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Entry version 93 (13 Feb 2019)
Sequence version 2 (18 Jul 2018)
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Protein

ADP-ribose glycohydrolase MACROD2

Gene

MACROD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Subject to product inhibition by ADP-ribose.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=107 µM for O-acetyl-ADP-ribose1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei224Substrate1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processDNA damage

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    ADP-ribose glycohydrolase MACROD2Curated
    Alternative name(s):
    MACRO domain-containing protein 21 Publication
    O-acetyl-ADP-ribose deacetylase MACROD2 (EC:3.5.1.-1 Publication)
    [Protein ADP-ribosylaspartate] hydrolase MACROD2Curated (EC:3.2.2.-1 Publication)
    [Protein ADP-ribosylglutamate] hydrolase MACROD2Curated (EC:3.2.2.-2 Publications)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:MACROD21 PublicationImported
    Synonyms:C20orf133Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000172264.16

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:16126 MACROD2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    611567 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_A1Z1Q3

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi92N → A: Reduced ADP-ribosyl hydrolase activity; when associated with A-102. 1 Publication1
    Mutagenesisi100G → A: Abolished hydrolase activity and ability to bind ADP-D-ribose. 1 Publication1
    Mutagenesisi102D → A: Reduced ADP-ribosyl hydrolase activity. Reduced ADP-ribosyl hydrolase activity; when associated with A-92. 2 Publications1
    Mutagenesisi106H → A: Reduced hydrolase activity. 1 Publication1
    Mutagenesisi188G → E: Abolishes interaction with ADP-ribosylated proteins. Strongly reduced ADP-ribosyl hydrolase activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    140733

    Open Targets

    More...
    OpenTargetsi
    ENSG00000172264

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA162394843

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    MACROD2

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003004611 – 425ADP-ribose glycohydrolase MACROD2Add BLAST425

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki170Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    A1Z1Q3

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    A1Z1Q3

    PRoteomics IDEntifications database

    More...
    PRIDEi
    A1Z1Q3

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    165
    166 [A1Z1Q3-2]
    167 [A1Z1Q3-4]
    168 [A1Z1Q3-5]
    169 [A1Z1Q3-6]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    A1Z1Q3

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    A1Z1Q3

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000172264 Expressed in 166 organ(s), highest expression level in visceral pleura

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    A1Z1Q3 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    A1Z1Q3 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA049076

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with ADP-ribosylated PARP1.1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    126679, 3 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    A1Z1Q3, 2 interactors

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1425
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4IQYX-ray1.55A/B7-243[»]

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    A1Z1Q3

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    A1Z1Q3

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini59 – 240MacroPROSITE-ProRule annotationAdd BLAST182

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni77 – 79Substrate binding1 Publication3
    Regioni90 – 92Substrate binding1 Publication3
    Regioni97 – 102Substrate binding1 Publication6
    Regioni185 – 191Substrate binding1 Publication7

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi6 – 9Poly-Lys4
    Compositional biasi247 – 388Glu-richAdd BLAST142

    Phylogenomic databases

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157404

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG099716

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    A1Z1Q3

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    PNGQEHD

    Database of Orthologous Groups

    More...
    OrthoDBi
    937161at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    A1Z1Q3

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF341440

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002589 Macro_dom
    IPR039658 Macro_domain_protein

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11106 PTHR11106, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01661 Macro, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00506 A1pp, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51154 MACRO, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 2 (identifier: A1Z1Q3-2) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MYPSNKKKKV WREEKERLLK MTLEERRKEY LRDYIPLNSI LSWKEEMKGK
    60 70 80 90 100
    GQNDEENTQE TSQVKKSLTE KVSLYRGDIT LLEVDAIVNA ANASLLGGGG
    110 120 130 140 150
    VDGCIHRAAG PCLLAECRNL NGCDTGHAKI TCGYDLPAKY VIHTVGPIAR
    160 170 180 190 200
    GHINGSHKED LANCYKSSLK LVKENNIRSV AFPCISTGIY GFPNEPAAVI
    210 220 230 240 250
    ALNTIKEWLA KNHHEVDRII FCVFLEVDFK IYKKKMNEFF SVDDNNEEEE
    260 270 280 290 300
    DVEMKEDSDE NGPEEKQSVE EMEEQSQDAD GVNTVTVPGP ASEEAVEDCK
    310 320 330 340 350
    DEDFAKDENI TKGGEVTDHS VRDQDHPDGQ ENDSTKNEIK IETESQSSYM
    360 370 380 390 400
    ETEELSSNQE DAVIVEQPEV IPLTEDQEEK EGEKAPGEDT PRMPGKSEGS
    410 420
    SDLENTPGPD AGAQDEAKEQ RNGTK
    Length:425
    Mass (Da):47,421
    Last modified:July 18, 2018 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2CB614734EDB6314
    GO
    Isoform 1 (identifier: A1Z1Q3-1) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         410-410: D → DVEMNSQVDKVNDPTESQQEDQLI

    Note: No experimental confirmation available.Curated
    Show »
    Length:448
    Mass (Da):50,050
    Checksum:iA0E49D46E76161DB
    GO
    Isoform 4 (identifier: A1Z1Q3-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-235: Missing.
         410-410: D → DVEMNSQVDKVNDPTESQQEDQLI

    Show »
    Length:213
    Mass (Da):23,616
    Checksum:i6697DB0A302DA7DC
    GO
    Isoform 5 (identifier: A1Z1Q3-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-235: Missing.

    Note: No experimental confirmation available.Curated
    Show »
    Length:190
    Mass (Da):20,987
    Checksum:iB631FBC82B66F388
    GO
    Isoform 6 (identifier: A1Z1Q3-6) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-349: Missing.
         411-411: A → VEMNSQVDKVNDPTESQQEDQLI

    Note: No experimental confirmation available.Curated
    Show »
    Length:98
    Mass (Da):10,769
    Checksum:i797D03BFA265AC2C
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A2R8YFN3A0A2R8YFN3_HUMAN
    ADP-ribose glycohydrolase MACROD2
    MACROD2
    453Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAD18504 differs from that shown. Reason: Frameshift at position 151.Curated

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05693558T → I1 PublicationCorresponds to variant dbSNP:rs2990505Ensembl.1
    Natural variantiVAR_061681335T → M. Corresponds to variant dbSNP:rs41275442Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0596411 – 349Missing in isoform 6. Add BLAST349
    Alternative sequenceiVSP_0596421 – 235Missing in isoform 4 and isoform 5. Add BLAST235
    Alternative sequenceiVSP_059643410D → DVEMNSQVDKVNDPTESQQE DQLI in isoform 1 and isoform 4. 1
    Alternative sequenceiVSP_059644411A → VEMNSQVDKVNDPTESQQED QLI in isoform 6. 1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    EF159161 mRNA Translation: ABM46908.1
    AK131348 mRNA Translation: BAD18504.1 Frameshift.
    AK125899 mRNA Translation: BAG54262.1
    AC006198 Genomic DNA No translation available.
    AL035073 Genomic DNA No translation available.
    AL049867 Genomic DNA No translation available.
    AL050324 Genomic DNA No translation available.
    AL118503 Genomic DNA No translation available.
    AL118510 Genomic DNA No translation available.
    AL132826 Genomic DNA No translation available.
    AL133462 Genomic DNA No translation available.
    AL136992 Genomic DNA No translation available.
    AL138808 Genomic DNA No translation available.
    AL139825 Genomic DNA No translation available.
    AL161800 Genomic DNA No translation available.
    AL355133 Genomic DNA No translation available.
    AL049633 Genomic DNA No translation available.
    AL079338 Genomic DNA No translation available.
    AL117333 Genomic DNA No translation available.
    AL121582 Genomic DNA No translation available.
    AL121584 Genomic DNA No translation available.
    AL136991 Genomic DNA No translation available.
    AL158088 Genomic DNA No translation available.
    AL353798 Genomic DNA No translation available.
    AL354773 Genomic DNA No translation available.
    AL357654 Genomic DNA No translation available.
    CH471133 Genomic DNA Translation: EAX10293.1
    CH471133 Genomic DNA Translation: EAX10302.1
    BC018687 mRNA Translation: AAH18687.1
    BC101216 mRNA No translation available.
    BC101217 mRNA No translation available.
    BC101218 mRNA No translation available.
    BC101219 mRNA No translation available.
    BC126936 mRNA No translation available.
    BC035876 mRNA No translation available.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS13120.2 [A1Z1Q3-2]
    CCDS33443.1 [A1Z1Q3-4]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001028259.1, NM_001033087.1 [A1Z1Q3-4]
    NP_542407.2, NM_080676.5 [A1Z1Q3-2]
    XP_016883166.1, XM_017027677.1

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.661576

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000217246; ENSP00000217246; ENSG00000172264 [A1Z1Q3-2]
    ENST00000378058; ENSP00000367297; ENSG00000172264 [A1Z1Q3-4]
    ENST00000402914; ENSP00000385290; ENSG00000172264 [A1Z1Q3-4]
    ENST00000407045; ENSP00000385516; ENSG00000172264 [A1Z1Q3-6]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    140733

