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UniProtKB - A1Z8J5 (A1Z8J5_DROME)

Entry version 107 (10 Feb 2021)
Sequence version 1 (06 Feb 2007)
Previous versions | rss
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Protein
Submitted name:

Shavenoid, isoform A

Gene

sha

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Shavenoid, isoform AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:shaImported
Synonyms:Dmel\CG13209Imported, kojImported, lincRNA.286Imported, ShaImported
ORF Names:CG13209Imported, Dmel_CG13209Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0003382, sha

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei351 – 374HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500264125626 – 1626Sequence analysisAdd BLAST1601

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0003382, Expressed in pupa and 14 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A1Z8J5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A1Z8J5, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		A1Z8J5, 20 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni103 – 125DisorderedSequence analysisAdd BLAST23
Regioni642 – 735DisorderedSequence analysisAdd BLAST94
Regioni856 – 876DisorderedSequence analysisAdd BLAST21
Regioni904 – 939DisorderedSequence analysisAdd BLAST36
Regioni962 – 983DisorderedSequence analysisAdd BLAST22
Regioni997 – 1027DisorderedSequence analysisAdd BLAST31
Regioni1145 – 1201DisorderedSequence analysisAdd BLAST57
Regioni1224 – 1245DisorderedSequence analysisAdd BLAST22
Regioni1275 – 1305DisorderedSequence analysisAdd BLAST31
Regioni1503 – 1615DisorderedSequence analysisAdd BLAST113

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili51 – 71Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi697 – 735PolarSequence analysisAdd BLAST39
Compositional biasi913 – 934PolarSequence analysisAdd BLAST22
Compositional biasi1001 – 1027PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1177 – 1191Pro-richSequence analysisAdd BLAST15
Compositional biasi1231 – 1245PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1503 – 1530PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1555 – 1596PolarSequence analysisAdd BLAST42

