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Protein

3-ketoacyl-CoA thiolase

Gene

fadA

Organism
Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.UniRule annotation

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.UniRule annotation

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95Acyl-thioester intermediateUniRule annotation1
Active sitei347Proton acceptorUniRule annotation1
Active sitei377Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00659

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolaseUniRule annotation (EC:2.3.1.16UniRule annotation)
Alternative name(s):
Acetyl-CoA acyltransferaseUniRule annotation
Beta-ketothiolaseUniRule annotation
Fatty acid oxidation complex subunit betaUniRule annotation
Gene namesi
Name:fadAUniRule annotation
Ordered Locus Names:Maqu_1145
OrganismiMarinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
Taxonomic identifieri351348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeMarinobacter
Proteomesi
  • UP000000998 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002928921 – 3913-ketoacyl-CoA thiolaseAdd BLAST391

Proteomic databases

PRIDEiA1TZR8

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).UniRule annotation

Protein-protein interaction databases

STRINGi351348.Maqu_1145

Structurei

3D structure databases

ProteinModelPortaliA1TZR8
SMRiA1TZR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHU Bacteria
COG0183 LUCA
HOGENOMiHOG000012239
KOiK00632
OMAiCGGTESM
OrthoDBiPOG091H0I7B

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.10, 4 hits
HAMAPiMF_01620 FadA, 1 hit
InterProiView protein in InterPro
IPR012805 FadA
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020610 Thiolase_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
TIGR02445 fadA, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit
PS00099 THIOLASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

A1TZR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLNPRDVVV VDCVRTPMGR AKNGCFRNVR AETLSAALIE ALFERNPKLD
60 70 80 90 100
PKEVEDVIWG CVNQTKEQGF NVARQISLLT RIPHESAAQT VNRLCGSAMS
110 120 130 140 150
AIHTAAQAIQ TGNGDVFLVG GVEHMGHVPM TEGFDHNPAA SKYSAKASNM
160 170 180 190 200
MGLTAEMLAK MHGITREQQD EFGARSHRLA HEATQEGRFK NEIVPIEGHD
210 220 230 240 250
ENGFVKLIEE DETIRPETTA ESLGQLRPAF DPKNGTVTAG TSSQLTDGAS
260 270 280 290 300
AMVLMSAERA EALGLTPIAK IRSMAVAGCD PAIMGYGPVP ATKKALKRAG
310 320 330 340 350
LKVEDIDFWE LNEAFAGQSL PVLKDLKLLG VMEEKVNLNG GAIALGHPLG
360 370 380 390
CSGARISTTL LNIMQAKGGK LGVSTMCIGL GQGIATVWER I
Length:391
Mass (Da):41,807
Last modified:February 6, 2007 - v1
Checksum:i4F41504DAF44E782
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000514 Genomic DNA Translation: ABM18237.1
RefSeqiWP_011784654.1, NC_008740.1

Genome annotation databases

EnsemblBacteriaiABM18237; ABM18237; Maqu_1145
GeneIDi31821539
KEGGimaq:Maqu_1145

Similar proteinsi

Entry informationi

Entry nameiFADA_MARHV
AccessioniPrimary (citable) accession number: A1TZR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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