UniProtKB - A1L443 (NTM2F_HUMAN)
Protein
NUT family member 2F
Gene
NUTM2F
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: NUT family member 2F |
Gene namesi | Name:NUTM2F Synonyms:FAM22F |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000130950.13 |
HGNCi | HGNC:23450, NUTM2F |
neXtProti | NX_A1L443 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 54754 |
OpenTargetsi | ENSG00000130950 |
PharmGKBi | PA134981634 |
Miscellaneous databases
Pharosi | A1L443, Tdark |
Polymorphism and mutation databases
BioMutai | NUTM2F |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000337995 | 1 – 756 | NUT family member 2FAdd BLAST | 756 |
Proteomic databases
MassIVEi | A1L443 |
PaxDbi | A1L443 |
PeptideAtlasi | A1L443 |
PRIDEi | A1L443 |
ProteomicsDBi | 146 |
PTM databases
iPTMneti | A1L443 |
PhosphoSitePlusi | A1L443 |
Expressioni
Gene expression databases
Bgeei | ENSG00000130950, Expressed in brain and 12 other tissues |
ExpressionAtlasi | A1L443, baseline and differential |
Genevisiblei | A1L443, HS |
Organism-specific databases
HPAi | ENSG00000130950, Tissue enriched (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120131, 20 interactors |
IntActi | A1L443, 1 interactor |
STRINGi | 9606.ENSP00000253262 |
Miscellaneous databases
RNActi | A1L443, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 156 – 162 | Poly-Pro | 7 | |
Compositional biasi | 302 – 392 | Pro-richAdd BLAST | 91 |
Sequence similaritiesi
Belongs to the NUT family.Curated
Phylogenomic databases
eggNOGi | ENOG502RU0F, Eukaryota |
GeneTreei | ENSGT00410000025793 |
HOGENOMi | CLU_021726_0_0_1 |
InParanoidi | A1L443 |
OMAi | EPEGQWE |
OrthoDBi | 425279at2759 |
PhylomeDBi | A1L443 |
TreeFami | TF337728 |
Family and domain databases
InterProi | View protein in InterPro IPR024310, NUT IPR024309, NUT_N |
PANTHERi | PTHR22879, PTHR22879, 1 hit |
Pfami | View protein in Pfam PF12881, NUT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A1L443-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASNGAYPVL GPGVTVNPGT SLSVFTALPF ATPAPGPAHR PPLVTAVVPP
60 70 80 90 100
AGPLVLSAFP STPLVAGQDG RGPSGAGASN VFVQMRTEVG PVKPPQAQTL
110 120 130 140 150
ILTQAPLVWQ APGTLCGGVM CPPPLLLAAA PGVPVTSAQV VGGTQACEGG
160 170 180 190 200
WSHGLPLPPP PPAAQVAPIV SPGNARPWPQ GAHGEGSLAP SQAKARPDDS
210 220 230 240 250
CKPKSVYENF RLWQHYKPLA RRHLPQSPDT EALSCFLIPV LRSLARRKPT
260 270 280 290 300
MTLEEGLWQA MREWQHTSNF DRMIFYEMAE KFLEFEAEEE MQIQKSQWMK
310 320 330 340 350
GPQSLPPPAP PRLEPRGPPA PEVVKQPVYL PSKDGPKAPT ACLPPPRPQR
360 370 380 390 400
PAETKAHLPP PRPQRPAETN AHLPPPRPQR PAETKVPEEI PPEVVQEYVD
410 420 430 440 450
IMEELLGSHP GDTGEPEGQR EKGKVEQPQE EDGITSDPGL LSYIDKLCSQ
460 470 480 490 500
EDFVTKVEAV IHPRFLEELL SPDPQMDFLA LSQELEQEEG LTLAQLVEKR
510 520 530 540 550
LLSLKEKGCG RAAPRHGTAR LDSSPSEFAA GQEAAREVPD PQQRVSVETS
560 570 580 590 600
PPQTAAQDPQ GQGRVRTGMA RSEDPAVLLG CQDSPRLKAV RPTSPPQDHR
610 620 630 640 650
PTCPGLGTKD ALGLPGESPV KESHGLAKGS SEETELPGMV YVVGSHHRLR
660 670 680 690 700
PWRLSQSPVP SSGLLSPGGR GPQGALQSPS AQKRGLSPSP SPASKSKKRP
710 720 730 740 750
LFGSPSPAEK TPHPGPGLRV SGEQSLAWGL GGPSQSQKRK GDPLASRRKK
KRHCSQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE2QRH1 | E2QRH1_HUMAN | NUT family member 2F | NUTM2F | 741 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 126 | L → F in AAI30391 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 691 | Missing in AAI30391 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 691 | Missing in CAB61394 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 731 | G → R in CAB61394 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068009 | 137 | S → C. Corresponds to variant dbSNP:rs202099818Ensembl. | 1 | |
Natural variantiVAR_068010 | 176 | R → G2 PublicationsCorresponds to variant dbSNP:rs190275133Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL691447 Genomic DNA No translation available. BC130390 mRNA Translation: AAI30391.1 AL133071 mRNA Translation: CAB61394.1 |
CCDSi | CCDS47994.1 |
PIRi | T42671 |
RefSeqi | NP_060031.1, NM_017561.1 |
Genome annotation databases
Ensembli | ENST00000253262; ENSP00000253262; ENSG00000130950 |
GeneIDi | 54754 |
KEGGi | hsa:54754 |
UCSCi | uc004aup.1, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL691447 Genomic DNA No translation available. BC130390 mRNA Translation: AAI30391.1 AL133071 mRNA Translation: CAB61394.1 |
CCDSi | CCDS47994.1 |
PIRi | T42671 |
RefSeqi | NP_060031.1, NM_017561.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120131, 20 interactors |
IntActi | A1L443, 1 interactor |
STRINGi | 9606.ENSP00000253262 |
PTM databases
iPTMneti | A1L443 |
PhosphoSitePlusi | A1L443 |
Polymorphism and mutation databases
BioMutai | NUTM2F |
Proteomic databases
MassIVEi | A1L443 |
PaxDbi | A1L443 |
PeptideAtlasi | A1L443 |
PRIDEi | A1L443 |
ProteomicsDBi | 146 |
Protocols and materials databases
Antibodypediai | 68451, 29 antibodies |
DNASUi | 54754 |
Genome annotation databases
Ensembli | ENST00000253262; ENSP00000253262; ENSG00000130950 |
GeneIDi | 54754 |
KEGGi | hsa:54754 |
UCSCi | uc004aup.1, human |
Organism-specific databases
CTDi | 54754 |
DisGeNETi | 54754 |
EuPathDBi | HostDB:ENSG00000130950.13 |
GeneCardsi | NUTM2F |
HGNCi | HGNC:23450, NUTM2F |
HPAi | ENSG00000130950, Tissue enriched (testis) |
neXtProti | NX_A1L443 |
OpenTargetsi | ENSG00000130950 |
PharmGKBi | PA134981634 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RU0F, Eukaryota |
GeneTreei | ENSGT00410000025793 |
HOGENOMi | CLU_021726_0_0_1 |
InParanoidi | A1L443 |
OMAi | EPEGQWE |
OrthoDBi | 425279at2759 |
PhylomeDBi | A1L443 |
TreeFami | TF337728 |
Enzyme and pathway databases
PathwayCommonsi | A1L443 |
Miscellaneous databases
BioGRID-ORCSi | 54754, 45 hits in 810 CRISPR screens |
GenomeRNAii | 54754 |
Pharosi | A1L443, Tdark |
PROi | PR:A1L443 |
RNActi | A1L443, protein |
Gene expression databases
Bgeei | ENSG00000130950, Expressed in brain and 12 other tissues |
ExpressionAtlasi | A1L443, baseline and differential |
Genevisiblei | A1L443, HS |
Family and domain databases
InterProi | View protein in InterPro IPR024310, NUT IPR024309, NUT_N |
PANTHERi | PTHR22879, PTHR22879, 1 hit |
Pfami | View protein in Pfam PF12881, NUT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NTM2F_HUMAN | |
Accessioni | A1L443Primary (citable) accession number: A1L443 Secondary accession number(s): B6ZDF0 Q9UFB1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | June 10, 2008 | |
Last modified: | December 2, 2020 | |
This is version 88 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations