UniProtKB - A1Z7P5 (A1Z7P5_DROME)
Protein
Submitted name:
Suppressor of variegation 2-10, isoform I
Gene
Su(var)2-10
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
: protein sumoylation Pathwayi
This protein is involved in the pathway protein sumoylation, which is part of Protein modification.ARBA annotationView all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 357 – 434 | SP-RING-typePROSITE-ProRule annotationAdd BLAST | 78 |
GO - Molecular functioni
- RNA polymerase II transcription factor binding Source: GO_Central
- STAT family protein binding Source: FlyBase
- SUMO ligase activity Source: FlyBase
- transcription coregulator activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- chromosome condensation Source: FlyBase
- chromosome organization Source: FlyBase
- compound eye development Source: FlyBase
- defense response to Gram-negative bacterium Source: FlyBase
- double-strand break repair via homologous recombination Source: FlyBase
- imaginal disc growth Source: FlyBase
- negative regulation of receptor signaling pathway via JAK-STAT Source: FlyBase
- positive regulation of innate immune response Source: FlyBase
- positive regulation of smoothened signaling pathway Source: FlyBase
- positive regulation of somatic stem cell division Source: FlyBase
- protein sumoylation Source: FlyBase
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | TransferaseARBA annotation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-DME-196791, Vitamin D (calciferol) metabolism R-DME-3108214, SUMOylation of DNA damage response and repair proteins R-DME-3232118, SUMOylation of transcription factors R-DME-3899300, SUMOylation of transcription cofactors R-DME-4090294, SUMOylation of intracellular receptors R-DME-4551638, SUMOylation of chromatin organization proteins R-DME-4615885, SUMOylation of DNA replication proteins R-DME-4755510, SUMOylation of immune response proteins R-DME-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5696395, Formation of Incision Complex in GG-NER |
UniPathwayi | UPA00886 |
Names & Taxonomyi
Protein namesi | Submitted name: Suppressor of variegation 2-10, isoform IImported |
Gene namesi | Name:Su(var)2-10Imported Synonyms:CLOT2057Imported, Dmel\CG8068Imported, DmPiasImported, DPIASImported, DpiasImported, dPIASImported, dpiasImported, i184Imported, l(2)03697Imported, PIASImported, piasImported, Su(var)-10Imported, SU(VAR)2-10Imported, Su(Var)2-10Imported, Su-var(2)10Imported, Suvar(2)10Imported, ZIMPImported, zimpImported, ZimpAImported, ZimpBImported ORF Names:CG8068Imported, Dmel_CG8068Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0003612, Su(var)2-10 |
Subcellular locationi
Nucleus
- Nucleus speckle ARBA annotation
Nucleus
- nuclear lamina Source: FlyBase
- nucleoplasm Source: FlyBase
- nucleus Source: FlyBase
Other locations
- chromosome, telomeric region Source: FlyBase
- cytoplasm Source: FlyBase
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | FBgn0003612, Expressed in embryo and 40 other tissues |
ExpressionAtlasi | A1Z7P5, baseline and differential |
Genevisiblei | A1Z7P5, DM |
Interactioni
GO - Molecular functioni
- RNA polymerase II transcription factor binding Source: GO_Central
- STAT family protein binding Source: FlyBase
Protein-protein interaction databases
IntActi | A1Z7P5, 4 interactors |
STRINGi | 7227.FBpp0087651 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 49 – 83 | SAPInterPro annotationAdd BLAST | 35 | |
Domaini | 160 – 325 | PINITInterPro annotationAdd BLAST | 166 | |
Domaini | 357 – 434 | SP-RING-typeInterPro annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 32 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 449 – 594 | DisorderedSequence analysisAdd BLAST | 146 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 8 – 32 | PolarSequence analysisAdd BLAST | 25 | |
Compositional biasi | 449 – 469 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 476 – 497 | PolyampholyteSequence analysisAdd BLAST | 22 | |
Compositional biasi | 499 – 515 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 535 – 593 | PolarSequence analysisAdd BLAST | 59 |
Sequence similaritiesi
Belongs to the PIAS family.ARBA annotation
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 357 – 434 | SP-RING-typePROSITE-ProRule annotationAdd BLAST | 78 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG2169, Eukaryota |
GeneTreei | ENSGT00990000203531 |
InParanoidi | A1Z7P5 |
PhylomeDBi | A1Z7P5 |
Family and domain databases
Gene3Di | 1.10.720.30, 1 hit 2.60.120.780, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR027226, PIAS1/PIAS3 IPR023321, PINIT IPR038654, PINIT_sf IPR003034, SAP_dom IPR036361, SAP_dom_sf IPR004181, Znf_MIZ IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR10782:SF11, PTHR10782:SF11, 1 hit |
Pfami | View protein in Pfam PF14324, PINIT, 1 hit PF02891, zf-MIZ, 1 hit |
SMARTi | View protein in SMART SM00513, SAP, 1 hit |
SUPFAMi | SSF68906, SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS51466, PINIT, 1 hit PS50800, SAP, 1 hit PS51044, ZF_SP_RING, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All
