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Protein

Protein FAM92A

Gene

FAM92A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in ciliogenesis (PubMed:27528616). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (PubMed:27528616).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cilium assembly Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM92A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM92AImported
Synonyms:FAM92A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000188343.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30452 FAM92A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
617273 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A1XBS5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi107K → E: Abolishes ability to induce membrane remodeling in the presence of CBY1; when associated with E-110; E-114; E-132; E-134 and E-136. 1 Publication1
Mutagenesisi110R → E: Abolishes ability to induce membrane remodeling in the presence of CBY1; when associated with E-107;E-114; E-132; E-134 and E-136. 1 Publication1
Mutagenesisi114K → E: Abolishes ability to induce membrane remodeling in the presence of CBY1; when associated with E-107; E-110; E-132; E-134 and E-136. 1 Publication1
Mutagenesisi132R → E: Abolishes ability to induce membrane remodeling in the presence of CBY1; when associated with E-107; E-110; E-114; E-134 and E-136. 1 Publication1
Mutagenesisi134R → E: Abolishes ability to induce membrane remodeling in the presence of CBY1; when associated with E-107; E-110; E-114; E-132 and E-136. 1 Publication1
Mutagenesisi136R → E: Abolishes ability to induce membrane remodeling in the presence of CBY1; when associated with E-107; E-110; E-114; E-132 and E-134. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
137392

Open Targets

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OpenTargetsi
ENSG00000188343

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671823

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM92A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002870801 – 289Protein FAM92AAdd BLAST289

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
A1XBS5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A1XBS5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A1XBS5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1XBS5

PRoteomics IDEntifications database

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PRIDEi
A1XBS5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
157
158 [A1XBS5-2]
159 [A1XBS5-3]
160 [A1XBS5-4]
161 [A1XBS5-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A1XBS5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A1XBS5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000188343 Expressed in 183 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_FAM92A1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A1XBS5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1XBS5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034760
HPA058942

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (via BAR-like domain) (PubMed:27528616). Heterodimer with FAM92B (via BAR-like domains) (PubMed:27528616). Interacts (via BAR-like domain) with CBY1; this interaction is required for targeting FAM92A to centriole (PubMed:27528616).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CBY1Q9Y3M23EBI-2349888,EBI-947308

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
126476, 5 interactors

Protein interaction database and analysis system

More...
IntActi
A1XBS5, 3 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A1XBS5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1XBS5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni10 – 220BAR-like1 PublicationAdd BLAST211

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili107 – 178Sequence analysisAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The BAR-like domain displays limited similarity to other BAR domains.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM92 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IHVX Eukaryota
ENOG410Z4I5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010285

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060253

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107895

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A1XBS5

Identification of Orthologs from Complete Genome Data

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OMAi
FILISMK

Database of Orthologous Groups

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OrthoDBi
1324464at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1XBS5

TreeFam database of animal gene trees

More...
TreeFami
TF324316

Family and domain databases

Conserved Domains Database

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CDDi
cd07598 BAR_FAM92, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1270.60, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR035590 BAR_FAM92
IPR009602 FAM92

The PANTHER Classification System

More...
PANTHERi
PTHR21223 PTHR21223, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06730 FAM92, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103657 SSF103657, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A1XBS5-1) [UniParc]FASTAAdd to basket
Also known as: FAM92A1-2891 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMRRTLENRN AQTKQLQTAV SNVEKHFGEL CQIFAAYVRK TARLRDKADL
60 70 80 90 100
LVNEINAYAA TETPHLKLGL MNFADEFAKL QDYRQAEVER LEAKVVEPLK
110 120 130 140 150
TYGTIVKMKR DDLKATLTAR NREAKQLTQL ERTRQRNPSD RHVISQAETE
160 170 180 190 200
LQRAAMDASR TSRHLEETIN NFERQKMKDI KTIFSEFITI EMLFHGKALE
210 220 230 240 250
VYTAAYQNIQ NIDEDEDLEV FRNSLYAPDY SSRLDIVRAN SKSPLQRSLS
260 270 280
AKCVSGTGQV STCRLRKDQQ AEDDEDDELD VTEEENFLK
Length:289
Mass (Da):33,431
Last modified:September 23, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC95F1A4217FDCA5
GO
Isoform 2 (identifier: A1XBS5-2) [UniParc]FASTAAdd to basket
Also known as: FAM92A1-2511 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     182-219: Missing.

