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Entry version 117 (18 Sep 2019)
Sequence version 1 (06 Feb 2007)
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Protein
Submitted name:

Secretory 31, isoform B

Gene

Sec31

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
A1Z7J6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Secretory 31, isoform BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sec31Imported
Synonyms:Dmel\CG8266Imported, dSec31pImported, SEC31Imported, sec31Imported
ORF Names:CG8266Imported, Dmel_CG8266Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0033339 Sec31

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1Z7J6

PRoteomics IDEntifications database

More...
PRIDEi
A1Z7J6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0033339 Expressed in 6 organ(s), highest expression level in larva

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A1Z7J6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1Z7J6 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0087724

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini112 – 338WD_REPEATS_REGIONInterPro annotationAdd BLAST227
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati112 – 154WDPROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni787 – 893DisorderedSequence analysisAdd BLAST107
Regioni992 – 1104DisorderedSequence analysisAdd BLAST113

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi821 – 844PolarSequence analysisAdd BLAST24
Compositional biasi845 – 864Pro-richSequence analysisAdd BLAST20
Compositional biasi865 – 891PolarSequence analysisAdd BLAST27
Compositional biasi992 – 1008Pro-richSequence analysisAdd BLAST17
Compositional biasi1065 – 1104PolarSequence analysisAdd BLAST40

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0307 Eukaryota
ENOG410XQ1D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003175

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1Z7J6

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1Z7J6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024298 ACE1_Sec16_Sec31
IPR040251 SEC31-like
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13923 PTHR13923, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12931 Sec16_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A1Z7J6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIKELQKTV NIAWSPAQQQ QILLAAGTAA QQFDSNANST LELYSPNFSD
60 70 80 90 100
ATYDLELRAS VSSQYKFQKL IWSPVGPHPS GLIVGGCEAG QINIYSADKL
110 120 130 140 150
LAGKEEPLLK RQDKHTGAVS GLDFNPFQNN LLASCASESE ILIWDLNNPE
160 170 180 190 200
TSMSPGTKTQ PLEDVKNVAW NRQVQHILAS VFSTRCVIWD LRKSQQIIKL
210 220 230 240 250
SDSQSRVRWH AIEWHPEAAT QVWLASEDDQ APVVQLWDLR YATAPAKTYQ
260 270 280 290 300
IHERGVLGMS WCLQDNDLMV SCGKDNRIYC WNPNTKIPEG EILSEVATTA
310 320 330 340 350
SWYSDVQFCP RNPALIASAS LEGAVSIYSL HGGTHHLVQT ANKIADSFPG
360 370 380 390 400
MDQFAQEPIP QQATQVVYHD LAHAPKWMKR PCGVAFGFGG KLVSFNGTSK
410 420 430 440 450
TVKVQQLTTE SALVDRANAL ERSLVDANYS DYCRQRADET PDQHGRYIWY
460 470 480 490 500
FIKANFELNP KEEMLNLLGY NKDDIDSKFN KFIKETDGNS HSDVDTLTTR
510 520 530 540 550
ISTLTHQTQD NKFDGNAIDS QNHNDFATPP RPQFKVPSGD HSDSLIAEAI
560 570 580 590 600
LTGNVDAAVE LCLEAQRIPE ALIIASTAGI ETLNRTQTRY LLQQKNELSH
610 620 630 640 650
VISALVSRDW LDFVNRCTVD SWKEALVAAL KHSERKVVDI CERLGDRLLS
660 670 680 690 700
ECASSAEFTR NAMLCYICAG SIDKLVTAWY QLKRLEQQNP GYKPNTTELQ
710 720 730 740 750
DLAEMVMLMC KSLEQQGISV DLAGRFAGFL TEYGGLLASQ GALTAALQYI
760 770 780 790 800
TTLGGGAAAS ESDVLQSLRD RINNAVNLDY TQPQAAVAAA PHGYQPTRGR
810 820 830 840 850
GSFSQPQPSA PMPYGQPPNQ YAQPSWPAQV PPLQTSYPGA QQPQAPPQIF
860 870 880 890 900
NPQPVKPEPL AQPPRPLSNA SSSGGPPPAG GASSSGGSGL SGRSKYVLDP
910 920 930 940 950
SVAAPTSSYG MPYNPVPAPV PSAVPFGGGG VPGPAPQPAS VPTYNSNAFN
960 970 980 990 1000
TNPIAAAQPY NPSPLMPAQQ NQFVPGVNPI ETMPPPAVPP VIQNVQRNPT
1010 1020 1030 1040 1050
PPPGWNDPPA LKSSRAPKPK PVVEPSAAIF HPLFPVDPNQ NQNGYVDPSQ
1060 1070 1080 1090 1100
YQHAAPLGGV PNTYYNPAAF NNNPQQQQQH QQSYLQPQQP APGIQQPNWQ
1110 1120 1130 1140 1150
GQQQTIGYTE QPAPIQQQRQ PAPPKEKPPL PEEYIYLQTV LEELKNRCLG
1160 1170 1180 1190 1200
ATNDPRTKRK FVDVVKRLEN LYDCLRDGKL TPTTVQYLNQ IVQYIQISDY
1210 1220 1230 1240
ANAMEIHTQI AFGTDFAQCA GFMQGLKVLL QSASELQLVL R
Length:1,241
Mass (Da):136,140
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16806865DD7D0541
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4LEZ1A0A0B4LEZ1_DROME
Secretory 31, isoform D
Sec31 Dmel\CG8266, dSec31p, SEC31, sec31, CG8266
1,260Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A1Z7J7A1Z7J7_DROME
Secretory 31, isoform A
Sec31 Dmel\CG8266, dSec31p, SEC31, sec31, CG8266
1,240Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4LEY1A0A0B4LEY1_DROME
Secretory 31, isoform C
Sec31 Dmel\CG8266, dSec31p, SEC31, sec31, CG8266
1,259Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAM71085.1

NCBI Reference Sequences

More...
RefSeqi
NP_724716.1, NM_165630.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
35877

UCSC genome browser

More...
UCSCi
CG8266-RB d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAM71085.1
RefSeqiNP_724716.1, NM_165630.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0087724

Proteomic databases

PaxDbiA1Z7J6
PRIDEiA1Z7J6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi35877
UCSCiCG8266-RB d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
35877
FlyBaseiFBgn0033339 Sec31

Phylogenomic databases

eggNOGiKOG0307 Eukaryota
ENOG410XQ1D LUCA
GeneTreeiENSGT00390000003175
InParanoidiA1Z7J6
PhylomeDBiA1Z7J6

Enzyme and pathway databases

SignaLinkiA1Z7J6

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
35877

Gene expression databases

BgeeiFBgn0033339 Expressed in 6 organ(s), highest expression level in larva
ExpressionAtlasiA1Z7J6 baseline and differential
GenevisibleiA1Z7J6 DM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR024298 ACE1_Sec16_Sec31
IPR040251 SEC31-like
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13923 PTHR13923, 1 hit
PfamiView protein in Pfam
PF12931 Sec16_C, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1Z7J6_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1Z7J6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 18, 2019
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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