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UniProtKB - A1RZ61 (A1RZ61_THEPD)

Entry version 82 (19 Jan 2022)
Sequence version 1 (06 Feb 2007)
Previous versions | rss
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Protein

Phosphoenolpyruvate-protein phosphotransferase

Gene

Tpen_1092

Organism
Thermofilum pendens (strain DSM 2475 / Hrk 5)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotationARBA annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei175Tele-phosphohistidine intermediateUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei282PEPUniRule annotation1
Binding sitei318PEPUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi417MagnesiumUniRule annotation1
Metal bindingi443MagnesiumUniRule annotation1
Binding sitei453PEPUniRule annotation1
Active sitei489Proton donorUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseImportedARBA annotation
Biological processPhosphotransferase systemARBA annotation, Sugar transportARBA annotation, Transport
LigandMagnesiumUniRule annotationARBA annotation, Metal-bindingUniRule annotationARBA annotation, PyruvateImported

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.7.1.6, the phosphotransferase system enzyme i (ei) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoenolpyruvate-protein phosphotransferaseARBA annotation (EC:2.7.3.9ARBA annotation)
Alternative name(s):
Phosphotransferase system, enzyme IARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:Tpen_1092Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiThermofilum pendens (strain DSM 2475 / Hrk 5)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri368408 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaea › Crenarchaeota › Thermoprotei › Thermofilales › Thermofilaceae › Thermofilum ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000641 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		368408.Tpen_1092

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 108PEP-utilisers_NInterPro annotationAdd BLAST107
Domaini140 – 211PEP-utilizersInterPro annotationAdd BLAST72
Domaini246 – 528PEP-utilizers_CInterPro annotationAdd BLAST283

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni442 – 443PEP bindingUniRule annotation2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili35 – 69Sequence analysisAdd BLAST35
Coiled coili379 – 406Sequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PEP-utilizing enzyme family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		arCOG01113, Archaea

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007308_7_0_2

Identification of Orthologs from Complete Genome Data

More...OMAi		CNAEWAL

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.274.10, 1 hit
3.20.20.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008279, PEP-util_enz_mobile_dom
IPR000121, PEP_util_C
IPR023151, PEP_util_CS
IPR036637, Phosphohistidine_dom_sf
IPR024692, PTS_EI
IPR006318, PTS_EI-like
IPR008731, PTS_EIN
IPR036618, PtsI_HPr-bd_sf
IPR015813, Pyrv/PenolPyrv_Kinase-like_dom
IPR040442, Pyrv_Kinase-like_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05524, PEP-utilisers_N, 1 hit
PF00391, PEP-utilizers, 1 hit
PF02896, PEP-utilizers_C, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000732, PTS_enzyme_I, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47831, SSF47831, 1 hit
SSF51621, SSF51621, 1 hit
SSF52009, SSF52009, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01417, PTS_I_fam, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00742, PEP_ENZYMES_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1RZ61-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSQGVARGR LLVVRAVDVL GLVEERRVGD VEGELERLSR AGSLVRERLE 
        60         70         80         90        100
ELKRVLPAAE REIVDAQLLM LESLVAEAGE LVKSSSLSAE YAVKSVYEKY 
       110        120        130        140        150
AEMLKSGSEL FALRVQDLRD LASRLVSVLT GGKTAGGGYS GRIAVAEELD 
       160        170        180        190        200
PIQFLEAAEE GLAGLVTRKG GLTAHVSILA RLKGVPYMIS GELDLGLVRD 
       210        220        230        240        250
GDEAVLDCVN GVLLVNPTAE EEERYGALAE EYNRMLALFS KEEGLEPVTL 
       260        270        280        290        300
DGRRVDVLCN AGGLEEVRAA PGYGCGGIGL FRIEFAYMVR QEAPGEEELY 
       310        320        330        340        350
GLFKKSLEVL GGRPLTVRAP DIGGDKPVNF LELPKEANPQ LGLRGTRLLL 
       360        370        380        390        400
EYRDKLLRPL LRAALRAAVH GDLRLMFPMV STVEEVEELS EEVRRAEEEL 
       410        420        430        440        450
RSEGFEARVP RLGVMVEVPS AALLSRELVE KGGLSFVSFG TNDLTQYVLA 
       460        470        480        490        500
ADRGSAHVGK VYDELNPAVL RLIAYAVDKL GGRAEVEVCG EMASRTLAVP 
       510        520        530        540        550
ALLGLGVQGL SVAPVFVGRV KYVVRRIDLE EASREVREVV ESASTSREVR 
       560 
AWARSYLERR GIRVFE
Length:566
Mass (Da):61,699
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74315992ED907A8A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CP000505 Genomic DNA Translation: ABL78491.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		ABL78491; ABL78491; Tpen_1092

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		tpe:Tpen_1092

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000505 Genomic DNA Translation: ABL78491.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi368408.Tpen_1092

Protein family/group databases

TCDBi8.A.7.1.6, the phosphotransferase system enzyme i (ei) family

Genome annotation databases

EnsemblBacteriaiABL78491; ABL78491; Tpen_1092
KEGGitpe:Tpen_1092

Phylogenomic databases

eggNOGiarCOG01113, Archaea
HOGENOMiCLU_007308_7_0_2
OMAiCNAEWAL

Family and domain databases

Gene3Di1.10.274.10, 1 hit
3.20.20.60, 1 hit
InterProiView protein in InterPro
IPR008279, PEP-util_enz_mobile_dom
IPR000121, PEP_util_C
IPR023151, PEP_util_CS
IPR036637, Phosphohistidine_dom_sf
IPR024692, PTS_EI
IPR006318, PTS_EI-like
IPR008731, PTS_EIN
IPR036618, PtsI_HPr-bd_sf
IPR015813, Pyrv/PenolPyrv_Kinase-like_dom
IPR040442, Pyrv_Kinase-like_dom_sf
PfamiView protein in Pfam
PF05524, PEP-utilisers_N, 1 hit
PF00391, PEP-utilizers, 1 hit
PF02896, PEP-utilizers_C, 1 hit
PIRSFiPIRSF000732, PTS_enzyme_I, 1 hit
SUPFAMiSSF47831, SSF47831, 1 hit
SSF51621, SSF51621, 1 hit
SSF52009, SSF52009, 1 hit
TIGRFAMsiTIGR01417, PTS_I_fam, 1 hit
PROSITEiView protein in PROSITE
PS00742, PEP_ENZYMES_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1RZ61_THEPD
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1RZ61
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: January 19, 2022
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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