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:140733

    UCSC genome browser

    More...
    UCSCi
    uc002wot.4 human [A1Z1Q3-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    EF159161 mRNA Translation: ABM46908.1
    AK131348 mRNA Translation: BAD18504.1 Frameshift.
    AK125899 mRNA Translation: BAG54262.1
    AC006198 Genomic DNA No translation available.
    AL035073 Genomic DNA No translation available.
    AL049867 Genomic DNA No translation available.
    AL050324 Genomic DNA No translation available.
    AL118503 Genomic DNA No translation available.
    AL118510 Genomic DNA No translation available.
    AL132826 Genomic DNA No translation available.
    AL133462 Genomic DNA No translation available.
    AL136992 Genomic DNA No translation available.
    AL138808 Genomic DNA No translation available.
    AL139825 Genomic DNA No translation available.
    AL161800 Genomic DNA No translation available.
    AL355133 Genomic DNA No translation available.
    AL049633 Genomic DNA No translation available.
    AL079338 Genomic DNA No translation available.
    AL117333 Genomic DNA No translation available.
    AL121582 Genomic DNA No translation available.
    AL121584 Genomic DNA No translation available.
    AL136991 Genomic DNA No translation available.
    AL158088 Genomic DNA No translation available.
    AL353798 Genomic DNA No translation available.
    AL354773 Genomic DNA No translation available.
    AL357654 Genomic DNA No translation available.
    CH471133 Genomic DNA Translation: EAX10293.1
    CH471133 Genomic DNA Translation: EAX10302.1
    BC018687 mRNA Translation: AAH18687.1
    BC101216 mRNA No translation available.
    BC101217 mRNA No translation available.
    BC101218 mRNA No translation available.
    BC101219 mRNA No translation available.
    BC126936 mRNA No translation available.
    BC035876 mRNA No translation available.
    CCDSiCCDS13120.2 [A1Z1Q3-2]
    CCDS33443.1 [A1Z1Q3-4]
    RefSeqiNP_001028259.1, NM_001033087.1 [A1Z1Q3-4]
    NP_542407.2, NM_080676.5 [A1Z1Q3-2]
    XP_016883166.1, XM_017027677.1
    UniGeneiHs.661576

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4IQYX-ray1.55A/B7-243[»]
    ProteinModelPortaliA1Z1Q3
    SMRiA1Z1Q3
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi126679, 3 interactors
    IntActiA1Z1Q3, 2 interactors

    PTM databases

    iPTMnetiA1Z1Q3
    PhosphoSitePlusiA1Z1Q3

    Polymorphism and mutation databases

    BioMutaiMACROD2

    Proteomic databases

    jPOSTiA1Z1Q3
    MaxQBiA1Z1Q3
    PRIDEiA1Z1Q3
    ProteomicsDBi165
    166 [A1Z1Q3-2]
    167 [A1Z1Q3-4]
    168 [A1Z1Q3-5]
    169 [A1Z1Q3-6]

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000217246; ENSP00000217246; ENSG00000172264 [A1Z1Q3-2]
    ENST00000378058; ENSP00000367297; ENSG00000172264 [A1Z1Q3-4]
    ENST00000402914; ENSP00000385290; ENSG00000172264 [A1Z1Q3-4]
    ENST00000407045; ENSP00000385516; ENSG00000172264 [A1Z1Q3-6]
    GeneIDi140733
    KEGGihsa:140733
    UCSCiuc002wot.4 human [A1Z1Q3-2]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    140733
    DisGeNETi140733
    EuPathDBiHostDB:ENSG00000172264.16

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    MACROD2
    HGNCiHGNC:16126 MACROD2
    HPAiHPA049076
    MIMi611567 gene
    neXtProtiNX_A1Z1Q3
    OpenTargetsiENSG00000172264
    PharmGKBiPA162394843

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    GeneTreeiENSGT00940000157404
    HOVERGENiHBG099716
    InParanoidiA1Z1Q3
    OMAiPNGQEHD
    OrthoDBi937161at2759
    PhylomeDBiA1Z1Q3
    TreeFamiTF341440

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    MACROD2 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    140733

    Protein Ontology

    More...
    PROi
    PR:A1Z1Q3

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000172264 Expressed in 166 organ(s), highest expression level in visceral pleura
    ExpressionAtlasiA1Z1Q3 baseline and differential
    GenevisibleiA1Z1Q3 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR002589 Macro_dom
    IPR039658 Macro_domain_protein
    PANTHERiPTHR11106 PTHR11106, 1 hit
    PfamiView protein in Pfam
    PF01661 Macro, 1 hit
    SMARTiView protein in SMART
    SM00506 A1pp, 1 hit
    PROSITEiView protein in PROSITE
    PS51154 MACRO, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMACD2_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1Z1Q3
    Secondary accession number(s): A6NFF7
    , B0QZ39, B3KWV0, Q0P6D5, Q495E0, Q5W199, Q6ZN71
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: July 18, 2018
    Last modified: February 13, 2019
    This is version 93 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
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