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Entry version 77 (13 Feb 2019)
Sequence version 1 (20 Feb 2007)
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Protein

PLAC8-like protein 1

Gene

PLAC8L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PLAC8-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLAC8L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000173261.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:31746 PLAC8L1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A1L4L8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000173261

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134890176

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLAC8L1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003113961 – 177PLAC8-like protein 1Add BLAST177

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1L4L8

PRoteomics IDEntifications database

More...
PRIDEi
A1L4L8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
153

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173261 Expressed in 124 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A1L4L8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1L4L8 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127518, 9 interactors

Protein interaction database and analysis system

More...
IntActi
A1L4L8, 1 interactor

Molecular INTeraction database

More...
MINTi
A1L4L8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000309087

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A1L4L8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1L4L8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cornifelin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXAT Eukaryota
ENOG4111ZQC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160864

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007259

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG094877

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1L4L8

Identification of Orthologs from Complete Genome Data

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OMAi
VVHCCWP

Database of Orthologous Groups

More...
OrthoDBi
1354725at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1L4L8

TreeFam database of animal gene trees

More...
TreeFami
TF330308

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006461 PLAC_motif_containing

The PANTHER Classification System

More...
PANTHERi
PTHR15907 PTHR15907, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04749 PLAC8, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01571 A_thal_Cys_rich, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A1L4L8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNWFGSNFFR CPEDLSLLNI YSPLLSHMSS EDEHFISNLR GHVPASAVVK
60 70 80 90 100
QPVRGASGRT TITAIVQTGG GWSTGLFSVC RDRRICFCGL FCPMCLECDI
110 120 130 140 150
ARHYGECLCW PLLPGSTFAL RIGTRERHKI QGTLCEDWLA VHCCWAFSIC
160 170
QVARELKMRT SQVYEICAVP MTKDTLV
Length:177
Mass (Da):19,885
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0BC4BE1E8CE7E76C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBV4D6RBV4_HUMAN
PLAC8-like protein 1
PLAC8L1
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03724511C → S. Corresponds to variant dbSNP:rs12187913Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471062 Genomic DNA Translation: EAW61851.1
BC130586 mRNA Translation: AAI30587.1
BC130588 mRNA Translation: AAI30589.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34264.1

NCBI Reference Sequences

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RefSeqi
NP_001025040.1, NM_001029869.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.162369

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311450; ENSP00000309087; ENSG00000173261

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
153770

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:153770

UCSC genome browser

More...
UCSCi
uc003lnv.4 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471062 Genomic DNA Translation: EAW61851.1
BC130586 mRNA Translation: AAI30587.1
BC130588 mRNA Translation: AAI30589.1
CCDSiCCDS34264.1
RefSeqiNP_001025040.1, NM_001029869.1
UniGeneiHs.162369

3D structure databases

ProteinModelPortaliA1L4L8
SMRiA1L4L8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127518, 9 interactors
IntActiA1L4L8, 1 interactor
MINTiA1L4L8
STRINGi9606.ENSP00000309087

Polymorphism and mutation databases

BioMutaiPLAC8L1

Proteomic databases

PaxDbiA1L4L8
PRIDEiA1L4L8
ProteomicsDBi153

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
153770
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311450; ENSP00000309087; ENSG00000173261
GeneIDi153770
KEGGihsa:153770
UCSCiuc003lnv.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
153770
EuPathDBiHostDB:ENSG00000173261.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLAC8L1
HGNCiHGNC:31746 PLAC8L1
neXtProtiNX_A1L4L8
OpenTargetsiENSG00000173261
PharmGKBiPA134890176

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IXAT Eukaryota
ENOG4111ZQC LUCA
GeneTreeiENSGT00940000160864
HOGENOMiHOG000007259
HOVERGENiHBG094877
InParanoidiA1L4L8
OMAiVVHCCWP
OrthoDBi1354725at2759
PhylomeDBiA1L4L8
TreeFamiTF330308

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
153770

Protein Ontology

More...
PROi
PR:A1L4L8

Gene expression databases

BgeeiENSG00000173261 Expressed in 124 organ(s), highest expression level in right testis
ExpressionAtlasiA1L4L8 baseline and differential
GenevisibleiA1L4L8 HS

Family and domain databases

InterProiView protein in InterPro
IPR006461 PLAC_motif_containing
PANTHERiPTHR15907 PTHR15907, 1 hit
PfamiView protein in Pfam
PF04749 PLAC8, 1 hit
TIGRFAMsiTIGR01571 A_thal_Cys_rich, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPL8L1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1L4L8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 20, 2007
Last modified: February 13, 2019
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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