RCG55748

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• corticotropin-releasing hormone receptor 2 binding Source: InterPro
• corticotropin-releasing hormone receptor binding Source: RGD
• hormone activity Source: InterPro

GO - Biological processⁱ

• adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: RGD
• cellular response to hypoxia Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes."
    Chanalaris A., Lawrence K.M., Stephanou A., Knight R.D., Hsu S.Y., Hsueh A.J., Latchman D.S.
    J Mol Cell Cardiol 35:1295-1305(2003) [PubMed] [Europe PMC] [Abstract]
• cellular response to nutrient levels Source: RGDInferred from expression patternⁱ
  • "Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis."
    Li C., Chen P., Vaughan J., Lee K.F., Vale W.
    Proc Natl Acad Sci U S A 104:4206-4211(2007) [PubMed] [Europe PMC] [Abstract]
• digestion Source: InterPro
• hormone-mediated signaling pathway Source: RGD
• positive regulation of insulin secretion Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis."
    Li C., Chen P., Vaughan J., Lee K.F., Vale W.
    Proc Natl Acad Sci U S A 104:4206-4211(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of membrane potential Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Chronic peripheral administration of corticotropin-releasing factor causes colonic barrier dysfunction similar to psychological stress."
    Teitelbaum A.A., Gareau M.G., Jury J., Yang P.C., Perdue M.H.
    Am J Physiol Gastrointest Liver Physiol 295:G452-9(2008) [PubMed] [Europe PMC] [Abstract]
• response to corticosterone Source: RGDInferred from expression patternⁱ
  • "Urocortin 3 modulates the neuroendocrine stress response and is regulated in rat amygdala and hypothalamus by stress and glucocorticoids."
    Jamieson P.M., Li C., Kukura C., Vaughan J., Vale W.
    Endocrinology 147:4578-4588(2006) [PubMed] [Europe PMC] [Abstract]
• response to glucose Source: RGDInferred from expression patternⁱ
  • "Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis."
    Li C., Chen P., Vaughan J., Lee K.F., Vale W.
    Proc Natl Acad Sci U S A 104:4206-4211(2007) [PubMed] [Europe PMC] [Abstract]
• response to immobilization stress Source: RGDInferred from expression patternⁱ
  • "Urocortin 3 modulates the neuroendocrine stress response and is regulated in rat amygdala and hypothalamus by stress and glucocorticoids."
    Jamieson P.M., Li C., Kukura C., Vaughan J., Vale W.
    Endocrinology 147:4578-4588(2006) [PubMed] [Europe PMC] [Abstract]
• response to starvation Source: RGDInferred from expression patternⁱ
  • "Urocortin 3 modulates the neuroendocrine stress response and is regulated in rat amygdala and hypothalamus by stress and glucocorticoids."
    Jamieson P.M., Li C., Kukura C., Vaughan J., Vale W.
    Endocrinology 147:4578-4588(2006) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• corticotropin-releasing hormone receptor 2 binding Source: InterPro
• corticotropin-releasing hormone receptor binding Source: RGD
• hormone activity Source: InterPro

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MLMPTYFLLL LLLLLGGPRT SLSHKFYNAG PVFSCLNTAL SEVKKNKLED 
        60         70         80         90        100
VPVLSKKNFG YLPTQDPSGE EEDEQKHIKN KRTFSDAVGG NGGRSIRYRY 
       110        120        130        140        150
QSQAQPKGKL YPDKVKNDRG TKFTLSLDVP TNIMNILFNI DKAKNLRAKA 
       160 
AANAQLMAQI GKKK                                        

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