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UniProtKB - A1X283 (SPD2B_HUMAN)

Entry version 114 (02 Dec 2020)
Sequence version 3 (05 May 2009)
Previous versions | rss
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Protein

SH3 and PX domain-containing protein 2B

Gene

SH3PXD2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A1X283

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH3 and PX domain-containing protein 2B
Alternative name(s):
Adapter protein HOFI
Factor for adipocyte differentiation 49
Tyrosine kinase substrate with four SH3 domains
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SH3PXD2B
Synonyms:FAD49, KIAA1295, TKS4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000174705.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:29242, SH3PXD2B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613293, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A1X283

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Frank-Ter Haar syndrome (FTHS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by brachycephaly, wide fontanels, prominent forehead, hypertelorism, prominent eyes, macrocornea with or without glaucoma, full cheeks, small chin, bowing of the long bones and flexion deformity of the fingers.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06376443R → W in FTHS. 1 PublicationCorresponds to variant dbSNP:rs267607046EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		285590

MalaCards human disease database

More...MalaCardsi		SH3PXD2B
MIMi249420, phenotype

Open Targets

More...OpenTargetsi		ENSG00000174705

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		137834, Frank-Ter Haar syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134864119

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A1X283, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SH3PXD2B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003122011 – 911SH3 and PX domain-containing protein 2BAdd BLAST911

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei25PhosphotyrosineBy similarity1
Modified residuei279PhosphoserineCombined sources1
Modified residuei291PhosphoserineCombined sources1
Modified residuei499PhosphoserineBy similarity1
Modified residuei528PhosphoserineBy similarity1
Modified residuei843PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in SRC-transformed cells.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A1X283

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A1X283

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		A1X283

MaxQB - The MaxQuant DataBase

More...MaxQBi		A1X283

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A1X283

PeptideAtlas

More...PeptideAtlasi		A1X283

PRoteomics IDEntifications database

More...PRIDEi		A1X283

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		156

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A1X283

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A1X283

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fibroblasts.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000174705, Expressed in uterine cervix and 190 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A1X283, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A1X283, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000174705, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ADAM15 (By similarity).

Interacts with NOXO1.

Interacts (via SH3 domains) with NOXA1; the interaction is direct.

Interacts with FASLG.

By similarity4 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		130149, 22 interactors

Protein interaction database and analysis system

More...IntActi		A1X283, 10 interactors

Molecular INTeraction database

More...MINTi		A1X283

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000309714

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A1X283, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A1X283

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 129PXPROSITE-ProRule annotationAdd BLAST125
Domaini152 – 211SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini221 – 280SH3 2PROSITE-ProRule annotationAdd BLAST60
Domaini368 – 427SH3 3PROSITE-ProRule annotationAdd BLAST60
Domaini850 – 911SH3 4PROSITE-ProRule annotationAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi729 – 806Pro-richAdd BLAST78

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PX domain is required for podosome localization because of its ability to bind phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and, to a lesser extent, phosphatidylinositol 4-phosphate (PtdIns4P), phosphatidylinositol 5-phosphate (PtdIns5P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Binds to the third intramolecular SH3 domain (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SH3PXD2 family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0905, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158396

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013051_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A1X283

Identification of Orthologs from Complete Genome Data

More...OMAi		PMIPTKH

Database of Orthologous Groups

More...OrthoDBi		1183210at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A1X283

TreeFam database of animal gene trees

More...TreeFami		TF329347

Family and domain databases

Conserved Domains Database

More...CDDi		cd06888, PX_FISH, 1 hit
cd12075, SH3_Tks4_1, 1 hit
cd12076, SH3_Tks4_2, 1 hit
cd12078, SH3_Tks4_3, 1 hit
cd12018, SH3_Tks4_4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001683, PX_dom
IPR036871, PX_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR037961, SH3PXD2_PX
IPR030512, SH3PXD2B
IPR035477, SH3PXD2B_SH3_1
IPR035478, SH3PXD2B_SH3_2
IPR035479, SH3PXD2B_SH3_3
IPR035480, SH3PXD2B_SH3_4

The PANTHER Classification System

More...PANTHERi		PTHR15706:SF19, PTHR15706:SF19, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00787, PX, 1 hit
PF00018, SH3_1, 3 hits
PF07653, SH3_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00312, PX, 1 hit
SM00326, SH3, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50044, SSF50044, 4 hits
SSF64268, SSF64268, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50195, PX, 1 hit
PS50002, SH3, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A1X283-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPRRSIVEV KVLDVQKRRV PNKHYVYIIR VTWSSGSTEA IYRRYSKFFD 
        60         70         80         90        100
LQMQMLDKFP MEGGQKDPKQ RIIPFLPGKI LFRRSHIRDV AVKRLIPIDE 
       110        120        130        140        150
YCKALIQLPP YISQCDEVLQ FFETRPEDLN PPKEEHIGKK KSGGDQTSVD 
       160        170        180        190        200
PMVLEQYVVV ANYQKQESSE ISLSVGQVVD IIEKNESGWW FVSTAEEQGW 
       210        220        230        240        250
VPATCLEGQD GVQDEFSLQP EEEEKYTVIY PYTARDQDEM NLERGAVVEV 
       260        270        280        290        300
IQKNLEGWWK IRYQGKEGWA PASYLKKNSG EPLPPKPGPG SPSHPGALDL 
       310        320        330        340        350
DGVSRQQNAV GREKELLSSQ RDGRFEGRPV PDGDAKQRSP KMRQRPPPRR 
       360        370        380        390        400
DMTIPRGLNL PKPPIPPQVE EEYYTIAEFQ TTIPDGISFQ AGLKVEVIEK 
       410        420        430        440        450
NLSGWWYIQI EDKEGWAPAT FIDKYKKTSN ASRPNFLAPL PHEVTQLRLG 
       460        470        480        490        500
EAAALENNTG SEATGPSRPL PDAPHGVMDS GLPWSKDWKG SKDVLRKASS 
       510        520        530        540        550
DMSASAGYEE ISDPDMEEKP SLPPRKESII KSEGELLERE RERQRTEQLR 
       560        570        580        590        600
GPTPKPPGVI LPMMPAKHIP PARDSRRPEP KPDKSRLFQL KNDMGLECGH 
       610        620        630        640        650
KVLAKEVKKP NLRPISKSKT DLPEEKPDAT PQNPFLKSRP QVRPKPAPSP 
       660        670        680        690        700
KTEPPQGEDQ VDICNLRSKL RPAKSQDKSL LDGEGPQAVG GQDVAFSRSF 
       710        720        730        740        750
LPGEGPGRAQ DRTGKQDGLS PKEISCRAPP RPAKTTDPVS KSVPVPLQEA 
       760        770        780        790        800
PQQRPVVPPR RPPPPKKTSS SSRPLPEVRG PQCEGHESRA APTPGRALLV 
       810        820        830        840        850
PPKAKPFLSN SLGGQDDTRG KGSLGPWGTG KIGENREKAA AASVPNADGL 
       860        870        880        890        900
KDSLYVAVAD FEGDKDTSSF QEGTVFEVRE KNSSGWWFCQ VLSGAPSWEG 
       910 
WIPSNYLRKK P
Length:911
Mass (Da):101,579
Last modified:May 5, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA5AA524F9AA21318
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V144G3V144_HUMAN
SH3 and PX domain-containing protei...
SH3PXD2B hCG_40282
430Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUF2A0A1B0GUF2_HUMAN
SH3 and PX domain-containing protei...
SH3PXD2B
444Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAU1H0YAU1_HUMAN
SH3 and PX domain-containing protei...
SH3PXD2B
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28I → V in AAZ99795 (Ref. 2) Curated1
Sequence conflicti72I → T in AAZ99795 (Ref. 2) Curated1
Sequence conflicti712R → G in AAZ99795 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06376443R → W in FTHS. 1 PublicationCorresponds to variant dbSNP:rs267607046EnsemblClinVar.1
Natural variantiVAR_046226101Y → F. Corresponds to variant dbSNP:rs6880739Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB430862 mRNA Translation: BAG81977.1
DQ109556 mRNA Translation: AAZ99795.1
AC008671 Genomic DNA No translation available.
AC011407 Genomic DNA No translation available.
AC090064 Genomic DNA No translation available.
AB037716 mRNA Translation: BAA92533.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34291.1

