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UniProtKB - A1Z734 (A1Z734_DROME)

Entry version 116 (16 Oct 2019)
Sequence version 2 (13 Nov 2007)
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Protein
Submitted name:

Leucine-rich repeat, isoform B

Gene

LRR

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Leucine-rich repeat, isoform BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRImported
Synonyms:CG1576Imported, Dmel\CG1399Imported, Dmel\LRRImported
ORF Names:CG1399Imported, Dmel_CG1399Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0033212 LRR

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		A1Z734

PTM databases

SwissPalm database of S-palmitoylation events

More...SwissPalmi		A1Z734

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0033212 Expressed in 30 organ(s), highest expression level in adult Malpighian tubule (Drosophila)

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A1Z734 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A1Z734 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		A1Z734, 16 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A1Z734

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini48 – 146Carm_PHInterPro annotationAdd BLAST99
Domaini800 – 1105CARMIL_CInterPro annotationAdd BLAST306

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni918 – 944DisorderedSequence analysisAdd BLAST27
Regioni1072 – 1117DisorderedSequence analysisAdd BLAST46
Regioni1148 – 1175DisorderedSequence analysisAdd BLAST28
Regioni1181 – 1200DisorderedSequence analysisAdd BLAST20
Regioni1227 – 1255DisorderedSequence analysisAdd BLAST29
Regioni1333 – 1400DisorderedSequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1072 – 1102PolarSequence analysisAdd BLAST31
Compositional biasi1103 – 1117PolyampholyteSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4242 Eukaryota
ENOG410Y5JZ LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000167677

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000239124

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A1Z734

Database for complete collections of gene phylogenies

More...PhylomeDBi		A1Z734

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031943 CARMIL_C
IPR041245 CARMIL_PH
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR011993 PH-like_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17888 Carm_PH, 1 hit
PF16000 CARMIL_C, 1 hit
PF13516 LRR_6, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51450 LRR, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A1Z734-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEMRTMEMM THIDQYLRRI IELQIRDVVK QNRDKESVKS ILGRHTKILV 
        60         70         80         90        100
KYMVKLETKG DKTENRVLVF TPVRVYLLSA KVPTKIECHF HYLDIVGVES 
       110        120        130        140        150
KKSTHFSIVT NDRPYSFVTT GDAGNFSSNA DVILTDLASA IKQIFPTVPL 
       160        170        180        190        200
KYIIRKIDIQ PPERETIFSE EFRPSDPRNV GPCGGFSAQY ACMCDFHGVP 
       210        220        230        240        250
YREEVAWDVD TIYLSHDTRV LNLRDFDHLE PKDLMAIVSA LEYNTFFRGL 
       260        270        280        290        300
KAAHMRLSHE TLERILHVLK RSMWLEELHL EALGLRWDFL NKLSISVITN 
       310        320        330        340        350
SNPAIRTIDL SHNIIEDKGA IHLAGPIAKV SKGLCKLALA HCGLTSKGVN 
       360        370        380        390        400
QMSHSLTLNQ SISNSLTYLD LSGNSLKDDI TNLHNFLAQP NVLEHLDLAS 
       410        420        430        440        450
TDITLENLFG ALLRGCATHL AHLNVSHNSF STKKGKEIPP SFKQFFTSTF 
       460        470        480        490        500
SLKHLNIAGC KLPMEALKNL LLGLACNEST AGLYLDLSSN TLGAQGAHVL 
       510        520        530        540        550
ESCIHGVRVL QSLDISDNNL DAELAPVLTA ISKNPSIRTL HLTRSLTGMK 
       560        570        580        590        600
PKHIPPVMDA LVNLIQKDDF PLVELVLSEN KLKHDLHDFI NALGSNQSLQ 
       610        620        630        640        650
KLDISGNFMG DVGARLLAKA LQINNRLRTI YMDKNGVTLQ GYADIVYALE 
       660        670        680        690        700
HNHSMRTIPF PVFDIAPHLK SHPDKTDAVM RKMQELLQRN CNGLKRATGQ 
       710        720        730        740        750
GFRLQHGFML SSTHQLVDKL VAETQDTISL AKGGSESASA VQRLITDAEN 
       760        770        780        790        800
CKQLMPKLQE AVRNESHPIE MKMTRVASEL SYTIKSYLEE TMETMMRTGI 
       810        820        830        840        850
EQCPKTLGNQ IVVQDLRKAL AERLVVPEEF LQICLLNNAG SEIMNKVGEI 
       860        870        880        890        900
EQSLAAAISD RATDEVLEAL TRYRRGMGIA ESPSVLLDEP QTPDIVRSRS 
       910        920        930        940        950
SHDADGLIIR PGGRGSILPK LGLESPTATP HLPTKRRSLA KKVRPQSVVE 
       960        970        980        990       1000
NLSLGHFPDL LESPSSHRSN SQLSARAAAG AAALVGAANM TDSIAVDDGG 
      1010       1020       1030       1040       1050
VDECCDSITE LPSASFQLQH LVKGRPKRAK TRAPTRPLVT TECAGGSREI 
      1060       1070       1080       1090       1100
GEGLEHFFRP GSVTPTTLTP LVSPTSEECS SLSFVDSPTM SRDGNGHMTS 
      1110       1120       1130       1140       1150
EETTPILEER RPIKLERQSP LLKSASWATR SRSTDNLEKY SPLVGRKSPL 
      1160       1170       1180       1190       1200
VKMRTEGGPG SGSATGAEET SMPSSNLLKA TAREDKTRSP SSDSIKSHAA 
      1210       1220       1230       1240       1250
GEGSVIVKTG NGILRTPIVL QKPRPWSVVG SEPKAGGDLI TGNGNADSSK 
      1260       1270       1280       1290       1300
TTPDKLEEDD VEIVTFGNTC SGSIVGITPG IALSTSGGGS IVGITPGGAL 
      1310       1320       1330       1340       1350
EKKSVRELAA GLNRMELPLK PPVMPRTLLN ATSVRTSTSS TGSTSNSVSV 
      1360       1370       1380       1390       1400
SSSTNANTSM TVLNQSQTRS RIVSSTSSTD STETITERST TSTSSSSSSS 
      1410       1420       1430       1440       1450
YEKQHAKACA NLISNEILSM RNGQLGAKSG SCAESGGVKR IAGKEISTLF 

