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Protein

Angiotensin-converting enzyme

Gene
N/A
Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M02.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Angiotensin-converting enzymeUniRule annotation (EC:3.4.-.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1263 – 1284HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500264120334 – 1309Angiotensin-converting enzymeSequence analysisAdd BLAST1276

Keywords - PTMi

GlycoproteinUniRule annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A1YQ85

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1YQ85 SS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
A1YQ85

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
A1YQ85

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M2 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3690 Eukaryota
ENOG410XPJ3 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007838

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000264

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06461 M2_ACE, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001548 Peptidase_M2

The PANTHER Classification System

More...
PANTHERi
PTHR10514 PTHR10514, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01401 Peptidase_M2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00791 PEPDIPTASEA

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1YQ85-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAAPGRRWP WPPLLPLLLM LLLPPPPLPV ALALDSALQP GNFTADEAGA
60 70 80 90 100
EDFAQSFNSS SEQVLFQSTA ASWAHDTNIT EENARRQEEA ALISQEFSEV
110 120 130 140 150
WGQKAKALYD PIWQNFTSRT PRRIIGVVRT LGSANLPGKR QQYNSLLSNM
160 170 180 190 200
TRIYSTARVC FPNKTATCWS LDPELTNILA TSRSYTLLLY AWEGWHNAAG
210 220 230 240 250
IPLKPLYQDF TALSNEAYKQ DGFSDTGAYW RSLYDSPTFT EDLERLYHQL
260 270 280 290 300
EPLYLNLHAY VRRALHRQYG DRFINLRGPI PAHLLGNMWA QSWNNIYDMV
310 320 330 340 350
VPFPGKPSLD VTSAMVQKGW NVTHMFRVAE EFFTSLGLLP MPPEFWAESM
360 370 380 390 400
LEKPSDRREV VCHASAWDFY NRKDFRIKQC TQVTIDQLST VHHEMGHVQY
410 420 430 440 450
YLQYKDRHVS LRRGANPGFH EAIGDVLALS VSTPAHLHKI GLLDHVTSDW
460 470 480 490 500
ESDINYLLKM ALEKIAFLPF GYLVDQWRWG VFSGRTPPSL YNYDWWYLRT
510 520 530 540 550
KYQGVCPPVV RNETHFDAGA KYHVPNVTPY IRYFVSFILQ FQFHQALCKE
560 570 580 590 600
AGHQGPLHQC DIYQSTRAGA KLRAVLQAGF SRPWQEVLKD MVGSGALDAQ
610 620 630 640 650
PLLDYFQPVT QWLEEQNQRS GDILGWPEYQ WRPPMPDNYP EGIDLVSDEA
660 670 680 690 700
EASKFVEEYD RRSQVVLNEY AEANWDYNTN ITAEGSKRVL EKSTQMANHT
710 720 730 740 750
VKYGIWARKF DVANIQNFTL KRMIKKIQDL ERAALPFKEL EEYNQILLDM
760 770 780 790 800
ETAYSVASVC HANSTCLQLE PDLTNLMATS RSYEELLWAW KGWRDKVGRA
810 820 830 840 850
ILPYFPKYVE LTNKAARLNG YEDGGDAWRA AYEMPFLEQE LEQLFQELQP
860 870 880 890 900
LYLNLHAYVR RALHHHYGPE HINLEGPIPA HLLGNMWAQT WSNIYDLVVP
910 920 930 940 950
FPSASKMDAS EAMINQGWTP QRMFKEADNF FTSLGLLPVP PEFWNKSMLE
960 970 980 990 1000
KPTDGREVVC HASAWDFFNG KDFRIKQCTT VNMEDLVVAH HEMGHIQYFM
1010 1020 1030 1040 1050
QYKDLPVTFR EGANPGFHEA IGDVLVLSVS TPKHLRSINL LKSEDDGYEE
1060 1070 1080 1090 1100
DINFLMKMAL DKVAFVPFSY LVDQWRWRVF DRSITKENYN QEWWSLRLKY
1110 1120 1130 1140 1150
QGLCPPVARS QGDFDPGAKF HIPSSVPYIR YFVSFIIQFQ FHEALCQAAG
1160 1170 1180 1190 1200
HKGPLHKCDI YQSKEAGRRL ADAMKLGLSK PWPEAMQLIT GQPNVSASAM
1210 1220 1230 1240 1250
MTYFKPLLDW LVTENGRHGE KLGWPQYSWT PNSARLEGSF AGTGRVNFLG
1260 1270 1280 1290 1300
LNLEEQQARV GQWVLLFLGV TLLVATMGLT QRLFSIRHQI LRRTHRGPQF

GSEVELRHS
Length:1,309
Mass (Da):150,543
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i09D9ACD74A715D59
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF121312 mRNA Translation: ABL73884.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Ssc.25769

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF121312 mRNA Translation: ABL73884.1
UniGeneiSsc.25769

3D structure databases

ProteinModelPortaliA1YQ85
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiA1YQ85

Protein family/group databases

MEROPSiM02.001

Proteomic databases

PRIDEiA1YQ85

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3690 Eukaryota
ENOG410XPJ3 LUCA
HOGENOMiHOG000007838
HOVERGENiHBG000264

Gene expression databases

GenevisibleiA1YQ85 SS

Family and domain databases

CDDicd06461 M2_ACE, 2 hits
InterProiView protein in InterPro
IPR001548 Peptidase_M2
PANTHERiPTHR10514 PTHR10514, 2 hits
PfamiView protein in Pfam
PF01401 Peptidase_M2, 2 hits
PRINTSiPR00791 PEPDIPTASEA

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1YQ85_PIG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1YQ85
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: January 31, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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