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Entry version 116 (17 Jun 2020)
Sequence version 1 (06 Feb 2007)
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Protein

NACHT, LRR and PYD domains-containing protein 1b allele 2

Gene

Nlrp1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of Nlrp1b, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (By similarity). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Might be activated by Toxoplasma gondii, although at a lower extent than allele 1 (PubMed:24218483). Contrary to Nlrp1b allele 1, allele 2 is not activated by Bacillus anthracis lethal toxin (PubMed:16429160, PubMed:21170303, PubMed:24492532).By similarity4 Publications

Miscellaneous

Three tandem Nrlp1 paralogs, Nrlp1a, Nrlp1b and Nrlp1c, have been identified. Nlrp1c is predicted to be a pseudogene.1 Publication1 Publication
In macrophages and dendritic cells, NLRP1 inflammasome activation of CASP1 and IL1B maturation can be dampened by direct contact with activated effector and memory T-cells. This effect may be mediated by hexameric TNF ligands, such as CD40LG.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi137 – 144ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Inflammatory response, Innate immunity
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S79.A01

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 1b allele 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nlrp1b
Synonyms:Nalp1b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3582959 Nlrp1b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Inflammasome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004351041 – 1177NACHT, LRR and PYD domains-containing protein 1b allele 2Add BLAST1177

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei927 – 928Cleavage; by autolysisPROSITE-ProRule annotationBy similarity2

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A1Z198

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1Z198

PRoteomics IDEntifications database

More...
PRIDEi
A1Z198

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A1Z198

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, including in macrophages and, at lower levels, in the peripheral nervous system, including in the sciatic nerve, Schwann cells, sensory neurons and motor neurons.3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated transiently following acute injury of the sciatic nerve with a peak after 44 hours.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000070390 Expressed in bone marrow macrophage and 15 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Sensor component of NLRP1 inflammasomes. Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation. Classical inflammasomes consist of a signal sensor component, an adapter (ASC/PYCARD), which recruits an effector proinflammatory caspase (CASP1 and possibly CASP4/CASP11). CASP1 filament formation increases local enzyme concentration, resulting in trans-autocleavage and activation. Active CASP1 then processes IL1B and IL18 precursors, leading to the release of mature cytokines in the extracellular milieu and inflammatory response. In NLRP1 inflammasome, the role of PYCARD is not clear. Following activation, Nlrp1b may directly interact with CASP1 (through the CARD domain) to form a functional inflammasome. Hence PYCARD may not be necessary for NLRP1 and CASP1 interaction, but is required for speck formation and full inflammasome activity (By similarity). Homomer (By similarity).

Interacts (via LRR repeats) with BCL2 and BCL2L1 (via the loop between motifs BH4 and BH3); these interactions reduce NLRP1 inflammasome-induced CASP1 activation and IL1B release, possibly by impairing NLRP1 interaction with PYCARD.

Interacts with NOD2; this interaction may increase IL1B release.

Interacts with EIF2AK2/PKR; this interaction requires EIF2AK2 activity, is accompanied by EIF2AK2 autophosphorylation and promotes inflammasome assembly in response to danger-associated signals.

Interacts with MEFV; this interaction targets NLRP1 to degradation by autophagy, hence preventing excessive IL1B- and IL18-mediated inflammation (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-4266 NLRP1b inflammasome, allele-2 variant

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000104155

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A1Z198 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1Z198

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini131 – 440NACHTPROSITE-ProRule annotationAdd BLAST310
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati632 – 652LRR 1Add BLAST21
Repeati689 – 709LRR 2Add BLAST21
Domaini794 – 1077FIINDPROSITE-ProRule annotationAdd BLAST284
Domaini1087 – 1170CARDPROSITE-ProRule annotationAdd BLAST84

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CARD domain is involved in the interaction with PYCARD, CASP1 and CASP4/CASP11.By similarity
The leucine-rich repeat (LRR) domain may be involved in autoinhibition in the absence of activating signal, possibly through intramolecular interaction with the NACHT domain.By similarity
The FIIND (domain with function to find) region is involved in homomerization, but not in CASP1-binding. In allele 1, autocatalytic cleavage in this region occurs constitutively, prior to activation signals, and is required for inflammasome activity (IL1B release), possibly by facilitating CASP1 binding. Both N- and C-terminal fragments remain associated (By similarity). It is not known whether this modification occurs in allele 2 (Probable).By similarityCurated

