Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 81 (02 Jun 2021)
Sequence version 1 (06 Feb 2007)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Zgc:158452

Gene

tp53bp1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • histone binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zgc:158452Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tp53bp1Imported
ORF Names:zgc:158452Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-3695, tp53bp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A1L1W2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1476 – 1592BRCTInterPro annotationAdd BLAST117
Domaini1607 – 1702BRCTInterPro annotationAdd BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni159 – 208DisorderedSequence analysisAdd BLAST50
Regioni242 – 264DisorderedSequence analysisAdd BLAST23
Regioni297 – 441DisorderedSequence analysisAdd BLAST145
Regioni467 – 798DisorderedSequence analysisAdd BLAST332
Regioni818 – 846DisorderedSequence analysisAdd BLAST29
Regioni930 – 982DisorderedSequence analysisAdd BLAST53
Regioni1012 – 1079DisorderedSequence analysisAdd BLAST68
Regioni1111 – 1247DisorderedSequence analysisAdd BLAST137
Regioni1390 – 1443DisorderedSequence analysisAdd BLAST54

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi164 – 202Polar residuesSequence analysisAdd BLAST39
Compositional biasi249 – 264Polar residuesSequence analysisAdd BLAST16
Compositional biasi297 – 327Polar residuesSequence analysisAdd BLAST31
Compositional biasi377 – 439Polar residuesSequence analysisAdd BLAST63
Compositional biasi467 – 493Polar residuesSequence analysisAdd BLAST27
Compositional biasi503 – 517Polar residuesSequence analysisAdd BLAST15
Compositional biasi529 – 579Polar residuesSequence analysisAdd BLAST51
Compositional biasi591 – 610Polar residuesSequence analysisAdd BLAST20
Compositional biasi622 – 636Polar residuesSequence analysisAdd BLAST15
Compositional biasi662 – 676Polar residuesSequence analysisAdd BLAST15
Compositional biasi693 – 734Polar residuesSequence analysisAdd BLAST42
Compositional biasi745 – 794Polar residuesSequence analysisAdd BLAST50
Compositional biasi931 – 945Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi946 – 982Polar residuesSequence analysisAdd BLAST37
Compositional biasi1024 – 1079Polar residuesSequence analysisAdd BLAST56
Compositional biasi1111 – 1125Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1131 – 1168Polar residuesSequence analysisAdd BLAST38
Compositional biasi1224 – 1247Polar residuesSequence analysisAdd BLAST24
Compositional biasi1399 – 1415Polar residuesSequence analysisAdd BLAST17
Compositional biasi1422 – 1436Basic and acidic residuesSequence analysisAdd BLAST15

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
27155at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1L1W2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04508, TUDOR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.30, 1 hit
3.40.50.10190, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015125, 53-BP1_Tudor
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR014722, Rib_L2_dom2
IPR002999, Tudor

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09038, 53-BP1_Tudor, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52113, SSF52113, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172, BRCT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1L1W2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPGESDLDS SFPQTENPCL IVEDSQPDSV ALEDDPDTSY CALLARRLSN
60 70 80 90 100
LQPTSQSPVL ELISSPTKSC CLQTGSQIDK GGNTAHSDNL QNNLGSAATE
110 120 130 140 150
HSQVFEVCSL PVSKRTVTEH MESEANSTTH CTEAHEEMSQ FGLLELSESQ
160 170 180 190 200
GVFEEDDLDG ANKKNVQKPT SQYVLKSSER VLSNKDGNST GSEVTSSCPL
210 220 230 240 250
KPQDGESRKL SIQAILHSQL PDSQEDEEDV LVSSQDDMFE KETNGTKADS
260 270 280 290 300
SVSEHLPTST PAQSLRLLHL SGQGTYVQES LSQQSVDFVA ATQDNLSQTP
310 320 330 340 350
YIVPNSPTEK DQNCNETAES PMDTSAPPED QPQGREEEPM DTDPCPKPQP
360 370 380 390 400
TASTPVSQNS PGFILEKRLS VPSQPEFSHD VFISTPSLEP VNNNQGTEAS
410 420 430 440 450
KRQLPHPNCT SATESTPPKP SSPEEQLNKS SSSFSQPCEA AEDFQLELSS
460 470 480 490 500
ENSCFALKTQ SFIVEEDSQA TQIQDQGTVV TDKSNSSPKP HSQNEDKNST
510 520 530 540 550
DSEPSKASNS NVPDSKITSA VPEKAEDLNI SQKLNNGGNQ IANATPGATL
560 570 580 590 600
SQLSVSSECV SATPNLPQTS KSTDAGCPQA SPLTDKPATP VPVAQHTQSQ
610 620 630 640 650
SVLTASSQKN TGNKEKHDGQ NQRLSQPMLH SHSVTTDSVR NVEEEEQMEE
660 670 680 690 700
GEIKSTVKGD DTGINLALSQ SQALSPEPME EEEEKGEASI RSSSREESFS
710 720 730 740 750
VMVLEESQRV SQEKVQKGKS PPFKSSSQPV SGSIQDKPEA LAKISGSQPV
760 770 780 790 800
SSTKVSPLRL EKTKSQNTQP SSSGQQKVNS DNAANKSLSD SSGELPFHFT
810 820 830 840 850
LPKEGELIRP AVSATPPQIS LLKKTPRHST PIEMNSFSEP SVGDVTRETM
860 870 880 890 900
ANSEISVEES REGEEPVAAE QDGKLSLRMK LVTPVEEGSS GPECFSLQKP
910 920 930 940 950
SLTDEEGSVS KATAVAMAVT SPSVFSRVRE VHRQTQVEDD AESSDPLIRQ
960 970 980 990 1000
PSQLLSPTIT NDSELSPNCP KETSNSSRAS VTEAVSLNPG ALEADSEALV
1010 1020 1030 1040 1050
SGLLSPARER EALDTFDRPQ TPVRKKAVSQ QTSVDISSTT SPPSKKAVSQ
1060 1070 1080 1090 1100
QTSFDLSGPH NLSGRGEPST PTRTQPVPSL RRHVRTIQEV RTTVTRIITD
1110 1120 1130 1140 1150
VYYEDGREVN RKVTQESEEP VVDRCVVEND ISPSRTGSSM TSGDLADVSS
1160 1170 1180 1190 1200
LSSKAPSHHS SSGTSSGGLG PIRMPDFLMP PSRGAKFGRG GRPGQRGGAH
1210 1220 1230 1240 1250
APGGASSSEE EPFAQRHVQM PISPVEPSAT SHSESLNTTS PDNSTGSSSF
1260 1270 1280 1290 1300
VGLRVLAKWS SNSYFYSGSI TRDLGENRFR LLFDDNQECE VQGKDILLCD
1310 1320 1330 1340 1350
PIPLETEVTA LTEEEYFNIG VVKGHKTQGS EFLYCVEKDG QSSYYSRTSV
1360 1370 1380 1390 1400
ILSMEQGSRL REQYGLGPYE PSTPQTMACD ISLDNLVEGK RRRRGNCSGA
1410 1420 1430 1440 1450
GTPTRSSSNS PRNPGPSGKR KLISCTEEER TPPKRGRRGA GARVGRRIAA
1460 1470 1480 1490 1500
CNTSGSGVDL PPDPNDLVAT HGPLPENSSL FMGFVFLLTA SSEGDRYSSH
1510 1520 1530 1540 1550
QSSDEDEEYV QRAPYNKHYT VSQLEAGGGM ILLDFNEEQC KAAYQSLLIA
1560 1570 1580 1590 1600
DQHCRTRKYL LCVAGGVPCV SQMWVRDCCQ EKKLLNYRNY LLPAGLGPEG
1610 1620 1630 1640 1650
RIVEWHPRSN PFKALKVMLI AEDRVDLWTS LLSMGGAEKV YRQESQNISD
1660 1670 1680 1690 1700
IPDVKFDVAV TSSACTSEEV KRVASDMPVV SLEWLIQSLI CGKCLNFDSN

SEFCHNTST
Length:1,709
Mass (Da):184,749
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0B209D9B5028AEC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC129236 mRNA Translation: AAI29237.1

NCBI Reference Sequences

More...
RefSeqi
NP_001073639.1, NM_001080170.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
557086

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:557086

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129236 mRNA Translation: AAI29237.1
RefSeqiNP_001073639.1, NM_001080170.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiA1L1W2

Genome annotation databases

GeneIDi557086
KEGGidre:557086

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7158
ZFINiZDB-GENE-030131-3695, tp53bp1

Phylogenomic databases

OrthoDBi27155at2759
PhylomeDBiA1L1W2

Family and domain databases

CDDicd04508, TUDOR, 1 hit
Gene3Di2.30.30.30, 1 hit
3.40.50.10190, 2 hits
InterProiView protein in InterPro
IPR015125, 53-BP1_Tudor
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR014722, Rib_L2_dom2
IPR002999, Tudor
PfamiView protein in Pfam
PF09038, 53-BP1_Tudor, 1 hit
SUPFAMiSSF52113, SSF52113, 2 hits
PROSITEiView protein in PROSITE
PS50172, BRCT, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1L1W2_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1L1W2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: June 2, 2021
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again