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Protein

Putative alpha-conotoxin Qc alphaL-1

Gene
N/A
Organism
Conus quercinus (Oak cone)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.By similarity

Miscellaneous

The mature peptide contains 3 cysteine residues.

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Putative alpha-conotoxin Qc alphaL-1
Short name:
QcaL-1
OrganismiConus quercinus (Oak cone)
Taxonomic identifieri101313 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusLividoconus

Organism-specific databases

ConoServeri548 QcaL-1 precursor
555 QcaL-1 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000037066522 – 49By similarityAdd BLAST28
PeptideiPRO_000037066650 – 68Putative alpha-conotoxin Qc alphaL-1Add BLAST19

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 64By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliA1X8B8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1X8B8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGMRMMFTMF LLVVLATTVV SINLDHAFDG RNAAANNKAT DLMARTVRRF
60
CSDPPCRISN PESCGWEP
Length:68
Mass (Da):7,580
Last modified:February 6, 2007 - v1
Checksum:i14C64303FB62FCAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ311058 Genomic DNA Translation: ABD33850.1
DQ311065 mRNA Translation: ABD33857.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ311058 Genomic DNA Translation: ABD33850.1
DQ311065 mRNA Translation: ABD33857.1

3D structure databases

ProteinModelPortaliA1X8B8
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri548 QcaL-1 precursor
555 QcaL-1 precursor

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCA1_CONQU
AccessioniPrimary (citable) accession number: A1X8B8
Secondary accession number(s): A1X8C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: February 6, 2007
Last modified: September 12, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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