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UniProtKB - A1YPR0 (ZBT7C_HUMAN)
Protein
Zinc finger and BTB domain-containing protein 7C
Gene
ZBTB7C
Organism
Homo sapiens (Human)
Status
Functioni
May be a tumor suppressor gene.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 364 – 386 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 392 – 414 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 420 – 442 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 448 – 478 | C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST | 31 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- negative regulation of cell population proliferation Source: UniProtKB
- positive regulation of fat cell differentiation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | A1YPR0 |
SignaLinki | A1YPR0 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and BTB domain-containing protein 7CAlternative name(s): Affected by papillomavirus DNA integration in ME180 cells protein 1 Short name: APM-1 Zinc finger and BTB domain-containing protein 36 Zinc finger protein 857C |
Gene namesi | Name:ZBTB7C Synonyms:APM1, ZBTB36, ZNF857C |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:31700, ZBTB7C |
MIMi | 616591, gene |
neXtProti | NX_A1YPR0 |
VEuPathDBi | HostDB:ENSG00000184828 |
Pathology & Biotechi
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 201501 |
OpenTargetsi | ENSG00000184828 |
PharmGKBi | PA134861865 |
Miscellaneous databases
Pharosi | A1YPR0, Tbio |
Genetic variation databases
BioMutai | ZBTB7C |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000337869 | 1 – 619 | Zinc finger and BTB domain-containing protein 7CAdd BLAST | 619 |
Proteomic databases
jPOSTi | A1YPR0 |
MassIVEi | A1YPR0 |
PaxDbi | A1YPR0 |
PeptideAtlasi | A1YPR0 |
PRIDEi | A1YPR0 |
ProteomicsDBi | 162 |
PTM databases
iPTMneti | A1YPR0 |
PhosphoSitePlusi | A1YPR0 |
Expressioni
Tissue specificityi
Detected in normal cervical keratinocytes, and in some cervical carcinoma cell lines.1 Publication
Gene expression databases
Bgeei | ENSG00000184828, Expressed in nasal cavity epithelium and 172 other tissues |
ExpressionAtlasi | A1YPR0, baseline and differential |
Genevisiblei | A1YPR0, HS |
Organism-specific databases
HPAi | ENSG00000184828, Tissue enhanced (esophagus) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 128390, 29 interactors |
DIPi | DIP-61583N |
IntActi | A1YPR0, 4 interactors |
MINTi | A1YPR0 |
STRINGi | 9606.ENSP00000468782 |
Miscellaneous databases
RNActi | A1YPR0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 101 | BTBPROSITE-ProRule annotationAdd BLAST | 68 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 129 – 218 | DisorderedSequence analysisAdd BLAST | 90 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 130 – 176 | Acidic residuesSequence analysisAdd BLAST | 47 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 364 – 386 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 392 – 414 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 420 – 442 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 448 – 478 | C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST | 31 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159814 |
HOGENOMi | CLU_025627_2_0_1 |
InParanoidi | A1YPR0 |
OMAi | ENDYSAY |
OrthoDBi | 1318335at2759 |
PhylomeDBi | A1YPR0 |
TreeFami | TF331824 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
A1YPR0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANDIDELIG IPFPNHSSEV LCSLNEQRHD GLLCDVLLVV QEQEYRTHRS
60 70 80 90 100
VLAACSKYFK KLFTAGTLAS QPYVYEIDFV QPEALAAILE FAYTSTLTIT
110 120 130 140 150
AGNVKHILNA ARMLEIQCIV NVCLEIMEPG GDGGEEDDKE DDDDDEDDDD
160 170 180 190 200
EEDEEEEEEE EEDDDDDTED FADQENLPDP QDISCHQSPS KTDHLTEKAY
210 220 230 240 250
SDTPRDFPDS FQAGSPGHLG VIRDFSIESL LRENLYPKAN IPDRRPSLSP
260 270 280 290 300
FAPDFFPHLW PGDFGAFAQL PEQPMDSGPL DLVIKNRKIK EEEKEELPPP
310 320 330 340 350
PPPPFPNDFF KDMFPDLPGG PLGPIKAEND YGAYLNFLSA THLGGLFPPW
360 370 380 390 400
PLVEERKLKP KASQQCPICH KVIMGAGKLP RHMRTHTGEK PYMCTICEVR
410 420 430 440 450
FTRQDKLKIH MRKHTGERPY LCIHCNAKFV HNYDLKNHMR IHTGVRPYQC
460 470 480 490 500
EFCYKSFTRS DHLHRHIKRQ SCRMARPRRG RKPAAWRAAS LLFGPGGPAP
510 520 530 540 550
DKAAFVMPPA LGEVGGHLGG AAVCLPGPSP AKHFLAAPKG ALSLQELERQ
560 570 580 590 600
FEETQMKLFG RAQLEAERNA GGLLAFALAE NVAAARPYFP LPDPWAAGLA
610
GLPGLAGLNH VASMSEANN
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GXF8 | A0A1B0GXF8_HUMAN | Zinc finger and BTB domain-containi... | ZBTB7C | 66 | Annotation score: | ||
B2RG63 | B2RG63_HUMAN | Zinc finger and BTB domain containi... | ZBTB7C | 25 | Annotation score: | ||
B2RG53 | B2RG53_HUMAN | Zinc finger and BTB domain-containi... | ZBTB7C | 18 | Annotation score: | ||
B2RG76 | B2RG76_HUMAN | Zinc finger and BTB domain containi... | ZBTB7C | 15 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y14591 mRNA Translation: CAA74933.1 EF120357 mRNA Translation: ABL98073.1 |
CCDSi | CCDS32830.1 |
RefSeqi | NP_001034449.1, NM_001039360.2 NP_001305770.1, NM_001318841.1 XP_005258286.1, XM_005258229.4 XP_011524172.1, XM_011525870.2 XP_011524173.1, XM_011525871.2 XP_016881098.1, XM_017025609.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y14591 mRNA Translation: CAA74933.1 EF120357 mRNA Translation: ABL98073.1 |
CCDSi | CCDS32830.1 |
RefSeqi | NP_001034449.1, NM_001039360.2 NP_001305770.1, NM_001318841.1 XP_005258286.1, XM_005258229.4 XP_011524172.1, XM_011525870.2 XP_011524173.1, XM_011525871.2 XP_016881098.1, XM_017025609.1 |
3D structure databases
AlphaFoldDBi | A1YPR0 |
SMRi | A1YPR0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128390, 29 interactors |
DIPi | DIP-61583N |
IntActi | A1YPR0, 4 interactors |
MINTi | A1YPR0 |
STRINGi | 9606.ENSP00000468782 |
PTM databases
iPTMneti | A1YPR0 |
PhosphoSitePlusi | A1YPR0 |
Genetic variation databases
BioMutai | ZBTB7C |
Proteomic databases
jPOSTi | A1YPR0 |
MassIVEi | A1YPR0 |
PaxDbi | A1YPR0 |
PeptideAtlasi | A1YPR0 |
PRIDEi | A1YPR0 |
ProteomicsDBi | 162 |
Protocols and materials databases
Antibodypediai | 2877, 77 antibodies from 15 providers |
DNASUi | 201501 |
Genome annotation databases
Organism-specific databases
CTDi | 201501 |
DisGeNETi | 201501 |
GeneCardsi | ZBTB7C |
HGNCi | HGNC:31700, ZBTB7C |
HPAi | ENSG00000184828, Tissue enhanced (esophagus) |
MIMi | 616591, gene |
neXtProti | NX_A1YPR0 |
OpenTargetsi | ENSG00000184828 |
PharmGKBi | PA134861865 |
VEuPathDBi | HostDB:ENSG00000184828 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159814 |
HOGENOMi | CLU_025627_2_0_1 |
InParanoidi | A1YPR0 |
OMAi | ENDYSAY |
OrthoDBi | 1318335at2759 |
PhylomeDBi | A1YPR0 |
TreeFami | TF331824 |
Enzyme and pathway databases
PathwayCommonsi | A1YPR0 |
SignaLinki | A1YPR0 |
Miscellaneous databases
BioGRID-ORCSi | 201501, 11 hits in 1132 CRISPR screens |
ChiTaRSi | ZBTB7C, human |
GenomeRNAii | 201501 |
Pharosi | A1YPR0, Tbio |
PROi | PR:A1YPR0 |
RNActi | A1YPR0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184828, Expressed in nasal cavity epithelium and 172 other tissues |
ExpressionAtlasi | A1YPR0, baseline and differential |
Genevisiblei | A1YPR0, HS |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZBT7C_HUMAN | |
Accessioni | A1YPR0Primary (citable) accession number: A1YPR0 Secondary accession number(s): O73453 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | February 6, 2007 | |
Last modified: | May 25, 2022 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot