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UniProtKB - A1Z6H7 (PO210_DROME)
Protein
Nuclear pore membrane glycoprotein 210
Gene
Gp210
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Component of the nuclear pore complex.
2 PublicationsGO - Biological processi
- mRNA transport Source: UniProtKB-KW
- nuclear pore organization Source: FlyBase
- protein import into nucleus Source: FlyBase
Keywordsi
Biological process | mRNA transport, Protein transport, Translocation, Transport |
Enzyme and pathway databases
Reactomei | R-DME-159227, Transport of the SLBP independent Mature mRNA R-DME-159230, Transport of the SLBP Dependant Mature mRNA R-DME-159231, Transport of Mature mRNA Derived from an Intronless Transcript R-DME-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-3108214, SUMOylation of DNA damage response and repair proteins R-DME-3301854, Nuclear Pore Complex (NPC) Disassembly R-DME-3371453, Regulation of HSF1-mediated heat shock response R-DME-4085377, SUMOylation of SUMOylation proteins R-DME-4551638, SUMOylation of chromatin organization proteins R-DME-4615885, SUMOylation of DNA replication proteins R-DME-5578749, Transcriptional regulation by small RNAs |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear pore membrane glycoprotein 210CuratedShort name: Nuclear pore protein gp210Curated Alternative name(s): Glycoprotein 210 kDa1 PublicationImported Nuclear pore membrane glycoprotein gp1881 PublicationImported Nucleoporin Nup210Curated Short name: Nup210Curated |
Gene namesi | ORF Names:CG7897Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0266580, Gp210 |
VEuPathDBi | VectorBase:FBgn0266580 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- Nucleus membrane 2 Publications; Single-pass type I membrane protein Sequence analysis
- nuclear pore complex 2 Publications
Note: During mitosis diffusively localized throughout the cytoplasm.1 Publication
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
- nuclear pore Source: UniProtKB
- nuclear pore inner ring Source: FlyBase
- nuclear pore nuclear basket Source: FlyBase
- nuclear pore transmembrane ring Source: FlyBase
Other locations
- cytoplasm Source: FlyBase
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 1775 | Perinuclear spaceCuratedAdd BLAST | 1755 | |
Transmembranei | 1776 – 1796 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1797 – 1876 | CytoplasmicCuratedAdd BLAST | 80 |
Keywords - Cellular componenti
Cytoplasm, Membrane, Nuclear pore complex, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_5015085938 | 21 – 1876 | Nuclear pore membrane glycoprotein 210Sequence analysisAdd BLAST | 1856 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 39 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 383 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 547 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 776 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 882 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 1412 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 1571 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 |
Post-translational modificationi
Glycosylated.1 Publication
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | A1Z6H7 |
PRIDEi | A1Z6H7 |
PTM databases
GlyGeni | A1Z6H7, 7 sites |
SwissPalmi | A1Z6H7 |
Expressioni
Tissue specificityi
Expressed in adult male accessory glands (at protein level).1 Publication
Developmental stagei
Expressed in embryos and third instar larvae (at protein level) (PubMed:3919018, PubMed:2517292, PubMed:7641726). Levels are highest during embryogenesis, decrease through larval stages, and finally increase during pupation and adult stages (PubMed:7641726).3 Publications