Show »
Length:251
Mass (Da):28,997
Checksum:iE87B09A3CDE53979
GO
Isoform 3 (identifier: A1XBS5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-289: VSTCRLRKDQQAEDDEDDELDVTEEENFLK → EAGWAATCQTLI

Show »
Length:271
Mass (Da):31,123
Checksum:iA80C340EF3439A3C
GO
Isoform 4 (identifier: A1XBS5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-289: VFRNSLYAPD...DVTEEENFLK → RWSFAMLPRL...LCMHQIIHLV

Note: No experimental confirmation available.
Show »
Length:262
Mass (Da):30,400
Checksum:i006FEAE8F6F755AC
GO
Isoform 5 (identifier: A1XBS5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-97: ERLEAKVVE → WSEITVSLL
     98-289: Missing.

Note: No experimental confirmation available.
Show »
Length:97
Mass (Da):11,188
Checksum:i80F952E0764B5083
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WTS3A0A087WTS3_HUMAN
Protein FAM92A
FAM92A
288Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC32H0YC32_HUMAN
Protein FAM92A
FAM92A
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RID3E5RID3_HUMAN
Protein FAM92A
FAM92A
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHK0E5RHK0_HUMAN
Protein FAM92A
FAM92A
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W7P5F8W7P5_HUMAN
Protein FAM92A
FAM92A
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGP4E5RGP4_HUMAN
Protein FAM92A
FAM92A
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGD0E5RGD0_HUMAN
Protein FAM92A
FAM92A
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J212A0A0B4J212_HUMAN
Protein FAM92A
FAM92A
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFH7E5RFH7_HUMAN
Protein FAM92A
FAM92A
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFS7E5RFS7_HUMAN
Protein FAM92A
FAM92A
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH14598 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI08708 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti137N → S in ABC55436 (PubMed:17646714).Curated1
Sequence conflicti150E → G in BAC04753 (PubMed:14702039).Curated1
Sequence conflicti281V → I in ABC55437 (PubMed:17646714).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_062190222R → Q. Corresponds to variant dbSNP:rs36117362Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02529289 – 97ERLEAKVVE → WSEITVSLL in isoform 5. 1 Publication9
Alternative sequenceiVSP_02529398 – 289Missing in isoform 5. 1 PublicationAdd BLAST192
Alternative sequenceiVSP_025294182 – 219Missing in isoform 2. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_025295220 – 289VFRNS…ENFLK → RWSFAMLPRLVLNSWGSSDP PALASQSVRFSEILCMHQII HLV in isoform 4. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_025296260 – 289VSTCR…ENFLK → EAGWAATCQTLI in isoform 3. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ327715 mRNA Translation: ABC55436.1
DQ327716 mRNA Translation: ABC55437.1
AK096298 mRNA Translation: BAC04753.1
CR627475 mRNA Translation: CAH10675.1
AC010834 Genomic DNA No translation available.
AC120053 Genomic DNA No translation available.
BC014598 mRNA Translation: AAH14598.2 Different initiation.
BC108707 mRNA Translation: AAI08708.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS47892.1 [A1XBS5-1]
CCDS64933.1 [A1XBS5-2]

NCBI Reference Sequences

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RefSeqi
NP_001269963.1, NM_001283034.1 [A1XBS5-2]
NP_660312.2, NM_145269.4 [A1XBS5-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.125038

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000423990; ENSP00000401774; ENSG00000188343 [A1XBS5-2]
ENST00000452913; ENSP00000391671; ENSG00000188343 [A1XBS5-3]
ENST00000518116; ENSP00000428065; ENSG00000188343 [A1XBS5-4]
ENST00000518322; ENSP00000429367; ENSG00000188343 [A1XBS5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
137392

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:137392

UCSC genome browser

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UCSCi
uc064onr.1 human [A1XBS5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ327715 mRNA Translation: ABC55436.1
DQ327716 mRNA Translation: ABC55437.1
AK096298 mRNA Translation: BAC04753.1
CR627475 mRNA Translation: CAH10675.1
AC010834 Genomic DNA No translation available.
AC120053 Genomic DNA No translation available.
BC014598 mRNA Translation: AAH14598.2 Different initiation.
BC108707 mRNA Translation: AAI08708.1 Different initiation.
CCDSiCCDS47892.1 [A1XBS5-1]
CCDS64933.1 [A1XBS5-2]
RefSeqiNP_001269963.1, NM_001283034.1 [A1XBS5-2]
NP_660312.2, NM_145269.4 [A1XBS5-1]
UniGeneiHs.125038

3D structure databases

ProteinModelPortaliA1XBS5
SMRiA1XBS5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126476, 5 interactors
IntActiA1XBS5, 3 interactors

PTM databases

iPTMnetiA1XBS5
PhosphoSitePlusiA1XBS5

Polymorphism and mutation databases

BioMutaiFAM92A

Proteomic databases

EPDiA1XBS5
jPOSTiA1XBS5
MaxQBiA1XBS5
PaxDbiA1XBS5
PRIDEiA1XBS5
ProteomicsDBi157
158 [A1XBS5-2]
159 [A1XBS5-3]
160 [A1XBS5-4]
161 [A1XBS5-5]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
137392
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423990; ENSP00000401774; ENSG00000188343 [A1XBS5-2]
ENST00000452913; ENSP00000391671; ENSG00000188343 [A1XBS5-3]
ENST00000518116; ENSP00000428065; ENSG00000188343 [A1XBS5-4]
ENST00000518322; ENSP00000429367; ENSG00000188343 [A1XBS5-1]
GeneIDi137392
KEGGihsa:137392
UCSCiuc064onr.1 human [A1XBS5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
137392
DisGeNETi137392
EuPathDBiHostDB:ENSG00000188343.12

GeneCards: human genes, protein and diseases

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GeneCardsi
FAM92A

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0007647
HIX0024596
HGNCiHGNC:30452 FAM92A
HPAiHPA034760
HPA058942
MIMi617273 gene
neXtProtiNX_A1XBS5
OpenTargetsiENSG00000188343
PharmGKBiPA142671823

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHVX Eukaryota
ENOG410Z4I5 LUCA
GeneTreeiENSGT00390000010285
HOGENOMiHOG000060253
HOVERGENiHBG107895
InParanoidiA1XBS5
OMAiFILISMK
OrthoDBi1324464at2759
PhylomeDBiA1XBS5
TreeFamiTF324316

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FAM92A1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
137392

Protein Ontology

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PROi
PR:A1XBS5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000188343 Expressed in 183 organ(s), highest expression level in testis
CleanExiHS_FAM92A1
ExpressionAtlasiA1XBS5 baseline and differential
GenevisibleiA1XBS5 HS

Family and domain databases

CDDicd07598 BAR_FAM92, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR035590 BAR_FAM92
IPR009602 FAM92
PANTHERiPTHR21223 PTHR21223, 1 hit
PfamiView protein in Pfam
PF06730 FAM92, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA92A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1XBS5
Secondary accession number(s): A1XBS4
, Q32ND3, Q6AHW7, Q8N8R1, Q96L09
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: September 23, 2008
Last modified: January 16, 2019
This is version 92 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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