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Protein

N-acetyl-gamma-glutamyl-phosphate reductase

Gene

argC

Organism
Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.UniRule annotation

Catalytic activityi

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Acetylglutamate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei147UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00068; UER00108

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductaseUniRule annotation (EC:1.2.1.38UniRule annotation)
Short name:
AGPRUniRule annotation
Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenaseUniRule annotation
Short name:
NAGSA dehydrogenaseUniRule annotation
Gene namesi
Name:argCUniRule annotation
Ordered Locus Names:CJJ81176_0249
OrganismiCampylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)
Taxonomic identifieri354242 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000646 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000109861 – 342N-acetyl-gamma-glutamyl-phosphate reductaseAdd BLAST342

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi354242.Cjejjejuni_010100001225

Structurei

3D structure databases

ProteinModelPortaliA1VXU6
SMRiA1VXU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C0N Bacteria
COG0002 LUCA
HOGENOMiHOG000254902
KOiK00145
OMAiTFVPHLT

Family and domain databases

HAMAPiMF_00150 ArgC_type1, 1 hit
InterProiView protein in InterPro
IPR023013 AGPR_AS
IPR000706 AGPR_type-1
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
IPR012280 Semialdhyde_DH_dimer_dom
PfamiView protein in Pfam
PF01118 Semialdhyde_dh, 1 hit
PF02774 Semialdhyde_dhC, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01850 argC, 1 hit
PROSITEiView protein in PROSITE
PS01224 ARGC, 1 hit

Sequencei

Sequence statusi: Complete.

A1VXU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKVGILGA SGYAGNELVR ILLNHPKVEI SYLGSSSSVG QNYQDLYPNT
60 70 80 90 100
LLNLCFENKN LDELELDLLF LATPHEFSAK LLNENLLKKM KIIDLSADFR
110 120 130 140 150
LKNPKDYELW YKFTHPNQEL LQNAVYGLCE LYKEEIKKAS LVANPGCYTT
160 170 180 190 200
CSILSLYPLF KEKIIDFSSV IIDAKSGVSG AGRSAKVENL FCEVNENIKA
210 220 230 240 250
YNLALHRHTP EIEEHLSYAA KKKITLQFTP HLVSMQRGIL ISAYANLKED
260 270 280 290 300
LQEQDIRDIY TKYYQNNKFI RLLPPQSLPQ TRWVKSSNFA DINFSVDQRT
310 320 330 340
KRVIVLGAID NLIKGAAGQA VQNMNLMFDF DEDEGLKFFA NL
Length:342
Mass (Da):38,902
Last modified:February 6, 2007 - v1
Checksum:i4B35FD35E4877792
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000538 Genomic DNA Translation: EAQ73473.1
RefSeqiWP_002869256.1, NC_008787.1

Genome annotation databases

EnsemblBacteriaiEAQ73473; EAQ73473; CJJ81176_0249
KEGGicjj:CJJ81176_0249

Similar proteinsi

Entry informationi

Entry nameiARGC_CAMJJ
AccessioniPrimary (citable) accession number: A1VXU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: October 25, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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