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Protein

Alanine racemase

Gene

Noca_0900

Organism
Nocardioides sp. (strain ATCC BAA-499 / JS614)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Noca_3485), Alanine racemase (Noca_0900)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei38Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei136SubstrateUniRule annotation1
Active sitei270Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei318Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciNSP196162:GH4V-891-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Noca_0900Imported
OrganismiNocardioides sp. (strain ATCC BAA-499 / JS614)Imported
Taxonomic identifieri196162 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesNocardioidaceaeNocardioides
Proteomesi
  • UP000000640 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi196162.Noca_0900

Structurei

3D structure databases

ProteinModelPortaliA1SF38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini249 – 376Ala_racemase_CInterPro annotationAdd BLAST128

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

A1SF38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAPPVARAE IVVDLAAIRN NVRRLREVTG VASMTVVKAD GYGHGMLEAA
60 70 80 90 100
RAAREAGSEW LGVATLDEAA ALRAAGDTGR VLTWLTVPGE DYASAIAADV
110 120 130 140 150
DVTAYSPAEL DEIAAGVRAA GRPARVQLKI DTGLSRGGAT VEQWPDLVAA
160 170 180 190 200
ARAGEEAGRW RVTGIWSHFA CSDEPDHPAN AAQETAFRHA LEVADRAGLR
210 220 230 240 250
PEVRHLANSA AGLLRPSARF DLVRFGLASY GLDPAPGHLA EADLGLVPAM
260 270 280 290 300
TARAVLVLTK PLPAGAGVSY GHTWVADTPT SVGLVPVGYG DGIPRHAGNH
310 320 330 340 350
AQVLVDGKRR AVRGQVCMDQ FVVDLGGDLL EPGHAVVLFG PGTAGEPTVQ
360 370
EWADAAGTIS YEIISRIGGR MSRRYVDS
Length:378
Mass (Da):39,543
Last modified:February 6, 2007 - v1
Checksum:iF7680894BD6FE930
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000509 Genomic DNA Translation: ABL80423.1
RefSeqiWP_011754372.1, NC_008699.1

Genome annotation databases

EnsemblBacteriaiABL80423; ABL80423; Noca_0900
KEGGinca:Noca_0900

Similar proteinsi

Entry informationi

Entry nameiA1SF38_NOCSJ
AccessioniPrimary (citable) accession number: A1SF38
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: February 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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