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Entry version 141 (12 Aug 2020)
Sequence version 1 (06 Feb 2007)
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Protein

Nidogen

Gene

Ndg

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell adhesion glycoprotein which is widely distributed in basement membranes (PubMed:30260959, PubMed:30567930). Involved in cell-extracellular matrix (ECM) interactions probably by connecting the laminin and collagen IV networks (PubMed:30260959, PubMed:30567930). Required for permeability and mechanical stability of basement membranes, and ECM dependent neural plasticity (PubMed:30567930). Not involved in assembly of the embryonic basement membrane (PubMed:30567930).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-913709, O-linked glycosylation of mucins
R-DME-977068, Termination of O-glycan biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nidogen1 PublicationImported
Alternative name(s):
Entactin1 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ndg1 PublicationImported
ORF Names:CG12908Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0026403, Ndg

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Reduces fertility (PubMed:30260959, PubMed:30567930). In larvae results in impaired climbing abilities and in multiple holes in the basal membrane surrounding the fat body adipose, the somatic muscles and the longitudinal and circular visceral muscles, affecting permeability and mechanical stability of the basement membrane (PubMed:30260959, PubMed:30567930). Impairs larvae movement including reduced crawling speed, smaller stride frequency and exploration area together with sudden motion defects in their crawling pattern, such as head shaking, and spontaneous rolling and bending (PubMed:30567930). Increases neuromuscular junction (NMJ) size including abnormal branching numbers, overall branch length and enhanced bouton density suggesting defective NMJ maturation (PubMed:30567930). Reduces reaction to vibrational stimuli with partial loss of alignment of sensory cilia and morphological defects of the larval peripheral nervous system (PubMed:30567930). Results in smaller pupae presenting an orientation shift of the pupal cases towards the horizontal axis (PubMed:30567930). Results in incompletely inflated wing blades in a small group of adults (PubMed:30567930).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501508594523 – 1350NidogenSequence analysisAdd BLAST1328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi231N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi285 ↔ 298PROSITE-ProRule annotation
Disulfide bondi292 ↔ 307PROSITE-ProRule annotation
Disulfide bondi309 ↔ 320PROSITE-ProRule annotation
Glycosylationi423N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi480N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi549 ↔ 562PROSITE-ProRule annotation
Disulfide bondi556 ↔ 571PROSITE-ProRule annotation
Disulfide bondi595 ↔ 608PROSITE-ProRule annotation
Disulfide bondi602 ↔ 617PROSITE-ProRule annotation
Disulfide bondi619 ↔ 630PROSITE-ProRule annotation
Glycosylationi633N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi792 ↔ 804PROSITE-ProRule annotation
Disulfide bondi798 ↔ 815PROSITE-ProRule annotation
Glycosylationi801N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi817 ↔ 828PROSITE-ProRule annotation
Disulfide bondi836 ↔ 849PROSITE-ProRule annotation
Disulfide bondi843 ↔ 860PROSITE-ProRule annotation
Disulfide bondi862 ↔ 873PROSITE-ProRule annotation
Disulfide bondi916 ↔ 927PROSITE-ProRule annotation
Disulfide bondi921 ↔ 938PROSITE-ProRule annotation
Disulfide bondi940 ↔ 952PROSITE-ProRule annotation
Disulfide bondi959 ↔ 971PROSITE-ProRule annotation
Disulfide bondi965 ↔ 982PROSITE-ProRule annotation
Disulfide bondi984 ↔ 995PROSITE-ProRule annotation
Disulfide bondi1001 ↔ 1014PROSITE-ProRule annotation
Disulfide bondi1008 ↔ 1023PROSITE-ProRule annotation
Disulfide bondi1025 ↔ 1036PROSITE-ProRule annotation
Glycosylationi1032N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1Z877

PRoteomics IDEntifications database

More...
PRIDEi
A1Z877

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the basement membrane around the follicular epithelium of the adult ovary (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in different patterns throughout embryogenesis (at protein levels) (PubMed:30260959, PubMed:30567930). At stage 11/12, embeds dorsal median cells and somatic myoblasts forming a thin layer between the ectoderm and the mesoderm and around the prospective anal plate (PubMed:30567930). At stage 12, after germ band retraction, accumulates in the forming basal membranes around the developing brain and ventral nerve cord, in the differentiating tracheal system, in the future digestive tract as well as in the forming somatic muscles (PubMed:30567930). At stage 13, accumulates around caudal visceral mesodermal cells (PubMed:30260959). At stage 16, expressed in the basal membrane surrounding most tissues, including muscles, gut and larval ventral nerve cord, brain, and in chordotonal organs (at protein level) (PubMed:30260959, PubMed:30567930). Expressed in embryonic macrophages (at protein level) (PubMed:30260959). In the larva, expressed mainly by fat body adipocytes and blood cells in the basal membranes that surround the fat body, imaginal disks, tracheae, salivary glands, midgut, mature muscles and heart (at protein level) (PubMed:30260959). Expressed during embryogenesis: at stage 11/12 detected in single cells of the head, especially in the gnathal segments as well as in segmentally located patches of cells in the dorsal mesoderm, detected in the midline-associated, mesodermal dorsal median cells and somatic myoblasts (PubMed:30567930). Only low expression in the amnioserosa (PubMed:30567930). After germ band retraction (stage 12), expressed in the forming dorsal and ventral muscles, the amnioserosa and the segmentally located chordotonal organs (PubMed:30567930). Expressed in the esophageal visceral muscle primordium and in the joint region between hind- and midgut (PubMed:30567930). At stage 16, expressed in somatic and visceral muscles, and in the cap cells of the chordotonal organs (PubMed:30567930).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0026403, Expressed in embryo and 32 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A1Z877, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
A1Z877, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0087439

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini107 – 260NIDOPROSITE-ProRule annotationAdd BLAST154
Domaini281 – 321EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini325 – 550Nidogen G2 beta-barrelPROSITE-ProRule annotationAdd BLAST226
Domaini545 – 583EGF-like 2PROSITE-ProRule annotationAdd BLAST39
Domaini591 – 631EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini788 – 829EGF-like 4PROSITE-ProRule annotationAdd BLAST42
Domaini832 – 874EGF-like 5PROSITE-ProRule annotationAdd BLAST43
Domaini912 – 953EGF-like 6PROSITE-ProRule annotationAdd BLAST42
Domaini955 – 996EGF-like 7PROSITE-ProRule annotationAdd BLAST42
Domaini997 – 1037EGF-like 8PROSITE-ProRule annotationAdd BLAST41
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1084 – 1126LDL-receptor class B 1PROSITE-ProRule annotationAdd BLAST43
Repeati1127 – 1170LDL-receptor class B 2PROSITE-ProRule annotationAdd BLAST44
Repeati1171 – 1216LDL-receptor class B 3PROSITE-ProRule annotationAdd BLAST46
Repeati1257 – 1282LDL-receptor class B 4PROSITE-ProRule annotationAdd BLAST26

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The NIDO domain (also known as globular region 1 or G1) contributes to the localization to the basal membrane probably by binding to vkg.1 Publication
The EGF-like 1 and nidogen G2 beta-barrel domain (also known as globular region 2 or G2) contribute to the localization to the basal membrane probably by binding to vkg.1 Publication
The EGF-like 2-8 domains (also known as the ROD domain) is necessary but not sufficient for localization to the basal membrane.1 Publication
The LDL-receptor class B 1-4 domains (also known as globular region 3 or G3) is necessary for cell-extracellular matrix (ECM) interactions. Also, contributes to the localization to the basal membrane probably by binding to laminins.1 Publication

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1214, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000170029

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_003163_0_0_1

KEGG Orthology (KO)

