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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Acidovorax sp. (strain JS42)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61SubstrateUniRule annotation1
Binding sitei140SubstrateUniRule annotation1
Binding sitei200SubstrateUniRule annotation1
Binding sitei230SubstrateUniRule annotation1
Binding sitei234SubstrateUniRule annotation1
Binding sitei235NADUniRule annotation1
Binding sitei287NADUniRule annotation1
Binding sitei322NADUniRule annotation1
Binding sitei389NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi201 – 203NADUniRule annotation3
Nucleotide bindingi264 – 269NADUniRule annotation6
Nucleotide bindingi343 – 345NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:Ajs_0618
OrganismiAcidovorax sp. (strain JS42)
Taxonomic identifieri232721 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
Proteomesi
  • UP000000645 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002120521 – 476AdenosylhomocysteinaseAdd BLAST476

Proteomic databases

PRIDEiA1W3P0

Interactioni

Protein-protein interaction databases

STRINGi232721.Ajs_0618

Structurei

3D structure databases

ProteinModelPortaliA1W3P0
SMRiA1W3P0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E Bacteria
COG0499 LUCA
HOGENOMiHOG000227986
KOiK01251
OMAiTGNRDII
OrthoDBiPOG091H00W2

Family and domain databases

CDDicd00401 SAHH, 1 hit
HAMAPiMF_00563 AdoHcyase, 1 hit
InterProiView protein in InterPro
IPR034373 Adenosylhomocysteinase
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420 PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221 AdoHcyase, 1 hit
PF00670 AdoHcyase_NAD, 1 hit
PIRSFiPIRSF001109 Ad_hcy_hydrolase, 1 hit
SMARTiView protein in SMART
SM00996 AdoHcyase, 1 hit
SM00997 AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00936 ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738 ADOHCYASE_1, 1 hit
PS00739 ADOHCYASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A1W3P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAVLKSPAD SAIADISLAD WGRKEIRIAE TEMPGLMAIR EEFAAKQPLK
60 70 80 90 100
GARITGSLHM TIQTAVLIET LKALGADVRW ASCNIFSTQD HAAAAIAATG
110 120 130 140 150
TPVFAIKGET LVDYWDYTHR IFDFGPKGSE GEGPNMILDD GGDATLLMHL
160 170 180 190 200
GKRAEKDASV LAHPGSEEER ILFAAIKAKL AEDSTWYSRK SAQIIGVTEE
210 220 230 240 250
TTTGVHRLKE MSAKGTLLFR AINVNDSVTK SKFDNLYGCR ESLVDGIKRA
260 270 280 290 300
TDVMIAGKVA VVAGYGDVGK GSAQALRALS AQVWVTEIDP INALQAAMEG
310 320 330 340 350
FKVVTMEWAA DKADIFVTTT GNRDVITFEH MKAMKDQAIV CNIGHFDNEI
360 370 380 390 400
QVAKLEEHCQ WEEIKPQVDH VIFPDGKRII LLAKGRLVNL GCGTGHPSFV
410 420 430 440 450
MSNSFANQTI AQIELFTHPE GYDVGKVYVL PKHLDEKVAR LHLKKVGAML
460 470
TELSDEQAAY IGVPKQGPYK PDTYRY
Length:476
Mass (Da):51,975
Last modified:February 6, 2007 - v1
Checksum:i99F4137BAF056EF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000539 Genomic DNA Translation: ABM40865.1
RefSeqiWP_011804072.1, NC_008782.1

Genome annotation databases

EnsemblBacteriaiABM40865; ABM40865; Ajs_0618
KEGGiajs:Ajs_0618

Similar proteinsi

Entry informationi

Entry nameiSAHH_ACISJ
AccessioniPrimary (citable) accession number: A1W3P0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: February 6, 2007
Last modified: October 25, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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