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Protein
Submitted name:

Pol protein

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl proteaseUniRule annotation, Hydrolase, Multifunctional enzymeSAAS annotation, Nucleotidyltransferase, Protease, RNA-directed DNA polymeraseSAAS annotation, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Pol proteinImported
Gene namesi
Name:polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeLentivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Structurei

3D structure databases

ProteinModelPortaliA1Y234
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 141Peptidase A2InterPro annotationAdd BLAST70
Domaini195 – 385Reverse transcriptaseInterPro annotationAdd BLAST191

Sequence similaritiesi

Belongs to the retroviral Pol polyprotein family.UniRule annotation

Family and domain databases

CDDicd05482 HIV_retropepsin_like, 1 hit
Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR001969 Aspartic_peptidase_AS
IPR001995 Peptidase_A2_cat
IPR021109 Peptidase_aspartic_dom_sf
IPR034170 Retropepsin-like_cat_dom
IPR018061 Retropepsins
IPR000477 RT_dom
IPR010659 RVT_connect
IPR010661 RVT_thumb
PfamiView protein in Pfam
PF00077 RVP, 1 hit
PF00078 RVT_1, 1 hit
PF06815 RVT_connect, 1 hit
PF06817 RVT_thumb, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS50175 ASP_PROT_RETROV, 1 hit
PS00141 ASP_PROTEASE, 1 hit
PS50878 RT_POL, 1 hit

Sequencei

Sequence statusi: Fragment.

A1Y234-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
FFRENLAFPQ GEAREFPPEQ TRANSPTSRE LQVRGDTPSS KAGAERQGTF
60 70 80 90 100
NFPQITLWQR PLVPIKVGGQ IKEALLDTGA DDTVLEEINL PGKWKPKMIG
110 120 130 140 150
GIGGFIKVRQ YDQIPIEICG KKAIGTVLVG PTPVNIIGRN MLTQLGCTLN
160 170 180 190 200
FPISPIETVP VKLKPGMDGP KVKQWPLTEE KIKALTAICD EMEKEGKITK
210 220 230 240 250
IGPENPYNTP IFAIKKKDST KWRKLVDFRE LNKRTQDFWE VQLGIPHPAG
260 270 280 290 300
LKKKKSVTVL DVGDAYFSVP LYEDFRKYTA FTIPSTNNET PGIRYQYNVL
310 320 330 340 350
PQGWKGSPAI FQASMTKILE PFRERNPEIV IYQYMDDLYV GSDLEIGQHR
360 370 380 390 400
AKIEELREHL LKWGFTTPDK KHQKEPPFLW MGYELHPDKW TVQPIQLPEK
410 420 430 440 450
DSWTVNDIQK LVGKLNWASQ IYPGIKVRQL CKLLRGAKAL TDIVXLTXEA
460 470 480 490 500
ELELAENREI LKEPVHGXYY DPSKDLIAEI QKQGQXQWTY QVYQEPFKXL
510 520 530 540 550
KTGKYAKMRT AHTNDVKQLT EAVQKIAMES IVIWGKTPKF RLPIQKETWE
560
TWWTDYWQAT WIPEWE
Length:566
Mass (Da):65,087
Last modified:February 6, 2007 - v1
Checksum:iF0E84670CB235580
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei566Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ826641 Genomic DNA Translation: ABI32126.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ826641 Genomic DNA Translation: ABI32126.1

3D structure databases

ProteinModelPortaliA1Y234
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd05482 HIV_retropepsin_like, 1 hit
Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR001969 Aspartic_peptidase_AS
IPR001995 Peptidase_A2_cat
IPR021109 Peptidase_aspartic_dom_sf
IPR034170 Retropepsin-like_cat_dom
IPR018061 Retropepsins
IPR000477 RT_dom
IPR010659 RVT_connect
IPR010661 RVT_thumb
PfamiView protein in Pfam
PF00077 RVP, 1 hit
PF00078 RVT_1, 1 hit
PF06815 RVT_connect, 1 hit
PF06817 RVT_thumb, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS50175 ASP_PROT_RETROV, 1 hit
PS00141 ASP_PROTEASE, 1 hit
PS50878 RT_POL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA1Y234_9HIV1
AccessioniPrimary (citable) accession number: A1Y234
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 18, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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