EV
Length:1,452
Mass (Da):158,066
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51176B14D2CD5257
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JGZ8E1JGZ8_DROME
Leucine-rich repeat, isoform C
LRR CG1576, Dmel\CG1399, Dmel\LRR, CG1399, Dmel_CG1399
1,429Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KEE7A0A0B4KEE7_DROME
Leucine-rich repeat, isoform F
LRR CG1576, Dmel\CG1399, Dmel\LRR, CG1399, Dmel_CG1399
1,486Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JGZ7E1JGZ7_DROME
Leucine-rich repeat, isoform G
LRR CG1576, Dmel\CG1399, Dmel\LRR, CG1399, Dmel_CG1399
1,296Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6NND6Q6NND6_DROME
Leucine-rich repeat, isoform D
LRR CG1576, Dmel\CG1399, Dmel\LRR, CG1399, Dmel_CG1399
492Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8IGL5Q8IGL5_DROME
Leucine-rich repeat, isoform A
LRR CG1576, Dmel\CG1399, Dmel\LRR, CG1399, Dmel_CG1399
655Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF59205.3

NCBI Reference Sequences

More...RefSeqi		NP_610316.3, NM_136472.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0088939; FBpp0088013; FBgn0033212

Database of genes from NCBI RefSeq genomes

More...GeneIDi		35715

UCSC genome browser

More...UCSCi		CG1399-RB d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF59205.3
RefSeqiNP_610316.3, NM_136472.6

3D structure databases

SMRiA1Z734
ModBaseiSearch...

Protein-protein interaction databases

IntActiA1Z734, 16 interactors

PTM databases

SwissPalmiA1Z734

Proteomic databases

PRIDEiA1Z734

Genome annotation databases

EnsemblMetazoaiFBtr0088939; FBpp0088013; FBgn0033212
GeneIDi35715
UCSCiCG1399-RB d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		35715
FlyBaseiFBgn0033212 LRR

Phylogenomic databases

eggNOGiKOG4242 Eukaryota
ENOG410Y5JZ LUCA
GeneTreeiENSGT00940000167677
HOGENOMiHOG000239124
InParanoidiA1Z734
PhylomeDBiA1Z734

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		35715

Gene expression databases

BgeeiFBgn0033212 Expressed in 30 organ(s), highest expression level in adult Malpighian tubule (Drosophila)
ExpressionAtlasiA1Z734 baseline and differential
GenevisibleiA1Z734 DM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR031943 CARMIL_C
IPR041245 CARMIL_PH
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR011993 PH-like_dom_sf
PfamiView protein in Pfam
PF17888 Carm_PH, 1 hit
PF16000 CARMIL_C, 1 hit
PF13516 LRR_6, 3 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1Z734_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1Z734
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: November 13, 2007
Last modified: October 16, 2019
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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