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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Psychromonas ingrahamii (strain 37)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).UniRule annotation

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (tpiA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95ElectrophileUniRule annotation1
Active sitei167Proton acceptorUniRule annotation1
Binding sitei173Substrate; via amide nitrogenUniRule annotation1
Binding sitei212SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciPING357804:G1G7R-2307-MONOMER
UniPathwayi
UPA00109;UER00189

UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIMUniRule annotation
Short name:
TPIUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotation
Ordered Locus Names:Ping_2199
OrganismiPsychromonas ingrahamii (strain 37)
Taxonomic identifieri357804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPsychromonadaceaePsychromonas
Proteomesi
  • UP000000639 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003075411 – 250Triosephosphate isomeraseAdd BLAST250

Proteomic databases

PRIDEiA1SWS5

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi357804.Ping_2199

Structurei

3D structure databases

ProteinModelPortaliA1SWS5
SMRiA1SWS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 11Substrate bindingUniRule annotation3
Regioni233 – 234Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CP7 Bacteria
COG0149 LUCA
HOGENOMiHOG000226413
KOiK01803
OMAiLCVGEGL
OrthoDBiPOG091H02GL

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

Sequencei

Sequence statusi: Complete.

A1SWS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTPLVMGNW KLNGTKESVS ALIKGIEAAA DAAKNVEVAV CPPTIFIEQV
60 70 80 90 100
ANLVANNSIE LGAQDVSTNI SGAFTGETSP VMVKEFGAKY SLVGHSERRQ
110 120 130 140 150
YHNETDAVVA AKFVAIQANG LVPVLCIGET LEERETDKTF NVVETQLKAV
160 170 180 190 200
IDVSGIDALE NAVIAYEPVW AIGTGKVASS EQAQDVHAHI RTWLAEQSKV
210 220 230 240 250
VAAKVQILYG GSVKASSAKE LFAQPDIDGG LVGGAALLVE EFVGIIEGAK
Length:250
Mass (Da):26,360
Last modified:February 6, 2007 - v1
Checksum:i507C6C5897D71ACF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000510 Genomic DNA Translation: ABM03940.1
RefSeqiWP_011770500.1, NC_008709.1

Genome annotation databases

EnsemblBacteriaiABM03940; ABM03940; Ping_2199
KEGGipin:Ping_2199

Similar proteinsi

Entry informationi

Entry nameiTPIS_PSYIN
AccessioniPrimary (citable) accession number: A1SWS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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