UniProtKB - A1YPR0 (ZBT7C_HUMAN)

BLAST

>sp|A1YPR0|ZBT7C_HUMAN Zinc finger and BTB domain-containing protein 7C OS=Homo sapiens OX=9606 GN=ZBTB7C PE=2 SV=1
MANDIDELIGIPFPNHSSEVLCSLNEQRHDGLLCDVLLVVQEQEYRTHRSVLAACSKYFK
KLFTAGTLASQPYVYEIDFVQPEALAAILEFAYTSTLTITAGNVKHILNAARMLEIQCIV
NVCLEIMEPGGDGGEEDDKEDDDDDEDDDDEEDEEEEEEEEEDDDDDTEDFADQENLPDP
QDISCHQSPSKTDHLTEKAYSDTPRDFPDSFQAGSPGHLGVIRDFSIESLLRENLYPKAN
IPDRRPSLSPFAPDFFPHLWPGDFGAFAQLPEQPMDSGPLDLVIKNRKIKEEEKEELPPP
PPPPFPNDFFKDMFPDLPGGPLGPIKAENDYGAYLNFLSATHLGGLFPPWPLVEERKLKP
KASQQCPICHKVIMGAGKLPRHMRTHTGEKPYMCTICEVRFTRQDKLKIHMRKHTGERPY
LCIHCNAKFVHNYDLKNHMRIHTGVRPYQCEFCYKSFTRSDHLHRHIKRQSCRMARPRRG
RKPAAWRAASLLFGPGGPAPDKAAFVMPPALGEVGGHLGGAAVCLPGPSPAKHFLAAPKG
ALSLQELERQFEETQMKLFGRAQLEAERNAGGLLAFALAENVAAARPYFPLPDPWAAGLA
GLPGLAGLNHVASMSEANN

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History
Entry version 102 (10 Oct 2018)
Sequence version 1 (06 Feb 2007)
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Protein

Zinc finger and BTB domain-containing protein 7C

Gene

ZBTB7C

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

May be a tumor suppressor gene.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	364 – 386	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	392 – 414	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	420 – 442	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	448 – 478	C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST	31

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
nucleic acid binding Source: InterPro
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 9427755
positive regulation of fat cell differentiation Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
regulation of RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger and BTB domain-containing protein 7C Alternative name(s): Affected by papillomavirus DNA integration in ME180 cells protein 1 Short name: APM-1 Zinc finger and BTB domain-containing protein 36 Zinc finger protein 857C
Gene namesⁱ	Name:ZBTB7C Synonyms:APM1, ZBTB36, ZNF857C
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000184828.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31700 ZBTB7C
MIMⁱ	616591 gene
neXtProtⁱ	NX_A1YPR0

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	201501
Open Targets More...OpenTargetsⁱ	ENSG00000184828
PharmGKBⁱ	PA134861865

Polymorphism and mutation databases

BioMutaⁱ	ZBTB7C

BioMutaⁱ

ZBTB7C

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000337869	1 – 619	Zinc finger and BTB domain-containing protein 7CAdd BLAST		619

Proteomic databases

PaxDbⁱ	A1YPR0
PRIDEⁱ	A1YPR0
ProteomicsDBⁱ	162

PTM databases

iPTMnetⁱ	A1YPR0
PhosphoSitePlusⁱ	A1YPR0

Expressionⁱ

Tissue specificityⁱ

Detected in normal cervical keratinocytes, and in some cervical carcinoma cell lines.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000184828 Expressed in 148 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_ZBTB7C
ExpressionAtlasⁱ	A1YPR0 baseline and differential
Genevisibleⁱ	A1YPR0 HS

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	128390, 4 interactors
Database of interacting proteins More...DIPⁱ	DIP-61583N
IntActⁱ	A1YPR0, 3 interactors
Molecular INTeraction database More...MINTⁱ	A1YPR0
STRINGⁱ	9606.ENSP00000328732

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A1YPR0
SMRⁱ	A1YPR0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	34 – 101	BTBPROSITE-ProRule annotationAdd BLAST		68

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	125 – 162	Glu-richAdd BLAST	38
Compositional biasⁱ	132 – 182	Asp-richAdd BLAST	51
Compositional biasⁱ	298 – 324	Pro-richAdd BLAST	27

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	364 – 386	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	392 – 414	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	420 – 442	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	448 – 478	C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST	31

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148950
HOGENOMⁱ	HOG000059674
HOVERGENⁱ	HBG101042
InParanoidⁱ	A1YPR0
KEGG Orthology (KO) More...KOⁱ	K10494
OMAⁱ	CIHCNAK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03XR
PhylomeDBⁱ	A1YPR0
TreeFamⁱ	TF331824

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF48371 SSF48371, 1 hit SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

A1YPR0-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MANDIDELIG IPFPNHSSEV LCSLNEQRHD GLLCDVLLVV QEQEYRTHRS 
        60         70         80         90        100
VLAACSKYFK KLFTAGTLAS QPYVYEIDFV QPEALAAILE FAYTSTLTIT 
       110        120        130        140        150
AGNVKHILNA ARMLEIQCIV NVCLEIMEPG GDGGEEDDKE DDDDDEDDDD 
       160        170        180        190        200
EEDEEEEEEE EEDDDDDTED FADQENLPDP QDISCHQSPS KTDHLTEKAY 
       210        220        230        240        250
SDTPRDFPDS FQAGSPGHLG VIRDFSIESL LRENLYPKAN IPDRRPSLSP 
       260        270        280        290        300
FAPDFFPHLW PGDFGAFAQL PEQPMDSGPL DLVIKNRKIK EEEKEELPPP 
       310        320        330        340        350
PPPPFPNDFF KDMFPDLPGG PLGPIKAEND YGAYLNFLSA THLGGLFPPW 
       360        370        380        390        400
PLVEERKLKP KASQQCPICH KVIMGAGKLP RHMRTHTGEK PYMCTICEVR 
       410        420        430        440        450
FTRQDKLKIH MRKHTGERPY LCIHCNAKFV HNYDLKNHMR IHTGVRPYQC 
       460        470        480        490        500
EFCYKSFTRS DHLHRHIKRQ SCRMARPRRG RKPAAWRAAS LLFGPGGPAP 
       510        520        530        540        550
DKAAFVMPPA LGEVGGHLGG AAVCLPGPSP AKHFLAAPKG ALSLQELERQ 
       560        570        580        590        600
FEETQMKLFG RAQLEAERNA GGLLAFALAE NVAAARPYFP LPDPWAAGLA 
       610 
GLPGLAGLNH VASMSEANN

Length:619

Mass (Da):69,017

Last modified:February 6, 2007 - v1

Checksum:ⁱ73D82A34502B55BF

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B2RG53	B2RG53_HUMAN	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing 7C (Zinc finger and BTB domain-containing protein 7C)	ZBTB7C	18	Annotation score:
A0A1B0GXF8	A0A1B0GXF8_HUMAN	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 7C	ZBTB7C	66	Annotation score:
B2RG63	B2RG63_HUMAN	Zinc finger and BTB domain containi... Zinc finger and BTB domain containing 7C (Zinc finger and BTB domain-containing protein 7C)	ZBTB7C	25	Annotation score:
B2RG76	B2RG76_HUMAN	Zinc finger and BTB domain containi... Zinc finger and BTB domain containing 7C (Zinc finger and BTB domain-containing protein 7C)	ZBTB7C	15	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y14591 mRNA Translation: CAA74933.1 EF120357 mRNA Translation: ABL98073.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32830.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001034449.1, NM_001039360.2 NP_001305770.1, NM_001318841.1 XP_005258286.1, XM_005258229.4 XP_011524172.1, XM_011525870.2 XP_011524173.1, XM_011525871.2 XP_016881098.1, XM_017025609.1
UniGeneⁱ	Hs.515388 Hs.730374 Hs.732162

Genome annotation databases

Ensemblⁱ	ENST00000535628; ENSP00000439781; ENSG00000184828 ENST00000586438; ENSP00000468254; ENSG00000184828 ENST00000588982; ENSP00000468782; ENSG00000184828 ENST00000590800; ENSP00000467877; ENSG00000184828
GeneIDⁱ	201501
KEGGⁱ	hsa:201501

Protein	Similar proteins		Species	Score	Length	Source
A1YPR0	Zinc finger and BTB domain containing 7C		HUMAN		619	UniRef100_A1YPR0
UPI0005D0350F		HUMAN		668
UPI00024D154E		HUMAN		628

Protein	Similar proteins		Species	Score	Length	Source
A1YPR0	Zinc finger and BTB domain-containing protein 7C		MOUSE		619	UniRef90_A1YPR0
Zinc finger and BTB domain containing 7C		HUMAN		619
Uncharacterized protein		MUSPF		704
zinc finger and BTB domain-containing protein 7C isoform X2		TURTR		665
Uncharacterized protein		RABIT		627
+123

Protein	Similar proteins		Species	Score	Length	Source
A1YPR0	Zinc finger and BTB domain-containing protein 7C		MOUSE		619	UniRef50_A1YPR0
Zinc finger and BTB domain containing 7C		HUMAN		619
Uncharacterized protein		MUSPF		704
zinc finger and BTB domain-containing protein 7C isoform X2		TURTR		665
Uncharacterized protein		RABIT		627
+223

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y14591 mRNA Translation: CAA74933.1 EF120357 mRNA Translation: ABL98073.1
CCDSⁱ	CCDS32830.1
RefSeqⁱ	NP_001034449.1, NM_001039360.2 NP_001305770.1, NM_001318841.1 XP_005258286.1, XM_005258229.4 XP_011524172.1, XM_011525870.2 XP_011524173.1, XM_011525871.2 XP_016881098.1, XM_017025609.1
UniGeneⁱ	Hs.515388 Hs.730374 Hs.732162

3D structure databases

ProteinModelPortalⁱ	A1YPR0
SMRⁱ	A1YPR0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	128390, 4 interactors
DIPⁱ	DIP-61583N
IntActⁱ	A1YPR0, 3 interactors
MINTⁱ	A1YPR0
STRINGⁱ	9606.ENSP00000328732

PTM databases

iPTMnetⁱ	A1YPR0
PhosphoSitePlusⁱ	A1YPR0

Polymorphism and mutation databases

BioMutaⁱ	ZBTB7C

BioMutaⁱ

ZBTB7C

Proteomic databases

PaxDbⁱ	A1YPR0
PRIDEⁱ	A1YPR0
ProteomicsDBⁱ	162

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	201501
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000535628; ENSP00000439781; ENSG00000184828 ENST00000586438; ENSP00000468254; ENSG00000184828 ENST00000588982; ENSP00000468782; ENSG00000184828 ENST00000590800; ENSP00000467877; ENSG00000184828
GeneIDⁱ	201501
KEGGⁱ	hsa:201501

Organism-specific databases

CTDⁱ	201501
DisGeNETⁱ	201501
EuPathDBⁱ	HostDB:ENSG00000184828.9
GeneCardsⁱ	ZBTB7C
HGNCⁱ	HGNC:31700 ZBTB7C
MIMⁱ	616591 gene
neXtProtⁱ	NX_A1YPR0
OpenTargetsⁱ	ENSG00000184828
PharmGKBⁱ	PA134861865
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00920000148950
HOGENOMⁱ	HOG000059674
HOVERGENⁱ	HBG101042
InParanoidⁱ	A1YPR0
KOⁱ	K10494
OMAⁱ	CIHCNAK
OrthoDBⁱ	EOG091G03XR
PhylomeDBⁱ	A1YPR0
TreeFamⁱ	TF331824

Miscellaneous databases

ChiTaRSⁱ	ZBTB7C human
GenomeRNAiⁱ	201501
Protein Ontology More...PROⁱ	PR:A1YPR0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000184828 Expressed in 148 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_ZBTB7C
ExpressionAtlasⁱ	A1YPR0 baseline and differential
Genevisibleⁱ	A1YPR0 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF48371 SSF48371, 1 hit SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZBT7C_HUMAN
Accessionⁱ	A1YPR0Primary (citable) accession number: A1YPR0 Secondary accession number(s): O73453
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
	Last sequence update:	February 6, 2007
	Last modified:	October 10, 2018
	This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - A1YPR0 (ZBT7C_HUMAN)

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Zinc finger and BTB domain-containing protein 7C

ZBTB7C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