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Entry version 106 (29 Sep 2021)
Sequence version 1 (06 Feb 2007)
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Protein
Submitted name:

Anastral spindle 3

Gene

ana3

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Anastral spindle 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ana3Imported
Synonyms:Ana3Imported, Dmel\CG13162Imported, l(2)SH0558Imported
ORF Names:CG13162Imported, Dmel_CG13162Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0266111, ana3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0266111

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1Z8X3

PRoteomics IDEntifications database

More...
PRIDEi
A1Z8X3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0266111, Expressed in oocyte and 28 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1Z8X3, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
A1Z8X3, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0087015

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 125RTTN_NInterPro annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni141 – 166DisorderedSequence analysisAdd BLAST26

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili9 – 29Sequence analysisAdd BLAST21
Coiled coili96 – 116Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPM7, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00640000091535

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_232193_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1Z8X3

Identification of Orthologs from Complete Genome Data

More...
OMAi
MINCCSC

Database of Orthologous Groups

More...
OrthoDBi
846261at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1Z8X3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030791, Rotatin
IPR029249, Rotatin_N

The PANTHER Classification System

More...
PANTHERi
PTHR31691, PTHR31691, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14726, RTTN_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1Z8X3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTKQSPALQ LAEGQLTKLT SESEEIRMRA LDQIETRFIR CLQLGEPIQF
60 70 80 90 100
KPVLLLKQLI RWFGYTPPLV PDRVLAMIME LLRSEYAEAV IRKIPYERFK
110 120 130 140 150
AELQKVRRVL HKQESKRVSE LLDDMNLLLL EKYNIDRVTP SVSSLSSNDI
160 170 180 190 200
PSQATESADS SSNQIYDNLK PEDYEPSWSH PCLDDVATMK SMIDLPRNSV
210 220 230 240 250
ELQLQLTELI IRMGDYPTEY FLQPPFVFLH LVQLQTMTDG SLIHVNRALI
260 270 280 290 300
ACLRLLQQRI LLRRNTLSYA DRFDPPSRPK QVKVVSALVI LLENCMKLIR
310 320 330 340 350
PLLFSCTNDN WHIMELIVEI VRTHDVLSSK IPLVSITLIA DAVKSLLAYC
360 370 380 390 400
NSVEGSCMTQ LMDSLRIPRL QSLILNGVLH DMVALNINYD KRMDRRQAKA
410 420 430 440 450
LIQPIVLDSA YLSGMPERMK SLNTLISSLD SGPSPDEELI KLKRAYSVAL
460 470 480 490 500
NQLHPNTELT GSLLIQKYRQ VCLVLVQLGS ETLVKQLFGA VVKCIPFYAG
510 520 530 540 550
NLKLRKDADE LLYTLVDLPA LKLRSLIYRL MIKSTVAHFH SFMNKTVYMT
560 570 580 590 600
GCSNVDLIRQ HILGVPLTPL LLRRMIIQSS EANTSERMQQ WCLDYPIMIM
610 620 630 640 650
KLNAILAPQD FSVVFPLLLP VLPLLISRSV THKILHNVIW NVLEPDSSRL
660 670 680 690 700
DPQLMLRGYV YFMFHPDGEV RSEATTTIAY VLQCQEQTNR YLPTASNVPV
710 720 730 740 750
EHIANDLCII QPPFCYRSIF IKCSDERFQG QRSLDALFRL LQAKDIKSNI
760 770 780 790 800
RKSTMTQLNV LLRNWRACEE FSTKEDGYRL IMESLHNALK KGNDTDILLP
810 820 830 840 850
TVSILMKLLF NDDEFRLEVA NTFGVYTLLL RALFLFPHLE QLRQDVSICL
860 870 880 890 900
FQMLFQNCIT STEDKLVLNA NMEPLILPVT YEIEHKVIPT AVTEGLELQQ
910 920 930 940 950
NVEATHFGRD RAKAAQHWRL YMAYRVCQVP SSITLESVSA LDIRESLKIK
960 970 980 990 1000
MADLALVRSS DLNEQLSCQF IAAENCSKHE DLQKTVSAIQ LFLVVLRNSL
1010 1020 1030 1040 1050
SDTVAENLWK LIHKYIRLAP GNEADDKVYK SMLDLCVTCI RFSQPHAING
1060 1070 1080 1090 1100
LSYALETDHH HSFQLLLHDS QISLDKLFLI CQCMMQLLSN ELSDDSMNWY
1110 1120 1130 1140 1150
GKFFMQLSAV AKTHFELRQL QHVRCILCML RFVSERNLKF SNAQLMSYSQ
1160 1170 1180 1190 1200
HFIQLSSNLR TSTQTGSEWQ RDCLYIICQL QIHLIYQEPK ASSKASIPND
1210 1220 1230 1240 1250
VGASYKVLRY FLTLCGHGDS EVRALSWVSL ANWITICGSQ VAEILPRLDF
1260 1270 1280 1290 1300
LPGGLPACCL TTLTDAHEMM LIRELAGRVF ILLMPLIGAE SSLELLRKHD
1310 1320 1330 1340 1350
LLKTAYNSLK AIHDTPWMFK KIVGERHSCE VISCYVAICT KMVAMKPEWC
1360 1370 1380 1390 1400
AALCGHSLMS GLSDVMKKLK SQASCSIPLV ELCASQICEL YSMCYTNNFE
1410 1420 1430 1440 1450
FLKMTICRDS VFLQNYLTLI NDVLSLECPE YMVIPLLKMF LIFCTDSNSN
1460 1470 1480 1490 1500
SFLIEQIKNK PSLFMDFFLF GLHVKLINSP FQRFTLSALS LVFTKAQLAA
1510 1520 1530 1540 1550
YDISMLSELE KFELAFSDPD IAKDGKQEFE SKKKQSVSQC IYDESSDNSD
1560 1570 1580 1590 1600
DNKQRPNHAI QATNAAIIIF HRLDQLFDRY YLSKALNFLE LPAVGQVQVC
1610 1620 1630 1640 1650
EALGELLKAS TWAVKAAGES KLLGKVVHIL DDFLNDEKIG NAAVYVKRVG
1660 1670 1680 1690 1700
PHKAQSIISN LLVLINMLSQ WHSSPNSEII QTSMAANIAK ILIRIWPWLS
1710 1720 1730 1740 1750
HSYHLKKVTV QLIMFLTEHS FEMCKQISLL QSGHAQSLLH LMARVADFET
1760 1770 1780 1790 1800
TKKEIPNKEP SLNMVPALRV MVNCCCCTEG RLSLSKMNLL DMFDTILPAN
1810 1820 1830 1840 1850
PCSTHLKVRP PVLIAWLGFW EVFSRYDVGG KACHLQSLIN TIRRSPPLSH
1860 1870 1880 1890 1900
KRILCLRILR NMCFFNGNRP RLVELADFIN LLRDILEQRV QKAPTSEKNG
1910 1920 1930 1940 1950
LNSFEEHRLA VLMLWKLFGF GAKYKGMLRG TKLFKLLIGL RVEMSVVFSE
1960 1970
EENKYAGVPY ANDLAKLLEK LMESMRQ
Length:1,977
Mass (Da):225,556
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i155A0E2A98F22B7C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58528.2

NCBI Reference Sequences

More...
RefSeqi
NP_610765.1, NM_136921.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087904; FBpp0087015; FBgn0266111

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36341

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG13162

UCSC genome browser

More...
UCSCi
CG13162-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58528.2
RefSeqiNP_610765.1, NM_136921.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiA1Z8X3, 2 interactors
STRINGi7227.FBpp0087015

Proteomic databases

PaxDbiA1Z8X3
PRIDEiA1Z8X3

Genome annotation databases

EnsemblMetazoaiFBtr0087904; FBpp0087015; FBgn0266111
GeneIDi36341
KEGGidme:Dmel_CG13162
UCSCiCG13162-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36341
FlyBaseiFBgn0266111, ana3
VEuPathDBiVectorBase:FBgn0266111

Phylogenomic databases

eggNOGiENOG502QPM7, Eukaryota
GeneTreeiENSGT00640000091535
HOGENOMiCLU_232193_0_0_1
InParanoidiA1Z8X3
OMAiMINCCSC
OrthoDBi846261at2759
PhylomeDBiA1Z8X3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
36341, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36341

Gene expression databases

BgeeiFBgn0266111, Expressed in oocyte and 28 other tissues
GenevisibleiA1Z8X3, DM

Family and domain databases

InterProiView protein in InterPro
IPR030791, Rotatin
IPR029249, Rotatin_N
PANTHERiPTHR31691, PTHR31691, 1 hit
PfamiView protein in Pfam
PF14726, RTTN_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1Z8X3_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1Z8X3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 29, 2021
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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