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Entry version 87 (16 Jan 2019)
Sequence version 1 (06 Feb 2007)
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Protein

G antigen 12B/C/D/E

Gene

GAGE12B

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products. GAGE12B is present as fragment in GRCh37 reference genome assembly due to an unsequenced gap between two clusters in the GAGE locus.Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G antigen 12B/C/D/E
Short name:
GAGE-12B
Short name:
GAGE-12C
Short name:
GAGE-12D
Short name:
GAGE-12E
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GAGE12B
AND
Name:GAGE12C
AND
Name:GAGE12D
AND
Name:GAGE12E
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000216649.3
HostDB:ENSG00000227488.2
HostDB:ENSG00000237671.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26779 GAGE12B
HGNC:28402 GAGE12C
HGNC:31904 GAGE12D
HGNC:31905 GAGE12E

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300727 gene
300728 gene
300729 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A1L429

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145148775

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GAGE12B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003119771 – 117G antigen 12B/C/D/EAdd BLAST117

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
A1L429

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A1L429

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1L429

PRoteomics IDEntifications database

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PRIDEi
A1L429

ProteomicsDB human proteome resource

More...
ProteomicsDBi
145

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A1L429

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A1L429

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000216649 Expressed in 50 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1L429 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043232

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
609829, 2 interactors

Protein interaction database and analysis system

More...
IntActi
A1L429, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A1L429

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KIHC Eukaryota
ENOG4110Q8D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153097

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000237345

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG056227

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1L429

Database of Orthologous Groups

More...
OrthoDBi
1575904at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1L429

TreeFam database of animal gene trees

More...
TreeFami
TF340669

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam

The PANTHER Classification System

More...
PANTHERi
PTHR14047 PTHR14047, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05831 GAGE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01379 GAGE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A1L429-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQC
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP
110
NPEEVKTPEE GEKQSQC
Length:117
Mass (Da):12,925
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC35ED8CEB9D1DD07
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y8ELK0A0A1Y8ELK0_HUMAN
G antigen 12B/C/D/E
GAGE12B
7Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC142497 Genomic DNA No translation available.
BC130374 mRNA Translation: AAI30375.1
BC143615 mRNA Translation: AAI43616.1
BC143619 mRNA Translation: AAI43620.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43943.1
CCDS43945.1
CCDS48113.1

NCBI Reference Sequences

More...
RefSeqi
NP_001091878.1, NM_001098408.1
NP_001091888.1, NM_001098418.1
NP_001120671.1, NM_001127199.1
NP_001120817.1, NM_001127345.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.632812
Hs.645554

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000381698; ENSP00000371117; ENSG00000216649
ENST00000405679; ENSP00000384214; ENSG00000227488
ENST00000420398; ENSP00000397103; ENSG00000237671

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100132399
729422
729428
729431

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100132399
hsa:729422
hsa:729428
hsa:729431

UCSC genome browser

More...
UCSCi
uc004doc.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC142497 Genomic DNA No translation available.
BC130374 mRNA Translation: AAI30375.1
BC143615 mRNA Translation: AAI43616.1
BC143619 mRNA Translation: AAI43620.1
CCDSiCCDS43943.1
CCDS43945.1
CCDS48113.1
RefSeqiNP_001091878.1, NM_001098408.1
NP_001091888.1, NM_001098418.1
NP_001120671.1, NM_001127199.1
NP_001120817.1, NM_001127345.1
UniGeneiHs.632812
Hs.645554

3D structure databases

ProteinModelPortaliA1L429
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi609829, 2 interactors
IntActiA1L429, 2 interactors

PTM databases

iPTMnetiA1L429
PhosphoSitePlusiA1L429

Polymorphism and mutation databases

BioMutaiGAGE12B

Proteomic databases

jPOSTiA1L429
MaxQBiA1L429
PaxDbiA1L429
PRIDEiA1L429
ProteomicsDBi145

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
729428
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381698; ENSP00000371117; ENSG00000216649
ENST00000405679; ENSP00000384214; ENSG00000227488
ENST00000420398; ENSP00000397103; ENSG00000237671
GeneIDi100132399
729422
729428
729431
KEGGihsa:100132399
hsa:729422
hsa:729428
hsa:729431
UCSCiuc004doc.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100132399
729422
729428
729431
EuPathDBiHostDB:ENSG00000216649.3
HostDB:ENSG00000227488.2
HostDB:ENSG00000237671.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GAGE12B
GAGE12C
GAGE12D
GAGE12E
HGNCiHGNC:26779 GAGE12B
HGNC:28402 GAGE12C
HGNC:31904 GAGE12D
HGNC:31905 GAGE12E
HPAiHPA043232
MIMi300727 gene
300728 gene
300729 gene
neXtProtiNX_A1L429
PharmGKBiPA145148775

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410KIHC Eukaryota
ENOG4110Q8D LUCA
GeneTreeiENSGT00940000153097
HOGENOMiHOG000237345
HOVERGENiHBG056227
InParanoidiA1L429
OrthoDBi1575904at2759
PhylomeDBiA1L429
TreeFamiTF340669

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A1L429

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000216649 Expressed in 50 organ(s), highest expression level in testis
GenevisibleiA1L429 HS

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit
PfamiView protein in Pfam
PF05831 GAGE, 1 hit
SMARTiView protein in SMART
SM01379 GAGE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGG12C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1L429
Secondary accession number(s): A6NHF1, B7ZL74
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 6, 2007
Last modified: January 16, 2019
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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