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Protein

Putative metallothionein MT1DP

Gene

MT1DP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity

Caution

Could be the product of a pseudogene.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster BBy similarity1
Metal bindingi7Divalent metal cation; cluster BBy similarity1
Metal bindingi13Divalent metal cation; cluster BBy similarity1
Metal bindingi15Divalent metal cation; cluster BBy similarity1
Metal bindingi19Divalent metal cation; cluster BBy similarity1
Metal bindingi21Divalent metal cation; cluster BBy similarity1
Metal bindingi26Divalent metal cation; cluster BBy similarity1
Metal bindingi29Divalent metal cation; cluster BBy similarity1
Metal bindingi33Divalent metal cation; cluster ABy similarity1
Metal bindingi34Divalent metal cation; cluster ABy similarity1
Metal bindingi36Divalent metal cation; cluster ABy similarity1
Metal bindingi37Divalent metal cation; cluster ABy similarity1
Metal bindingi41Divalent metal cation; cluster ABy similarity1
Metal bindingi44Divalent metal cation; cluster ABy similarity1
Metal bindingi48Divalent metal cation; cluster ABy similarity1

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Putative metallothionein MT1DP
Gene namesi
Name:MT1DP
Synonyms:MTM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:7396 MT1DP
neXtProtiNX_A1L3X4

Pathology & Biotechi

Organism-specific databases

DisGeNETi326343

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003434261 – 49Putative metallothionein MT1DPAdd BLAST49

Proteomic databases

PRIDEiA1L3X4
ProteomicsDBi144

Interactioni

Binary interactionsi

Protein-protein interaction databases

IntActiA1L3X4, 6 interactors

Structurei

3D structure databases

ProteinModelPortaliA1L3X4
SMRiA1L3X4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 49AlphaAdd BLAST20

Sequence similaritiesi

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit

Sequencei

Sequence statusi: Complete.

A1L3X4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
MDLSCSCATG GSCTCASSCK CKEYKCTSCK KNCCSCCPMG CAKCAQGCT
Length:49
Mass (Da):4,983
Last modified:February 6, 2007 - v1
Checksum:iD3FCBF95F9FBEFA1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45A → S in AAO32959 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348999 mRNA Translation: AAO32959.2
UniGeneiHs.679600

Similar proteinsi

Entry informationi

Entry nameiMT1DP_HUMAN
AccessioniPrimary (citable) accession number: A1L3X4
Secondary accession number(s): Q86YX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: February 6, 2007
Last modified: July 18, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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