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UniProtKB - A1Z6E0 (GUS_DROME)

Entry version 115 (12 Aug 2020)
Sequence version 2 (16 Mar 2016)
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Protein

Protein gustavus

Gene

gus

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the localization of vas to the posterior pole of the oocyte. Required maternally in the germ line for efficient primordial germ cell formation.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-8951664, Neddylation
R-DME-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein gustavusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gus
ORF Names:CG2944
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0026238, gus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Homozygous females produce defective eggs, which desiccate and collapse soon after egg laying, or embryos, which hatch very rarely. Mutants exhibit wing morphology defects, including blistering, formation of ectopic vein material, and loss of material at the margin.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi131Y → A: Does not affect binding to Elongin BC complex. Abolishes interaction with vas. 1 Publication1
Mutagenesisi147G → Y: Does not affect binding to Elongin BC complex. Abolishes interaction with vas. 1 Publication1
Mutagenesisi148R → W: Does not affect binding to Elongin BC complex. Abolishes interaction with vas. 1 Publication1
Mutagenesisi187E → A: Does not affect binding to Elongin BC complex or vas. 1 Publication1
Mutagenesisi204R → S: Does not affect binding to Elongin BC complex or vas. 1 Publication1
Mutagenesisi219W → L: Does not affect binding to Elongin BC complex. Decreases interaction with vas. 3 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004221581 – 279Protein gustavusAdd BLAST279

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A1Z6E0

PRoteomics IDEntifications database

More...PRIDEi		A1Z6E0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in ovaries, primarily in nurse cells and oocytes (at protein level).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during oogenesis, in early embryos (0 to 4 hours) and in fertile adult females (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0026238, Expressed in embryo and 40 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A1Z6E0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A1Z6E0, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via B30.2/SPRY domain) with vas; this interaction may be necessary for the transport of vas to the posterior pole of the oocyte.

Interacts with Cul-5. May associate with the Elongin BC complex composed of Elongin-B and Elongin-C.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		61396, 50 interactors

Protein interaction database and analysis system

More...IntActi		A1Z6E0, 35 interactors

Molecular INTeraction database

More...MINTi		A1Z6E0

STRING: functional protein association networks

More...STRINGi		7227.FBpp0301582

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1279
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A1Z6E0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		A1Z6E0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 233B30.2/SPRYPROSITE-ProRule annotationAdd BLAST198
Domaini234 – 279SOCS boxPROSITE-ProRule annotationAdd BLAST46

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni236 – 279Involved in binding to the Elongin BC complex1 PublicationAdd BLAST44

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SPSB family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3953, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182795

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_046756_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A1Z6E0

KEGG Orthology (KO)

More...KOi		K10343

Identification of Orthologs from Complete Genome Data

More...OMAi		DLCRRCI

Database of Orthologous Groups

More...OrthoDBi		938259at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.920, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR001496, SOCS_box
IPR036036, SOCS_box-like_dom_sf
IPR003877, SPRY_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07525, SOCS_box, 1 hit
PF00622, SPRY, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00969, SOCS_box, 1 hit
SM00449, SPRY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF158235, SSF158235, 1 hit
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS50225, SOCS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A1Z6E0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQKISGGVK TVSRNDSQST FKPIIPRELQ ADFVKPARID ILLDMPPASR 
        60         70         80         90        100
DLQLKHSWNS EDRSLNIFVK EDDKLTFHRH PVAQSTDCIR GKVGLTKGLH 
       110        120        130        140        150
IWEIYWPTRQ RGTHAVVGVC TADAPLHSVG YQSLVGSTEQ SWGWDLGRNK 
       160        170        180        190        200
LYHDSKNCAG VTYPAILKND EAFLVPDKFL VALDMDEGTL SFIVDQQYLG 
       210        220        230        240        250
IAFRGLRGKK LYPIVSAVWG HCEITMRYIG GLDPEPLPLM DLCRRTIRQK 
       260        270 
IGRTNLEEHI QQLQLPLSMK TYLLYKNRR
Length:279
Mass (Da):31,713
Last modified:March 16, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDCA657FEEA83D785
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4K6X3A0A0B4K6X3_DROME
Gustavus, isoform G
gus A11, CG2946, Dmel\CG2944, dmSSB4, GUS
279Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM50263 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence ACU12389 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence ACX32987 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence ADZ74173 differs from that shown. Reason: Frameshift.Curated
The sequence ADZ74173 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57346.2
AE013599 Genomic DNA Translation: AAF57347.3
AE013599 Genomic DNA Translation: AAG22337.2
AE013599 Genomic DNA Translation: AAM68372.1
AE013599 Genomic DNA Translation: AAM68373.2
AE013599 Genomic DNA Translation: AAM68374.2
AY119609 mRNA Translation: AAM50263.1 Different initiation.
BT089043 mRNA Translation: ACU12389.1 Different initiation.
BT099916 mRNA Translation: ACX32987.1 Different initiation.
BT126146 mRNA Translation: ADZ74173.1 Sequence problems.

NCBI Reference Sequences

More...RefSeqi		NP_001246140.1, NM_001259211.2
NP_610158.3, NM_136314.4
NP_724398.2, NM_165418.3
NP_724399.2, NM_165419.3
NP_724400.2, NM_165420.3
NP_724401.2, NM_165421.3
NP_724402.2, NM_165422.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0309846; FBpp0301580; FBgn0026238
FBtr0309847; FBpp0301581; FBgn0026238
FBtr0309848; FBpp0301582; FBgn0026238
FBtr0309849; FBpp0301583; FBgn0026238
FBtr0309850; FBpp0301584; FBgn0026238
FBtr0309851; FBpp0301585; FBgn0026238
FBtr0309852; FBpp0301586; FBgn0026238

Database of genes from NCBI RefSeq genomes

More...GeneIDi		35478

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG2944

UCSC genome browser

More...UCSCi		CG2944-RA, d. melanogaster
CG2944-RB, d. melanogaster
CG2944-RD, d. melanogaster
CG2944-RE, d. melanogaster
CG2944-RF, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57346.2
AE013599 Genomic DNA Translation: AAF57347.3
AE013599 Genomic DNA Translation: AAG22337.2
AE013599 Genomic DNA Translation: AAM68372.1
AE013599 Genomic DNA Translation: AAM68373.2
AE013599 Genomic DNA Translation: AAM68374.2
AY119609 mRNA Translation: AAM50263.1 Different initiation.
BT089043 mRNA Translation: ACU12389.1 Different initiation.
BT099916 mRNA Translation: ACX32987.1 Different initiation.
BT126146 mRNA Translation: ADZ74173.1 Sequence problems.
RefSeqiNP_001246140.1, NM_001259211.2
NP_610158.3, NM_136314.4
NP_724398.2, NM_165418.3
NP_724399.2, NM_165419.3
NP_724400.2, NM_165420.3
NP_724401.2, NM_165421.3
NP_724402.2, NM_165422.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FNJX-ray1.80A27-251[»]
2IHSX-ray2.20A/B27-232[»]
SMRiA1Z6E0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi61396, 50 interactors
IntActiA1Z6E0, 35 interactors
MINTiA1Z6E0
STRINGi7227.FBpp0301582

Proteomic databases

PaxDbiA1Z6E0
PRIDEiA1Z6E0

Genome annotation databases

EnsemblMetazoaiFBtr0309846; FBpp0301580; FBgn0026238
FBtr0309847; FBpp0301581; FBgn0026238
FBtr0309848; FBpp0301582; FBgn0026238
FBtr0309849; FBpp0301583; FBgn0026238
FBtr0309850; FBpp0301584; FBgn0026238
FBtr0309851; FBpp0301585; FBgn0026238
FBtr0309852; FBpp0301586; FBgn0026238
GeneIDi35478
KEGGidme:Dmel_CG2944
UCSCiCG2944-RA, d. melanogaster
CG2944-RB, d. melanogaster
CG2944-RD, d. melanogaster
CG2944-RE, d. melanogaster
CG2944-RF, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		35478
FlyBaseiFBgn0026238, gus

Phylogenomic databases

eggNOGiKOG3953, Eukaryota
GeneTreeiENSGT00950000182795
HOGENOMiCLU_046756_0_1_1
InParanoidiA1Z6E0
KOiK10343
OMAiDLCRRCI
OrthoDBi938259at2759

Enzyme and pathway databases

ReactomeiR-DME-8951664, Neddylation
R-DME-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		35478, 0 hits in 5 CRISPR screens
EvolutionaryTraceiA1Z6E0

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		35478

Protein Ontology

More...PROi		PR:A1Z6E0

Gene expression databases

BgeeiFBgn0026238, Expressed in embryo and 40 other tissues
ExpressionAtlasiA1Z6E0, baseline and differential
GenevisibleiA1Z6E0, DM

Family and domain databases

Gene3Di2.60.120.920, 1 hit
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR001496, SOCS_box
IPR036036, SOCS_box-like_dom_sf
IPR003877, SPRY_dom
PfamiView protein in Pfam
PF07525, SOCS_box, 1 hit
PF00622, SPRY, 1 hit
SMARTiView protein in SMART
SM00969, SOCS_box, 1 hit
SM00449, SPRY, 1 hit
SUPFAMiSSF158235, SSF158235, 1 hit
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS50225, SOCS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGUS_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1Z6E0
Secondary accession number(s): A1Z6D7
, A1Z6D9, A1Z6E2, F2FB59, Q7JUY1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: March 16, 2016
Last modified: August 12, 2020
This is version 115 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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