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Protein

Alpha-conotoxin Lp1.4

Gene
N/A
Organism
Conus leopardus (Leopard cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin inhibits mouse muscle alpha-1-beta-1-gamma-delta (CHRNA1-CHRNB1-CHRNG-CHRND), and weakly rat neuronal alpha-6/alpha-3-beta-2 (CHRNA6/CHRNA3-CHRNB2).1 Publication

Miscellaneous

Does not or very weakly inhibits rat neuronal alpha-7 (CHRNA7), alpha-3-beta-2 (CHRNA3-CHRNB2), alpha-6/alpha-3-beta-4 (CHRNA6/CHRNA3-CHRNB4), alpha-3-beta-4 (CHRNA3-CHRNB4), alpha-4-beta-4 (CHRNA4-CHRNB4) and alpha-4-beta-2 (CHRNA4-CHRNB2) nAChR.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin Lp1.41 Publication
OrganismiConus leopardus (Leopard cone)
Taxonomic identifieri101306 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusLithoconus

Organism-specific databases

ConoServeri122 Lp1.4 precursor
546 Lp1.4 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000037065022 – 481 PublicationAdd BLAST27
PeptideiPRO_000037065149 – 65Alpha-conotoxin Lp1.41 PublicationAdd BLAST17

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 561 Publication
Disulfide bondi51 ↔ 641 Publication
Modified residuei65Aspartic acid 1-amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

3D structure databases

ProteinModelPortaliA1X8B6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/7 pattern.Curated

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1X8B6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGMRMMSIMF MLVVLATTVV SFTSDRALDA MNAAASKKAS RLIALAVRGC
60
CSHPACSGNH QELCDGRR
Length:68
Mass (Da):7,292
Last modified:February 6, 2007 - v1
Checksum:i2FD44A064F2E2F37
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7S → F in AAS93427 (PubMed:17400270).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ311056 Genomic DNA Translation: ABD33848.1
AY580324 mRNA Translation: AAS93427.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ311056 Genomic DNA Translation: ABD33848.1
AY580324 mRNA Translation: AAS93427.1

3D structure databases

ProteinModelPortaliA1X8B6
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri122 Lp1.4 precursor
546 Lp1.4 precursor

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCA14_CONLE
AccessioniPrimary (citable) accession number: A1X8B6
Secondary accession number(s): Q6PTD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: February 6, 2007
Last modified: September 12, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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