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UniProtKB - A1L1W9 (MOT10_DANRE)
Protein
Monocarboxylate transporter 10
Gene
slc16a10
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Sodium-independent transporter that mediates the uptake of aromatic acids.
By similarityGO - Molecular functioni
- aromatic amino acid transmembrane transporter activity Source: InterPro
- thyroid hormone transmembrane transporter activity Source: InterPro
Enzyme and pathway databases
Reactomei | R-DRE-352230, Amino acid transport across the plasma membrane |
Protein family/group databases
TCDBi | 2.A.1.13.26, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Monocarboxylate transporter 10Short name: MCT 10 Alternative name(s): Solute carrier family 16 member 10 |
Gene namesi | Name:slc16a10 ORF Names:si:ch211-241j12.1, zgc:158478 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040724-214, slc16a10 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: InterPro
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 66 | CytoplasmicSequence analysisAdd BLAST | 66 | |
Transmembranei | 67 – 87 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 115 – 135 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 143 – 163 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 172 – 192 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 205 – 225 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 236 – 256 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 287 – 307 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 322 – 342 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 344 – 364 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 378 – 400 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 412 – 432 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 444 – 464 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 465 – 505 | CytoplasmicSequence analysisAdd BLAST | 41 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000314256 | 1 – 505 | Monocarboxylate transporter 10Add BLAST | 505 |
Proteomic databases
PaxDbi | A1L1W9 |
PeptideAtlasi | A1L1W9 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000020984, Expressed in intestine and 27 other tissues |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 64 | DisorderedSequence analysisAdd BLAST | 64 | |
Regioni | 474 – 505 | DisorderedSequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 9 – 31 | Pro residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 38 – 62 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 485 – 505 | Basic and acidic residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2504, Eukaryota |
GeneTreei | ENSGT00940000157966 |
HOGENOMi | CLU_001265_59_1_1 |
InParanoidi | A1L1W9 |
OMAi | FYSLWIM |
OrthoDBi | 916876at2759 |
PhylomeDBi | A1L1W9 |
TreeFami | TF313792 |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR030762, MCT10 IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
PANTHERi | PTHR11360:SF119, PTHR11360:SF119, 1 hit |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
A1L1W9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEPEPTLEQ EPTPEPEPTQ EPTPEPTPEP EPTQEPESEP ELELKQENGC
60 70 80 90 100
TKASEQKSPE EFEPPEGGWG WVVMLASMWC NGSVFGIQNA FGIMFVYLLN
110 120 130 140 150
EFGSEHDADL RFKTAWVGSL SMGMIFFCSP IVSVFTDLLG CRITAVGGAA
160 170 180 190 200
VGCVGLLASS FVTSLGPMYF TYGIVFACGC SFAYQPSLVI LGHYFKRRLG
210 220 230 240 250
LVNGIVTAGS SVFTITLPYM LSGLLKSVGL YHTLRVLAIF MFILMLAGLT
260 270 280 290 300
YKPLLPKPVS SSKPGSRCPP LSRIFNVNIW KSLGYRIWAF GIPAALYGYF
310 320 330 340 350
VPYVHLMTHV EERFGPEANK EVLLACIGIT SGVGRLIFGR VADYVPGVNK
360 370 380 390 400
VFLQVSSFMV IGVMSMMIPL CHVFGGLIAV CLLMGLFDGC FICIMAPIAF
410 420 430 440 450
ELVGSQNVSQ AIGFLLGMMS IPMTVGPPIA GFLRDRLGSY DVAFYLAGIP
460 470 480 490 500
PLIGGAVLCA IPWVEARRKR REAANTAENT EKMLESRSPP LEDTVCRTEE
PESVI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC129246 mRNA Translation: AAI29247.1 BX511077 Genomic DNA Translation: CAI11884.1 |
RefSeqi | NP_001073497.1, NM_001080028.1 XP_005160357.1, XM_005160300.3 |
Genome annotation databases
Ensembli | ENSDART00000104762; ENSDARP00000095532; ENSDARG00000020984 ENSDART00000131635; ENSDARP00000119035; ENSDARG00000020984 |
GeneIDi | 566499 |
KEGGi | dre:566499 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC129246 mRNA Translation: AAI29247.1 BX511077 Genomic DNA Translation: CAI11884.1 |
RefSeqi | NP_001073497.1, NM_001080028.1 XP_005160357.1, XM_005160300.3 |
3D structure databases
SMRi | A1L1W9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000095532 |
Protein family/group databases
TCDBi | 2.A.1.13.26, the major facilitator superfamily (mfs) |
Proteomic databases
PaxDbi | A1L1W9 |
PeptideAtlasi | A1L1W9 |
Genome annotation databases
Ensembli | ENSDART00000104762; ENSDARP00000095532; ENSDARG00000020984 ENSDART00000131635; ENSDARP00000119035; ENSDARG00000020984 |
GeneIDi | 566499 |
KEGGi | dre:566499 |
Organism-specific databases
CTDi | 117247 |
ZFINi | ZDB-GENE-040724-214, slc16a10 |
Phylogenomic databases
eggNOGi | KOG2504, Eukaryota |
GeneTreei | ENSGT00940000157966 |
HOGENOMi | CLU_001265_59_1_1 |
InParanoidi | A1L1W9 |
OMAi | FYSLWIM |
OrthoDBi | 916876at2759 |
PhylomeDBi | A1L1W9 |
TreeFami | TF313792 |
Enzyme and pathway databases
Reactomei | R-DRE-352230, Amino acid transport across the plasma membrane |
Miscellaneous databases
PROi | PR:A1L1W9 |
Gene expression databases
Bgeei | ENSDARG00000020984, Expressed in intestine and 27 other tissues |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR030762, MCT10 IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
PANTHERi | PTHR11360:SF119, PTHR11360:SF119, 1 hit |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MOT10_DANRE | |
Accessioni | A1L1W9Primary (citable) accession number: A1L1W9 Secondary accession number(s): Q5RHJ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | February 6, 2007 | |
Last modified: | February 23, 2022 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families