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KOi
K06826

Identification of Orthologs from Complete Genome Data

More...
OMAi
CERWKES

Database of Orthologous Groups

More...
OrthoDBi
95286at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00255, nidG2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.120.10.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR024731, EGF_dom
IPR006605, G2_nidogen/fibulin_G2F
IPR009017, GFP
IPR009030, Growth_fac_rcpt_cys_sf
IPR000033, LDLR_classB_rpt
IPR003886, NIDO_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12947, EGF_3, 2 hits
PF07645, EGF_CA, 1 hit
PF07474, G2F, 1 hit
PF00058, Ldl_recept_b, 2 hits
PF06119, NIDO, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 11 hits
SM00179, EGF_CA, 2 hits
SM00682, G2F, 1 hit
SM00135, LY, 5 hits
SM00539, NIDO, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54511, SSF54511, 1 hit
SSF57184, SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS01186, EGF_2, 7 hits
PS50026, EGF_3, 8 hits
PS01187, EGF_CA, 1 hit
PS51120, LDLRB, 4 hits
PS51220, NIDO, 1 hit
PS50993, NIDOGEN_G2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A1Z877-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTFGSKLLA CLLLSSVILV SGQFEHYLDS LRASELYEFE DGSLGSIHLL
60 70 80 90 100
PKGDSETIVL QLEQPIHFYG EQYEQLYINT NGILTFNSEF PEYLNQPFPL
110 120 130 140 150
EYASIAAFYS NVDTSFSDEG TSISLFESKE QSILDRASSL VRYAFSSQSE
160 170 180 190 200
FEARQVIVAT WRNVGYFDSK TDRLNTFQVA LIANEQSTFV QFIYPDGGLN
210 220 230 240 250
WLQGETAGLG LPDIRAQAGF VAEDGRFYTL NGSGSENARF LSESTNLGVP
260 270 280 290 300
GVWLFEVAPI ENEQNVRSPD NAESLTESPA LALSCQAHAH QCHEKAECHD
310 320 330 340 350
KAEGYCCVCG SGFYGNGKSC LANDQPIRVT GTLTGELNKQ PVSEEAKLQS
360 370 380 390 400
YVVTSEGRTY TTINPLTPEL GAQLRLVLPL LTTVPWLFAK SVGGVANGYQ
410 420 430 440 450
LTGGVYTHVS RLQFDSGENL HVNQTFEGLN YWDQLSVKIE IYGEVPAVAA
460 470 480 490 500
DAVLILPDYV EEYTFERPGE LKSVQVLNIN ITEEQRVLGL QVEQRILYRS
510 520 530 540 550
CLRDDEADPS ATKVLQKISK VALDYVERDQ ALRIGAMSKV GVTPESNACN
560 570 580 590 600
DGTADCVENS VCVPYEDTYR CDCYHGFAAQ LDERGVEVCL DIDECATGSH
610 620 630 640 650
VCDENAVCDN TEGGFNCYCT EGFEGNGYRC LSNSTADNIE YPPAVEGQAE
660 670 680 690 700
PTSEPSPNPS PYPDQGQDQE REREDDQYPQ PNPYPYPEEQ IPQHPDECYR
710 720 730 740 750
CSKDADCYQG RCTCHEGFDG DGYTCTNICG HGEVWENGRC EPLLLERHDV
760 770 780 790 800
DPLCDALGEC RCPYGYELSE DSQRCTYVQE FDGERNADLI PCDVDENCHI
810 820 830 840 850
NATCNWYGQE LRHICTCQPG FRGDGYNCDP ISDDSCAIRP DICDVHADCV
860 870 880 890 900
YEEHLGKSEC QCQAGYTGNG FNCQLAAECQ SAEHCGENAF CDDGVCRCQA
910 920 930 940 950
DFERDVSDRC VPAGRCGSVF CGSNAICKWD SAEGVQYCDC LDGYQGDALT
960 970 980 990 1000
GCTSKPLSCH VLNNCGIHAT CEPTEDPANY ECQCIAGFKG DGYVCIEEQN
1010 1020 1030 1040 1050
CLNNPTLCDM NAQCRSTNSG LVCVCNQGFF GNGSLCQERQ HQDSDFLIVS
1060 1070 1080 1090 1100
QGVMIARVPL NGRNVRPISV AQMAIGLDKD CVEGRVYWGD ISTKKIVSTK
1110 1120 1130 1140 1150
YDGTDLRPFI TTDIESPEGI AIDVISRRLY WADSAKDTIE VASLDDPSLR
1160 1170 1180 1190 1200
AVIINKQLVN PRGIAVDPYR EKLFWSDWDR ESPKIEMSNL DGTGRELLLG
1210 1220 1230 1240 1250
KDDVTLPNSL VVLENSGEVC YADAGTKKVE CIEPQNRQIR TISNELSYPF
1260 1270 1280 1290 1300
GITFTHDQFY WTDWTTKKVE IVDSLGARQT PIQPPFFGSH KMYGMTVVEQ
1310 1320 1330 1340 1350
HCPQYQSPCQ ISNGGCTDSR LCLVNRQAPS GKSCKCTSAS TGCTVLAPGY
Length:1,350
Mass (Da):149,081
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i482243B79347A341
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti979N → S in ACK77669 (Ref. 4) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58809.3
AE013599 Genomic DNA Translation: AAS64880.2
BT031149 mRNA Translation: ABX00771.1
BT053751 mRNA Translation: ACK77669.1

NCBI Reference Sequences

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RefSeqi
NP_610575.1, NM_136731.2
NP_995796.2, NM_206074.2

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0088349; FBpp0087438; FBgn0026403
FBtr0339459; FBpp0308545; FBgn0026403

Database of genes from NCBI RefSeq genomes

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GeneIDi
36089

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG12908

UCSC genome browser

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UCSCi
CG12908-RA, d. melanogaster
CG12908-RB, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58809.3
AE013599 Genomic DNA Translation: AAS64880.2
BT031149 mRNA Translation: ABX00771.1
BT053751 mRNA Translation: ACK77669.1
RefSeqiNP_610575.1, NM_136731.2
NP_995796.2, NM_206074.2

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiA1Z877, 1 interactor
STRINGi7227.FBpp0087439

Proteomic databases

PaxDbiA1Z877
PRIDEiA1Z877

Genome annotation databases

EnsemblMetazoaiFBtr0088349; FBpp0087438; FBgn0026403
FBtr0339459; FBpp0308545; FBgn0026403
GeneIDi36089
KEGGidme:Dmel_CG12908
UCSCiCG12908-RA, d. melanogaster
CG12908-RB, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
36089
FlyBaseiFBgn0026403, Ndg

Phylogenomic databases

eggNOGiKOG1214, Eukaryota
GeneTreeiENSGT00940000170029
HOGENOMiCLU_003163_0_0_1
KOiK06826
OMAiCERWKES
OrthoDBi95286at2759

Enzyme and pathway databases

ReactomeiR-DME-913709, O-linked glycosylation of mucins
R-DME-977068, Termination of O-glycan biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
36089, 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
36089

Gene expression databases

BgeeiFBgn0026403, Expressed in embryo and 32 other tissues
ExpressionAtlasiA1Z877, baseline and differential

Family and domain databases

CDDicd00255, nidG2, 1 hit
Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR024731, EGF_dom
IPR006605, G2_nidogen/fibulin_G2F
IPR009017, GFP
IPR009030, Growth_fac_rcpt_cys_sf
IPR000033, LDLR_classB_rpt
IPR003886, NIDO_dom
PfamiView protein in Pfam
PF12947, EGF_3, 2 hits
PF07645, EGF_CA, 1 hit
PF07474, G2F, 1 hit
PF00058, Ldl_recept_b, 2 hits
PF06119, NIDO, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 11 hits
SM00179, EGF_CA, 2 hits
SM00682, G2F, 1 hit
SM00135, LY, 5 hits
SM00539, NIDO, 1 hit
SUPFAMiSSF54511, SSF54511, 1 hit
SSF57184, SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS01186, EGF_2, 7 hits
PS50026, EGF_3, 8 hits
PS01187, EGF_CA, 1 hit
PS51120, LDLRB, 4 hits
PS51220, NIDO, 1 hit
PS50993, NIDOGEN_G2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDG_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1Z877
Secondary accession number(s): A1Z876, B7FNR1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 18, 2019
Last sequence update: February 6, 2007
Last modified: August 12, 2020
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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