NCBI Reference Sequences

More...RefSeqi		NP_001017995.1, NM_001017995.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000311601; ENSP00000309714; ENSG00000174705

Database of genes from NCBI RefSeq genomes

More...GeneIDi		285590

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:285590

UCSC genome browser

More...UCSCi		uc003mbr.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB430862 mRNA Translation: BAG81977.1
DQ109556 mRNA Translation: AAZ99795.1
AC008671 Genomic DNA No translation available.
AC011407 Genomic DNA No translation available.
AC090064 Genomic DNA No translation available.
AB037716 mRNA Translation: BAA92533.1
CCDSiCCDS34291.1
RefSeqiNP_001017995.1, NM_001017995.2

3D structure databases

SMRiA1X283
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi130149, 22 interactors
IntActiA1X283, 10 interactors
MINTiA1X283
STRINGi9606.ENSP00000309714

PTM databases

iPTMnetiA1X283
PhosphoSitePlusiA1X283

Polymorphism and mutation databases

BioMutaiSH3PXD2B

Proteomic databases

EPDiA1X283
jPOSTiA1X283
MassIVEiA1X283
MaxQBiA1X283
PaxDbiA1X283
PeptideAtlasiA1X283
PRIDEiA1X283
ProteomicsDBi156

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		A1X283, 20 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		49665, 84 antibodies

The DNASU plasmid repository

More...DNASUi		285590

Genome annotation databases

EnsembliENST00000311601; ENSP00000309714; ENSG00000174705
GeneIDi285590
KEGGihsa:285590
UCSCiuc003mbr.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		285590
DisGeNETi285590
EuPathDBiHostDB:ENSG00000174705.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		SH3PXD2B
HGNCiHGNC:29242, SH3PXD2B
HPAiENSG00000174705, Low tissue specificity
MalaCardsiSH3PXD2B
MIMi249420, phenotype
613293, gene
neXtProtiNX_A1X283
OpenTargetsiENSG00000174705
Orphaneti137834, Frank-Ter Haar syndrome
PharmGKBiPA134864119

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0905, Eukaryota
GeneTreeiENSGT00940000158396
HOGENOMiCLU_013051_1_0_1
InParanoidiA1X283
OMAiPMIPTKH
OrthoDBi1183210at2759
PhylomeDBiA1X283
TreeFamiTF329347

Enzyme and pathway databases

PathwayCommonsiA1X283

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		285590, 7 hits in 842 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SH3PXD2B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		285590
PharosiA1X283, Tbio

Protein Ontology

More...PROi		PR:A1X283
RNActiA1X283, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000174705, Expressed in uterine cervix and 190 other tissues
ExpressionAtlasiA1X283, baseline and differential
GenevisibleiA1X283, HS

Family and domain databases

CDDicd06888, PX_FISH, 1 hit
cd12075, SH3_Tks4_1, 1 hit
cd12076, SH3_Tks4_2, 1 hit
cd12078, SH3_Tks4_3, 1 hit
cd12018, SH3_Tks4_4, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683, PX_dom
IPR036871, PX_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR037961, SH3PXD2_PX
IPR030512, SH3PXD2B
IPR035477, SH3PXD2B_SH3_1
IPR035478, SH3PXD2B_SH3_2
IPR035479, SH3PXD2B_SH3_3
IPR035480, SH3PXD2B_SH3_4
PANTHERiPTHR15706:SF19, PTHR15706:SF19, 1 hit
PfamiView protein in Pfam
PF00787, PX, 1 hit
PF00018, SH3_1, 3 hits
PF07653, SH3_2, 1 hit
SMARTiView protein in SMART
SM00312, PX, 1 hit
SM00326, SH3, 4 hits
SUPFAMiSSF50044, SSF50044, 4 hits
SSF64268, SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195, PX, 1 hit
PS50002, SH3, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPD2B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1X283
Secondary accession number(s): B6F0V2, Q9P2Q1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 5, 2009
Last modified: December 2, 2020
This is version 114 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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