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UniProtKB - A1Z734 (A1Z734_DROME)
Protein
Submitted name:
Leucine-rich repeat, isoform B
Gene
LRR
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Biological processi
- barbed-end actin filament uncapping Source: InterPro
- cilium assembly Source: FlyBase
- immune response Source: FlyBase
- negative regulation of barbed-end actin filament capping Source: InterPro
- negative regulation of immune response Source: FlyBase
- negative regulation of NIK/NF-kappaB signaling Source: FlyBase
- positive regulation of cell migration Source: InterPro
- positive regulation of lamellipodium organization Source: InterPro
- response to insecticide Source: FlyBase
Names & Taxonomyi
Protein namesi | Submitted name: Leucine-rich repeat, isoform BImported |
Gene namesi | ORF Names:CG1399Imported, Dmel_CG1399Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0033212, LRR |
VEuPathDBi | VectorBase:FBgn0033212 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-KW
Other locations
- cytoplasm Source: UniProtKB-SubCell
- lamellipodium Source: InterPro
- muscle tendon junction Source: FlyBase
Keywords - Cellular componenti
CytoplasmARBA annotationExpressioni
Gene expression databases
Bgeei | FBgn0033212, Expressed in digestive system element and 36 other tissues |
ExpressionAtlasi | A1Z734, baseline and differential |
Genevisiblei | A1Z734, DM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 48 – 146 | Carm_PHInterPro annotationAdd BLAST | 99 | |
Domaini | 800 – 1105 | CARMIL_CInterPro annotationAdd BLAST | 306 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 918 – 944 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 1072 – 1117 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 1148 – 1175 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 1181 – 1200 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1227 – 1255 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 1333 – 1400 | DisorderedSequence analysisAdd BLAST | 68 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1072 – 1102 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 1103 – 1117 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the CARMIL family.ARBA annotation
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000167677 |
InParanoidi | A1Z734 |
PhylomeDBi | A1Z734 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR029764, CARMIL1 IPR031943, CARMIL_C IPR041245, CARMIL_PH IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR011993, PH-like_dom_sf |
PANTHERi | PTHR24112:SF39, PTHR24112:SF39, 1 hit |
Pfami | View protein in Pfam PF17888, Carm_PH, 1 hit PF16000, CARMIL_C, 1 hit PF13516, LRR_6, 3 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
A1Z734-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGEMRTMEMM THIDQYLRRI IELQIRDVVK QNRDKESVKS ILGRHTKILV
60 70 80 90 100
KYMVKLETKG DKTENRVLVF TPVRVYLLSA KVPTKIECHF HYLDIVGVES
110 120 130 140 150
KKSTHFSIVT NDRPYSFVTT GDAGNFSSNA DVILTDLASA IKQIFPTVPL
160 170 180 190 200
KYIIRKIDIQ PPERETIFSE EFRPSDPRNV GPCGGFSAQY ACMCDFHGVP
210 220 230 240 250
YREEVAWDVD TIYLSHDTRV LNLRDFDHLE PKDLMAIVSA LEYNTFFRGL
260 270 280 290 300
KAAHMRLSHE TLERILHVLK RSMWLEELHL EALGLRWDFL NKLSISVITN
310 320 330 340 350
SNPAIRTIDL SHNIIEDKGA IHLAGPIAKV SKGLCKLALA HCGLTSKGVN
360 370 380 390 400
QMSHSLTLNQ SISNSLTYLD LSGNSLKDDI TNLHNFLAQP NVLEHLDLAS
410 420 430 440 450
TDITLENLFG ALLRGCATHL AHLNVSHNSF STKKGKEIPP SFKQFFTSTF
460 470 480 490 500
SLKHLNIAGC KLPMEALKNL LLGLACNEST AGLYLDLSSN TLGAQGAHVL
510 520 530 540 550
ESCIHGVRVL QSLDISDNNL DAELAPVLTA ISKNPSIRTL HLTRSLTGMK
560 570 580 590 600
PKHIPPVMDA LVNLIQKDDF PLVELVLSEN KLKHDLHDFI NALGSNQSLQ
610 620 630 640 650
KLDISGNFMG DVGARLLAKA LQINNRLRTI YMDKNGVTLQ GYADIVYALE
660 670 680 690 700
HNHSMRTIPF PVFDIAPHLK SHPDKTDAVM RKMQELLQRN CNGLKRATGQ
710 720 730 740 750
GFRLQHGFML SSTHQLVDKL VAETQDTISL AKGGSESASA VQRLITDAEN
760 770 780 790 800
CKQLMPKLQE AVRNESHPIE MKMTRVASEL SYTIKSYLEE TMETMMRTGI
810 820 830 840 850
EQCPKTLGNQ IVVQDLRKAL AERLVVPEEF LQICLLNNAG SEIMNKVGEI
860 870 880 890 900
EQSLAAAISD RATDEVLEAL TRYRRGMGIA ESPSVLLDEP QTPDIVRSRS
910 920 930 940 950
SHDADGLIIR PGGRGSILPK LGLESPTATP HLPTKRRSLA KKVRPQSVVE
960 970 980 990 1000
NLSLGHFPDL LESPSSHRSN SQLSARAAAG AAALVGAANM TDSIAVDDGG
1010 1020 1030 1040 1050
VDECCDSITE LPSASFQLQH LVKGRPKRAK TRAPTRPLVT TECAGGSREI
1060 1070 1080 1090 1100
GEGLEHFFRP GSVTPTTLTP LVSPTSEECS SLSFVDSPTM SRDGNGHMTS
1110 1120 1130 1140 1150
EETTPILEER RPIKLERQSP LLKSASWATR SRSTDNLEKY SPLVGRKSPL
1160 1170 1180 1190 1200
VKMRTEGGPG SGSATGAEET SMPSSNLLKA TAREDKTRSP SSDSIKSHAA
1210 1220 1230 1240 1250
GEGSVIVKTG NGILRTPIVL QKPRPWSVVG SEPKAGGDLI TGNGNADSSK
1260 1270 1280 1290 1300
TTPDKLEEDD VEIVTFGNTC SGSIVGITPG IALSTSGGGS IVGITPGGAL
1310 1320 1330 1340 1350
EKKSVRELAA GLNRMELPLK PPVMPRTLLN ATSVRTSTSS TGSTSNSVSV
1360 1370 1380 1390 1400
SSSTNANTSM TVLNQSQTRS RIVSSTSSTD STETITERST TSTSSSSSSS
1410 1420 1430 1440 1450
YEKQHAKACA NLISNEILSM RNGQLGAKSG SCAESGGVKR IAGKEISTLF
EV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4KEE7 | A0A0B4KEE7_DROME | Leucine-rich repeat, isoform F | LRR CG1576, Dmel\CG1399, Dmel\LRR, CG1399, Dmel_CG1399 | 1,486 | Annotation score: | ||
E1JGZ8 | E1JGZ8_DROME | Leucine-rich repeat, isoform C | LRR CG1576, Dmel\CG1399, Dmel\LRR, CG1399, Dmel_CG1399 | 1,429 | Annotation score: | ||
E1JGZ7 | E1JGZ7_DROME | Leucine-rich repeat, isoform G | LRR CG1576, Dmel\CG1399, Dmel\LRR, CG1399, Dmel_CG1399 | 1,296 | Annotation score: | ||
Q6NND6 | Q6NND6_DROME | Leucine-rich repeat, isoform D | LRR CG1576, Dmel\CG1399, Dmel\LRR, CG1399, Dmel_CG1399 | 492 | Annotation score: | ||
Q8IGL5 | Q8IGL5_DROME | Leucine-rich repeat, isoform A | LRR CG1576, Dmel\CG1399, Dmel\LRR, CG1399, Dmel_CG1399 | 655 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF59205.3 |
RefSeqi | NP_610316.3, NM_136472.6 |
Genome annotation databases
EnsemblMetazoai | FBtr0088939; FBpp0088013; FBgn0033212 |
GeneIDi | 35715 |
UCSCi | CG1399-RB, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF59205.3 |
RefSeqi | NP_610316.3, NM_136472.6 |
3D structure databases
SMRi | A1Z734 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A1Z734, 16 interactors |
PTM databases
SwissPalmi | A1Z734 |
Proteomic databases
PRIDEi | A1Z734 |
Protocols and materials databases
DNASUi | 35715 |
Genome annotation databases
EnsemblMetazoai | FBtr0088939; FBpp0088013; FBgn0033212 |
GeneIDi | 35715 |
UCSCi | CG1399-RB, d. melanogaster |
Organism-specific databases
CTDi | 35715 |
FlyBasei | FBgn0033212, LRR |
VEuPathDBi | VectorBase:FBgn0033212 |
Phylogenomic databases
GeneTreei | ENSGT00940000167677 |
InParanoidi | A1Z734 |
PhylomeDBi | A1Z734 |
Miscellaneous databases
BioGRID-ORCSi | 35715, 0 hits in 3 CRISPR screens |
GenomeRNAii | 35715 |
Gene expression databases
Bgeei | FBgn0033212, Expressed in digestive system element and 36 other tissues |
ExpressionAtlasi | A1Z734, baseline and differential |
Genevisiblei | A1Z734, DM |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR029764, CARMIL1 IPR031943, CARMIL_C IPR041245, CARMIL_PH IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR011993, PH-like_dom_sf |
PANTHERi | PTHR24112:SF39, PTHR24112:SF39, 1 hit |
Pfami | View protein in Pfam PF17888, Carm_PH, 1 hit PF16000, CARMIL_C, 1 hit PF13516, LRR_6, 3 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A1Z734_DROME | |
Accessioni | A1Z734Primary (citable) accession number: A1Z734 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 6, 2007 |
Last sequence update: | November 13, 2007 | |
Last modified: | May 25, 2022 | |
This is version 128 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |