UniProtKB - A1V753 (UBIE_BURMS)
Protein
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE
Gene
ubiE
Organism
Burkholderia mallei (strain SAVP1)
Status
Functioni
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).UniRule annotation
Catalytic activityi
- a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H+ + S-adenosyl-L-homocysteineUniRule annotationEC:2.1.1.163UniRule annotation
- a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H+ + S-adenosyl-L-homocysteineUniRule annotationEC:2.1.1.201UniRule annotation
: menaquinone biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate.UniRule annotationProteins known to be involved in the 2 steps of the subpathway in this organism are:
- no protein annotated in this organism
- Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE (ubiE)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate, the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.
Pathwayi: ubiquinone biosynthesis
This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotationView all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 69 | S-adenosyl-L-methionineUniRule annotation | 1 | |
Binding sitei | 90 | S-adenosyl-L-methionineUniRule annotation | 1 |
GO - Molecular functioni
- 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity Source: UniProtKB-EC
- demethylmenaquinone methyltransferase activity Source: UniProtKB-EC
- S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity Source: UniProtKB-EC
- S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity Source: UniProtKB-EC
- S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- aerobic respiration Source: UniProtKB-UniRule
- menaquinone biosynthetic process Source: UniProtKB-UniRule
- methylation Source: UniProtKB-KW
- ubiquinone biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | Menaquinone biosynthesis, Ubiquinone biosynthesis |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
UniPathwayi | UPA00079;UER00169 UPA00232 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEUniRule annotation (EC:2.1.1.163UniRule annotation, EC:2.1.1.201UniRule annotation)Alternative name(s): 2-methoxy-6-polyprenyl-1,4-benzoquinol methylaseUniRule annotation Demethylmenaquinone methyltransferaseUniRule annotation |
Gene namesi | Name:ubiEUniRule annotation Ordered Locus Names:BMASAVP1_A2760 |
Organismi | Burkholderia mallei (strain SAVP1) |
Taxonomic identifieri | 320388 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group › |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000056230 | 1 – 243 | Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEAdd BLAST | 243 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 116 – 117 | S-adenosyl-L-methionine bindingUniRule annotation | 2 |
Sequence similaritiesi
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_037990_0_0_4 |
OMAi | VRNFENL |
Family and domain databases
HAMAPi | MF_01813, MenG_UbiE_methyltr, 1 hit |
InterProi | View protein in InterPro IPR029063, SAM-dependent_MTases IPR004033, UbiE/COQ5_MeTrFase IPR023576, UbiE/COQ5_MeTrFase_CS |
Pfami | View protein in Pfam PF01209, Ubie_methyltran, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
TIGRFAMsi | TIGR01934, MenG_MenH_UbiE, 1 hit |
PROSITEi | View protein in PROSITE PS51608, SAM_MT_UBIE, 1 hit PS01183, UBIE_1, 1 hit |
i Sequence
Sequence statusi: Complete.
A1V753-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKTHFGFET VEENEKAKKV AGVFHSVASN YDLMNDLMSA GLHRAWKAFT
60 70 80 90 100
IAQANVRPGG KVLDIAAGTG DLTKAFAKAA GPTGEVWHTD INESMLRVGR
110 120 130 140 150
DRLLDKGVVT PSLLCDAEKL PFPDNYFDVV TVAFGLRNMT HKDSALAEMR
160 170 180 190 200
RVAKPGGRVM VLEFSKVWEP LKKAYDVYSF KVLPWLGDKF AKDADSYRYL
210 220 230 240
AESIRMHPDQ ETLKTMMEQA GLDAVKYYNL SGGVVALHVG TKY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000526 Genomic DNA Translation: ABM51277.1 |
RefSeqi | WP_004189973.1, NC_008785.1 |
Genome annotation databases
GeneIDi | 56527152 |
KEGGi | bmv:BMASAVP1_A2760 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000526 Genomic DNA Translation: ABM51277.1 |
RefSeqi | WP_004189973.1, NC_008785.1 |
3D structure databases
SMRi | A1V753 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 56527152 |
KEGGi | bmv:BMASAVP1_A2760 |
Phylogenomic databases
HOGENOMi | CLU_037990_0_0_4 |
OMAi | VRNFENL |
Enzyme and pathway databases
UniPathwayi | UPA00079;UER00169 UPA00232 |
Family and domain databases
HAMAPi | MF_01813, MenG_UbiE_methyltr, 1 hit |
InterProi | View protein in InterPro IPR029063, SAM-dependent_MTases IPR004033, UbiE/COQ5_MeTrFase IPR023576, UbiE/COQ5_MeTrFase_CS |
Pfami | View protein in Pfam PF01209, Ubie_methyltran, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
TIGRFAMsi | TIGR01934, MenG_MenH_UbiE, 1 hit |
PROSITEi | View protein in PROSITE PS51608, SAM_MT_UBIE, 1 hit PS01183, UBIE_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBIE_BURMS | |
Accessioni | A1V753Primary (citable) accession number: A1V753 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | February 6, 2007 | |
Last modified: | April 7, 2021 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families