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Protein

Zinc finger and BTB domain-containing protein 7C

Gene

ZBTB7C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a tumor suppressor gene.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri364 – 386C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 478C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 7C
Alternative name(s):
Affected by papillomavirus DNA integration in ME180 cells protein 1
Short name:
APM-1
Zinc finger and BTB domain-containing protein 36
Zinc finger protein 857C
Gene namesi
Name:ZBTB7C
Synonyms:APM1, ZBTB36, ZNF857C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000184828.9
HGNCiHGNC:31700 ZBTB7C
MIMi616591 gene
neXtProtiNX_A1YPR0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi201501
OpenTargetsiENSG00000184828
PharmGKBiPA134861865

Polymorphism and mutation databases

BioMutaiZBTB7C

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003378691 – 619Zinc finger and BTB domain-containing protein 7CAdd BLAST619

Proteomic databases

PaxDbiA1YPR0
PRIDEiA1YPR0
ProteomicsDBi162

PTM databases

iPTMnetiA1YPR0
PhosphoSitePlusiA1YPR0

Expressioni

Tissue specificityi

Detected in normal cervical keratinocytes, and in some cervical carcinoma cell lines.1 Publication

Gene expression databases

BgeeiENSG00000184828
CleanExiHS_ZBTB7C
ExpressionAtlasiA1YPR0 baseline and differential
GenevisibleiA1YPR0 HS

Interactioni

Protein-protein interaction databases

BioGridi128390, 4 interactors
DIPiDIP-61583N
IntActiA1YPR0, 3 interactors
MINTiA1YPR0
STRINGi9606.ENSP00000328732

Structurei

3D structure databases

ProteinModelPortaliA1YPR0
SMRiA1YPR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 101BTBPROSITE-ProRule annotationAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi125 – 162Glu-richAdd BLAST38
Compositional biasi132 – 182Asp-richAdd BLAST51
Compositional biasi298 – 324Pro-richAdd BLAST27

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri364 – 386C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 478C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000148950
HOGENOMiHOG000059674
HOVERGENiHBG101042
InParanoidiA1YPR0
KOiK10494
OMAiCIHCNAK
OrthoDBiEOG091G03XR
PhylomeDBiA1YPR0
TreeFamiTF331824

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

A1YPR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANDIDELIG IPFPNHSSEV LCSLNEQRHD GLLCDVLLVV QEQEYRTHRS
60 70 80 90 100
VLAACSKYFK KLFTAGTLAS QPYVYEIDFV QPEALAAILE FAYTSTLTIT
110 120 130 140 150
AGNVKHILNA ARMLEIQCIV NVCLEIMEPG GDGGEEDDKE DDDDDEDDDD
160 170 180 190 200
EEDEEEEEEE EEDDDDDTED FADQENLPDP QDISCHQSPS KTDHLTEKAY
210 220 230 240 250
SDTPRDFPDS FQAGSPGHLG VIRDFSIESL LRENLYPKAN IPDRRPSLSP
260 270 280 290 300
FAPDFFPHLW PGDFGAFAQL PEQPMDSGPL DLVIKNRKIK EEEKEELPPP
310 320 330 340 350
PPPPFPNDFF KDMFPDLPGG PLGPIKAEND YGAYLNFLSA THLGGLFPPW
360 370 380 390 400
PLVEERKLKP KASQQCPICH KVIMGAGKLP RHMRTHTGEK PYMCTICEVR
410 420 430 440 450
FTRQDKLKIH MRKHTGERPY LCIHCNAKFV HNYDLKNHMR IHTGVRPYQC
460 470 480 490 500
EFCYKSFTRS DHLHRHIKRQ SCRMARPRRG RKPAAWRAAS LLFGPGGPAP
510 520 530 540 550
DKAAFVMPPA LGEVGGHLGG AAVCLPGPSP AKHFLAAPKG ALSLQELERQ
560 570 580 590 600
FEETQMKLFG RAQLEAERNA GGLLAFALAE NVAAARPYFP LPDPWAAGLA
610
GLPGLAGLNH VASMSEANN
Length:619
Mass (Da):69,017
Last modified:February 6, 2007 - v1
Checksum:i73D82A34502B55BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14591 mRNA Translation: CAA74933.1
EF120357 mRNA Translation: ABL98073.1
CCDSiCCDS32830.1
RefSeqiNP_001034449.1, NM_001039360.2
NP_001305770.1, NM_001318841.1
XP_005258286.1, XM_005258229.4
XP_011524172.1, XM_011525870.2
XP_011524173.1, XM_011525871.2
XP_016881098.1, XM_017025609.1
UniGeneiHs.515388
Hs.730374
Hs.732162

Genome annotation databases

EnsembliENST00000535628; ENSP00000439781; ENSG00000184828
ENST00000586438; ENSP00000468254; ENSG00000184828
ENST00000588982; ENSP00000468782; ENSG00000184828
ENST00000590800; ENSP00000467877; ENSG00000184828
GeneIDi201501
KEGGihsa:201501

Similar proteinsi

Entry informationi

Entry nameiZBT7C_HUMAN
AccessioniPrimary (citable) accession number: A1YPR0
Secondary accession number(s): O73453
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 6, 2007
Last modified: June 20, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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