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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (Hhal_0050), Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56SubstrateUniRule annotation1
Binding sitei131SubstrateUniRule annotation1
Binding sitei156SubstrateUniRule annotation1
Binding sitei186SubstrateUniRule annotation1
Binding sitei190SubstrateUniRule annotation1
Binding sitei191NADUniRule annotation1
Binding sitei243NADUniRule annotation1
Binding sitei278NADUniRule annotation1
Binding sitei344NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi157 – 159NADUniRule annotation3
Nucleotide bindingi220 – 225NADUniRule annotation6
Nucleotide bindingi299 – 301NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:Hhal_1675
OrganismiHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Taxonomic identifieri349124 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira
Proteomesi
  • UP000000647 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000611251 – 430AdenosylhomocysteinaseAdd BLAST430

Proteomic databases

PRIDEiA1WXM7

Interactioni

Protein-protein interaction databases

STRINGi349124.Hhal_1675

Structurei

3D structure databases

ProteinModelPortaliA1WXM7
SMRiA1WXM7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E Bacteria
COG0499 LUCA
HOGENOMiHOG000227987
KOiK01251
OMAiTGNRDII
OrthoDBiPOG091H00W2

Family and domain databases

CDDicd00401 SAHH, 1 hit
HAMAPiMF_00563 AdoHcyase, 1 hit
InterProiView protein in InterPro
IPR034373 Adenosylhomocysteinase
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420 PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221 AdoHcyase, 1 hit
PF00670 AdoHcyase_NAD, 1 hit
PIRSFiPIRSF001109 Ad_hcy_hydrolase, 1 hit
SMARTiView protein in SMART
SM00996 AdoHcyase, 1 hit
SM00997 AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00936 ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738 ADOHCYASE_1, 1 hit
PS00739 ADOHCYASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A1WXM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNQDYKVAD ISLADWGRKE IKIAESEMPG LMETRREFAA QKPLKGARIA
60 70 80 90 100
GCLHMTIQTA VLIETLQELG AEVRWSSCNI FSTQDQAAAA VAANGTPVFA
110 120 130 140 150
WKGETEEEYW WCIEQTINGP DGWKPNMLLD DGGDLTAVIH EQYPDMMKDI
160 170 180 190 200
YGVSEETTTG VHRLYEMSRK GELGMPAFNV NDSVTKSKFD NLYGCRESLV
210 220 230 240 250
DSIKRATDVM IAGKVAVVAG FGDVGKGSAQ SLRGLGAQVW VTEVDPICAL
260 270 280 290 300
QASMDGYKVV TMEEAAPVAD IFVTATGNYN VITHDHMKAM KDEAIVCNIG
310 320 330 340 350
HFDNEIDVAS LKQYKWDEIK PQVDHVEFPD GKKITLLAEG RLVNLGCATG
360 370 380 390 400
HPSFVMSNSF TNQVMAQMEL YNNPGKYEKD VYVLPKHLDE KVAALHLGRV
410 420 430
GANLTRLSEE QAGYIGVSVD GPFKPEWYRY
Length:430
Mass (Da):47,510
Last modified:February 6, 2007 - v1
Checksum:i1B0D75461642D506
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000544 Genomic DNA Translation: ABM62439.1
RefSeqiWP_011814461.1, NC_008789.1

Genome annotation databases

EnsemblBacteriaiABM62439; ABM62439; Hhal_1675
KEGGihha:Hhal_1675

Similar proteinsi

Entry informationi

Entry nameiSAHH_HALHL
AccessioniPrimary (citable) accession number: A1WXM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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