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UniProtKB - A1L4K1 (FSD2_HUMAN)

Entry version 112 (07 Apr 2021)
Sequence version 1 (06 Feb 2007)
Previous versions | rss
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Protein

Fibronectin type III and SPRY domain-containing protein 2

Gene

FSD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A1L4K1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibronectin type III and SPRY domain-containing protein 2
Alternative name(s):
SPRY domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FSD2
Synonyms:SPRYD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18024, FSD2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A1L4K1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000186628.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		123722

Open Targets

More...OpenTargetsi		ENSG00000186628

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38279

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A1L4K1, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FSD2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003173621 – 749Fibronectin type III and SPRY domain-containing protein 2Add BLAST749

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A1L4K1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		A1L4K1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A1L4K1

PeptideAtlas

More...PeptideAtlasi		A1L4K1

PRoteomics IDEntifications database

More...PRIDEi		A1L4K1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		152 [A1L4K1-1]
7242

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A1L4K1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A1L4K1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000186628, Expressed in deltoid and 86 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A1L4K1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A1L4K1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000186628, Group enriched (heart muscle, skeletal muscle, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CMYA5 (By similarity). In cardiac muscles, identified in a complex composed of FSD2, CMYA5 and RYR2 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

A1L4K1
With#Exp.IntAct
AQP1 [P29972]3EBI-5661036,EBI-745213
ARFIP2 [P53365]3EBI-5661036,EBI-638194
ATG14 [Q6ZNE5]3EBI-5661036,EBI-2690371
BEX2 [Q9BXY8]3EBI-5661036,EBI-745073
BEX3 [Q00994]6EBI-5661036,EBI-741753
BRD8 - isoform 2 [Q9H0E9-2]6EBI-5661036,EBI-10304361
C1orf216 [Q8TAB5]3EBI-5661036,EBI-747505
CAMSAP3 - isoform 2 [Q9P1Y5-2]3EBI-5661036,EBI-18121830
CBX8 [Q9HC52]6EBI-5661036,EBI-712912
CCDC112 [Q8NEF3]3EBI-5661036,EBI-745040
CCDC120 [Q96HB5]3EBI-5661036,EBI-744556
CCDC146 [Q8IYE0]3EBI-5661036,EBI-10749669
CCHCR1 - isoform 3 [Q8TD31-3]6EBI-5661036,EBI-10175300
CDC73 [Q6P1J9]9EBI-5661036,EBI-930143
CDK18 [Q07002]3EBI-5661036,EBI-746238
CORO1A [P31146]7EBI-5661036,EBI-1046676
CTAG1B [P78358]3EBI-5661036,EBI-1188472
CWF19L2 [Q2TBE0]3EBI-5661036,EBI-5453285
DCX - isoform 2 [O43602-2]3EBI-5661036,EBI-14148644
DTNB - isoform 5 [O60941-5]3EBI-5661036,EBI-11984733
ENKD1 [Q9H0I2]3EBI-5661036,EBI-744099
ESD [P10768]7EBI-5661036,EBI-1052334
EXOC3 [O60645]3EBI-5661036,EBI-1052278
FAM107A - isoform 3 [O95990-3]3EBI-5661036,EBI-10192902
FAM110A [Q9BQ89]3EBI-5661036,EBI-1752811
FAM161A [Q3B820]3EBI-5661036,EBI-719941
FAM50B [Q9Y247]3EBI-5661036,EBI-742802
FAM90A1 [Q86YD7]6EBI-5661036,EBI-6658203
FARS2 [O95363]3EBI-5661036,EBI-2513774
FMR1 - isoform 8 [Q06787-8]3EBI-5661036,EBI-10224470
HDAC4 - isoform 2 [P56524-2]3EBI-5661036,EBI-11953488
HGS [O14964]3EBI-5661036,EBI-740220
IFT20 [Q8IY31]3EBI-5661036,EBI-744203
KANSL1 [Q7Z3B3]3EBI-5661036,EBI-740244
KLHL40 [Q2TBA0]3EBI-5661036,EBI-7851314
LATS1 [Q6PJG3]3EBI-5661036,EBI-10253976
LENG1 [Q96BZ8]6EBI-5661036,EBI-726510
LNX1 [Q8TBB1]3EBI-5661036,EBI-739832
MCRS1 [Q96EZ8]3EBI-5661036,EBI-348259
MGC50722 [Q8IVT4]3EBI-5661036,EBI-14086479
MID2 - isoform 2 [Q9UJV3-2]3EBI-5661036,EBI-10172526
MRPL11 [Q9Y3B7]6EBI-5661036,EBI-5453723
OIP5 [O43482]3EBI-5661036,EBI-536879
OXNAD1 [Q96HP4]3EBI-5661036,EBI-2862111
PBX3 [Q5JS98]3EBI-5661036,EBI-10244393
PBX3 [Q96AL5]3EBI-5661036,EBI-741171
PIK3R3 [Q8N381]3EBI-5661036,EBI-749096
PNMA5 [Q96PV4]3EBI-5661036,EBI-10171633
POLL - isoform 2 [Q9UGP5-2]4EBI-5661036,EBI-10320765
PPP1R18 [Q6NYC8]6EBI-5661036,EBI-2557469
PPP2R5D [Q14738]3EBI-5661036,EBI-396563
PRPF18 [Q99633]3EBI-5661036,EBI-2798416
PRPF31 [Q8WWY3]3EBI-5661036,EBI-1567797
PSMB4 [P28070]3EBI-5661036,EBI-603350
RCOR3 - isoform 2 [Q9P2K3-2]3EBI-5661036,EBI-1504830
RNF8 [O76064]3EBI-5661036,EBI-373337
SCNM1 [Q9BWG6]3EBI-5661036,EBI-748391
SH2D4A [Q9H788]6EBI-5661036,EBI-747035
SH2D4A - isoform 2 [Q9H788-2]3EBI-5661036,EBI-10308083
SMARCE1 [Q969G3]3EBI-5661036,EBI-455078
SNAPIN [O95295]3EBI-5661036,EBI-296723
SPATC1L [Q9H0A9]4EBI-5661036,EBI-372911
SPATC1L - isoform 2 [Q9H0A9-2]3EBI-5661036,EBI-11995806
TCEANC [Q8N8B7]3EBI-5661036,EBI-954696
THAP7 [Q9BT49]3EBI-5661036,EBI-741350
TLE5 [Q08117]4EBI-5661036,EBI-717810
TLE5 - isoform 2 [Q08117-2]3EBI-5661036,EBI-11741437
TSGA10IP [Q3SY00]3EBI-5661036,EBI-10241197
TTC23 - isoform 3 [Q5W5X9-3]3EBI-5661036,EBI-9090990
UBTFL1 [P0CB47]3EBI-5661036,EBI-17208936
VEZF1 [Q14119]3EBI-5661036,EBI-11980193
ZC2HC1C [Q53FD0]3EBI-5661036,EBI-740767
ZMAT2 [Q96NC0]3EBI-5661036,EBI-2682299
ZNF124 [Q15973]3EBI-5661036,EBI-2555767
ZNF20 [P17024]3EBI-5661036,EBI-717634
ZNF230 [Q9UIE0]3EBI-5661036,EBI-1105361
ZNF35 [P13682]3EBI-5661036,EBI-11041653
ZNF408 [Q9H9D4]3EBI-5661036,EBI-347633
ZNF410 [Q86VK4]3EBI-5661036,EBI-720304
ZNF410 - isoform 3 [Q86VK4-3]3EBI-5661036,EBI-11741890
ZNF417 [Q8TAU3]6EBI-5661036,EBI-740727
ZNF490 [Q9ULM2]3EBI-5661036,EBI-1105370
ZNF572 [Q7Z3I7]7EBI-5661036,EBI-10172590
ZNF580 [Q9UK33]3EBI-5661036,EBI-746277
ZNF581 [Q9P0T4]6EBI-5661036,EBI-745520
ZNF587 [Q96SQ5]6EBI-5661036,EBI-6427977
ZNF648 [Q5T619]3EBI-5661036,EBI-11985915
ZNF76 [P36508]3EBI-5661036,EBI-7254550
ZNF774 [Q6NX45]3EBI-5661036,EBI-10251462
ZNF777 [Q9ULD5]3EBI-5661036,EBI-11975599
ZNF835 [Q9Y2P0]3EBI-5661036,EBI-5667516
ZNF837 [Q96EG3]3EBI-5661036,EBI-11962574
ZSCAN26 [Q16670]3EBI-5661036,EBI-3920053
Q9H6F03EBI-5661036,EBI-10307481

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125831, 115 interactors

Protein interaction database and analysis system

More...IntActi		A1L4K1, 96 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000335651

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A1L4K1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A1L4K1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini375 – 470Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini471 – 564Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST94
Domaini546 – 744B30.2/SPRYPROSITE-ProRule annotationAdd BLAST199

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili205 – 317Sequence analysisAdd BLAST113

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2177, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158441

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022856_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A1L4K1

Identification of Orthologs from Complete Genome Data

More...OMAi		HKNMFKL

Database of Orthologous Groups

More...OrthoDBi		508782at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A1L4K1

TreeFam database of animal gene trees

More...TreeFami		TF315216

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.920, 1 hit
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR003879, Butyrophylin_SPRY
IPR013320, ConA-like_dom_sf
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR003877, SPRY_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041, fn3, 1 hit
PF00622, SPRY, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01407, BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060, FN3, 2 hits
SM00449, SPRY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265, SSF49265, 1 hit
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS50853, FN3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A1L4K1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEESGEELG LDRSTPKDFH FYHMDLYDSE DRLHLFPEEN TRMRKVVQAE 
        60         70         80         90        100
MANESRGAGD GKAQRDLQEE VDELVHLYGL EDDHELGDEF VDENIPRTGV 
       110        120        130        140        150
SEYPPYMMKR RDPAREQRDW RLSGEAAEAE DLGFGGWGSA GQCQDLREAY 
       160        170        180        190        200
RYTHGRASEE YECYVIPEEE DEEEAADVFC VTCKTPIRAF QKVFDEHKEH 
       210        220        230        240        250
EVIPLNEALE SAKDEIHKNM YKLEKQIIEM ENFANHLEEV FITVEENFGK 
       260        270        280        290        300
QEQNFESHYN EILETLAQKY EEKIQALGEK KKEKLEALYG QLVSCGENLD 
       310        320        330        340        350
TCKELMETIE EMCHEEKVDF IKDAVAMADR LGKFLKTKTD VEISAQPEFE 
       360        370        380        390        400
DQTLDFSDVE QLMGSINTIP APSAPVINPQ VPNSATGSSV RVCWSLYSDD 
       410        420        430        440        450
TVESYQLSYR PVQDSSPGTD QAEFTVTVKE TYCSVTNLVP NTQYEFWVTA 
       460        470        480        490        500
HNRAGPSPSS ERAVYMTAPS PPIIKTKEIR SCEEAVLICW ESGNLNPVDS 
       510        520        530        540        550
YTVELTQAES PEASGVTESV VGIPTCESVV QLQPGRSYII YVRALNMGGP 
       560        570        580        590        600
SVRSEPATVH TIGSYFRLNK DTCHPWLTIS EDGLTAVRSE RRTPARELSP 
       610        620        630        640        650
SDTHFTRCVA VMGNLIPVRG HHYWEVEVDE HLDYRVGVAF ADVRKQEDLG 
       660        670        680        690        700
ANCLSWCMRH TFASSRHKYE FLHNRTTPDI RITVPPKKIG ILLDYEHSKL 
       710        720        730        740 
SFFNVDLSQH LYTFSCQLHE FVHPCFSLEK PGCLKVHNGI SMPKHVTFY
Length:749
Mass (Da):85,385
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4AFC0677A4FE38B
GO
Isoform 2 (identifier: A1L4K1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     423-467: Missing.

