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Entry version 129 (10 Feb 2021)
Sequence version 1 (06 Feb 2007)
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Protein

F-spondin

Gene

CG17740

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-spondinARBA annotation
Alternative name(s):
Spondin-1ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CG17740Imported
Synonyms:CG30046-RBImported, CT39323Imported, Dmel\CG30046Imported
ORF Names:CG30046Imported, Dmel_CG30046Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0050046, CG30046

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501508595326 – 839F-spondinSequence analysisAdd BLAST814

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0050046, Expressed in embryonic/larval hemocyte (Drosophila) and 26 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0087008

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 179ReelinInterPro annotationAdd BLAST167
Domaini184 – 376SpondinInterPro annotationAdd BLAST193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni567 – 606DisorderedSequence analysisAdd BLAST40
Regioni636 – 690DisorderedSequence analysisAdd BLAST55
Regioni815 – 839DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi649 – 684PolyampholyteSequence analysisAdd BLAST36

Keywords - Domaini

RepeatARBA annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3539, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154910

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014540_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
CMLFAAD

Database of Orthologous Groups

More...
OrthoDBi
517669at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08544, Reeler, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 2 hits
2.60.40.2130, 1 hit
2.60.40.4060, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036880, Kunitz_BPTI_sf
IPR002861, Reeler_dom
IPR042307, Reeler_sf
IPR009465, Spondin_N
IPR038678, Spondin_N_sf
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02014, Reeler, 1 hit
PF06468, Spond_N, 1 hit
PF00090, TSP_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00209, TSP1, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57362, SSF57362, 1 hit
SSF82895, SSF82895, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51019, REELIN, 1 hit
PS51020, SPONDIN, 1 hit
PS50092, TSP1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1Z8W6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWWSSGAPLV ELLLLGSLVI GRVSSLICTR RPANTGSPKS PVDENFMISV
60 70 80 90 100
SGNPETYILG QEYNVSLNAF NGHRYISFIM ALENENGDFS YNDDLGRFEL
110 120 130 140 150
SDLIETRFSP NCINMVENTN TNSKTHMHLT WVAPSEPGSG CVLIRATVQQ
160 170 180 190 200
HREVWHMDDG GLTKRICEEV TDDVESQPTA PAAVDVPCCA CDEARYELIF
210 220 230 240 250
EGVWSRNLHP KDFPTRGWET RFCELLGAAH SSDYRFWESG ELASVAMKEY
260 270 280 290 300
AEHCSSRLLE REFSINFRDQ KIRTIIKARG PSYPNISSKT MASVRVDPIH
310 320 330 340 350
HMVSFASKIE PSPDWIVGVT GLELCLRNCT WMEEKVINLY PWDVGTDSGP
360 370 380 390 400
TYTSSDQPQV PPDVIRRMRS DFPNDPRSPF YDISGTPMKP MAILTVKRQR
410 420 430 440 450
IYERRCADED SNNDPDVPRE CFTHPWSSWS DCSSKCGVGM QYRRRVYKQP
460 470 480 490 500
ELARVYNCNE AQYEERECQG EMCGQNNLMR EPEEFEDLEP DPRRIGYQPS
510 520 530 540 550
QQRRAECELS SWGSWSPCSV TCGDGYEMRQ RQYLNPQAEF DCQGVHRMEL
560 570 580 590 600
QETRKCSGRD CLGSLPGSYS TDMDSPYGGA SPGRIGGNMY GPQLEPEAEN
610 620 630 640 650
FGDYDDSRNG AVGGFEVGNL KGNIGNWALN RQTNLGRDVP SLRPTNYDRA
660 670 680 690 700
RQQAEKSERT TWSGQSRPDD PRLEDVERAP WHRQRPSNKY GSIVEAPEMV
710 720 730 740 750
SPREPWQRAN NFGNPDMYTP GGDVDPSLSY RCFQMVQTAQ PRCHDQTITG
760 770 780 790 800
HFWFYNFCAD ECMLYAADQC DRNVNKFRRW EDCEKCRQPG MAALQQEHTN
810 820 830
SPQCEDFRAI WQAEQRAREE KRPSNRRRNY GDSRYRTRN
Length:839
Mass (Da):96,062
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE56740DD1CEC3DF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAM68663.1
BT133491 mRNA Translation: AFI71921.1
AE013599 Genomic DNA Translation: AHN56139.1

NCBI Reference Sequences

More...
RefSeqi
NP_001286341.1, NM_001299412.1
NP_725129.1, NM_165878.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087895; FBpp0087008; FBgn0050046
FBtr0339627; FBpp0308690; FBgn0050046

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36334

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG30046

UCSC genome browser

More...
UCSCi
CG30046-RB, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAM68663.1
BT133491 mRNA Translation: AFI71921.1
AE013599 Genomic DNA Translation: AHN56139.1
RefSeqiNP_001286341.1, NM_001299412.1
NP_725129.1, NM_165878.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0087008

Genome annotation databases

EnsemblMetazoaiFBtr0087895; FBpp0087008; FBgn0050046
FBtr0339627; FBpp0308690; FBgn0050046
GeneIDi36334
KEGGidme:Dmel_CG30046
UCSCiCG30046-RB, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0050046, CG30046

Phylogenomic databases

eggNOGiKOG3539, Eukaryota
GeneTreeiENSGT00940000154910
HOGENOMiCLU_014540_0_0_1
OMAiCMLFAAD
OrthoDBi517669at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
36334, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36334

Gene expression databases

BgeeiFBgn0050046, Expressed in embryonic/larval hemocyte (Drosophila) and 26 other tissues

Family and domain databases

CDDicd08544, Reeler, 1 hit
Gene3Di2.20.100.10, 2 hits
2.60.40.2130, 1 hit
2.60.40.4060, 1 hit
InterProiView protein in InterPro
IPR036880, Kunitz_BPTI_sf
IPR002861, Reeler_dom
IPR042307, Reeler_sf
IPR009465, Spondin_N
IPR038678, Spondin_N_sf
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF02014, Reeler, 1 hit
PF06468, Spond_N, 1 hit
PF00090, TSP_1, 2 hits
SMARTiView protein in SMART
SM00209, TSP1, 2 hits
SUPFAMiSSF57362, SSF57362, 1 hit
SSF82895, SSF82895, 2 hits
PROSITEiView protein in PROSITE
PS51019, REELIN, 1 hit
PS51020, SPONDIN, 1 hit
PS50092, TSP1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1Z8W6_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1Z8W6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: February 10, 2021
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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