UniProtKB - A1L4F5 (A1L4F5_HUMAN)
Protein
Submitted name:
Receptor tyrosine kinase-like orphan receptor 2
Gene
ROR2
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 507 | ATPUniRule annotation | 1 | |
Active sitei | 615 | Proton acceptorUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 479 – 487 | ATPUniRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein kinase activity Source: InterPro
GO - Biological processi
- transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Keywordsi
Molecular function | KinaseImported, ReceptorUniRule annotationImportedARBA annotation, Transferase |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Receptor tyrosine kinase-like orphan receptor 2Imported |
Gene namesi | Name:ROR2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 403 – 425 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | Sequence analysisAdd BLAST | 33 | |
ChainiPRO_5002635890 | 34 – 943 | Sequence analysisAdd BLAST | 910 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotation, PhosphoproteinARBA annotationInteractioni
Binary interactionsi
Hide detailsA1L4F5
Protein-protein interaction databases
IntActi | A1L4F5, 7 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 55 – 145 | Ig-likeInterPro annotationAdd BLAST | 91 | |
Domaini | 169 – 303 | FZInterPro annotationAdd BLAST | 135 | |
Domaini | 315 – 394 | KringleInterPro annotationAdd BLAST | 80 | |
Domaini | 473 – 746 | Protein kinaseInterPro annotationAdd BLAST | 274 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 757 – 796 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 850 – 931 | DisorderedSequence analysisAdd BLAST | 82 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 757 – 786 | PolarSequence analysisAdd BLAST | 30 | |
Compositional biasi | 856 – 886 | PolarSequence analysisAdd BLAST | 31 | |
Compositional biasi | 908 – 923 | AcidicSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.UniRule annotation
Keywords - Domaini
Immunoglobulin domainARBA annotation, KringlePROSITE-ProRule annotationARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationFamily and domain databases
CDDi | cd00108, KR, 1 hit |
Gene3Di | 1.10.2000.10, 1 hit 2.40.20.10, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR020067, Frizzled_dom IPR036790, Frizzled_dom_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR016247, Tyr_kinase_rcpt_ROR |
Pfami | View protein in Pfam PF01392, Fz, 1 hit PF07679, I-set, 1 hit PF00051, Kringle, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF000624, TyrPK_TMrec_ROR, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit SM00130, KR, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56112, SSF56112, 1 hit SSF57440, SSF57440, 1 hit |
PROSITEi | View protein in PROSITE PS50038, FZ, 1 hit PS50835, IG_LIKE, 1 hit PS00021, KRINGLE_1, 1 hit PS50070, KRINGLE_2, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
i Sequence
Sequence statusi: Complete.
A1L4F5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARGSALPRR PLLCIPAVWA AAALLLSVSR TSGEVEVLDP NDPLGPLDGQ
60 70 80 90 100
DGPIPTLKGY FLNFLEPVNN ITIVQGQTAI LHCKVAGNPP PNVRWLKNDA
110 120 130 140 150
PVVQEPRRII IRKTEYGSRL RIQDLDTTDT GYYQCVATNG MKTITATGVL
160 170 180 190 200
FVRLGPTHSP NHNFQDDYHE DGFCQPYRGI ACARFIGNRT IYVDSLQMQG
210 220 230 240 250
EIENRITAAF TMIGTSTHLS DQCSQFAIPS FCHFVFPLCD ARSRAPKPRE
260 270 280 290 300
LCRDECEVLE SDLCRQEYTI ARSNPLILMR LQLPKCEALP MPESPDAANC
310 320 330 340 350
MRIGIPAERL GRYHQCYNGS GMDYRGTAST TKSGHQCQPW ALQHPHSHHL
360 370 380 390 400
SSTDFPELGG GHAYCRNPGG QMEGPWCFTQ NKNVRMELCD VPSCSPRDSS
410 420 430 440 450
KMGILYILVP SIAIPLVIAC LFFLVCMCRN KQKASASTPQ RRQLMASPSQ
460 470 480 490 500
DMEMPLINQH KQAKLKEISL SAVRFMEELG EDRFGKVYKG HLFGPAPGEQ
510 520 530 540 550
TQAVAIKTLK DKAEGPLREE FRHEAMLRAR LQHPNVVCLL GVVTKDQPLS
560 570 580 590 600
MIFSYCSHGD LHEFLVMRSP HSDVGSTDDD RTVKSALEPP DFVHLVAQIA
610 620 630 640 650
AGMEYLSSHH VVHKDLATRN VLVYDKLNVK ISDLGLFREV YAADYYKLLG
660 670 680 690 700
NSLLPIRWMA PEAIMYGKFS IDSDIWSYGV VLWEVFSYGL QPYCGYSNQD
710 720 730 740 750
VVEMIRNRQV LPCPDDCPAW VYALMIECWN EFPSRRPRFK DIHSRLRAWG
760 770 780 790 800
NLSNYNSSAQ TSGASNTTQT SSLSTSPVSN VSNARYVGPK QKAPPFPQPQ
810 820 830 840 850
FIPMKGQIRP MVPPPQLYIP VNGYQPVPAY GAYLPNFYPV QIPMQMAPQQ
860 870 880 890 900
VPPQMVPKPS SHHSGSGSTS TGYVTTAPSN TSMADRAALL SEGADDTQNA
910 920 930 940
PEDGAQSTVQ EAEEEEEGSV PETELLGDCD TLQVDEAQVQ LEA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC130522 mRNA Translation: AAI30523.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC130522 mRNA Translation: AAI30523.1 |
3D structure databases
SMRi | A1L4F5 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A1L4F5, 7 interactors |
Miscellaneous databases
ChiTaRSi | ROR2, human |
Family and domain databases
CDDi | cd00108, KR, 1 hit |
Gene3Di | 1.10.2000.10, 1 hit 2.40.20.10, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR020067, Frizzled_dom IPR036790, Frizzled_dom_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR016247, Tyr_kinase_rcpt_ROR |
Pfami | View protein in Pfam PF01392, Fz, 1 hit PF07679, I-set, 1 hit PF00051, Kringle, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF000624, TyrPK_TMrec_ROR, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit SM00130, KR, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56112, SSF56112, 1 hit SSF57440, SSF57440, 1 hit |
PROSITEi | View protein in PROSITE PS50038, FZ, 1 hit PS50835, IG_LIKE, 1 hit PS00021, KRINGLE_1, 1 hit PS50070, KRINGLE_2, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A1L4F5_HUMAN | |
Accessioni | A1L4F5Primary (citable) accession number: A1L4F5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 6, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | February 10, 2021 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |