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Entry version 117 (10 Feb 2021)
Sequence version 2 (03 Mar 2009)
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Protein

Latrophilin Cirl

Gene

Cirl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandLectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-373080, Class B/2 (Secretin family receptors)
R-DME-6798695, Neutrophil degranulation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
P02.A01

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Latrophilin Cirl1 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CirlImported
ORF Names:CG8639
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0033313, Cirl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 753ExtracellularSequence analysisAdd BLAST753
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei754 – 774Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini775 – 787CytoplasmicSequence analysisAdd BLAST13
Transmembranei788 – 808Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini809 – 814ExtracellularSequence analysis6
Transmembranei815 – 835Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini836 – 861CytoplasmicSequence analysisAdd BLAST26
Transmembranei862 – 882Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini883 – 906ExtracellularSequence analysisAdd BLAST24
Transmembranei907 – 927Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini928 – 954CytoplasmicSequence analysisAdd BLAST27
Transmembranei955 – 975Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini976 – 985ExtracellularSequence analysis10
Transmembranei986 – 1006Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1007 – 1697CytoplasmicSequence analysisAdd BLAST691

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003933751 – 1697Latrophilin CirlAdd BLAST1697

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi242N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi384N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi641N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi689N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi716N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1142Phosphoserine1 Publication1
Modified residuei1239Phosphoserine1 Publication1
Modified residuei1246Phosphoserine1 Publication1
Modified residuei1315Phosphoserine1 Publication1
Modified residuei1316Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1Z7G7

PRoteomics IDEntifications database

More...
PRIDEi
A1Z7G7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A1Z7G7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0033313, Expressed in arthropod fat body and 36 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A1Z7G7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1Z7G7, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety.

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A1Z7G7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0302596

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 100SUEL-type lectinPROSITE-ProRule annotationAdd BLAST90
Domaini692 – 739GPSPROSITE-ProRule annotationAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi112 – 168Pro-richSequence analysisAdd BLAST57
Compositional biasi1292 – 1358Gln-richSequence analysisAdd BLAST67
Compositional biasi1452 – 1468Gln-richSequence analysisAdd BLAST17
Compositional biasi1648 – 1677His-richSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4193, Eukaryota
KOG4729, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000173774

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1Z7G7

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1Z7G7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.740, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032471, GAIN_dom_N
IPR017981, GPCR_2-like
IPR000203, GPS
IPR000922, Lectin_gal-bd_dom
IPR043159, Lectin_gal-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16489, GAIN, 1 hit
PF02140, Gal_Lectin, 1 hit
PF01825, GPS, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00303, GPS, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS50228, SUEL_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform C1 Publication (identifier: A1Z7G7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MILSKYQTAY ACEGKKLTIE CDPGDVINLI RANYGRFSIT ICNDHGNVEW
60 70 80 90 100
SVNCMFPKSL SVLNSRCAHK QSCGVLAATS MFGDPCPGTH KYLEAHYQCI
110 120 130 140 150
SAAQTSTTTN RPSPPPWVLS NGPPIFGNGS GLIHPPGVGA GAPPPPRLPT
160 170 180 190 200
LPGVVGISGN PGLFNVPPQH TAVTHSTPSS STTAVGGGRL KGGATSTTTT
210 220 230 240 250
KHPAGRHDGL PPPPQLHHHH NHHGEDTASP TKPSSKLPAG GNATSPSNTR
260 270 280 290 300
ILTGVGGSGT DDGTLLTTKS SPNRPPGTAA SGSVVPGNGS VVRTINNINL
310 320 330 340 350
NAAGMSGGDD ESKLFCGPTH ARNLYWNMTR VGDVNVQPCP GGAAGIAKWR
360 370 380 390 400
CVLMKRIPDS GYDEYDDDIS STTPAPSGGD CLHNSSSCEP PVSMAHKVNQ
410 420 430 440 450
RLRNFEPTWH PATPDLTQCR SLWLNNLEMR VNQRDSSLIS IANDMSEVTS
460 470 480 490 500
SKTLYGGDML VTTKIIQTVS EKMMHDKETF PDQRQREAMI MELLHCVVKT
510 520 530 540 550
GSNLLDESQL SSWLDLNPED QMRVATSLLT GLEYNAFLLA DTIIRERSVV
560 570 580 590 600
QKVKNILLSV RVLETKTIQS SVVFPDSDQW PLSSDRIELP RAALIDNSEG
610 620 630 640 650
GLVRIVFAAF DRLESILKPS YDHFDLKSSR SYVRNTAILS NDSDVNAGEI
660 670 680 690 700
QQRLRILNSK VISASLGKGR HIQLSQPITL TLKHLKTENV TNPTCVFWNY
710 720 730 740 750
IDHAWSANGC SLESTNRTHS VCSCNHLTNF AILMDVVDEH QHSLFTMFDG
760 770 780 790 800
NMRIFIYISI GICVVFIVIA LLTLKLFNGV FVKSARTSIY TSIYLCLLAI
810 820 830 840 850
ELLFLLGIEQ TETSIFCGFI TIFLHCAILS GTAWFCYEAF HSYSTLTSDE
860 870 880 890 900
LLLEVDQTPK VNCYYLLSYG LSLSVVAISL VIDPSTYTQN DYCVLMEANA
910 920 930 940 950
LFYATFVIPV LVFFVAAIGY TFLSWIIMCR KSRTGLKTKE HTRLASVRFD
960 970 980 990 1000
IRCSFVFLLL LSAVWCSAYF YLRGAKMDDD TADVYGYCFI CFNTLLGLYI
1010 1020 1030 1040 1050
FVFHCIQNEK IRREYRKYVR QHAWLPKCLR CSKTSISSGI VTGNGPTAGT
1060 1070 1080 1090 1100
LCSVSTSKKP KLPLGVSEEA HDDPQQQQQT PVPITEDAIM GATSDCELNE
1110 1120 1130 1140 1150
AQQRRTLKSG LMTGTLQAPP QTLGGHVVLE RGSTLRSTGH ASPTSSAGST
1160 1170 1180 1190 1200
HLIFAHKQQQ QQQQQGPLGE SYYHQPDYYS WKQPSTGTGG LKTPREYYNN
1210 1220 1230 1240 1250
AGAAASSPQQ AHEVFYWTQK PNSGHNGKKK RGAGGVPASP SGSLHSRTAA
1260 1270 1280 1290 1300
ASQVLFYPSY KKTKPGQPTG YPQYAEALDP PLATGNAAAY YQQQQQLRRQ
1310 1320 1330 1340 1350
QLHQQQQQQQ QQQLSSDEEQ AEQHAHLLHL QRRAGSQQQL PAPPPHMAQY
1360 1370 1380 1390 1400
QQEFMQRQYR NKHSNCDLGM GDAYYNQGSV GGADGGPVYE EILSNRNSDV
1410 1420 1430 1440 1450
QHYEVGDFDV DEVYNNSVGT GVFNNMRAAV AAGGSRYGGG SLSGGSVSSR
1460 1470 1480 1490 1500
SQQQQLKKQQ QQQSLAQQRS ARRCTADDDD DEDEEEDEEA TAAEQLHDSV
1510 1520 1530 1540 1550
CDEDEEEDES DLEDDAHGLP PQSDERMRRL MAMQDEDFKR RFQRQLRKHG
1560 1570 1580 1590 1600
APLDYGALPP GAGPQPEHNG AVFGVSGGVG EGSLRGAFRQ QQQQALNAKS
1610 1620 1630 1640 1650
PGGRLAVNEL FGHGNSGPPL PPANQTPAQK RQQLQKLSPQ STTSSSSHTS
1660 1670 1680 1690
HSNPNPHPHQ LTHPHPHQHP PHHQQRHLSA MLDENNTVRC YLEPLAK
Length:1,697
Mass (Da):186,065
Last modified:March 3, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51FBB405BBECE6F3
GO
Isoform B1 Publication (identifier: A1Z7G7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Show »
Length:1,643
Mass (Da):180,014
Checksum:iE4CC77C5B96A0C73
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JH11E1JH11_DROME
Latrophilin Cirl
Cirl ADGRL3, anon-WO0170980.7, anon-WO0170980.8, BcDNA:GH07331, CIRL
1,639Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K6T3A0A0B4K6T3_DROME
Latrophilin Cirl
Cirl ADGRL3, anon-WO0170980.7, anon-WO0170980.8, BcDNA:GH07331, CIRL
1,643Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KEG9A0A0B4KEG9_DROME
Latrophilin Cirl
Cirl ADGRL3, anon-WO0170980.7, anon-WO0170980.8, BcDNA:GH07331, CIRL
1,711Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K7U8A0A0B4K7U8_DROME
Latrophilin Cirl
Cirl ADGRL3, anon-WO0170980.7, anon-WO0170980.8, BcDNA:GH07331, CIRL
932Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KEF5A0A0B4KEF5_DROME
Latrophilin Cirl
Cirl ADGRL3, anon-WO0170980.7, anon-WO0170980.8, BcDNA:GH07331, CIRL
1,000Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM11425 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAT47768 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti633 – 636Missing in AAT47768 (Ref. 3) Curated4
Sequence conflicti772L → I in AAT47768 (Ref. 3) Curated1
Sequence conflicti882I → V in AAT47768 (Ref. 3) Curated1
Sequence conflicti975A → G in AAT47768 (Ref. 3) Curated1
Sequence conflicti1458K → N in AAM11425 (PubMed:12537569).Curated1
Sequence conflicti1584L → M in AAM11425 (PubMed:12537569).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0389661 – 54Missing in isoform B. 2 PublicationsAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF59067.3
AE013599 Genomic DNA Translation: ACL83074.1
BT014917 mRNA Translation: AAT47768.1 Different initiation.
AY095097 mRNA Translation: AAM11425.1 Different initiation.

NCBI Reference Sequences

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RefSeqi
NP_001137620.1, NM_001144148.4 [A1Z7G7-2]
NP_001246205.1, NM_001259276.2 [A1Z7G7-2]
NP_610397.4, NM_136553.5

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0290112; FBpp0288551; FBgn0033313 [A1Z7G7-2]
FBtr0305082; FBpp0293619; FBgn0033313 [A1Z7G7-2]
FBtr0310448; FBpp0302596; FBgn0033313

Database of genes from NCBI RefSeq genomes

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GeneIDi
35846

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG8639

UCSC genome browser

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UCSCi
CG8639-RB, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF59067.3
AE013599 Genomic DNA Translation: ACL83074.1
BT014917 mRNA Translation: AAT47768.1 Different initiation.
AY095097 mRNA Translation: AAM11425.1 Different initiation.
RefSeqiNP_001137620.1, NM_001144148.4 [A1Z7G7-2]
NP_001246205.1, NM_001259276.2 [A1Z7G7-2]
NP_610397.4, NM_136553.5

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiA1Z7G7, 1 interactor
STRINGi7227.FBpp0302596

Protein family/group databases

MEROPSiP02.A01

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
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PTM databases

iPTMnetiA1Z7G7

Proteomic databases

PaxDbiA1Z7G7
PRIDEiA1Z7G7

Genome annotation databases

EnsemblMetazoaiFBtr0290112; FBpp0288551; FBgn0033313 [A1Z7G7-2]
FBtr0305082; FBpp0293619; FBgn0033313 [A1Z7G7-2]
FBtr0310448; FBpp0302596; FBgn0033313
GeneIDi35846
KEGGidme:Dmel_CG8639
UCSCiCG8639-RB, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
35846
FlyBaseiFBgn0033313, Cirl

Phylogenomic databases

eggNOGiKOG4193, Eukaryota
KOG4729, Eukaryota
GeneTreeiENSGT00940000173774
InParanoidiA1Z7G7
PhylomeDBiA1Z7G7

Enzyme and pathway databases

ReactomeiR-DME-373080, Class B/2 (Secretin family receptors)
R-DME-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
35846, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Cirl, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
35846

Protein Ontology

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PROi
PR:A1Z7G7

Gene expression databases

BgeeiFBgn0033313, Expressed in arthropod fat body and 36 other tissues
ExpressionAtlasiA1Z7G7, baseline and differential
GenevisibleiA1Z7G7, DM

Family and domain databases

Gene3Di2.60.120.740, 1 hit
InterProiView protein in InterPro
IPR032471, GAIN_dom_N
IPR017981, GPCR_2-like
IPR000203, GPS
IPR000922, Lectin_gal-bd_dom
IPR043159, Lectin_gal-bd_sf
PfamiView protein in Pfam
PF16489, GAIN, 1 hit
PF02140, Gal_Lectin, 1 hit
PF01825, GPS, 1 hit
SMARTiView protein in SMART
SM00303, GPS, 1 hit
PROSITEiView protein in PROSITE
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS50228, SUEL_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLPHN_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1Z7G7
Secondary accession number(s): B7YZT6, Q6GKZ7, Q8T3I8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: March 3, 2009
Last modified: February 10, 2021
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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