Gene expression databases
Bgeei | FBgn0266580, Expressed in eye disc (Drosophila) and 33 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | A1Z6H7, 5 interactors |
MINTi | A1Z6H7 |
STRINGi | 7227.FBpp0085380 |
Structurei
3D structure databases
AlphaFoldDBi | A1Z6H7 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1819 – 1876 | DisorderedSequence analysisAdd BLAST | 58 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1819 – 1837 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1859 – 1876 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the NUP210 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1833, Eukaryota |
GeneTreei | ENSGT00390000009491 |
HOGENOMi | CLU_001205_1_1_1 |
InParanoidi | A1Z6H7 |
OMAi | YVCIIKV |
OrthoDBi | 843414at2759 |
PhylomeDBi | A1Z6H7 |
Family and domain databases
InterProi | View protein in InterPro IPR008964, Invasin/intimin_cell_adhesion IPR045197, NUP210-like |
PANTHERi | PTHR23019, PTHR23019, 1 hit |
SUPFAMi | SSF49373, SSF49373, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
A1Z6H7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSILCMILL ILVRNHASEA ARLNHPRVLL PIFEDKAINF TLEVDEPNCY
60 70 80 90 100
KWSSSRQDLI SVMPIYKGFS ECAYQAVVTV RTHDRRRNTA IVFAEEVQTG
110 120 130 140 150
ETLRSDVIVD VIASLNVRTA TRQLYLEEAP AMFELHAFDE QGNEFFTLEG
160 170 180 190 200
IEFDWEILEP GSKRPTAMRY LTFTDSPYHT VPPTIEKFEA DGKKGHMILL
210 220 230 240 250
EGINTGTAKV TIAMPQAEYK HVRPVEVYIS VLANIIIEPS EVTIMAGDSV
260 270 280 290 300
SFRILQLKMD RLHVIDNNQY YLEVEDSSIA YLRGNSATGA ALGRTQVFLR
310 320 330 340 350
DRNMADSDEV QKGPSALLTV AYPNRLSISL LPHLNWVTVQ GEHHAIALDL
360 370 380 390 400
FAADGQKITM GTKYSINSEV DESFFAIVDR TRNGSRLFGQ AKKEGITQVY
410 420 430 440 450
GSYKDLSVQA ELQIFEELQL APTKVVLPYD PNSLKPLKLQ FHASGGDNNY
460 470 480 490 500
AWFSGNPQVI QIDTQGQATT EIRDVKSAYV NQEVLKDGGK LTAHTTVKVA
510 520 530 540 550
LSKNQKISRV AHIYFLPPER LQITRSNFET ALKDFVHVHV GVYARINNSE
560 570 580 590 600
VPYTSCDNLH FQLDFSQPIL QLEGNEGAEA AHEACHVLRL RATAVGTTSL
610 620 630 640 650
RVSYMYMDKV LYDIIDLYVF EPLVVLNPIE NEVVLPVGSS RNIIYANGPQ
660 670 680 690 700
RSFTVAAEII QSTAFDEKIL KVSKLEFDTQ NLITAFTVLC RELGETQFTY
710 720 730 740 750
RVHNSLPTSS FALYQSEVTT KVHCVRPRFL KLYARHNLRD SCPLEKRTSL
760 770 780 790 800
LFLKDPENKI EIEIEVHDSN NRRLMNISSL GLDWEFSAGE ERYQKNIIPH
810 820 830 840 850
RQISELEFNH GVTLPSRDLL VLTLSEVATN FRIKGTVSQY NDKLLAQHGI
860 870 880 890 900
HAERPPFGIK NPQTGLIYTP LIENEIRLHA VNSTLLPKDY MSIFLASGYS
910 920 930 940 950
ERIPIAQGSG YLQLELSEAG IVQVEYNENT RILVLTPLRL GHVRLELTDR
960 970 980 990 1000
CLMNEPSHLS ISVVGIGAIE VVSMDRLERT TRIEAIVRLF DTNDNLLLVD
1010 1020 1030 1040 1050
QSKLSAYDLS EVVADQSILS VRLGEQENVG PGEIRYTITG NQVGETKILF
1060 1070 1080 1090 1100
QSGKGIYKVA SDPLNIQVFA PIRLFPRDST LVVGSSIQVY FHGGPHPNTN
1110 1120 1130 1140 1150
MIISVEKEQV ATISSTVVTA HKLGTTKIVG KCLLKNPVTG KDEVVSQDSV
1160 1170 1180 1190 1200
EVHVVALKGV QIRTPLVRIH SGAVMPATLW GLSDLSPMIL GTLQNTKISW
1210 1220 1230 1240 1250
KVSQPQVVEI FNVFTTAGIE YQSGDLISVR VRALNPGKAT ITASVTLADG
1260 1270 1280 1290 1300
TILPPATVDL QVFKTLELVT PNAIKMDSIL AAPRSILQLK SNMDNVVYKL
1310 1320 1330 1340 1350
DDRSNGIVSV TPDGLVHTKD SLGRDLIIAT TADQSLPIGI EVKNVQYILV
1360 1370 1380 1390 1400
TLMPILKLRE LEHKIPRGMN FVFKVSLHDN LGNELSHNIE DFNGLRYELG
1410 1420 1430 1440 1450
NKDDVDVQID NNLTFALNLM RETNNVIGIS LKDSTGVKHS MDFIKLSVVE
1460 1470 1480 1490 1500
SDNLFPTKTI FSVGDIICFD SPLTLSSTWR SSNEQIVYIN KHTGIAQVLS
1510 1520 1530 1540 1550
HRLKPGEKIE ITNGDETKRG GFLKYDLEVR ESDTILFVKS VDTFSGPEYR
1560 1570 1580 1590 1600
GQLVIRNHLQ SEKYSNLIAQ NVSKCARELG SVPVNFFTCR LAAKDALGRN
1610 1620 1630 1640 1650
LLKMYKVDAL FEPSIGQYSC RLQLLTGFIE LLSIVKTHDV YLELEAVVAK
1660 1670 1680 1690 1700
GVSDKMSLKL VPGIKVFPES VRVTDLKPHE IHISGLDKAL LKVQVKPSDS
1710 1720 1730 1740 1750
KYFAVDFIEH GHGLSKYRLE LFDDLPLDEN FYILVVSPDT KQSIEVPIIG
1760 1770 1780 1790 1800
NTMLAPKCTD RRYGGPLVYR ILENLGFVLT TTVIVIISIW VYMSCFQTQG
1810 1820 1830 1840 1850
VTQVNFEAFK KGKSRTELMQ QSGRSSQDDT FGDSFNVRNF SPDRRRPPSN
1860 1870
ALSESYIYGH PRLNSSNRSE NSTSFS
Sequence cautioni
The sequence AAG42828 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAR82780 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 183 | P → A in AAG42828 (Ref. 4) Curated | 1 | |
Sequence conflicti | 1177 | A → G in AAG42828 (Ref. 4) Curated | 1 | |
Sequence conflicti | 1379 | D → A in AAG42828 (Ref. 4) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF57309.2 AE013599 Genomic DNA Translation: AGB93249.1 BT011113 mRNA Translation: AAR82780.1 Different initiation. AF322889 mRNA Translation: AAG42828.1 Different initiation. |
RefSeqi | NP_001260714.1, NM_001273785.1 NP_610184.2, NM_136340.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0086044; FBpp0085380; FBgn0266580 FBtr0335270; FBpp0307249; FBgn0266580 |
GeneIDi | 35512 |
KEGGi | dme:Dmel_CG7897 |
UCSCi | CG7897-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF57309.2 AE013599 Genomic DNA Translation: AGB93249.1 BT011113 mRNA Translation: AAR82780.1 Different initiation. AF322889 mRNA Translation: AAG42828.1 Different initiation. |
RefSeqi | NP_001260714.1, NM_001273785.1 NP_610184.2, NM_136340.3 |
3D structure databases
AlphaFoldDBi | A1Z6H7 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | A1Z6H7, 5 interactors |
MINTi | A1Z6H7 |
STRINGi | 7227.FBpp0085380 |
PTM databases
GlyGeni | A1Z6H7, 7 sites |
SwissPalmi | A1Z6H7 |
Proteomic databases
PaxDbi | A1Z6H7 |
PRIDEi | A1Z6H7 |
Protocols and materials databases
DNASUi | 35512 |
Genome annotation databases
EnsemblMetazoai | FBtr0086044; FBpp0085380; FBgn0266580 FBtr0335270; FBpp0307249; FBgn0266580 |
GeneIDi | 35512 |
KEGGi | dme:Dmel_CG7897 |
UCSCi | CG7897-RA, d. melanogaster |
Organism-specific databases
CTDi | 35512 |
FlyBasei | FBgn0266580, Gp210 |
VEuPathDBi | VectorBase:FBgn0266580 |
Phylogenomic databases
eggNOGi | KOG1833, Eukaryota |
GeneTreei | ENSGT00390000009491 |
HOGENOMi | CLU_001205_1_1_1 |
InParanoidi | A1Z6H7 |
OMAi | YVCIIKV |
OrthoDBi | 843414at2759 |
PhylomeDBi | A1Z6H7 |
Enzyme and pathway databases
Reactomei | R-DME-159227, Transport of the SLBP independent Mature mRNA R-DME-159230, Transport of the SLBP Dependant Mature mRNA R-DME-159231, Transport of Mature mRNA Derived from an Intronless Transcript R-DME-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-3108214, SUMOylation of DNA damage response and repair proteins R-DME-3301854, Nuclear Pore Complex (NPC) Disassembly R-DME-3371453, Regulation of HSF1-mediated heat shock response R-DME-4085377, SUMOylation of SUMOylation proteins R-DME-4551638, SUMOylation of chromatin organization proteins R-DME-4615885, SUMOylation of DNA replication proteins R-DME-5578749, Transcriptional regulation by small RNAs |
Miscellaneous databases
BioGRID-ORCSi | 35512, 1 hit in 3 CRISPR screens |
GenomeRNAii | 35512 |
PROi | PR:A1Z6H7 |
Gene expression databases
Bgeei | FBgn0266580, Expressed in eye disc (Drosophila) and 33 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR008964, Invasin/intimin_cell_adhesion IPR045197, NUP210-like |
PANTHERi | PTHR23019, PTHR23019, 1 hit |
SUPFAMi | SSF49373, SSF49373, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PO210_DROME | |
Accessioni | A1Z6H7Primary (citable) accession number: A1Z6H7 Secondary accession number(s): Q6NP18, Q9GPI0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 8, 2019 |
Last sequence update: | February 6, 2007 | |
Last modified: | May 25, 2022 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families