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Protein

Protein FAM92A

Gene

FAM92A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in ciliogenesis (PubMed:27528616). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (PubMed:27528616).1 Publication

GO - Biological processi

  • cilium assembly Source: UniProtKB

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM92A
Gene namesi
Name:FAM92AImported
Synonyms:FAM92A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000188343.12
HGNCiHGNC:30452 FAM92A
MIMi617273 gene
neXtProtiNX_A1XBS5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi107K → E: Abolishes ability to induce membrane remodeling in the presence of CBY1; when associated with E-110; E-114; E-132; E-134 and E-136. 1 Publication1
Mutagenesisi110R → E: Abolishes ability to induce membrane remodeling in the presence of CBY1; when associated with E-107;E-114; E-132; E-134 and E-136. 1 Publication1
Mutagenesisi114K → E: Abolishes ability to induce membrane remodeling in the presence of CBY1; when associated with E-107; E-110; E-132; E-134 and E-136. 1 Publication1
Mutagenesisi132R → E: Abolishes ability to induce membrane remodeling in the presence of CBY1; when associated with E-107; E-110; E-114; E-134 and E-136. 1 Publication1
Mutagenesisi134R → E: Abolishes ability to induce membrane remodeling in the presence of CBY1; when associated with E-107; E-110; E-114; E-132 and E-136. 1 Publication1
Mutagenesisi136R → E: Abolishes ability to induce membrane remodeling in the presence of CBY1; when associated with E-107; E-110; E-114; E-132 and E-134. 1 Publication1

Organism-specific databases

DisGeNETi137392
OpenTargetsiENSG00000188343
PharmGKBiPA142671823

Polymorphism and mutation databases

BioMutaiFAM92A1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002870801 – 289Protein FAM92AAdd BLAST289

Proteomic databases

EPDiA1XBS5
MaxQBiA1XBS5
PaxDbiA1XBS5
PRIDEiA1XBS5
ProteomicsDBi157
158 [A1XBS5-2]
159 [A1XBS5-3]
160 [A1XBS5-4]
161 [A1XBS5-5]

PTM databases

iPTMnetiA1XBS5
PhosphoSitePlusiA1XBS5

Expressioni

Gene expression databases

BgeeiENSG00000188343 Expressed in 183 organ(s), highest expression level in testis
CleanExiHS_FAM92A1
ExpressionAtlasiA1XBS5 baseline and differential
GenevisibleiA1XBS5 HS

Organism-specific databases

HPAiHPA034760
HPA058942

Interactioni

Subunit structurei

Homodimer (via BAR-like domain) (PubMed:27528616). Heterodimer with FAM92B (via BAR-like domains) (PubMed:27528616). Interacts (via BAR-like domain) with CBY1; this interaction is required for targeting FAM92A to centriole (PubMed:27528616).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CBY1Q9Y3M23EBI-2349888,EBI-947308

Protein-protein interaction databases

BioGridi126476, 5 interactors
IntActiA1XBS5, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliA1XBS5
SMRiA1XBS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 220BAR-like1 PublicationAdd BLAST211

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili107 – 178Sequence analysisAdd BLAST72

Domaini

The BAR-like domain displays limited similarity to other BAR domains.1 Publication

Sequence similaritiesi

Belongs to the FAM92 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHVX Eukaryota
ENOG410Z4I5 LUCA
GeneTreeiENSGT00390000010285
HOGENOMiHOG000060253
HOVERGENiHBG107895
InParanoidiA1XBS5
OMAiFILISMK
OrthoDBiEOG091G0T7H
PhylomeDBiA1XBS5
TreeFamiTF324316

Family and domain databases

CDDicd07598 BAR_FAM92, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR035590 BAR_FAM92
IPR009602 FAM92
PANTHERiPTHR21223 PTHR21223, 1 hit
PfamiView protein in Pfam
PF06730 FAM92, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A1XBS5-1) [UniParc]FASTAAdd to basket
Also known as: FAM92A1-2891 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMRRTLENRN AQTKQLQTAV SNVEKHFGEL CQIFAAYVRK TARLRDKADL
60 70 80 90 100
LVNEINAYAA TETPHLKLGL MNFADEFAKL QDYRQAEVER LEAKVVEPLK
110 120 130 140 150
TYGTIVKMKR DDLKATLTAR NREAKQLTQL ERTRQRNPSD RHVISQAETE
160 170 180 190 200
LQRAAMDASR TSRHLEETIN NFERQKMKDI KTIFSEFITI EMLFHGKALE
210 220 230 240 250
VYTAAYQNIQ NIDEDEDLEV FRNSLYAPDY SSRLDIVRAN SKSPLQRSLS
260 270 280
AKCVSGTGQV STCRLRKDQQ AEDDEDDELD VTEEENFLK
Length:289
Mass (Da):33,431
Last modified:September 23, 2008 - v2
Checksum:iCC95F1A4217FDCA5
GO
Isoform 2 (identifier: A1XBS5-2) [UniParc]FASTAAdd to basket
Also known as: FAM92A1-2511 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     182-219: Missing.

Show »
Length:251
Mass (Da):28,997
Checksum:iE87B09A3CDE53979
GO
Isoform 3 (identifier: A1XBS5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-289: VSTCRLRKDQQAEDDEDDELDVTEEENFLK → EAGWAATCQTLI

Show »
Length:271
Mass (Da):31,123
Checksum:iA80C340EF3439A3C
GO
Isoform 4 (identifier: A1XBS5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-289: VFRNSLYAPD...DVTEEENFLK → RWSFAMLPRL...LCMHQIIHLV

Note: No experimental confirmation available.
Show »
Length:262
Mass (Da):30,400
Checksum:i006FEAE8F6F755AC
GO
Isoform 5 (identifier: A1XBS5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-97: ERLEAKVVE → WSEITVSLL
     98-289: Missing.

Note: No experimental confirmation available.
Show »
Length:97
Mass (Da):11,188
Checksum:i80F952E0764B5083
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WTS3A0A087WTS3_HUMAN
Protein FAM92A
FAM92A
288Annotation score:
H0YC32H0YC32_HUMAN
Protein FAM92A
FAM92A
188Annotation score:
E5RID3E5RID3_HUMAN
Protein FAM92A
FAM92A
110Annotation score:
E5RHK0E5RHK0_HUMAN
Protein FAM92A
FAM92A
132Annotation score:
F8W7P5F8W7P5_HUMAN
Protein FAM92A
FAM92A
163Annotation score:
E5RGD0E5RGD0_HUMAN
Protein FAM92A
FAM92A
168Annotation score:
E5RGP4E5RGP4_HUMAN
Protein FAM92A
FAM92A
114Annotation score:
A0A0B4J212A0A0B4J212_HUMAN
Protein FAM92A
FAM92A
162Annotation score:
E5RFS7E5RFS7_HUMAN
Protein FAM92A
FAM92A
65Annotation score:
E5RGE3E5RGE3_HUMAN
Protein FAM92A
FAM92A
79Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAH14598 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI08708 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137N → S in ABC55436 (PubMed:17646714).Curated1
Sequence conflicti150E → G in BAC04753 (PubMed:14702039).Curated1
Sequence conflicti281V → I in ABC55437 (PubMed:17646714).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062190222R → Q. Corresponds to variant dbSNP:rs36117362Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02529289 – 97ERLEAKVVE → WSEITVSLL in isoform 5. 1 Publication9
Alternative sequenceiVSP_02529398 – 289Missing in isoform 5. 1 PublicationAdd BLAST192
Alternative sequenceiVSP_025294182 – 219Missing in isoform 2. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_025295220 – 289VFRNS…ENFLK → RWSFAMLPRLVLNSWGSSDP PALASQSVRFSEILCMHQII HLV in isoform 4. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_025296260 – 289VSTCR…ENFLK → EAGWAATCQTLI in isoform 3. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ327715 mRNA Translation: ABC55436.1
DQ327716 mRNA Translation: ABC55437.1
AK096298 mRNA Translation: BAC04753.1
CR627475 mRNA Translation: CAH10675.1
AC010834 Genomic DNA No translation available.
AC120053 Genomic DNA No translation available.
BC014598 mRNA Translation: AAH14598.2 Different initiation.
BC108707 mRNA Translation: AAI08708.1 Different initiation.
CCDSiCCDS47892.1 [A1XBS5-1]
CCDS64933.1 [A1XBS5-2]
RefSeqiNP_001269963.1, NM_001283034.1 [A1XBS5-2]
NP_660312.2, NM_145269.4 [A1XBS5-1]
UniGeneiHs.125038

Genome annotation databases

EnsembliENST00000423990; ENSP00000401774; ENSG00000188343 [A1XBS5-2]
ENST00000452913; ENSP00000391671; ENSG00000188343 [A1XBS5-3]
ENST00000518116; ENSP00000428065; ENSG00000188343 [A1XBS5-4]
ENST00000518322; ENSP00000429367; ENSG00000188343 [A1XBS5-1]
GeneIDi137392
KEGGihsa:137392
UCSCiuc064onr.1 human [A1XBS5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ327715 mRNA Translation: ABC55436.1
DQ327716 mRNA Translation: ABC55437.1
AK096298 mRNA Translation: BAC04753.1
CR627475 mRNA Translation: CAH10675.1
AC010834 Genomic DNA No translation available.
AC120053 Genomic DNA No translation available.
BC014598 mRNA Translation: AAH14598.2 Different initiation.
BC108707 mRNA Translation: AAI08708.1 Different initiation.
CCDSiCCDS47892.1 [A1XBS5-1]
CCDS64933.1 [A1XBS5-2]
RefSeqiNP_001269963.1, NM_001283034.1 [A1XBS5-2]
NP_660312.2, NM_145269.4 [A1XBS5-1]
UniGeneiHs.125038

3D structure databases

ProteinModelPortaliA1XBS5
SMRiA1XBS5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126476, 5 interactors
IntActiA1XBS5, 3 interactors

PTM databases

iPTMnetiA1XBS5
PhosphoSitePlusiA1XBS5

Polymorphism and mutation databases

BioMutaiFAM92A1

Proteomic databases

EPDiA1XBS5
MaxQBiA1XBS5
PaxDbiA1XBS5
PRIDEiA1XBS5
ProteomicsDBi157
158 [A1XBS5-2]
159 [A1XBS5-3]
160 [A1XBS5-4]
161 [A1XBS5-5]

Protocols and materials databases

DNASUi137392
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423990; ENSP00000401774; ENSG00000188343 [A1XBS5-2]
ENST00000452913; ENSP00000391671; ENSG00000188343 [A1XBS5-3]
ENST00000518116; ENSP00000428065; ENSG00000188343 [A1XBS5-4]
ENST00000518322; ENSP00000429367; ENSG00000188343 [A1XBS5-1]
GeneIDi137392
KEGGihsa:137392
UCSCiuc064onr.1 human [A1XBS5-1]

Organism-specific databases

CTDi137392
DisGeNETi137392
EuPathDBiHostDB:ENSG00000188343.12
GeneCardsiFAM92A
H-InvDBiHIX0007647
HIX0024596
HGNCiHGNC:30452 FAM92A
HPAiHPA034760
HPA058942
MIMi617273 gene
neXtProtiNX_A1XBS5
OpenTargetsiENSG00000188343
PharmGKBiPA142671823
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHVX Eukaryota
ENOG410Z4I5 LUCA
GeneTreeiENSGT00390000010285
HOGENOMiHOG000060253
HOVERGENiHBG107895
InParanoidiA1XBS5
OMAiFILISMK
OrthoDBiEOG091G0T7H
PhylomeDBiA1XBS5
TreeFamiTF324316

Miscellaneous databases

ChiTaRSiFAM92A1 human
GenomeRNAii137392
PROiPR:A1XBS5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188343 Expressed in 183 organ(s), highest expression level in testis
CleanExiHS_FAM92A1
ExpressionAtlasiA1XBS5 baseline and differential
GenevisibleiA1XBS5 HS

Family and domain databases

CDDicd07598 BAR_FAM92, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR035590 BAR_FAM92
IPR009602 FAM92
PANTHERiPTHR21223 PTHR21223, 1 hit
PfamiView protein in Pfam
PF06730 FAM92, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFA92A_HUMAN
AccessioniPrimary (citable) accession number: A1XBS5
Secondary accession number(s): A1XBS4
, Q32ND3, Q6AHW7, Q8N8R1, Q96L09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: September 23, 2008
Last modified: September 12, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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