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003356_0_0_1

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A1Z8J5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLQSLPLLL LLAVVTLPPA TPTSAARPLT HPRARNHYPS EDLAEEPLMP 
        60         70         80         90        100
ASLLLEELQQ TNGQLVNLTR QHDGDTFHTS GLSSACNADT CIGLSSGTAS 
       110        120        130        140        150
LVRSTGDGSG QGNDGLNPAT SSLGGGQMEL LTRRLKLQKG RGQVANIDAS 
       160        170        180        190        200
GETGCTCRCL PYQRAYREDL GICVDDIHEC SLSPFVSGSS SEKIPFVFLP 
       210        220        230        240        250
LKGQIIYPSR EISFASIHTP VCAVTGAQYL GSNGWSDLRN PIDTDYPFRM 
       260        270        280        290        300
FRDEGRSFLL WLGEADLRQK MQGRLIVVHL VCRDMTVALN ASNHVKGEPL 
       310        320        330        340        350
MPPRNVHSPC VAFRVNGSPV KYAHNVPEVF FQPANSTTLA STSDGMTMRE 
       360        370        380        390        400
YVVIGICSLL LGLIYVASVF LYLYMKKRKR HSSRHSLDNL TNDINYPKND 
       410        420        430        440        450
QVTYGAPFSR VGSIYSSNSM GLGNGNESNT RTSIGSLKED MGIVKNNPLL 
       460        470        480        490        500
QHFPQLSERE HNSGFASDIS NSNSECEMEE KIKTSVLVHP QLSKSPKPSG 
       510        520        530        540        550
GTDNAAMDVD DFLQDNECLP AENVAVIDEL MSEEKLENLR AMVSGNVRKK 
       560        570        580        590        600
LYFNPAYFEP HLLAEPPQAA IEFLQKIREV IAIAKYKMAS KRYQPSLNII 
       610        620        630        640        650
PEEQHPESSS SSPMFNIPLQ QSLAGKGMGD KRNSIEQWLQ SVPNSDATPA 
       660        670        680        690        700
PKTLDRPAPP TAKKPSSGSP NKGSLRKEIS APKERPPPPP MQKSKADEGN 
       710        720        730        740        750
AKSSSPAPSG PHSSRSTGKS SPEQSPKPKT NVGSTYEGFS AFSVAANVYG 
       760        770        780        790        800
FAETGGEIYN NPKFMLADSP AASLRSASSR SKSMKKRSEV LDQFAAANST 
       810        820        830        840        850
PTSLTSFDRQ HYNMLRNMKA PEVIYDSLKR EFAAHIPTPD YDSTIEKRIK 
       860        870        880        890        900
DIYSSTQSSI PSVPTPDYSS LSRKSLKQFQ PDSPIYRRKS PQYLIVDYET 
       910        920        930        940        950
DSLERLEPSK RKSSHSSSSP SSDVSSQLSP SLSTALPLEE EMEISHTVYD 
       960        970        980        990       1000
RMNGFRKEGE MKKRLAAKHQ HPHPGQQQRQ KEAAARIKYD TPFRGSMTIE 
      1010       1020       1030       1040       1050
VEHEPPSDLE RTDSDQFEPD TLDRKPKKQS FCDISAWDGH KPIDSDFSQI 
      1060       1070       1080       1090       1100
SSLPDLSRQI SPAPNQGIKP RTASFILRSS NSFRNLREIY ESPLIAQDNI 
      1110       1120       1130       1140       1150
KYEKKVAQTP EEEGRILTLE AKHSRRQRLM ETSPTHSVMD ITKVNKTTIT 
      1160       1170       1180       1190       1200
ISSPKPADKA PPTRPKVNQH YCPPLVQSKR PLPPPPPNSS EHQAPDEDAY 
      1210       1220       1230       1240       1250
SLHSEITGTS EFENSCNNTM SSAISATTEE RTHAKGSRSP KINAKIPEED 
      1260       1270       1280       1290       1300
YEGMYNKKIN SLRNDYSLTK YLNRRKSQRE EVSKAGPDSP KDVAPEPEFG 
      1310       1320       1330       1340       1350
GSNKSVKEVD VAQFDALSIS SRSNRSSSHL SERTKEMYRN AGVPVGIAYP 
      1360       1370       1380       1390       1400
QRAASSSGNA SAGGNVQTVY RCEIEQAQLT AGMQIAIGLK DRAKKAKDLK 
      1410       1420       1430       1440       1450
NAWRKFVTMA ANKFSPSQSP APTYGSKTAA GFLEDDGIAS IIEDAAQSAG 
      1460       1470       1480       1490       1500
MGQPGSQTYY EQRFGQLDSG YMSTDSTELY KRNVYDRYNF KMPCGRGQII 
      1510       1520       1530       1540       1550
RVDTIEDNEE ESGPNDNRFE DLEHMVSPSH SRRSPENNAV VACDLSDAES 
      1560       1570       1580       1590       1600
DKTLTRSHSQ TNSQERNVRG STTTMSSYSS DENGRGRSTC CGSSETDEET 
      1610       1620 
NAEDMWESGA ESIETHSVLY KMIRKS
Length:1,626
Mass (Da):179,312
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9444AB4626D09F0D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7YZF2B7YZF2_DROME
Shavenoid, isoform B
sha Dmel\CG13209, koj, lincRNA.286, Sha, CG13209
1,633Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KEL5A0A0B4KEL5_DROME
Shavenoid, isoform C
sha Dmel\CG13209, koj, lincRNA.286, Sha, CG13209
1,618Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58666.2

NCBI Reference Sequences

More...RefSeqi		NP_610672.1, NM_136828.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0088120; FBpp0087221; FBgn0003382

Database of genes from NCBI RefSeq genomes

More...GeneIDi		36213

UCSC genome browser

More...UCSCi		CG13209-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58666.2
RefSeqiNP_610672.1, NM_136828.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiA1Z8J5, 20 interactors

Genome annotation databases

EnsemblMetazoaiFBtr0088120; FBpp0087221; FBgn0003382
GeneIDi36213
UCSCiCG13209-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		109556
FlyBaseiFBgn0003382, sha

Phylogenomic databases

HOGENOMiCLU_003356_0_0_1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		36213, 0 hits in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Sh, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		36213

Gene expression databases

BgeeiFBgn0003382, Expressed in pupa and 14 other tissues
ExpressionAtlasiA1Z8J5, baseline and differential
GenevisibleiA1Z8J5, DM

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1Z8J5_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1Z8J5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: February 10, 2021
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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