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Protein

Acetate kinase

Gene

ackA

Organism
Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumUniRule annotation1
Binding sitei14ATPUniRule annotation1
Binding sitei88SubstrateUniRule annotation1
Active sitei145Proton donor/acceptorUniRule annotation1
Sitei177Transition state stabilizerUniRule annotation1
Sitei238Transition state stabilizerUniRule annotation1
Metal bindingi381MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi205 – 209ATPUniRule annotation5
Nucleotide bindingi279 – 281ATPUniRule annotation3
Nucleotide bindingi327 – 331ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00340;UER00458

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:CJJ81176_0712
OrganismiCampylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)
Taxonomic identifieri354242 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000646 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000022171 – 396Acetate kinaseAdd BLAST396

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi354242.Cjejjejuni_010100003630

Structurei

3D structure databases

ProteinModelPortaliA1VZ44
SMRiA1VZ44
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H Bacteria
COG0282 LUCA
HOGENOMiHOG000288398
KOiK00925
OMAiWKALTGT

Family and domain databases

HAMAPiMF_00020 Acetate_kinase, 1 hit
InterProiView protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
PANTHERiPTHR21060 PTHR21060, 1 hit
PfamiView protein in Pfam
PF00871 Acetate_kinase, 1 hit
PIRSFiPIRSF000722 Acetate_prop_kin, 1 hit
PRINTSiPR00471 ACETATEKNASE
TIGRFAMsiTIGR00016 ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A1VZ44-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKILVLNSGS SSIKFKFFDN KIVKASGLVE KIGEQNSKVI LKNVLNNESF
60 70 80 90 100
ERELTINNHE EGLSIVNELF KESGILADLN ALDGCGHRIV HGGRNLSEHC
110 120 130 140 150
LVDDYVLKEI DRVSIFAPLH NPAHLAGIKT MIKAAPSVAN VAIFDTAFHR
160 170 180 190 200
TMPDFAYMYA LPYDFYDKHN IRRYGFHGTS HAFVSSRAAS LLEKDKSELN
210 220 230 240 250
VISAHLGNGA SVCAIEKGKS VDTSMGFTPL EGLVMGTRCG DLDPAILPFI
260 270 280 290 300
SHLKGLTIEE IDTLMNKKSG VYGICGYNDF RDIEREIEQG NDKARLALDM
310 320 330 340 350
FCYRLVKYIG SYFAVLPKTD AIIFTGGIGE NDSLVRQKVC ERLAHLGIEL
360 370 380 390
DFELNKQRIS GERMINHANS KVKVLVIPTD EELEIARITE ELIGKN
Length:396
Mass (Da):43,995
Last modified:February 6, 2007 - v1
Checksum:iCB9CF0740B506B67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000538 Genomic DNA Translation: EAQ72452.1
RefSeqiWP_009882368.1, NC_008787.1

Genome annotation databases

EnsemblBacteriaiEAQ72452; EAQ72452; CJJ81176_0712
KEGGicjj:CJJ81176_0712

Similar proteinsi

Entry informationi

Entry nameiACKA_CAMJJ
AccessioniPrimary (citable) accession number: A1VZ44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: July 5, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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