UniProtKB - A1PUP8 (A1PUP8_HUMAN)
Protein
Endothelin-converting enzyme 1
Gene
ECE1
Organism
Homo sapiens (Human)
Status
Functioni
Converts big endothelin-1 to endothelin-1.ARBA annotation
Catalytic activityi
- Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.ARBA annotation EC:3.4.24.71
Cofactori
Zn2+ARBA annotation
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- metalloendopeptidase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Hydrolase, MetalloproteaseARBA annotation, Protease |
Ligand | Metal-bindingARBA annotation, ZincARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ECE1Imported ORF Names:hCG_38869Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 69 – 91 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 121 – 507 | Peptidase_M13_NInterPro annotationAdd BLAST | 387 | |
Domaini | 566 – 769 | Peptidase_M13InterPro annotationAdd BLAST | 204 |
Sequence similaritiesi
Belongs to the peptidase M13 family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
OMAi | DQRFFMN |
Family and domain databases
CDDi | cd08662, M13, 1 hit |
Gene3Di | 1.10.1380.10, 1 hit 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR029734, ECE1 IPR024079, MetalloPept_cat_dom_sf IPR000718, Peptidase_M13 IPR018497, Peptidase_M13_C IPR042089, Peptidase_M13_dom_2 IPR008753, Peptidase_M13_N |
PANTHERi | PTHR11733, PTHR11733, 1 hit PTHR11733:SF130, PTHR11733:SF130, 1 hit |
Pfami | View protein in Pfam PF01431, Peptidase_M13, 1 hit PF05649, Peptidase_M13_N, 1 hit |
PRINTSi | PR00786, NEPRILYSIN |
PROSITEi | View protein in PROSITE PS51885, NEPRILYSIN, 1 hit |
i Sequence
Sequence statusi: Complete.
A1PUP8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRGVWPPPVS ALLSALGMST YKRATLDEED LVDSLSEGDA YPNGLQVNFH
60 70 80 90 100
SPRSGQRCWA ARTQVEKRLV VLVVLLAAGL VACLAALGIQ YQTRSPSVCL
110 120 130 140 150
SEACVSVTSS ILSSMDPTVD PCHDFFSYAC GGWIKANPVP DGHSRWGTFS
160 170 180 190 200
NLWEHNQAII KHLLENSTAS VSEAERKAQV YYRACMNETR IEELRAKPLM
210 220 230 240 250
ELIERLGGWN ITGPWAKDNF QDTLQVVTAH YRTSPFFSVY VSADSKNSNS
260 270 280 290 300
NVIQVDQSGL GLPSRDYYLN KTENEKVLTG YLNYMVQLGK LLGGGDEEAI
310 320 330 340 350
RPQMQQILDF ETALANITIP QEKRRDEELI YHKVTAAELQ TLAPAINWLP
360 370 380 390 400
FLNTIFYPVE INESEPIVVY DKEYLEQIST LINTTDRCLL NNYMIWNLVR
410 420 430 440 450
KTSSFLDQRF QDADEKFMEV MYGTKKTCLP RWKFCVSDTE NNLGFALGPM
460 470 480 490 500
FVKATFAEDS KSIATEIILE IKKAFEESLS TLKWMDEETR KSAKEKADAI
510 520 530 540 550
YNMIGYPNFI MDPKELDKVF NDYTAVPDLY FENAMRFFNF SWRVTADQLR
560 570 580 590 600
KAPNRDQWSM TPPMVNAYYS PTKNEIVFPA GILQAPFYTR SSPKALNFGG
610 620 630 640 650
IGVVVGHELT HAFDDQGREY DKDGNLRPWW KNSSVEAFKR QTECMVEQYS
660 670 680 690 700
NYSVNGEPVN GRHTLGENIA DNGGLKAAYR AYQNWVKKNG AEHSLPTLGL
710 720 730 740 750
TNNQLFFLGF AQVWCSVRTP ESSHEGLITD PHSPSRFRVI GSLSNSKEFS
760 770
EHFRCPPGSP MNPPHKCEVW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471134 Genomic DNA Translation: EAW94958.1 CH471134 Genomic DNA Translation: EAW94962.1 CH471134 Genomic DNA Translation: EAW94963.1 CH471134 Genomic DNA Translation: EAW94965.1 |
RefSeqi | NP_001388.1, NM_001397.2 |
Genome annotation databases
GeneIDi | 1889 |
KEGGi | hsa:1889 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471134 Genomic DNA Translation: EAW94958.1 CH471134 Genomic DNA Translation: EAW94962.1 CH471134 Genomic DNA Translation: EAW94963.1 CH471134 Genomic DNA Translation: EAW94965.1 |
RefSeqi | NP_001388.1, NM_001397.2 |
3D structure databases
SMRi | A1PUP8 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A1PUP8 |
Protocols and materials databases
DNASUi | 1889 |
Genome annotation databases
GeneIDi | 1889 |
KEGGi | hsa:1889 |
Organism-specific databases
CTDi | 1889 |
Phylogenomic databases
OMAi | DQRFFMN |
Miscellaneous databases
ChiTaRSi | ECE1, human |
GenomeRNAii | 1889 |
Family and domain databases
CDDi | cd08662, M13, 1 hit |
Gene3Di | 1.10.1380.10, 1 hit 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR029734, ECE1 IPR024079, MetalloPept_cat_dom_sf IPR000718, Peptidase_M13 IPR018497, Peptidase_M13_C IPR042089, Peptidase_M13_dom_2 IPR008753, Peptidase_M13_N |
PANTHERi | PTHR11733, PTHR11733, 1 hit PTHR11733:SF130, PTHR11733:SF130, 1 hit |
Pfami | View protein in Pfam PF01431, Peptidase_M13, 1 hit PF05649, Peptidase_M13_N, 1 hit |
PRINTSi | PR00786, NEPRILYSIN |
PROSITEi | View protein in PROSITE PS51885, NEPRILYSIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A1PUP8_HUMAN | |
Accessioni | A1PUP8Primary (citable) accession number: A1PUP8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 11, 2019 |
Last sequence update: | December 11, 2019 | |
Last modified: | April 7, 2021 | |
This is version 9 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |