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UniProtKB - A1RWF5 (A1RWF5_THEPD)
Protein
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase
Gene
taw3
Organism
Thermofilum pendens (strain DSM 2475 / Hrk 5)
Status
Functioni
S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.
UniRule annotationCatalytic activityi
- 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine37 in tRNAPhe + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine37 in tRNAPhe + H+ + S-adenosyl-L-homocysteineUniRule annotationEC:2.1.1.282UniRule annotation
GO - Molecular functioni
- tRNA methyltransferase activity Source: InterPro
GO - Biological processi
- wybutosine biosynthetic process Source: InterPro
Keywordsi
Molecular function | MethyltransferaseUniRule annotationARBA annotation, Transferase |
Biological process | tRNA processingUniRule annotationARBA annotation |
Ligand | S-adenosyl-L-methionineUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferaseUniRule annotation (EC:2.1.1.282UniRule annotation)Alternative name(s): tRNA wyosine derivatives biosynthesis protein Taw3UniRule annotation |
Gene namesi | Name:taw3UniRule annotation Ordered Locus Names:Tpen_0125Imported |
Organismi | Thermofilum pendens (strain DSM 2475 / Hrk 5)Imported |
Taxonomic identifieri | 368408 [NCBI] |
Taxonomic lineagei | Archaea › Crenarchaeota › Thermoprotei › Thermofilales › Thermofilaceae › Thermofilum › |
Proteomesi |
|
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 197 | TYW3InterPro annotationAdd BLAST | 179 |
Sequence similaritiesi
Belongs to the TYW3 family.UniRule annotation
Phylogenomic databases
eggNOGi | arCOG04156, Archaea |
HOGENOMi | CLU_047426_2_2_2 |
OMAi | GKWHHYA |
OrthoDBi | 118297at2157 |
Family and domain databases
Gene3Di | 3.30.1960.10, 1 hit |
HAMAPi | MF_00266, TYW3_archaea, 1 hit |
InterProi | View protein in InterPro IPR022908, Taw3 IPR003827, tRNA_yW-synthesising IPR036602, tRNA_yW-synthesising-like_sf |
Pfami | View protein in Pfam PF02676, TYW3, 1 hit |
SUPFAMi | SSF111278, SSF111278, 1 hit |
i Sequence
Sequence statusi: Complete.
A1RWF5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFHARSSAG GDPWEYLRRK ALEQFERHLE EGRVDEDIVD LLRLVNNTKN
60 70 80 90 100
CYTTSSCSGR IQVSCGEHPG AKGRLVVVAK WHRTVSLQEL VSVLDSLQEE
110 120 130 140 150
SVWLSVHPPI FHVVARDLSV ARKLLAGARN SGFKHSGIQG LGRRVVVEIM
160 170 180 190 200
SMERLEVPIR VQGVEVVRRE SLPILLETAN EFLLRGKSRL GVLRKVFTEA
CD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000505 Genomic DNA Translation: ABL77535.1 |
RefSeqi | WP_011751800.1, NC_008698.1 |
Genome annotation databases
EnsemblBacteriai | ABL77535; ABL77535; Tpen_0125 |
GeneIDi | 4602187 |
KEGGi | tpe:Tpen_0125 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000505 Genomic DNA Translation: ABL77535.1 |
RefSeqi | WP_011751800.1, NC_008698.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 368408.Tpen_0125 |
Genome annotation databases
EnsemblBacteriai | ABL77535; ABL77535; Tpen_0125 |
GeneIDi | 4602187 |
KEGGi | tpe:Tpen_0125 |
Phylogenomic databases
eggNOGi | arCOG04156, Archaea |
HOGENOMi | CLU_047426_2_2_2 |
OMAi | GKWHHYA |
OrthoDBi | 118297at2157 |
Family and domain databases
Gene3Di | 3.30.1960.10, 1 hit |
HAMAPi | MF_00266, TYW3_archaea, 1 hit |
InterProi | View protein in InterPro IPR022908, Taw3 IPR003827, tRNA_yW-synthesising IPR036602, tRNA_yW-synthesising-like_sf |
Pfami | View protein in Pfam PF02676, TYW3, 1 hit |
SUPFAMi | SSF111278, SSF111278, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A1RWF5_THEPD | |
Accessioni | A1RWF5Primary (citable) accession number: A1RWF5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 6, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | January 19, 2022 | |
This is version 62 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |