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Entry version 119 (02 Jun 2021)
Sequence version 1 (06 Feb 2007)
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Protein

Pleckstrin homology domain-containing family G member 3

Gene

PLEKHG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
A1L390

SIGNOR Signaling Network Open Resource

More...
SIGNORi
A1L390

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleckstrin homology domain-containing family G member 3
Short name:
PH domain-containing family G member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLEKHG3
Synonyms:KIAA0599
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20364, PLEKHG3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617940, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A1L390

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000126822.16

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26030

Open Targets

More...
OpenTargetsi
ENSG00000126822

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134925358

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
A1L390, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLEKHG3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003068631 – 1219Pleckstrin homology domain-containing family G member 3Add BLAST1219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei76PhosphoserineCombined sources1
Modified residuei433PhosphoserineBy similarity1
Modified residuei576PhosphoserineCombined sources1
Modified residuei577PhosphoserineCombined sources1
Modified residuei618PhosphoserineBy similarity1
Modified residuei631PhosphoserineCombined sources1
Modified residuei640PhosphoserineCombined sources1
Modified residuei643PhosphoserineCombined sources1
Modified residuei647PhosphoserineCombined sources1
Modified residuei741PhosphoserineCombined sources1
Modified residuei779PhosphoserineBy similarity1
Modified residuei827PhosphoserineCombined sources1
Modified residuei962PhosphoserineCombined sources1
Modified residuei1011PhosphoserineCombined sources1
Modified residuei1023PhosphoserineBy similarity1
Modified residuei1037PhosphoserineCombined sources1
Modified residuei1040PhosphoserineCombined sources1
Modified residuei1081PhosphoserineCombined sources1
Modified residuei1107Omega-N-methylarginineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A1L390

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A1L390

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
A1L390

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A1L390

PeptideAtlas

More...
PeptideAtlasi
A1L390

PRoteomics IDEntifications database

More...
PRIDEi
A1L390

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
140 [A1L390-1]
141 [A1L390-2]
142 [A1L390-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A1L390

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A1L390

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000126822, Expressed in corpus callosum and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A1L390, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1L390, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000126822, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
117496, 58 interactors

Protein interaction database and analysis system

More...
IntActi
A1L390, 39 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000247226

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A1L390, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1L390

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini93 – 272DHPROSITE-ProRule annotationAdd BLAST180
Domaini296 – 394PHPROSITE-ProRule annotationAdd BLAST99

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 66DisorderedSequence analysisAdd BLAST66
Regioni431 – 599DisorderedSequence analysisAdd BLAST169
Regioni613 – 708DisorderedSequence analysisAdd BLAST96
Regioni756 – 780DisorderedSequence analysisAdd BLAST25
Regioni821 – 840DisorderedSequence analysisAdd BLAST20
Regioni859 – 878DisorderedSequence analysisAdd BLAST20
Regioni955 – 1133DisorderedSequence analysisAdd BLAST179
Regioni1146 – 1207DisorderedSequence analysisAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi446 – 481Basic and acidic residuesSequence analysisAdd BLAST36
Compositional biasi482 – 499Polar residuesSequence analysisAdd BLAST18
Compositional biasi528 – 542Polar residuesSequence analysisAdd BLAST15
Compositional biasi613 – 645Polar residuesSequence analysisAdd BLAST33
Compositional biasi861 – 875Polar residuesSequence analysisAdd BLAST15
Compositional biasi1004 – 1044Polar residuesSequence analysisAdd BLAST41
Compositional biasi1054 – 1068Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1158 – 1187Polar residuesSequence analysisAdd BLAST30

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3518, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156521

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007600_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1L390

Identification of Orthologs from Complete Genome Data

More...
OMAi
SEIVKMW

Database of Orthologous Groups

More...
OrthoDBi
147068at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1L390

TreeFam database of animal gene trees

More...
TreeFami
TF328565

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13243, PH_PLEKHG1_G2_G3, 1 hit
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR043324, PH_PLEKHG1_G2_G3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169, PH, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A1L390-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVSTSLHQD GSQERPVSLT STTSSSGSSC DSRSAMEEPS SSEAPAKNGA
60 70 80 90 100
GSLRSRHLPN SNNNSSSWLN VKGPLSPFNS RAAAGPAHHK LSYLGRVVRE
110 120 130 140 150
IVETERMYVQ DLRSIVEDYL LKIIDTPGLL KPEQVSALFG NIENIYALNS
160 170 180 190 200
QLLRDLDSCN SDPVAVASCF VERSQEFDIY TQYCNNYPNS VAALTECMRD
210 220 230 240 250
KQQAKFFRDR QELLQHSLPL GSYLLKPVQR ILKYHLLLQE IAKHFDEEED
260 270 280 290 300
GFEVVEDAID TMTCVAWYIN DMKRRHEHAV RLQEIQSLLI NWKGPDLTTY
310 320 330 340 350
GELVLEGTFR VHRVRNERTF FLFDKTLLIT KKRGDHFVYK GNIPCSSLML
360 370 380 390 400
IESTRDSLCF TVTHYKHSKQ QYSIQAKTVE EKRNWTHHIK RLILENHHAT
410 420 430 440 450
IPQKAKEAIL EMDSYYPNRY RCSPERLKKA WSSQDEVSTN VRQGRRQSEP
460 470 480 490 500
TKHLLRQLNE KARAAGMKGK GRRESESSRS SRRPSGRSPT STEKRMSFES
510 520 530 540 550
ISSLPEVEPD PEAGSEQEVF SAVEGPSAEE TPSDTESPEV LETQLDAHQG
560 570 580 590 600
LLGMDPPGDM VDFVAAESTE DLKALSSEEE EEMGGAAQEP ESLLPPSVLD
610 620 630 640 650
QASVIAERFV SSFSRRSSVA QEDSKSSGFG SPRLVSRSSS VLSLEGSEKG
660 670 680 690 700
LARHGSATDS LSCQLSPEVD ISVGVATEDS PSVNGMEPPS PGCPVEPDRS
710 720 730 740 750
SCKKKESALS TRDRLLLDKI KSYYENAEHH DAGFSVRRRE SLSYIPKGLV
760 770 780 790 800
RNSISRFNSL PRPDPEPVPP VGSKRQVGSR PTSWALFELP GPSQAVKGDP
810 820 830 840 850
PPISDAEFRP SSEIVKIWEG MESSGGSPGK GPGQGQANGF DLHEPLFILE
860 870 880 890 900
EHELGAITEE SATASPESSS PTEGRSPAHL ARELKELVKE LSSSTQGELV
910 920 930 940 950
APLHPRIVQL SHVMDSHVSE RVKNKVYQLA RQYSLRIKSN KPVMARPPLQ
960 970 980 990 1000
WEKVAPERDG KSPTVPCLQE EAGEPLGGKG KRKPVLSLFD YEQLMAQEHS
1010 1020 1030 1040 1050
PPKPSSAGEM SPQRFFFNPS AVSQRTTSPG GRPSARSPLS PTETFSWPDV
1060 1070 1080 1090 1100
RELCSKYASR DEARRAGGGR PRGPPVNRSH SVPENMVEPP LSGRVGRCRS
1110 1120 1130 1140 1150
LSTKRGRGGG EAAQSPGPLP QSKPDGGETL YVTADLTLED NRRVIVMEKG
1160 1170 1180 1190 1200
PLPSPTAGLE ESSGQGPSSP VALLGQVQDF QQSAECQPKE EGSRDPADPS
1210
QQGRVRNLRE KFQALNSVG
Length:1,219
Mass (Da):134,412
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDAEB5673340F4FBD
GO
Isoform 2 (identifier: A1L390-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-466: Missing.
     467-468: MK → M

Show »
Length:752
Mass (Da):80,886
Checksum:iED46C97F19A331BC
GO
Isoform 3 (identifier: A1L390-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-173: Missing.

Show »
Length:1,163
Mass (Da):128,247
Checksum:i110333017DAC3A6F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RR71A0A0U1RR71_HUMAN
Pleckstrin homology domain-containi...
PLEKHG3
603Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V311G3V311_HUMAN
Pleckstrin homology domain-containi...
PLEKHG3
724Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2V2G3V2V2_HUMAN
Pleckstrin homology domain-containi...
PLEKHG3
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V278G3V278_HUMAN
Pleckstrin homology domain-containi...
PLEKHG3
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3I3G3V3I3_HUMAN
Pleckstrin homology domain-containi...
PLEKHG3
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB84995 differs from that shown. Intron retention. There are two regions of intron retention within the sequence which cause it to shift frame.Curated
The sequence CAD66586 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti443 – 468QGRRQ…AAGMK → KGAGPEPPGSEEEEEEQEES LAVAEQ in AAH04298 (PubMed:15489334).CuratedAdd BLAST26
Sequence conflicti461 – 468KARAAGMK → ESLAVAEQ in AAH73907 (PubMed:15489334).Curated8
Sequence conflicti723 – 736YYENA…AGFSV → WWPHCTPASCSSPT in AAH04298 (PubMed:15489334).CuratedAdd BLAST14
Sequence conflicti921R → S in AAI29953 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0615181014R → H. Corresponds to variant dbSNP:rs41309246Ensembl.1
Natural variantiVAR_0353301036R → W1 PublicationCorresponds to variant dbSNP:rs229649Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0285331 – 466Missing in isoform 2. 1 PublicationAdd BLAST466
Alternative sequenceiVSP_028534118 – 173Missing in isoform 3. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_041513467 – 468MK → M in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL121774 Genomic DNA No translation available.
BC004298 mRNA Translation: AAH04298.1
BC011891 mRNA Translation: AAH11891.2
BC063554 mRNA Translation: AAH63554.1
BC073907 mRNA Translation: AAH73907.1
BC129952 mRNA Translation: AAI29953.1
BC129953 mRNA Translation: AAI29954.1
BX248779 mRNA Translation: CAD66586.1 Different initiation.
AK074169 mRNA Translation: BAB84995.1 Sequence problems.
AB011171 mRNA Translation: BAA25525.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS76690.1 [A1L390-1]

Protein sequence database of the Protein Information Resource

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PIRi
T00267

NCBI Reference Sequences

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RefSeqi
NP_001295076.1, NM_001308147.1 [A1L390-1]
XP_016876646.1, XM_017021157.1 [A1L390-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000247226; ENSP00000247226; ENSG00000126822 [A1L390-1]
ENST00000394691; ENSP00000378183; ENSG00000126822 [A1L390-3]
ENST00000471182; ENSP00000450945; ENSG00000126822 [A1L390-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
26030

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:26030

UCSC genome browser

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UCSCi
uc001xhn.2, human [A1L390-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121774 Genomic DNA No translation available.
BC004298 mRNA Translation: AAH04298.1
BC011891 mRNA Translation: AAH11891.2
BC063554 mRNA Translation: AAH63554.1
BC073907 mRNA Translation: AAH73907.1
BC129952 mRNA Translation: AAI29953.1
BC129953 mRNA Translation: AAI29954.1
BX248779 mRNA Translation: CAD66586.1 Different initiation.
AK074169 mRNA Translation: BAB84995.1 Sequence problems.
AB011171 mRNA Translation: BAA25525.1
CCDSiCCDS76690.1 [A1L390-1]
PIRiT00267
RefSeqiNP_001295076.1, NM_001308147.1 [A1L390-1]
XP_016876646.1, XM_017021157.1 [A1L390-1]

3D structure databases

SMRiA1L390
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117496, 58 interactors
IntActiA1L390, 39 interactors
STRINGi9606.ENSP00000247226

PTM databases

iPTMnetiA1L390
PhosphoSitePlusiA1L390

Genetic variation databases

BioMutaiPLEKHG3

Proteomic databases

EPDiA1L390
jPOSTiA1L390
MassIVEiA1L390
MaxQBiA1L390
PeptideAtlasiA1L390
PRIDEiA1L390
ProteomicsDBi140 [A1L390-1]
141 [A1L390-2]
142 [A1L390-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
57155, 79 antibodies

The DNASU plasmid repository

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DNASUi
26030

Genome annotation databases

EnsembliENST00000247226; ENSP00000247226; ENSG00000126822 [A1L390-1]
ENST00000394691; ENSP00000378183; ENSG00000126822 [A1L390-3]
ENST00000471182; ENSP00000450945; ENSG00000126822 [A1L390-2]
GeneIDi26030
KEGGihsa:26030
UCSCiuc001xhn.2, human [A1L390-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26030
DisGeNETi26030

GeneCards: human genes, protein and diseases

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GeneCardsi
PLEKHG3
HGNCiHGNC:20364, PLEKHG3
HPAiENSG00000126822, Low tissue specificity
MIMi617940, gene
neXtProtiNX_A1L390
OpenTargetsiENSG00000126822
PharmGKBiPA134925358
VEuPathDBiHostDB:ENSG00000126822.16

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3518, Eukaryota
GeneTreeiENSGT00940000156521
HOGENOMiCLU_007600_0_0_1
InParanoidiA1L390
OMAiSEIVKMW
OrthoDBi147068at2759
PhylomeDBiA1L390
TreeFamiTF328565

Enzyme and pathway databases

PathwayCommonsiA1L390
SIGNORiA1L390

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
26030, 119 hits in 986 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26030
PharosiA1L390, Tdark

Protein Ontology

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PROi
PR:A1L390
RNActiA1L390, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000126822, Expressed in corpus callosum and 210 other tissues
ExpressionAtlasiA1L390, baseline and differential
GenevisibleiA1L390, HS

Family and domain databases

CDDicd13243, PH_PLEKHG1_G2_G3, 1 hit
cd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR043324, PH_PLEKHG1_G2_G3
PfamiView protein in Pfam
PF00169, PH, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKHG3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1L390
Secondary accession number(s): A1L389
, B5MEC9, O60339, Q6GMS3, Q6P4B1, Q7L3S3, Q86SW7, Q8TEF5, Q96EW6, Q9BT82
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 6, 2007
Last modified: June 2, 2021
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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