Show »
Length:704
Mass (Da):80,291
Checksum:i43BB59195155712A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YLA8H0YLA8_HUMAN
Fibronectin type III and SPRY domai...
FSD2
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051001333K → T. Corresponds to variant dbSNP:rs4779061Ensembl.1
Natural variantiVAR_051002720E → K. Corresponds to variant dbSNP:rs1108134Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054600423 – 467Missing in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK122875 mRNA Translation: BAG53773.1
AC044907 Genomic DNA No translation available.
AC105339 Genomic DNA No translation available.
BC130569 mRNA Translation: AAI30570.1
BC144175 mRNA Translation: AAI44176.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45332.1 [A1L4K1-1]
CCDS61738.1 [A1L4K1-2]

NCBI Reference Sequences

More...RefSeqi		NP_001007123.1, NM_001007122.3 [A1L4K1-1]
NP_001268734.1, NM_001281805.1 [A1L4K1-2]
NP_001268735.1, NM_001281806.1 [A1L4K1-2]
XP_005272482.1, XM_005272425.4 [A1L4K1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000334574; ENSP00000335651; ENSG00000186628 [A1L4K1-1]
ENST00000541889; ENSP00000444078; ENSG00000186628 [A1L4K1-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		123722

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:123722

UCSC genome browser

More...UCSCi		uc002bjd.4, human [A1L4K1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122875 mRNA Translation: BAG53773.1
AC044907 Genomic DNA No translation available.
AC105339 Genomic DNA No translation available.
BC130569 mRNA Translation: AAI30570.1
BC144175 mRNA Translation: AAI44176.1
CCDSiCCDS45332.1 [A1L4K1-1]
CCDS61738.1 [A1L4K1-2]
RefSeqiNP_001007123.1, NM_001007122.3 [A1L4K1-1]
NP_001268734.1, NM_001281805.1 [A1L4K1-2]
NP_001268735.1, NM_001281806.1 [A1L4K1-2]
XP_005272482.1, XM_005272425.4 [A1L4K1-1]

3D structure databases

SMRiA1L4K1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125831, 115 interactors
IntActiA1L4K1, 96 interactors
STRINGi9606.ENSP00000335651

PTM databases

iPTMnetiA1L4K1
PhosphoSitePlusiA1L4K1

Genetic variation databases

BioMutaiFSD2

Proteomic databases

jPOSTiA1L4K1
MassIVEiA1L4K1
PaxDbiA1L4K1
PeptideAtlasiA1L4K1
PRIDEiA1L4K1
ProteomicsDBi152 [A1L4K1-1]
7242

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		55562, 117 antibodies

The DNASU plasmid repository

More...DNASUi		123722

Genome annotation databases

EnsembliENST00000334574; ENSP00000335651; ENSG00000186628 [A1L4K1-1]
ENST00000541889; ENSP00000444078; ENSG00000186628 [A1L4K1-2]
GeneIDi123722
KEGGihsa:123722
UCSCiuc002bjd.4, human [A1L4K1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		123722
DisGeNETi123722

GeneCards: human genes, protein and diseases

More...GeneCardsi		FSD2
HGNCiHGNC:18024, FSD2
HPAiENSG00000186628, Group enriched (heart muscle, skeletal muscle, tongue)
neXtProtiNX_A1L4K1
OpenTargetsiENSG00000186628
PharmGKBiPA38279
VEuPathDBiHostDB:ENSG00000186628.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2177, Eukaryota
GeneTreeiENSGT00940000158441
HOGENOMiCLU_022856_0_0_1
InParanoidiA1L4K1
OMAiHKNMFKL
OrthoDBi508782at2759
PhylomeDBiA1L4K1
TreeFamiTF315216

Enzyme and pathway databases

PathwayCommonsiA1L4K1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		123722, 7 hits in 982 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FSD2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		123722
PharosiA1L4K1, Tdark

Protein Ontology

More...PROi		PR:A1L4K1
RNActiA1L4K1, protein

Gene expression databases

BgeeiENSG00000186628, Expressed in deltoid and 86 other tissues
ExpressionAtlasiA1L4K1, baseline and differential
GenevisibleiA1L4K1, HS

Family and domain databases

CDDicd00063, FN3, 2 hits
Gene3Di2.60.120.920, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR003879, Butyrophylin_SPRY
IPR013320, ConA-like_dom_sf
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR003877, SPRY_dom
PfamiView protein in Pfam
PF00041, fn3, 1 hit
PF00622, SPRY, 1 hit
PRINTSiPR01407, BUTYPHLNCDUF
SMARTiView protein in SMART
SM00060, FN3, 2 hits
SM00449, SPRY, 1 hit
SUPFAMiSSF49265, SSF49265, 1 hit
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS50853, FN3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFSD2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1L4K1
Secondary accession number(s): B3KVG1, B7ZM02
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: April 7, 2021
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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