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Protein

Sodium/hydrogen exchanger

Gene

Slc9a6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • potassium:proton antiporter activity Source: GO_Central
  • sodium:proton antiporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processAntiportUniRule annotationSAAS annotation, Ion transport, Sodium transportUniRule annotation, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-MMU-425986 Sodium/Proton exchangers

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchangerUniRule annotation
Gene namesi
Name:Slc9a6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2443511 Slc9a6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei104 – 121HelicalSequence analysisAdd BLAST18
Transmembranei183 – 200HelicalSequence analysisAdd BLAST18
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Transmembranei327 – 349HelicalSequence analysisAdd BLAST23
Transmembranei369 – 393HelicalSequence analysisAdd BLAST25
Transmembranei414 – 435HelicalSequence analysisAdd BLAST22
Transmembranei447 – 469HelicalSequence analysisAdd BLAST23
Transmembranei481 – 500HelicalSequence analysisAdd BLAST20
Transmembranei506 – 527HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000060681 Expressed in 246 organ(s), highest expression level in lumbar subsegment of spinal cord

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076922

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 535Na_H_ExchangerInterPro annotationAdd BLAST456

Sequence similaritiesi

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1965 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00760000119074
HOGENOMiHOG000172307
HOVERGENiHBG055575
OrthoDBiEOG091G0HN5
TreeFamiTF318755

Family and domain databases

InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR002090 Na/H_exchanger_6
IPR004709 NaH_exchanger
PANTHERiPTHR10110 PTHR10110, 1 hit
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PRINTSiPR01084 NAHEXCHNGR
PR01088 NAHEXCHNGR6
TIGRFAMsiTIGR00840 b_cpa1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A1L3P4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGARRGWRL APVRRGVCGP RARPLMRPLW LLFAVSFFGW TGALDGSGGT
60 70 80 90 100
TRAMDEEIVS EKQAEESHRQ DSANLLIFIL LLTLTILTIW LFKHRRARFL
110 120 130 140 150
HETGLAMIYG LLVGLVLRYG IHVPSDVNNV TLSCEVQSSP TTLLVNVSGK
160 170 180 190 200
FYEYTLKGEI SSHELNNVQD NEMLRKVTFD PEVFFNILLP PIIFYAGYSL
210 220 230 240 250
KRRHFFRNLG SILAYAFLGT AISCFVIGSI MYGCVTLMKV TGQLAGDFYF
260 270 280 290 300
TDCLLFGAIV SATDPVTVLA IFHELQVDVE LYALLFGESV LNDAVAIVLS
310 320 330 340 350
SSIVAYQPAG DNSHTFDVTA MFKSIGIFLG IFSGSFAMGA ATGVVTALVT
360 370 380 390 400
KFTKLREFQL LETGLFFLMS WSTFLLAEAW GFTGVVAVLF CGITQAHYTY
410 420 430 440 450
NNLSTESQHR TKQLFELLNF LAENFIFSYM GLTLFTFQNH VFNPTFVVGA
460 470 480 490 500
FIAIFLGRAA NIYPLSLLLN LGRRSKIGSN FQHMMMFAGL RGAMAFALAI
510 520 530 540 550
RDTATYARQM MFSTTLLIVF FTVWVFGGGT TAMLSCLHIR VGVDSDQEHL
560 570 580 590 600
GVPDNERRTT KAESAWLFRM WYNFDHNYLK PLLTHSGPPL TTTLPACCGP
610 620 630 640 650
IARCLTSPQA YENQEQLKDD DSDLILNDGD ISLTYGDSTV NTESATASAP
660 670 680 690 700
RRFMGNSSED ALDRELTFGD HELVIRGTRL VLPMDDSEPA LNSLDDTRHS

PA
Length:702
Mass (Da):77,953
Last modified:February 6, 2007 - v1
Checksum:i243F0126533B5547
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QZV3B0QZV3_MOUSE
Sodium/hydrogen exchanger
Slc9a6
670Annotation score:
D3Z0Q9D3Z0Q9_MOUSE
Solute carrier family 9 (sodium/hyd...
Slc9a6
313Annotation score:
A0A140LJ55A0A140LJ55_MOUSE
Solute carrier family 9 (sodium/hyd...
Slc9a6
206Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC048362 Genomic DNA No translation available.
AL672085 Genomic DNA No translation available.
BC130221 mRNA Translation: AAI30222.1
RefSeqiNP_766368.2, NM_172780.3
UniGeneiMm.17815

Genome annotation databases

EnsembliENSMUST00000077741; ENSMUSP00000076922; ENSMUSG00000060681
GeneIDi236794
UCSCiuc009tgk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC048362 Genomic DNA No translation available.
AL672085 Genomic DNA No translation available.
BC130221 mRNA Translation: AAI30222.1
RefSeqiNP_766368.2, NM_172780.3
UniGeneiMm.17815

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076922

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077741; ENSMUSP00000076922; ENSMUSG00000060681
GeneIDi236794
UCSCiuc009tgk.2 mouse

Organism-specific databases

CTDi10479
MGIiMGI:2443511 Slc9a6

Phylogenomic databases

eggNOGiKOG1965 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00760000119074
HOGENOMiHOG000172307
HOVERGENiHBG055575
OrthoDBiEOG091G0HN5
TreeFamiTF318755

Enzyme and pathway databases

ReactomeiR-MMU-425986 Sodium/Proton exchangers

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060681 Expressed in 246 organ(s), highest expression level in lumbar subsegment of spinal cord

Family and domain databases

InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR002090 Na/H_exchanger_6
IPR004709 NaH_exchanger
PANTHERiPTHR10110 PTHR10110, 1 hit
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PRINTSiPR01084 NAHEXCHNGR
PR01088 NAHEXCHNGR6
TIGRFAMsiTIGR00840 b_cpa1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA1L3P4_MOUSE
AccessioniPrimary (citable) accession number: A1L3P4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: November 7, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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