RL13_DROME | Glutaminase | GLS CG8772, CG8872, Dmel\CG42708, nemy, CG42708 | 775 | Annotation score: | ||
A1Z943 | A1Z943_DROME | Glutaminase | GLS CG8772, CG8872, Dmel\CG42708, nemy, CG42708 | 658 | Annotation score: | ||
Q7JQK6 | Q7JQK6_DROME | Glutaminase | GLS CG8772, CG8872, Dmel\CG42708, nemy, CG42708 | 706 | Annotation score: | ||
E1JH47 | E1JH47_DROME | Glutaminase | GLS CG8772, CG8872, Dmel\CG42708, CG42708, Dmel_CG42708 | 701 | Annotation score: | ||
Q961I1 | Q961I1_DROME | Glutaminase | GLS CG8872, Dmel\CG42708, nemy, CG42708, CG8772 | 716 | Annotation score: | ||
A0A0B4LF95 | A0A0B4LF95_DROME | Glutaminase | GLS CG8772, CG8872, Dmel\CG42708, CG42708, Dmel_CG42708 | 727 | Annotation score: | ||
A0A0B4LGA3 | A0A0B4LGA3_DROME | Glutaminase | GLS CG8772, CG8872, Dmel\CG42708, CG42708, Dmel_CG42708 | 712 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAM68645.1 |
RefSeqi | NP_725215.1, NM_165941.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0302975; FBpp0292100; FBgn0261625 |
GeneIDi | 36396 |
UCSCi | CG8772-RE, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAM68645.1 |
RefSeqi | NP_725215.1, NM_165941.2 |
3D structure databases
SMRi | A1Z942 |
ModBasei | Search... |
PTM databases
SwissPalmi | A1Z942 |
Protocols and materials databases
DNASUi | 36396 |
Genome annotation databases
EnsemblMetazoai | FBtr0302975; FBpp0292100; FBgn0261625 |
GeneIDi | 36396 |
UCSCi | CG8772-RE, d. melanogaster |
Organism-specific databases
CTDi | 2744 |
FlyBasei | FBgn0261625, GLS |
VEuPathDBi | VectorBase:FBgn0261625 |
Phylogenomic databases
GeneTreei | ENSGT00390000010463 |
OMAi | QCCSMEA |
Miscellaneous databases
BioGRID-ORCSi | 36396, 0 hits in 3 CRISPR screens |
ChiTaRSi | GLS, fly |
GenomeRNAii | 36396 |
Gene expression databases
Bgeei | FBgn0261625, Expressed in adult hindgut (Drosophila) and 41 other tissues |
ExpressionAtlasi | A1Z942, baseline and differential |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 3.40.710.10, 1 hit |
HAMAPi | MF_00313, Glutaminase, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR012338, Beta-lactam/transpept-like IPR015868, Glutaminase IPR041541, Glutaminase_EF-hand |
PANTHERi | PTHR12544, PTHR12544, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF17959, EF-hand_14, 1 hit PF04960, Glutaminase, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF56601, SSF56601, 1 hit |
TIGRFAMsi | TIGR03814, Gln_ase, 1 hit |
PROSITEi | View protein in PROSITE PS50088, ANK_REPEAT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A1Z942_DROME | |
Accessioni | A1Z942Primary (citable) accession number: A1Z942 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 6, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | January 19, 2022 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |