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Entry version 99 (07 Oct 2020)
Sequence version 1 (06 Feb 2007)
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Protein
Submitted name:

A kinase (PRKA) anchor protein 4

Gene

Akap4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseImported, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
A kinase (PRKA) anchor protein 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Akap4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:102794, Akap4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A1L3T6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000050089, Expressed in testis and 62 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A1L3T6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1L3T6, MM

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini215 – 233RII_binding_1InterPro annotationAdd BLAST19
Domaini294 – 514AKAP_110InterPro annotationAdd BLAST221
Domaini526 – 727AKAP_110InterPro annotationAdd BLAST202
Domaini743 – 849AKAP_110InterPro annotationAdd BLAST107

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni183 – 210DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi183 – 208PolarSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AKAP110 family.ARBA annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K16521

Database of Orthologous Groups

More...
OrthoDBi
221175at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1L3T6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020799, AKAP_110
IPR018292, AKAP_110_C
IPR018459, RII_binding_1
IPR008382, SPHK1-interactor_AKAP_110

The PANTHER Classification System

More...
PANTHERi
PTHR10226, PTHR10226, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05716, AKAP_110, 3 hits
PF10522, RII_binding_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00807, AKAP_110, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1L3T6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIAYCGTTTM SDDIDWLHSR RGVCKVDLYS PKGQQDQDRK VICFVDVSTL
60 70 80 90 100
NVEDKDSKGA AGSRSEGELN LETLEEKEII VIKDTEKQDQ SKTEGSVCLF
110 120 130 140 150
KQAPSDPISV LNWLLNDLQK YALGFQHALS PSASSCKHKV GDLEGDYSKI
160 170 180 190 200
PSENCYSVYA DQVNFDYLNK GPQNLRLEMA ASKNTNNNQS PSNPATKSPS
210 220 230 240 250
NQRSVATPEG ECSMDDLSFY VNRLSSLVIQ MARKEIKDKL EGGSKCLHHS
260 270 280 290 300
MYTSGDKGKT SPRSAVSKIA SEMAHEAVEL TSSEMRGNGE DCRDGRKTFL
310 320 330 340 350
YSEMCNKNKC GEKQQMCPKD SKEFADSISK GLMVYANQVA SDMMVSVMKT
360 370 380 390 400
LKVHSCGKPI PACVVLKRVL LKHTKEIVSD LIDSCMKNLH NITGVLMTDS
410 420 430 440 450
DFVSAVKRNL FNHGKQNAAD IMEAMLKRLV SALLGEKKET KSQSLAYATL
460 470 480 490 500
KAGTNDPKCK NQSLEFSAMK AEMKGKDKCK SKADPCCKSL TSAERVSEHI
510 520 530 540 550
LKESLTMWNN QKQGNQGKVT NKVCCTSKDE KREKISPSTD SLAKDLIVSA
560 570 580 590 600
LMLIQYHLTQ QAKGKDPCEE ECPGSSMGYM SQSAQYEKCG GGQSSKSLSM
610 620 630 640 650
KHFETRGAPG PSTCMKENQL ESQKMDMSNM VLSLIQKLLS ESPFSCDELT
660 670 680 690 700
ESDNKRCCDP RSSKAAPMAK RPEEQCQDNA ELDFISGMKQ MNRQFIDQLV
710 720 730 740 750
ESVMKLCLIM AKYSNNGAAL AELEEQAALV GSGSRCGRDA MMSQNYSETP
760 770 780 790 800
GPEVIVNNQC STTNLQKQLQ AVLQWIAASQ FNVPMLYFMG DDDGQLEKLP
810 820 830 840
EVSAKAAEKG YSVGDLLQEV MKFAKERQLD EAVGNMARKQ LLDWLLANL
Length:849
Mass (Da):93,796
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8DAC8939CF1CB81A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC130271 mRNA Translation: AAI30272.1

NCBI Reference Sequences

More...
RefSeqi
NP_033781.2, NM_009651.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11643

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:11643

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC130271 mRNA Translation: AAI30272.1
RefSeqiNP_033781.2, NM_009651.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA1L3T6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
470, 142 antibodies

Genome annotation databases

GeneIDi11643
KEGGimmu:11643

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8852
MGIiMGI:102794, Akap4

Phylogenomic databases

KOiK16521
OrthoDBi221175at2759
PhylomeDBiA1L3T6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
11643, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Akap4, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000050089, Expressed in testis and 62 other tissues
ExpressionAtlasiA1L3T6, baseline and differential
GenevisibleiA1L3T6, MM

Family and domain databases

InterProiView protein in InterPro
IPR020799, AKAP_110
IPR018292, AKAP_110_C
IPR018459, RII_binding_1
IPR008382, SPHK1-interactor_AKAP_110
PANTHERiPTHR10226, PTHR10226, 1 hit
PfamiView protein in Pfam
PF05716, AKAP_110, 3 hits
PF10522, RII_binding_1, 1 hit
SMARTiView protein in SMART
SM00807, AKAP_110, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1L3T6_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1L3T6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: October 7, 2020
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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