We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - A1RZ61 (A1RZ61_THEPD)
Protein
Phosphoenolpyruvate-protein phosphotransferase
Gene
Tpen_1092
Organism
Thermofilum pendens (strain DSM 2475 / Hrk 5)
Status
Functioni
Catalytic activityi
- L-histidyl-[protein] + phosphoenolpyruvate = Nπ-phospho-L-histidyl-[protein] + pyruvateARBA annotationEC:2.7.3.9ARBA annotation
Cofactori
Mg2+UniRule annotationARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 175 | Tele-phosphohistidine intermediateUniRule annotation | 1 | |
Binding sitei | 282 | PEPUniRule annotation | 1 | |
Binding sitei | 318 | PEPUniRule annotation | 1 | |
Metal bindingi | 417 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 443 | MagnesiumUniRule annotation | 1 | |
Binding sitei | 453 | PEPUniRule annotation | 1 | |
Active sitei | 489 | Proton donorUniRule annotation | 1 |
GO - Molecular functioni
- kinase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- phosphoenolpyruvate-protein phosphotransferase activity Source: UniProtKB-EC
GO - Biological processi
- phosphoenolpyruvate-dependent sugar phosphotransferase system Source: UniProtKB-KW
Keywordsi
Molecular function | TransferaseImportedARBA annotation |
Biological process | Phosphotransferase systemARBA annotation, Sugar transportARBA annotation, Transport |
Ligand | MagnesiumUniRule annotationARBA annotation, Metal-bindingUniRule annotationARBA annotation, PyruvateImported |
Protein family/group databases
TCDBi | 8.A.7.1.6, the phosphotransferase system enzyme i (ei) family |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphoenolpyruvate-protein phosphotransferaseARBA annotation (EC:2.7.3.9ARBA annotation)Alternative name(s): Phosphotransferase system, enzyme IARBA annotation |
Gene namesi | Ordered Locus Names:Tpen_1092Imported |
Organismi | Thermofilum pendens (strain DSM 2475 / Hrk 5)Imported |
Taxonomic identifieri | 368408 [NCBI] |
Taxonomic lineagei | Archaea › Crenarchaeota › Thermoprotei › Thermofilales › Thermofilaceae › Thermofilum › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmARBA annotationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 108 | PEP-utilisers_NInterPro annotationAdd BLAST | 107 | |
Domaini | 140 – 211 | PEP-utilizersInterPro annotationAdd BLAST | 72 | |
Domaini | 246 – 528 | PEP-utilizers_CInterPro annotationAdd BLAST | 283 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 442 – 443 | PEP bindingUniRule annotation | 2 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 35 – 69 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 379 – 406 | Sequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the PEP-utilizing enzyme family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | arCOG01113, Archaea |
HOGENOMi | CLU_007308_7_0_2 |
OMAi | CNAEWAL |
Family and domain databases
Gene3Di | 1.10.274.10, 1 hit 3.20.20.60, 1 hit |
InterProi | View protein in InterPro IPR008279, PEP-util_enz_mobile_dom IPR000121, PEP_util_C IPR023151, PEP_util_CS IPR036637, Phosphohistidine_dom_sf IPR024692, PTS_EI IPR006318, PTS_EI-like IPR008731, PTS_EIN IPR036618, PtsI_HPr-bd_sf IPR015813, Pyrv/PenolPyrv_Kinase-like_dom IPR040442, Pyrv_Kinase-like_dom_sf |
Pfami | View protein in Pfam PF05524, PEP-utilisers_N, 1 hit PF00391, PEP-utilizers, 1 hit PF02896, PEP-utilizers_C, 1 hit |
PIRSFi | PIRSF000732, PTS_enzyme_I, 1 hit |
SUPFAMi | SSF47831, SSF47831, 1 hit SSF51621, SSF51621, 1 hit SSF52009, SSF52009, 1 hit |
TIGRFAMsi | TIGR01417, PTS_I_fam, 1 hit |
PROSITEi | View protein in PROSITE PS00742, PEP_ENZYMES_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A1RZ61-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSQGVARGR LLVVRAVDVL GLVEERRVGD VEGELERLSR AGSLVRERLE
60 70 80 90 100
ELKRVLPAAE REIVDAQLLM LESLVAEAGE LVKSSSLSAE YAVKSVYEKY
110 120 130 140 150
AEMLKSGSEL FALRVQDLRD LASRLVSVLT GGKTAGGGYS GRIAVAEELD
160 170 180 190 200
PIQFLEAAEE GLAGLVTRKG GLTAHVSILA RLKGVPYMIS GELDLGLVRD
210 220 230 240 250
GDEAVLDCVN GVLLVNPTAE EEERYGALAE EYNRMLALFS KEEGLEPVTL
260 270 280 290 300
DGRRVDVLCN AGGLEEVRAA PGYGCGGIGL FRIEFAYMVR QEAPGEEELY
310 320 330 340 350
GLFKKSLEVL GGRPLTVRAP DIGGDKPVNF LELPKEANPQ LGLRGTRLLL
360 370 380 390 400
EYRDKLLRPL LRAALRAAVH GDLRLMFPMV STVEEVEELS EEVRRAEEEL
410 420 430 440 450
RSEGFEARVP RLGVMVEVPS AALLSRELVE KGGLSFVSFG TNDLTQYVLA
460 470 480 490 500
ADRGSAHVGK VYDELNPAVL RLIAYAVDKL GGRAEVEVCG EMASRTLAVP
510 520 530 540 550
ALLGLGVQGL SVAPVFVGRV KYVVRRIDLE EASREVREVV ESASTSREVR
560
AWARSYLERR GIRVFE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000505 Genomic DNA Translation: ABL78491.1 |
Genome annotation databases
EnsemblBacteriai | ABL78491; ABL78491; Tpen_1092 |
KEGGi | tpe:Tpen_1092 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000505 Genomic DNA Translation: ABL78491.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 368408.Tpen_1092 |
Protein family/group databases
TCDBi | 8.A.7.1.6, the phosphotransferase system enzyme i (ei) family |
Genome annotation databases
EnsemblBacteriai | ABL78491; ABL78491; Tpen_1092 |
KEGGi | tpe:Tpen_1092 |
Phylogenomic databases
eggNOGi | arCOG01113, Archaea |
HOGENOMi | CLU_007308_7_0_2 |
OMAi | CNAEWAL |
Family and domain databases
Gene3Di | 1.10.274.10, 1 hit 3.20.20.60, 1 hit |
InterProi | View protein in InterPro IPR008279, PEP-util_enz_mobile_dom IPR000121, PEP_util_C IPR023151, PEP_util_CS IPR036637, Phosphohistidine_dom_sf IPR024692, PTS_EI IPR006318, PTS_EI-like IPR008731, PTS_EIN IPR036618, PtsI_HPr-bd_sf IPR015813, Pyrv/PenolPyrv_Kinase-like_dom IPR040442, Pyrv_Kinase-like_dom_sf |
Pfami | View protein in Pfam PF05524, PEP-utilisers_N, 1 hit PF00391, PEP-utilizers, 1 hit PF02896, PEP-utilizers_C, 1 hit |
PIRSFi | PIRSF000732, PTS_enzyme_I, 1 hit |
SUPFAMi | SSF47831, SSF47831, 1 hit SSF51621, SSF51621, 1 hit SSF52009, SSF52009, 1 hit |
TIGRFAMsi | TIGR01417, PTS_I_fam, 1 hit |
PROSITEi | View protein in PROSITE PS00742, PEP_ENZYMES_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A1RZ61_THEPD | |
Accessioni | A1RZ61Primary (citable) accession number: A1RZ61 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 6, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | January 19, 2022 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |