UniProtKB - A1L4U4 (A1L4U4_ARATH)
Protein
GTP cyclohydrolase II
Gene
At5g64300
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Catalytic activityi
- GTP + 3 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 2 H+ARBA annotationEC:3.5.4.25ARBA annotation
Cofactori
Zn2+ARBA annotation
: riboflavin biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes 5-amino-6-(D-ribitylamino)uracil from GTP.ARBA annotationProteins known to be involved in the 4 steps of the subpathway in this organism are:
- GTP cyclohydrolase II (AXX17_At5g63900), GTP cyclohydrolase II (AXX17_At5g59170), GTP cyclohydrolase II (AXX17_At5g59170), Bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic (RIBA1), GTP cyclohydrolase II (At5g64300), GTP cyclohydrolase II (AN1_LOCUS26274), GTP cyclohydrolase II (AN1_LOCUS26745), GTP cyclohydrolase II (RIBA3), Monofunctional riboflavin biosynthesis protein RIBA 3, chloroplastic (RIBA3), GTP cyclohydrolase II (RIBA3)
- Diaminohydroxyphosphoribosylaminopyrimidine deaminase (AXX17_At4g24290), Riboflavin biosynthesis protein PYRD, chloroplastic (PYRD)
- 5-amino-6-(5-phosphoribosylamino)uracil reductase (PHS1), 5-amino-6-(5-phosphoribosylamino)uracil reductase (AN1_LOCUS15074), 5-amino-6-(5-phosphoribosylamino)uracil reductase (C24_LOCUS14954), Riboflavin biosynthesis protein PYRR, chloroplastic (PYRR), 5-amino-6-(5-phosphoribosylamino)uracil reductase (AXX17_At3g41370)
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-6-(D-ribitylamino)uracil from GTP, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.
GO - Molecular functioni
- 3,4-dihydroxy-2-butanone-4-phosphate synthase activity Source: InterPro
- GTP binding Source: UniProtKB-KW
- GTP cyclohydrolase II activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- riboflavin biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | HydrolaseARBA annotation |
Biological process | Riboflavin biosynthesisARBA annotation |
Ligand | GTP-bindingARBA annotation, Metal-bindingARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00275;UER00400 |
Names & Taxonomyi
Protein namesi | Recommended name: GTP cyclohydrolase IIARBA annotation (EC:3.5.4.25ARBA annotation)Alternative name(s): GTP cyclohydrolase-2ARBA annotation |
Gene namesi | Ordered Locus Names:At5g64300Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress)Imported |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Organism-specific databases
Araporti | AT5G64300 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 178 – 342 | GTP_cyclohydro2InterPro annotationAdd BLAST | 165 |
Sequence similaritiesi
In the C-terminal section; belongs to the GTP cyclohydrolase II family.ARBA annotation
In the N-terminal section; belongs to the DHBP synthase family.ARBA annotation
Family and domain databases
CDDi | cd00641, GTP_cyclohydro2, 1 hit |
Gene3Di | 3.40.50.10990, 1 hit |
HAMAPi | MF_00179, RibA, 1 hit |
InterProi | View protein in InterPro IPR017945, DHBP_synth_RibB-like_a/b_dom IPR000422, DHBP_synthase_RibB IPR032677, GTP_cyclohydro_II IPR000926, RibA IPR036144, RibA-like_sf |
Pfami | View protein in Pfam PF00926, DHBP_synthase, 1 hit PF00925, GTP_cyclohydro2, 1 hit |
SUPFAMi | SSF142695, SSF142695, 1 hit SSF55821, SSF55821, 1 hit |
TIGRFAMsi | TIGR00505, ribA, 1 hit TIGR00506, ribB, 1 hit |
i Sequence
Sequence statusi: Complete.
A1L4U4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAQLATPEA MAFIVRHGTG IVCVSMKEDD LERLHLPLMV NQKENEEKLS
60 70 80 90 100
TAFTVTVDAK HGTTTGVSAR DRATTILSLA SRDSKPEDFN RPGHIFPLKY
110 120 130 140 150
REGGVLKRAG HTEASVDLTV LAGLDPVGVL CEIVDDDGSM ARLPKLREFA
160 170 180 190 200
AENNLKVVSI ADLIRYRRKR DKLVERASAA RIPTMWGPFT AYCYRSILDG
210 220 230 240 250
IEHIAMVKGE IGDGQDILVR VHSECLTGDI FGSARCDCGN QLALSMQQIE
260 270 280 290 300
ATGRGVLVYL RGHEGRGIGL GHKLRAYNLQ DAGRDTVEAN EELGLPVDSR
310 320 330 340 350
EYGIGAQIIR DLGVRTMKLM TNNPAKYVGL KGYGLAIVGR VPLLSLITKE
360 370 380
NKRYLETKRT KMGHMYGLKF KGDVVEKIES ESES
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT029731 mRNA Translation: ABM06001.1 |
Genome annotation databases
EnsemblPlantsi | AT5G64300.1; AT5G64300.1; AT5G64300 |
Gramenei | AT5G64300.1; AT5G64300.1; AT5G64300 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT029731 mRNA Translation: ABM06001.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
EnsemblPlantsi | AT5G64300.1; AT5G64300.1; AT5G64300 |
Gramenei | AT5G64300.1; AT5G64300.1; AT5G64300 |
Organism-specific databases
Araporti | AT5G64300 |
Enzyme and pathway databases
UniPathwayi | UPA00275;UER00400 |
Gene expression databases
ExpressionAtlasi | A1L4U4, baseline and differential |
Family and domain databases
CDDi | cd00641, GTP_cyclohydro2, 1 hit |
Gene3Di | 3.40.50.10990, 1 hit |
HAMAPi | MF_00179, RibA, 1 hit |
InterProi | View protein in InterPro IPR017945, DHBP_synth_RibB-like_a/b_dom IPR000422, DHBP_synthase_RibB IPR032677, GTP_cyclohydro_II IPR000926, RibA IPR036144, RibA-like_sf |
Pfami | View protein in Pfam PF00926, DHBP_synthase, 1 hit PF00925, GTP_cyclohydro2, 1 hit |
SUPFAMi | SSF142695, SSF142695, 1 hit SSF55821, SSF55821, 1 hit |
TIGRFAMsi | TIGR00505, ribA, 1 hit TIGR00506, ribB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A1L4U4_ARATH | |
Accessioni | A1L4U4Primary (citable) accession number: A1L4U4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 6, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | October 7, 2020 | |
This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |