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Entry version 75 (02 Jun 2021)
Sequence version 1 (06 Feb 2007)
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Protein

Equilibrative nucleoside transporter 4

Gene

slc29a4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-83936, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Equilibrative nucleoside transporter 4
Alternative name(s):
Solute carrier family 29 member 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:slc29a4
ORF Names:zgc:158679
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-070112-1932, slc29a4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 66ExtracellularSequence analysisAdd BLAST66
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Topological domaini88 – 99CytoplasmicSequence analysisAdd BLAST12
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 133ExtracellularSequence analysisAdd BLAST13
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Topological domaini155 – 157CytoplasmicSequence analysis3
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 198ExtracellularSequence analysisAdd BLAST20
Transmembranei199 – 218HelicalSequence analysisAdd BLAST20
Topological domaini219 – 229CytoplasmicSequence analysisAdd BLAST11
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 342ExtracellularSequence analysisAdd BLAST92
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 376CytoplasmicSequence analysisAdd BLAST13
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 407ExtracellularSequence analysis10
Transmembranei408 – 428HelicalSequence analysisAdd BLAST21
Topological domaini429 – 439CytoplasmicSequence analysisAdd BLAST11
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Topological domaini461 – 476ExtracellularSequence analysisAdd BLAST16
Transmembranei477 – 497HelicalSequence analysisAdd BLAST21
Topological domaini498 – 518CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003262531 – 518Equilibrative nucleoside transporter 4Add BLAST518

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1L272

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000117850

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1L272

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1479, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1L272

Database of Orthologous Groups

More...
OrthoDBi
674800at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1L272

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030198, ENT4
IPR002259, Eqnu_transpt
IPR036259, MFS_trans_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10332, PTHR10332, 1 hit
PTHR10332:SF4, PTHR10332:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01733, Nucleoside_tran, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF016379, ENT, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01130, DERENTRNSPRT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A1L272-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSKGAERRK QATPGQTPEG NVVMSFSFES YQLEEEDCQG KDISDKGVLA
60 70 80 90 100
LSEPAFEEAV PDDRYHGIYF AMLLAGVGFL LPYNSFITDV DYLHHKFEGT
110 120 130 140 150
SIVFDMGLTY ILVALVAVIL NNVLVEMLSL HTRITVGYLF ALGPLLFVTI
160 170 180 190 200
FDVWLERFTI KQAYVINLMS MGTVAFGCTV QQSSFYGYMG MLPKRYTQGV
210 220 230 240 250
MTGESTAGVI ISLSRIFTKL LIKDERKNTI IFFVISICMV LVCFILHLLV
260 270 280 290 300
RRTRFVQYYT SLARRGLSHA KDHSQHASQY QVHHDVITEE GNGAVGCSPA
310 320 330 340 350
GDGCADFAGG NTYVRFDVPK PKMKRSWPGV KDMILHRYVV ARVIWTYMLS
360 370 380 390 400
IAVTYFITLC LFPGLESEIK NATLGEWLPI LIMAIFNISD FVGKILAAVP
410 420 430 440 450
YEWNGTRLLF FSCVRVVFIP LFIMCVYPAQ MPMFSHPAWP CIFSLFMGIT
460 470 480 490 500
NGYFGSVPMI HAAGKVAPEQ RELAGNIMTV SYMSGLMLGS VVAYAAYSFT
510
ASGSSFHSQT GYNFTQGY
Length:518
Mass (Da):57,779
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D0AA3532572350F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QE61F1QE61_DANRE
Equilibrative nucleoside transporte...
slc29a4
518Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC129376 mRNA Translation: AAI29377.1

NCBI Reference Sequences

More...
RefSeqi
NP_001074041.1, NM_001080572.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
559668

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:559668

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129376 mRNA Translation: AAI29377.1
RefSeqiNP_001074041.1, NM_001080572.1

3D structure databases

SMRiA1L272
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000117850

Proteomic databases

PaxDbiA1L272

Genome annotation databases

GeneIDi559668
KEGGidre:559668

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
222962
ZFINiZDB-GENE-070112-1932, slc29a4

Phylogenomic databases

eggNOGiKOG1479, Eukaryota
InParanoidiA1L272
OrthoDBi674800at2759
PhylomeDBiA1L272

Enzyme and pathway databases

ReactomeiR-DRE-83936, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A1L272

Family and domain databases

InterProiView protein in InterPro
IPR030198, ENT4
IPR002259, Eqnu_transpt
IPR036259, MFS_trans_sf
PANTHERiPTHR10332, PTHR10332, 1 hit
PTHR10332:SF4, PTHR10332:SF4, 1 hit
PfamiView protein in Pfam
PF01733, Nucleoside_tran, 1 hit
PIRSFiPIRSF016379, ENT, 1 hit
PRINTSiPR01130, DERENTRNSPRT
SUPFAMiSSF103473, SSF103473, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS29A4_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1L272
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 6, 2007
Last modified: June 2, 2021
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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