UniProtKB - A1X283 (SPD2B_HUMAN)

BLAST

>sp|A1X283|SPD2B_HUMAN SH3 and PX domain-containing protein 2B OS=Homo sapiens OX=9606 GN=SH3PXD2B PE=1 SV=3
MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP
MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ
FFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVD
IIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEM
NLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDL
DGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNL
PKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPAT
FIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDS
GLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERE
RERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGH
KVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQ
VDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLS
PKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRG
PQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAA
AASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEG
WIPSNYLRKKP

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History
Entry version 100 (10 Oct 2018)
Sequence version 3 (05 May 2009)
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Protein

SH3 and PX domain-containing protein 2B

Gene

SH3PXD2B

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity).By similarity3 Publications

GO - Molecular functionⁱ

phosphatidylinositol-3,5-bisphosphate binding Source: UniProtKB
phosphatidylinositol-3-phosphate binding Source: UniProtKB
phosphatidylinositol-4-phosphate binding Source: GO_Central
phosphatidylinositol-5-phosphate binding Source: UniProtKB
SH2 domain binding Source: UniProtKB
superoxide-generating NADPH oxidase activator activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adipose tissue development Source: UniProtKB
bone development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20137777
cranial skeletal system development Source: Ensembl
extracellular matrix disassembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19755710
eye development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20137777
heart development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20137777
osteoblast fate commitment Source: Ensembl
oxidation-reduction process Source: GO_Central
podosome assembly Source: UniProtKB
positive regulation of adipose tissue development Source: Ensembl
positive regulation of fat cell differentiation Source: Ensembl
positive regulation of gene expression Source: Ensembl
positive regulation of multicellular organism growth Source: Ensembl
positive regulation of stress fiber assembly Source: Ensembl
protein localization to membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 19755710
regulation of brood size Source: Ensembl
skeletal system development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20137777
skeletal system morphogenesis Source: Ensembl
superoxide metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 19755710

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Differentiation

Biological process

Differentiation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SH3 and PX domain-containing protein 2B Alternative name(s): Adapter protein HOFI Factor for adipocyte differentiation 49 Tyrosine kinase substrate with four SH3 domains
Gene namesⁱ	Name:SH3PXD2B Synonyms:FAD49, KIAA1295, TKS4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000174705.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29242 SH3PXD2B
MIMⁱ	613293 gene
neXtProtⁱ	NX_A1X283

Keywords - Cellular componentⁱ

Cell junction, Cell projection, Cytoplasm

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Frank-Ter Haar syndrome (FTHS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA syndrome characterized by brachycephaly, wide fontanels, prominent forehead, hypertelorism, prominent eyes, macrocornea with or without glaucoma, full cheeks, small chin, bowing of the long bones and flexion deformity of the fingers.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	285590
MalaCards human disease database More...MalaCardsⁱ	SH3PXD2B
MIMⁱ	249420 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000174705
Orphanetⁱ	1266 Dermato-cardio-skeletal syndrome, Borrone type 137834 Frank-Ter Haar syndrome
PharmGKBⁱ	PA134864119

Polymorphism and mutation databases

BioMutaⁱ	SH3PXD2B

BioMutaⁱ

SH3PXD2B

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000312201	1 – 911	SH3 and PX domain-containing protein 2BAdd BLAST		911

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	25	PhosphotyrosineBy similarity	1
Modified residueⁱ	279	PhosphoserineCombined sources	1
Modified residueⁱ	291	PhosphoserineCombined sources	1
Modified residueⁱ	499	PhosphoserineBy similarity	1
Modified residueⁱ	528	PhosphoserineBy similarity	1
Modified residueⁱ	843	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated in SRC-transformed cells.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	A1X283
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A1X283
PaxDbⁱ	A1X283
PRIDEⁱ	A1X283
ProteomicsDBⁱ	156

PTM databases

iPTMnetⁱ	A1X283
PhosphoSitePlusⁱ	A1X283

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000174705 Expressed in 177 organ(s), highest expression level in uterine cervix
CleanExⁱ	HS_SH3PXD2B
ExpressionAtlasⁱ	A1X283 baseline and differential
Genevisibleⁱ	A1X283 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA036471

HPAⁱ

HPA036471

Interactionⁱ

Subunit structureⁱ

Interacts with ADAM15 (By similarity). Interacts with NOXO1. Interacts (via SH3 domains) with NOXA1; the interaction is direct. Interacts with FASLG.By similarity4 Publications

GO - Molecular functionⁱ

SH2 domain binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	130149, 18 interactors
IntActⁱ	A1X283, 5 interactors
Molecular INTeraction database More...MINTⁱ	A1X283
STRINGⁱ	9606.ENSP00000309714

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A1X283
SMRⁱ	A1X283
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	5 – 129	PXPROSITE-ProRule annotationAdd BLAST	125
Domainⁱ	152 – 211	SH3 1PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	221 – 280	SH3 2PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	368 – 427	SH3 3PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	850 – 911	SH3 4PROSITE-ProRule annotationAdd BLAST	62

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	729 – 806	Pro-richAdd BLAST		78

Domainⁱ

The PX domain is required for podosome localization because of its ability to bind phosphatidylinositol 3-phosphate (PtdIns₃P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and, to a lesser extent, phosphatidylinositol 4-phosphate (PtdIns₄P), phosphatidylinositol 5-phosphate (PtdIns₅P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Binds to the third intramolecular SH3 domain (By similarity).By similarity

Sequence similaritiesⁱ

Belongs to the SH3PXD2 family.Curated

Keywords - Domainⁱ

Repeat, SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG4773 Eukaryota ENOG410YBFF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063010
HOGENOMⁱ	HOG000154376
HOVERGENⁱ	HBG107128
InParanoidⁱ	A1X283
OMAⁱ	WFCQVLS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00YX
PhylomeDBⁱ	A1X283
TreeFamⁱ	TF329347

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06888 PX_FISH, 1 hit cd12075 SH3_Tks4_1, 1 hit cd12076 SH3_Tks4_2, 1 hit cd12078 SH3_Tks4_3, 1 hit cd12018 SH3_Tks4_4, 1 hit
Gene3Dⁱ	3.30.1520.10, 1 hit
InterProⁱ	View protein in InterPro IPR001683 Phox IPR036871 PX_dom_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR037961 SH3PXD2_PX IPR030512 SH3PXD2B IPR035477 SH3PXD2B_SH3_1 IPR035478 SH3PXD2B_SH3_2 IPR035479 SH3PXD2B_SH3_3 IPR035480 SH3PXD2B_SH3_4
PANTHERⁱ	PTHR15706:SF2 PTHR15706:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00787 PX, 1 hit PF00018 SH3_1, 3 hits PF07653 SH3_2, 1 hit
SMARTⁱ	View protein in SMART SM00312 PX, 1 hit SM00326 SH3, 4 hits
SUPFAMⁱ	SSF50044 SSF50044, 4 hits SSF64268 SSF64268, 1 hit
PROSITEⁱ	View protein in PROSITE PS50195 PX, 1 hit PS50002 SH3, 4 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

A1X283-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MPPRRSIVEV KVLDVQKRRV PNKHYVYIIR VTWSSGSTEA IYRRYSKFFD 
        60         70         80         90        100
LQMQMLDKFP MEGGQKDPKQ RIIPFLPGKI LFRRSHIRDV AVKRLIPIDE 
       110        120        130        140        150
YCKALIQLPP YISQCDEVLQ FFETRPEDLN PPKEEHIGKK KSGGDQTSVD 
       160        170        180        190        200
PMVLEQYVVV ANYQKQESSE ISLSVGQVVD IIEKNESGWW FVSTAEEQGW 
       210        220        230        240        250
VPATCLEGQD GVQDEFSLQP EEEEKYTVIY PYTARDQDEM NLERGAVVEV 
       260        270        280        290        300
IQKNLEGWWK IRYQGKEGWA PASYLKKNSG EPLPPKPGPG SPSHPGALDL 
       310        320        330        340        350
DGVSRQQNAV GREKELLSSQ RDGRFEGRPV PDGDAKQRSP KMRQRPPPRR 
       360        370        380        390        400
DMTIPRGLNL PKPPIPPQVE EEYYTIAEFQ TTIPDGISFQ AGLKVEVIEK 
       410        420        430        440        450
NLSGWWYIQI EDKEGWAPAT FIDKYKKTSN ASRPNFLAPL PHEVTQLRLG 
       460        470        480        490        500
EAAALENNTG SEATGPSRPL PDAPHGVMDS GLPWSKDWKG SKDVLRKASS 
       510        520        530        540        550
DMSASAGYEE ISDPDMEEKP SLPPRKESII KSEGELLERE RERQRTEQLR 
       560        570        580        590        600
GPTPKPPGVI LPMMPAKHIP PARDSRRPEP KPDKSRLFQL KNDMGLECGH 
       610        620        630        640        650
KVLAKEVKKP NLRPISKSKT DLPEEKPDAT PQNPFLKSRP QVRPKPAPSP 
       660        670        680        690        700
KTEPPQGEDQ VDICNLRSKL RPAKSQDKSL LDGEGPQAVG GQDVAFSRSF 
       710        720        730        740        750
LPGEGPGRAQ DRTGKQDGLS PKEISCRAPP RPAKTTDPVS KSVPVPLQEA 
       760        770        780        790        800
PQQRPVVPPR RPPPPKKTSS SSRPLPEVRG PQCEGHESRA APTPGRALLV 
       810        820        830        840        850
PPKAKPFLSN SLGGQDDTRG KGSLGPWGTG KIGENREKAA AASVPNADGL 
       860        870        880        890        900
KDSLYVAVAD FEGDKDTSSF QEGTVFEVRE KNSSGWWFCQ VLSGAPSWEG 
       910 
WIPSNYLRKK P

Length:911

Mass (Da):101,579

Last modified:May 5, 2009 - v3

Checksum:ⁱA5AA524F9AA21318

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3V144	G3V144_HUMAN	SH3 and PX domain-containing protei... SH3 and PX domain-containing protein 2B (SH3 and PX domains 2B, isoform CRA_b)	SH3PXD2B hCG_40282	430	Annotation score:
A0A1B0GUF2	A0A1B0GUF2_HUMAN	SH3 and PX domain-containing protei... SH3 and PX domain-containing protein 2B	SH3PXD2B	444	Annotation score:
H0YAU1	H0YAU1_HUMAN	SH3 and PX domain-containing protei... SH3 and PX domain-containing protein 2B	SH3PXD2B	81	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	28	I → V in AAZ99795 (Ref. 2) Curated	1
Sequence conflictⁱ	72	I → T in AAZ99795 (Ref. 2) Curated	1
Sequence conflictⁱ	712	R → G in AAZ99795 (Ref. 2) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_063764	43	R → W in FTHS. 1 PublicationCorresponds to variant dbSNP:rs267607046EnsemblClinVar.		1
Natural variantⁱVAR_046226	101	Y → F. Corresponds to variant dbSNP:rs6880739Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB430862 mRNA Translation: BAG81977.1 DQ109556 mRNA Translation: AAZ99795.1 AC008671 Genomic DNA No translation available. AC011407 Genomic DNA No translation available. AC090064 Genomic DNA No translation available. AB037716 mRNA Translation: BAA92533.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34291.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001017995.1, NM_001017995.2
UniGeneⁱ	Hs.285666

Genome annotation databases

Ensemblⁱ	ENST00000311601; ENSP00000309714; ENSG00000174705
GeneIDⁱ	285590
KEGGⁱ	hsa:285590
UCSC genome browser More...UCSCⁱ	uc003mbr.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A1X283	SH3 and PX domains 2B		GORGO		918	UniRef90_A1X283
Uncharacterized protein		MACMU		914
Uncharacterized protein		MACFA		914
Uncharacterized protein		RHIBE		914
Uncharacterized protein		MACNE		914
+28

Protein	Similar proteins		Species	Score	Length	Source
A1X283	SH3 and PX domain-containing protein 2B		MOUSE		908	UniRef50_A2AAY5
SH3 and PX domain-containing protein 2B isoform X2		MESAU		906
SH3 and PX domain-containing protein 2B		CRIGR		880
SH3 and PX domains 2B		RAT		804
SH3 and PX domains 2B		NOTKU		900
+421

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB430862 mRNA Translation: BAG81977.1 DQ109556 mRNA Translation: AAZ99795.1 AC008671 Genomic DNA No translation available. AC011407 Genomic DNA No translation available. AC090064 Genomic DNA No translation available. AB037716 mRNA Translation: BAA92533.1
CCDSⁱ	CCDS34291.1
RefSeqⁱ	NP_001017995.1, NM_001017995.2
UniGeneⁱ	Hs.285666

3D structure databases

ProteinModelPortalⁱ	A1X283
SMRⁱ	A1X283
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	130149, 18 interactors
IntActⁱ	A1X283, 5 interactors
MINTⁱ	A1X283
STRINGⁱ	9606.ENSP00000309714

PTM databases

iPTMnetⁱ	A1X283
PhosphoSitePlusⁱ	A1X283

Polymorphism and mutation databases

BioMutaⁱ	SH3PXD2B

BioMutaⁱ

SH3PXD2B

Proteomic databases

EPDⁱ	A1X283
MaxQBⁱ	A1X283
PaxDbⁱ	A1X283
PRIDEⁱ	A1X283
ProteomicsDBⁱ	156

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	285590
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000311601; ENSP00000309714; ENSG00000174705
GeneIDⁱ	285590
KEGGⁱ	hsa:285590
UCSCⁱ	uc003mbr.3 human

Organism-specific databases

CTDⁱ	285590
DisGeNETⁱ	285590
EuPathDBⁱ	HostDB:ENSG00000174705.11
GeneCardsⁱ	SH3PXD2B
H-InvDBⁱ	HIX0005417
HGNCⁱ	HGNC:29242 SH3PXD2B
HPAⁱ	HPA036471
MalaCardsⁱ	SH3PXD2B
MIMⁱ	249420 phenotype 613293 gene
neXtProtⁱ	NX_A1X283
OpenTargetsⁱ	ENSG00000174705
Orphanetⁱ	1266 Dermato-cardio-skeletal syndrome, Borrone type 137834 Frank-Ter Haar syndrome
PharmGKBⁱ	PA134864119
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4773 Eukaryota ENOG410YBFF LUCA
GeneTreeⁱ	ENSGT00530000063010
HOGENOMⁱ	HOG000154376
HOVERGENⁱ	HBG107128
InParanoidⁱ	A1X283
OMAⁱ	WFCQVLS
OrthoDBⁱ	EOG091G00YX
PhylomeDBⁱ	A1X283
TreeFamⁱ	TF329347

Miscellaneous databases

ChiTaRSⁱ	SH3PXD2B human
GenomeRNAiⁱ	285590
Protein Ontology More...PROⁱ	PR:A1X283
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000174705 Expressed in 177 organ(s), highest expression level in uterine cervix
CleanExⁱ	HS_SH3PXD2B
ExpressionAtlasⁱ	A1X283 baseline and differential
Genevisibleⁱ	A1X283 HS

Family and domain databases

CDDⁱ	cd06888 PX_FISH, 1 hit cd12075 SH3_Tks4_1, 1 hit cd12076 SH3_Tks4_2, 1 hit cd12078 SH3_Tks4_3, 1 hit cd12018 SH3_Tks4_4, 1 hit
Gene3Dⁱ	3.30.1520.10, 1 hit
InterProⁱ	View protein in InterPro IPR001683 Phox IPR036871 PX_dom_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR037961 SH3PXD2_PX IPR030512 SH3PXD2B IPR035477 SH3PXD2B_SH3_1 IPR035478 SH3PXD2B_SH3_2 IPR035479 SH3PXD2B_SH3_3 IPR035480 SH3PXD2B_SH3_4
PANTHERⁱ	PTHR15706:SF2 PTHR15706:SF2, 1 hit
Pfamⁱ	View protein in Pfam PF00787 PX, 1 hit PF00018 SH3_1, 3 hits PF07653 SH3_2, 1 hit
SMARTⁱ	View protein in SMART SM00312 PX, 1 hit SM00326 SH3, 4 hits
SUPFAMⁱ	SSF50044 SSF50044, 4 hits SSF64268 SSF64268, 1 hit
PROSITEⁱ	View protein in PROSITE PS50195 PX, 1 hit PS50002 SH3, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SPD2B_HUMAN
Accessionⁱ	A1X283Primary (citable) accession number: A1X283 Secondary accession number(s): B6F0V2, Q9P2Q1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
	Last sequence update:	May 5, 2009
	Last modified:	October 10, 2018
	This is version 100 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A1X283 (SPD2B_HUMAN)

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SH3 and PX domain-containing protein 2B

SH3PXD2B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytoskeleton

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