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NLRP family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JAIN Eukaryota
ENOG410YGKV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162176

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1Z198

KEGG Orthology (KO)

More...
KOi
K12798

Identification of Orthologs from Complete Genome Data

More...
OMAi
GSERMEI

Database of Orthologous Groups

More...
OrthoDBi
114368at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1Z198

TreeFam database of animal gene trees

More...
TreeFami
TF340267

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08330 CARD_ASC_NALP1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001315 CARD
IPR033516 CARD8/ASC/NALP1_CARD
IPR011029 DEATH-like_dom_sf
IPR025307 FIIND_dom
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR041267 NLRC_HD2
IPR041075 NOD2_WH
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00619 CARD, 1 hit
PF13553 FIIND, 1 hit
PF13516 LRR_6, 1 hit
PF05729 NACHT, 1 hit
PF17776 NLRC4_HD2, 1 hit
PF17779 NOD2_WH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50209 CARD, 1 hit
PS51830 FIIND, 1 hit
PS50837 NACHT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A1Z198-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEESQYKQEH NKKVAQDEGQ EDKDTIFETI EAIEAKLMEL KTNPESTFNY
60 70 80 90 100
GIFPEVYMNQ GEEILYPAWS LKEENLFQTF KSLRLFQKLC PRGSGNLVKK
110 120 130 140 150
SWYPCVPEEG GHIINIQDLF GPNIGTQKEP QLVIIEGAAG IGKSTLARQV
160 170 180 190 200
KRAWMEGELY RDHFQHVFFF SCRELAQCKK LSLAELITQG QDVPTAPINQ
210 220 230 240 250
ILSHPEKLLF ILDGIDEPAW VLADQNPELC LYWSQTQPVH TLLGSLLGKS
260 270 280 290 300
ILPEASFLLT TRTTALQKFI PSLPQSCQVE VLGFSDFEQE IYIYKYFAKQ
310 320 330 340 350
IFGIKALMMV ESNPVLLTLC EVPWVCWLVC NCLKKQMEQG GDVSLTSQTT
360 370 380 390 400
TAICLKYISL TIPVHHMRTQ LRALCSLAAE GIWKRRTLFS ESDLCKQGLD
410 420 430 440 450
EDAVAIFLKT GVLQKQASSL SYSFAHLCLQ EFFASMSCIL EDSEERHGDM
460 470 480 490 500
EMDRIVETLV ERYGRQNLFE APTVRFLFGL LSKEGLKEME KLFSCSLPGK
510 520 530 540 550
TKLKLLWHIL GKSQPHQPPC LGLLHCLYEN QDMKLLTHVM HDLQGTIVPD
560 570 580 590 600
TDDITHTVLQ TNVKHLVVRT DMELMVVTFC IQFCSHMRSL QLNMEGQQGY
610 620 630 640 650
ALTAPRMVLY RWTPITNASW KILFYNLKFN SNLEGLDLSG NPLSYSAVQY
660 670 680 690 700
LCDAMIYPGC QLKTLWLVEC GLTPTYCSLL ASVLSACSSL RELDLQLNDL
710 720 730 740 750
CDDGVRMLCE GLRNRACNLR ILRLDLYSLS AQVITELRTL EENNLKLHIS
760 770 780 790 800
SIWMPQMMVP TENMDEEDIL TSFKQQRQQS GANPMEILGT EEDFWGPIGP
810 820 830 840 850
VATEVVYRER NLYRVQLPMA GSYHCPSTRL HFVVTRAVTI EIEFCAWSQF
860 870 880 890 900
LDKTPLQQSH MVVGPLFDIK AEQGAVTAVY LPHFVSLKDT KASTFDFKVA
910 920 930 940 950
HFQEHGMVLE TPDRVKPGYT VLKNPSFSPM GVVLRIIPAA RHFIPITSIT
960 970 980 990 1000
LIYYRVNQEE VTLHLYLVPN DCTIQKAIDD EEMKFQFVRI NKPPPVDNLF
1010 1020 1030 1040 1050
IGSRYIVSGS ENLEITPKEL ELCYRSSKEF QLFSEIYVGN MGSEIKLQIK
1060 1070 1080 1090 1100
NKKHMKLIWE ALLKPGDLRP ALPRIAQALK DAPSLLHFMD QHREQLVARV
1110 1120 1130 1140 1150
TSVDPLLDKL HGLVLNEESY EAVRAENTNQ DKMRKLFNLS RSWSRACKDL
1160 1170
FYQALKETHP HLVMDLLEKS GGVSLGS
Length:1,177
Mass (Da):134,163
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E7116B0523AB17C
GO
Isoform 2 (identifier: A1Z198-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-606: MEESQYKQEH...QQGYALTAPR → MEQSQPKKKS...QQGHKLTVAS

Show »
Length:1,174
Mass (Da):134,052
Checksum:i47C5310FCA17DBE0
GO
Isoform 3 (identifier: A1Z198-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-606: MEESQYKQEH...QQGYALTAPR → MEQSQPKKKS...QQGHKLTVAS
     666-676: WLVECGLTPTY → CSAVESLEFCT
     677-1177: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:673
Mass (Da):76,829
Checksum:i782F2BD88D7E9E49
GO

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Nlrp1b gene is extremely polymorphic. 5 alleles have been described in 18 inbred strains: 1, 2, 3, 4 and 5. These alleles define susceptibility to Bacillus anthracis lethal toxin (LT). Alleles 2 (carried by A/J, C57BL/6J and I/LnJ), 3 (AKR/J, NOD/LtJ and SJL/J) or 4 (DBA/2J, P/J and SM/J) are not activated by LT. Alleles 1 (carried by 129S1/SvImJ, BALB/cJ, C3H/HeJ, CBA/J, FVB/NJ, NON/ShiLtJ, NZO (NZO/HlLtJ) and SWR/J strains) and 5 (CAST/EiJ) confer macrophage susceptibility to LT. In susceptible strains, infection by Bacillus anthracis leads to IL1B release, neutrophil recruitment and macrophage pyroptosis. This early inflammatory response confers increased resistance to infection (PubMed:16429160). The sequence shown in this entry is that of allele 2 (PubMed:16429160).1 Publication1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0580051 – 606MEESQ…LTAPR → MEQSQPKKKSRTKVAQHEGQ LNLNPTFKTRKRKEVELMKR RPKPEGHLKLGTIPKVHIKQ KGETLDPTWSRKRKNLVQKL TNLLLFEKLCSRGSENLIRK SWYSCEEEERGHMIEIQDLF GPNRGTHKKPQLVIIEGAAG IGKSTLARQVKRAWKEGQLY RNHFQHVFFLSCRELAQYEQ LSLAELIAQGQEVPTVPIRQ ILSHPKELLFILDGIDEPAW VLADQNPELCLHWSQRQPVH TLLGSLLGKSILPGASFLLT ARTTALQKIIPYVGQPRRVE VLGFSKFEREVYFRKYFVKE SDAIAAFRLVVSNPVLLTLC EVPWVCWLVCTCLKKQMEQG GELSLTSQTTTALCLKYLSL TIPGQHMRTQLRALCSLAAE GICQRRTLFSESDLCKQGLA EDAIATFLKIGILQKQASSL SYSFAHLCLQEFFAVMSYIL EDSDERCDGMEFKRTVETLI EVYGRHTLCEEPTVHFLFGL VNEQGMREMKKIFDCKLPLG TELKMLKSTLGNPTYQHHLG LLHCLYESQEEVLLTYVLCN LHLTGPDKNYMEATVSQTNV KHLVIQTDMELMVVTFCIQF CCHVRSLRVNMKGQQGHKLT VAS in isoform 2 and isoform 3. 2 PublicationsAdd BLAST606
Alternative sequenceiVSP_058006666 – 676WLVECGLTPTY → CSAVESLEFCT in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_058007677 – 1177Missing in isoform 3. 1 PublicationAdd BLAST501

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
DQ117591 mRNA Translation: AAZ40517.1
DQ117592 mRNA Translation: AAZ40518.1
DQ117593 mRNA Translation: AAZ40519.1
DQ153214 mRNA Translation: AAZ40529.1
EF158039 mRNA Translation: ABM45712.1
AL662908 Genomic DNA No translation available.
AL663042 Genomic DNA No translation available.
BC141354 mRNA Translation: AAI41355.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS36210.1 [A1Z198-2]
CCDS48839.1 [A1Z198-1]

NCBI Reference Sequences

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RefSeqi
NP_001035786.1, NM_001040696.1 [A1Z198-2]
NP_001155886.1, NM_001162414.1 [A1Z198-1]
XP_017170187.1, XM_017314698.1 [A1Z198-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000094046; ENSMUSP00000091588; ENSMUSG00000070390 [A1Z198-2]
ENSMUST00000108514; ENSMUSP00000104154; ENSMUSG00000070390 [A1Z198-1]
ENSMUST00000108515; ENSMUSP00000104155; ENSMUSG00000070390 [A1Z198-1]
ENSMUST00000108516; ENSMUSP00000104156; ENSMUSG00000070390 [A1Z198-2]
ENSMUST00000136493; ENSMUSP00000121155; ENSMUSG00000070390 [A1Z198-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
637515

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:637515

UCSC genome browser

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UCSCi
uc007jxs.1 mouse [A1Z198-1]
uc007jxt.1 mouse

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ117591 mRNA Translation: AAZ40517.1
DQ117592 mRNA Translation: AAZ40518.1
DQ117593 mRNA Translation: AAZ40519.1
DQ153214 mRNA Translation: AAZ40529.1
EF158039 mRNA Translation: ABM45712.1
AL662908 Genomic DNA No translation available.
AL663042 Genomic DNA No translation available.
BC141354 mRNA Translation: AAI41355.1
CCDSiCCDS36210.1 [A1Z198-2]
CCDS48839.1 [A1Z198-1]
RefSeqiNP_001035786.1, NM_001040696.1 [A1Z198-2]
NP_001155886.1, NM_001162414.1 [A1Z198-1]
XP_017170187.1, XM_017314698.1 [A1Z198-2]

3D structure databases

SMRiA1Z198
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-4266 NLRP1b inflammasome, allele-2 variant
STRINGi10090.ENSMUSP00000104155

Protein family/group databases

MEROPSiS79.A01

PTM databases

iPTMnetiA1Z198

Proteomic databases

MaxQBiA1Z198
PaxDbiA1Z198
PRIDEiA1Z198

Genome annotation databases

EnsembliENSMUST00000094046; ENSMUSP00000091588; ENSMUSG00000070390 [A1Z198-2]
ENSMUST00000108514; ENSMUSP00000104154; ENSMUSG00000070390 [A1Z198-1]
ENSMUST00000108515; ENSMUSP00000104155; ENSMUSG00000070390 [A1Z198-1]
ENSMUST00000108516; ENSMUSP00000104156; ENSMUSG00000070390 [A1Z198-2]
ENSMUST00000136493; ENSMUSP00000121155; ENSMUSG00000070390 [A1Z198-3]
GeneIDi637515
KEGGimmu:637515
UCSCiuc007jxs.1 mouse [A1Z198-1]
uc007jxt.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
637515
MGIiMGI:3582959 Nlrp1b

Phylogenomic databases

eggNOGiENOG410JAIN Eukaryota
ENOG410YGKV LUCA
GeneTreeiENSGT00940000162176
InParanoidiA1Z198
KOiK12798
OMAiGSERMEI
OrthoDBi114368at2759
PhylomeDBiA1Z198
TreeFamiTF340267

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
637515 0 hits in 12 CRISPR screens
RNActiA1Z198 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000070390 Expressed in bone marrow macrophage and 15 other tissues

Family and domain databases

CDDicd08330 CARD_ASC_NALP1, 1 hit
Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR033516 CARD8/ASC/NALP1_CARD
IPR011029 DEATH-like_dom_sf
IPR025307 FIIND_dom
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR041267 NLRC_HD2
IPR041075 NOD2_WH
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PF13553 FIIND, 1 hit
PF13516 LRR_6, 1 hit
PF05729 NACHT, 1 hit
PF17776 NLRC4_HD2, 1 hit
PF17779 NOD2_WH, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS51830 FIIND, 1 hit
PS50837 NACHT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNL1B2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1Z198
Secondary accession number(s): F6R9S5, Q2LK61, Q2LKV8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 9, 2015
Last sequence update: February 6, 2007
Last modified: June 17, 2020
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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