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Entry version 74 (07 Oct 2020)
Sequence version 1 (06 Feb 2007)
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Protein

GTP cyclohydrolase II

Gene

At5g64300

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+ARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: riboflavin biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-6-(D-ribitylamino)uracil from GTP.ARBA annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. GTP cyclohydrolase II (AXX17_At5g63900), GTP cyclohydrolase II (AXX17_At5g59170), GTP cyclohydrolase II (AXX17_At5g59170), Bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic (RIBA1), GTP cyclohydrolase II (At5g64300), GTP cyclohydrolase II (AN1_LOCUS26274), GTP cyclohydrolase II (AN1_LOCUS26745), GTP cyclohydrolase II (RIBA3), Monofunctional riboflavin biosynthesis protein RIBA 3, chloroplastic (RIBA3), GTP cyclohydrolase II (RIBA3)
  2. Diaminohydroxyphosphoribosylaminopyrimidine deaminase (AXX17_At4g24290), Riboflavin biosynthesis protein PYRD, chloroplastic (PYRD)
  3. 5-amino-6-(5-phosphoribosylamino)uracil reductase (PHS1), 5-amino-6-(5-phosphoribosylamino)uracil reductase (AN1_LOCUS15074), 5-amino-6-(5-phosphoribosylamino)uracil reductase (C24_LOCUS14954), Riboflavin biosynthesis protein PYRR, chloroplastic (PYRR), 5-amino-6-(5-phosphoribosylamino)uracil reductase (AXX17_At3g41370)
  4. no protein annotated in this organism
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-6-(D-ribitylamino)uracil from GTP, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseARBA annotation
Biological processRiboflavin biosynthesisARBA annotation
LigandGTP-bindingARBA annotation, Metal-bindingARBA annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00275;UER00400

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GTP cyclohydrolase IIARBA annotation (EC:3.5.4.25ARBA annotation)
Alternative name(s):
GTP cyclohydrolase-2ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:At5g64300Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G64300

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A1L4U4, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini178 – 342GTP_cyclohydro2InterPro annotationAdd BLAST165

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the GTP cyclohydrolase II family.ARBA annotation
In the N-terminal section; belongs to the DHBP synthase family.ARBA annotation

Family and domain databases

Conserved Domains Database

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CDDi
cd00641, GTP_cyclohydro2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.10990, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00179, RibA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017945, DHBP_synth_RibB-like_a/b_dom
IPR000422, DHBP_synthase_RibB
IPR032677, GTP_cyclohydro_II
IPR000926, RibA
IPR036144, RibA-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00926, DHBP_synthase, 1 hit
PF00925, GTP_cyclohydro2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF142695, SSF142695, 1 hit
SSF55821, SSF55821, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00505, ribA, 1 hit
TIGR00506, ribB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1L4U4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQLATPEA MAFIVRHGTG IVCVSMKEDD LERLHLPLMV NQKENEEKLS
60 70 80 90 100
TAFTVTVDAK HGTTTGVSAR DRATTILSLA SRDSKPEDFN RPGHIFPLKY
110 120 130 140 150
REGGVLKRAG HTEASVDLTV LAGLDPVGVL CEIVDDDGSM ARLPKLREFA
160 170 180 190 200
AENNLKVVSI ADLIRYRRKR DKLVERASAA RIPTMWGPFT AYCYRSILDG
210 220 230 240 250
IEHIAMVKGE IGDGQDILVR VHSECLTGDI FGSARCDCGN QLALSMQQIE
260 270 280 290 300
ATGRGVLVYL RGHEGRGIGL GHKLRAYNLQ DAGRDTVEAN EELGLPVDSR
310 320 330 340 350
EYGIGAQIIR DLGVRTMKLM TNNPAKYVGL KGYGLAIVGR VPLLSLITKE
360 370 380
NKRYLETKRT KMGHMYGLKF KGDVVEKIES ESES
Length:384
Mass (Da):42,224
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7BD739D6546FB035
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BT029731 mRNA Translation: ABM06001.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G64300.1; AT5G64300.1; AT5G64300

Gramene; a comparative resource for plants

More...
Gramenei
AT5G64300.1; AT5G64300.1; AT5G64300

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT029731 mRNA Translation: ABM06001.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblPlantsiAT5G64300.1; AT5G64300.1; AT5G64300
GrameneiAT5G64300.1; AT5G64300.1; AT5G64300

Organism-specific databases

AraportiAT5G64300

Enzyme and pathway databases

UniPathwayiUPA00275;UER00400

Gene expression databases

ExpressionAtlasiA1L4U4, baseline and differential

Family and domain databases

CDDicd00641, GTP_cyclohydro2, 1 hit
Gene3Di3.40.50.10990, 1 hit
HAMAPiMF_00179, RibA, 1 hit
InterProiView protein in InterPro
IPR017945, DHBP_synth_RibB-like_a/b_dom
IPR000422, DHBP_synthase_RibB
IPR032677, GTP_cyclohydro_II
IPR000926, RibA
IPR036144, RibA-like_sf
PfamiView protein in Pfam
PF00926, DHBP_synthase, 1 hit
PF00925, GTP_cyclohydro2, 1 hit
SUPFAMiSSF142695, SSF142695, 1 hit
SSF55821, SSF55821, 1 hit
TIGRFAMsiTIGR00505, ribA, 1 hit
TIGR00506, ribB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1L4U4_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1L4U4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: October 7, 2020
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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