UniProtKB - A1Z892 (A1Z892_DROME)
Protein
Submitted name:
LD11278p
Gene
Prx2540-1
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 43 | Cysteine sulfenic acid (-SOH) intermediateUniRule annotation | 1 |
GO - Molecular functioni
- peroxidase activity Source: FlyBase
- peroxiredoxin activity Source: UniProtKB-EC
GO - Biological processi
- cell redox homeostasis Source: GO_Central
- hydrogen peroxide catabolic process Source: FlyBase
Keywordsi
Molecular function | AntioxidantUniRule annotationARBA annotation, Oxidoreductase, PeroxidaseUniRule annotationImportedARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Prx2540-1Imported Synonyms:BEST:LD11278Imported, Dmel\CG12405Imported, dPrx6aImported, DPx-2540-1Imported, DPx2540Imported, Prx2540Imported, Prx2540-1-RAImported ORF Names:CG12405Imported, Dmel_CG12405Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0033520, Prx2540-1 |
Subcellular locationi
Cytosol
- cytosol Source: FlyBase
Mitochondrion
- mitochondrion Source: GO_Central
Expressioni
Gene expression databases
Bgeei | FBgn0033520, Expressed in seminal fluid secreting gland and 18 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | A1Z892, 3 interactors |
STRINGi | 7227.FBpp0087356 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 164 | ThioredoxinInterPro annotationAdd BLAST | 164 |
Sequence similaritiesi
Belongs to the peroxiredoxin family.UniRule annotation
Keywords - Domaini
Redox-active centerUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG0854, Eukaryota |
GeneTreei | ENSGT00940000169794 |
HOGENOMi | CLU_042529_4_1_1 |
OMAi | WINDITE |
OrthoDBi | 1129256at2759 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000866, AhpC/TSA IPR024706, Peroxiredoxin_AhpC-typ IPR019479, Peroxiredoxin_C IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF10417, 1-cysPrx_C, 1 hit PF00578, AhpC-TSA, 1 hit |
PIRSFi | PIRSF000239, AHPC, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A1Z892-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLGQTVPNF EADTTKGPIK FHEWQGNSWV VLFSHPADFT PVCTTELGRI
60 70 80 90 100
AVHQPEFAKR NTKCLAHSVD ALNSHVDWVN DIKSYCLDIP GDFPYPIIAD
110 120 130 140 150
PTRDLAVTLG MLDEEQKKDP EVGKTIRALF IISPDHKVRL SMFYPMSTGR
160 170 180 190 200
NVDEILRTID SLQLTDRLKV VATPANWTPG TKVMILPTVT DEEAHKLFPK
210 220
GFDKVSMPSG VNYVRTTENY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF58797.1 BT120318 mRNA Translation: ADC54209.1 |
RefSeqi | NP_724931.1, NM_165769.1 |
Genome annotation databases
EnsemblMetazoai | FBtr0088261; FBpp0087356; FBgn0033520 |
GeneIDi | 246663 |
KEGGi | dme:Dmel_CG12405 |
UCSCi | CG12405-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF58797.1 BT120318 mRNA Translation: ADC54209.1 |
RefSeqi | NP_724931.1, NM_165769.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | A1Z892, 3 interactors |
STRINGi | 7227.FBpp0087356 |
Genome annotation databases
EnsemblMetazoai | FBtr0088261; FBpp0087356; FBgn0033520 |
GeneIDi | 246663 |
KEGGi | dme:Dmel_CG12405 |
UCSCi | CG12405-RA, d. melanogaster |
Organism-specific databases
CTDi | 246663 |
FlyBasei | FBgn0033520, Prx2540-1 |
Phylogenomic databases
eggNOGi | KOG0854, Eukaryota |
GeneTreei | ENSGT00940000169794 |
HOGENOMi | CLU_042529_4_1_1 |
OMAi | WINDITE |
OrthoDBi | 1129256at2759 |
Miscellaneous databases
BioGRID-ORCSi | 246663, 1 hit in 1 CRISPR screen |
GenomeRNAii | 246663 |
Gene expression databases
Bgeei | FBgn0033520, Expressed in seminal fluid secreting gland and 18 other tissues |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000866, AhpC/TSA IPR024706, Peroxiredoxin_AhpC-typ IPR019479, Peroxiredoxin_C IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF10417, 1-cysPrx_C, 1 hit PF00578, AhpC-TSA, 1 hit |
PIRSFi | PIRSF000239, AHPC, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A1Z892_DROME | |
Accessioni | A1Z892Primary (citable) accession number: A1Z892 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 6, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | February 10, 2021 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |