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Protein

NUT family member 2F

Gene

NUTM2F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
NUT family member 2F
Gene namesi
Name:NUTM2F
Synonyms:FAM22F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000130950.13
HGNCiHGNC:23450 NUTM2F
neXtProtiNX_A1L443

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130950
PharmGKBiPA134981634

Polymorphism and mutation databases

BioMutaiNUTM2F

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003379951 – 756NUT family member 2FAdd BLAST756

Proteomic databases

PaxDbiA1L443
PRIDEiA1L443
ProteomicsDBi146

PTM databases

iPTMnetiA1L443
PhosphoSitePlusiA1L443

Expressioni

Gene expression databases

BgeeiENSG00000130950 Expressed in 9 organ(s), highest expression level in testis
CleanExiHS_FAM22F
ExpressionAtlasiA1L443 baseline and differential
GenevisibleiA1L443 HS

Interactioni

Protein-protein interaction databases

BioGridi120131, 3 interactors
STRINGi9606.ENSP00000253262

Structurei

3D structure databases

ProteinModelPortaliA1L443
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi156 – 162Poly-Pro7
Compositional biasi302 – 392Pro-richAdd BLAST91

Sequence similaritiesi

Belongs to the NUT family.Curated

Phylogenomic databases

eggNOGiENOG410J94Q Eukaryota
ENOG4111C0H LUCA
GeneTreeiENSGT00410000025793
HOGENOMiHOG000112470
HOVERGENiHBG107898
InParanoidiA1L443
OMAiEPEGQWE
OrthoDBiEOG091G034P
PhylomeDBiA1L443
TreeFamiTF337728

Family and domain databases

InterProiView protein in InterPro
IPR024310 NUT
IPR024309 NUT_N
PANTHERiPTHR22879 PTHR22879, 1 hit
PfamiView protein in Pfam
PF12881 NUT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A1L443-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASNGAYPVL GPGVTVNPGT SLSVFTALPF ATPAPGPAHR PPLVTAVVPP
60 70 80 90 100
AGPLVLSAFP STPLVAGQDG RGPSGAGASN VFVQMRTEVG PVKPPQAQTL
110 120 130 140 150
ILTQAPLVWQ APGTLCGGVM CPPPLLLAAA PGVPVTSAQV VGGTQACEGG
160 170 180 190 200
WSHGLPLPPP PPAAQVAPIV SPGNARPWPQ GAHGEGSLAP SQAKARPDDS
210 220 230 240 250
CKPKSVYENF RLWQHYKPLA RRHLPQSPDT EALSCFLIPV LRSLARRKPT
260 270 280 290 300
MTLEEGLWQA MREWQHTSNF DRMIFYEMAE KFLEFEAEEE MQIQKSQWMK
310 320 330 340 350
GPQSLPPPAP PRLEPRGPPA PEVVKQPVYL PSKDGPKAPT ACLPPPRPQR
360 370 380 390 400
PAETKAHLPP PRPQRPAETN AHLPPPRPQR PAETKVPEEI PPEVVQEYVD
410 420 430 440 450
IMEELLGSHP GDTGEPEGQR EKGKVEQPQE EDGITSDPGL LSYIDKLCSQ
460 470 480 490 500
EDFVTKVEAV IHPRFLEELL SPDPQMDFLA LSQELEQEEG LTLAQLVEKR
510 520 530 540 550
LLSLKEKGCG RAAPRHGTAR LDSSPSEFAA GQEAAREVPD PQQRVSVETS
560 570 580 590 600
PPQTAAQDPQ GQGRVRTGMA RSEDPAVLLG CQDSPRLKAV RPTSPPQDHR
610 620 630 640 650
PTCPGLGTKD ALGLPGESPV KESHGLAKGS SEETELPGMV YVVGSHHRLR
660 670 680 690 700
PWRLSQSPVP SSGLLSPGGR GPQGALQSPS AQKRGLSPSP SPASKSKKRP
710 720 730 740 750
LFGSPSPAEK TPHPGPGLRV SGEQSLAWGL GGPSQSQKRK GDPLASRRKK

KRHCSQ
Length:756
Mass (Da):80,770
Last modified:June 10, 2008 - v2
Checksum:i51642CA607C736E0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E2QRH1E2QRH1_HUMAN
NUT family member 2F
NUTM2F
741Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126L → F in AAI30391 (PubMed:15489334).Curated1
Sequence conflicti691Missing in AAI30391 (PubMed:15489334).Curated1
Sequence conflicti691Missing in CAB61394 (PubMed:17974005).Curated1
Sequence conflicti731G → R in CAB61394 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068009137S → C. Corresponds to variant dbSNP:rs202099818Ensembl.1
Natural variantiVAR_068010176R → G2 PublicationsCorresponds to variant dbSNP:rs190275133Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691447 Genomic DNA No translation available.
BC130390 mRNA Translation: AAI30391.1
AL133071 mRNA Translation: CAB61394.1
CCDSiCCDS47994.1
PIRiT42671
RefSeqiNP_060031.1, NM_017561.1
UniGeneiHs.648183

Genome annotation databases

EnsembliENST00000253262; ENSP00000253262; ENSG00000130950
GeneIDi54754
KEGGihsa:54754
UCSCiuc004aup.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691447 Genomic DNA No translation available.
BC130390 mRNA Translation: AAI30391.1
AL133071 mRNA Translation: CAB61394.1
CCDSiCCDS47994.1
PIRiT42671
RefSeqiNP_060031.1, NM_017561.1
UniGeneiHs.648183

3D structure databases

ProteinModelPortaliA1L443
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120131, 3 interactors
STRINGi9606.ENSP00000253262

PTM databases

iPTMnetiA1L443
PhosphoSitePlusiA1L443

Polymorphism and mutation databases

BioMutaiNUTM2F

Proteomic databases

PaxDbiA1L443
PRIDEiA1L443
ProteomicsDBi146

Protocols and materials databases

DNASUi54754
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253262; ENSP00000253262; ENSG00000130950
GeneIDi54754
KEGGihsa:54754
UCSCiuc004aup.1 human

Organism-specific databases

CTDi54754
EuPathDBiHostDB:ENSG00000130950.13
GeneCardsiNUTM2F
H-InvDBiHIX0008188
HGNCiHGNC:23450 NUTM2F
neXtProtiNX_A1L443
OpenTargetsiENSG00000130950
PharmGKBiPA134981634
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J94Q Eukaryota
ENOG4111C0H LUCA
GeneTreeiENSGT00410000025793
HOGENOMiHOG000112470
HOVERGENiHBG107898
InParanoidiA1L443
OMAiEPEGQWE
OrthoDBiEOG091G034P
PhylomeDBiA1L443
TreeFamiTF337728

Miscellaneous databases

GenomeRNAii54754
PROiPR:A1L443

Gene expression databases

BgeeiENSG00000130950 Expressed in 9 organ(s), highest expression level in testis
CleanExiHS_FAM22F
ExpressionAtlasiA1L443 baseline and differential
GenevisibleiA1L443 HS

Family and domain databases

InterProiView protein in InterPro
IPR024310 NUT
IPR024309 NUT_N
PANTHERiPTHR22879 PTHR22879, 1 hit
PfamiView protein in Pfam
PF12881 NUT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNTM2F_HUMAN
AccessioniPrimary (citable) accession number: A1L443
Secondary accession number(s): B6ZDF0
, Q5SR58, Q5SR59, Q9UFB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: September 12, 2018
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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