A1Z7P5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRKTRSQTAR TQAENAATSS SPGHQSTSSA PIAVNPFDST KYKECEQMVQ
60 70 80 90 100
MLRVVELQKI LSFLNISFAG RKTDLQSRIL SFLRTNLELL APKVQEVYAQ
110 120 130 140 150
SVQEQNATLQ YIDPTRMYSH IQLPPTVQPN PVGLVGSGQG VQVPGGQMNV
160 170 180 190 200
VGGAPFLHTH SINSQLPIHP DVRLKKLAFY DVLGTLIKPS TLVPRNTQRV
210 220 230 240 250
QEVPFYFTLT PQQATEIASN RDIRNSSKVE HAIQVQLRFC LVETSCDQED
260 270 280 290 300
CFPPNVNVKV NNKLCQLPNV IPTNRPNVEP KRPPRPVNVT SNVKLSPTVT
310 320 330 340 350
NTITVQWCPD YTRSYCLAVY LVKKLTSTQL LQRMKTKGVK PADYTRGLIK
360 370 380 390 400
EKLTEDADCE IATTMLKVSL NCPLGKMKML LPCRASTCSH LQCFDASLYL
410 420 430 440 450
QMNERKPTWN CPVCDKPAIY DNLVIDGYFQ EVLGSSLLKS DDTEIQLHQD
460 470 480 490 500
GSWSTPGLRS ETQILDTPSK PAQKVEVISD DIELISDDAK PVKRDLSPAQ
510 520 530 540 550
DEQPTSTSNS ETVDLTLSDS DDDMPLAKRR PPAKQAVASS TSNGSGGGQR
560 570 580 590 600
AYTPAQQPQQ SESPEQQASR QSPEKQTVSE QQLQQQQHEQ PATAAVHASL
610 620 630 640
LESLAAAVAD QKHFQLLDLA AVAAAAAATA SSGQSQNAGP
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ7KNF5 | Q7KNF5_DROME | Suppressor of variegation 2-10, iso... | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 554 | Annotation score: | ||
Q5BIG7 | Q5BIG7_DROME | RE55465p | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 533 | Annotation score: | ||
A0A0B4JD03 | A0A0B4JD03_DROME | Suppressor of variegation 2-10, iso... | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 537 | Annotation score: | ||
A0A0B4JCQ7 | A0A0B4JCQ7_DROME | Suppressor of variegation 2-10, iso... | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 537 | Annotation score: | ||
Q8IGK3 | Q8IGK3_DROME | RE73180p | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 601 | Annotation score: | ||
A1Z7P7 | A1Z7P7_DROME | Suppressor of variegation 2-10, iso... | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 569 | Annotation score: | ||
A1Z7P8 | A1Z7P8_DROME | Suppressor of variegation 2-10, iso... | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 604 | Annotation score: | ||
A1Z7P9 | A1Z7P9_DROME | Suppressor of variegation 2-10, iso... | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 565 | Annotation score: | ||
A1Z7Q1 | A1Z7Q1_DROME | Suppressor of variegation 2-10, iso... | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 593 | Annotation score: | ||
Q9XYM5 | Q9XYM5_DROME | LD27861p | Su(var)2-10 CLOT2057, Dmel\CG8068, DmPias, DPIAS, Dpias | 522 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAM68805.1 |
RefSeqi | NP_724749.1, NM_165645.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0088570; FBpp0087651; FBgn0003612 |
GeneIDi | 35927 |
UCSCi | CG8068-RI, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAM68805.1 |
RefSeqi | NP_724749.1, NM_165645.2 |
3D structure databases
SMRi | A1Z7P5 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A1Z7P5, 4 interactors |
STRINGi | 7227.FBpp0087651 |
Proteomic databases
PaxDbi | A1Z7P5 |
PRIDEi | A1Z7P5 |
Genome annotation databases
EnsemblMetazoai | FBtr0088570; FBpp0087651; FBgn0003612 |
GeneIDi | 35927 |
UCSCi | CG8068-RI, d. melanogaster |
Organism-specific databases
CTDi | 35927 |
FlyBasei | FBgn0003612, Su(var)2-10 |
Phylogenomic databases
eggNOGi | KOG2169, Eukaryota |
GeneTreei | ENSGT00990000203531 |
InParanoidi | A1Z7P5 |
PhylomeDBi | A1Z7P5 |
Enzyme and pathway databases
UniPathwayi | UPA00886 |
Reactomei | R-DME-196791, Vitamin D (calciferol) metabolism R-DME-3108214, SUMOylation of DNA damage response and repair proteins R-DME-3232118, SUMOylation of transcription factors R-DME-3899300, SUMOylation of transcription cofactors R-DME-4090294, SUMOylation of intracellular receptors R-DME-4551638, SUMOylation of chromatin organization proteins R-DME-4615885, SUMOylation of DNA replication proteins R-DME-4755510, SUMOylation of immune response proteins R-DME-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5696395, Formation of Incision Complex in GG-NER |
Miscellaneous databases
BioGRID-ORCSi | 35927, 0 hits in 3 CRISPR screens |
GenomeRNAii | 35927 |
Gene expression databases
Bgeei | FBgn0003612, Expressed in embryo and 40 other tissues |
ExpressionAtlasi | A1Z7P5, baseline and differential |
Genevisiblei | A1Z7P5, DM |
Family and domain databases
Gene3Di | 1.10.720.30, 1 hit 2.60.120.780, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR027226, PIAS1/PIAS3 IPR023321, PINIT IPR038654, PINIT_sf IPR003034, SAP_dom IPR036361, SAP_dom_sf IPR004181, Znf_MIZ IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR10782:SF11, PTHR10782:SF11, 1 hit |
Pfami | View protein in Pfam PF14324, PINIT, 1 hit PF02891, zf-MIZ, 1 hit |
SMARTi | View protein in SMART SM00513, SAP, 1 hit |
SUPFAMi | SSF68906, SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS51466, PINIT, 1 hit PS50800, SAP, 1 hit PS51044, ZF_SP_RING, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A1Z7P5_DROME | |
Accessioni | A1Z7P5Primary (citable) accession number: A1Z7P5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 6, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | February 10, 2021 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |